CA2759706A1 - Piperazinyl azetidinyl amides heteroaromatiques et aromatiques en tant qu'inhibiteurs de la monoacylglycerol lipase - Google Patents

Piperazinyl azetidinyl amides heteroaromatiques et aromatiques en tant qu'inhibiteurs de la monoacylglycerol lipase Download PDF

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Publication number
CA2759706A1
CA2759706A1 CA2759706A CA2759706A CA2759706A1 CA 2759706 A1 CA2759706 A1 CA 2759706A1 CA 2759706 A CA2759706 A CA 2759706A CA 2759706 A CA2759706 A CA 2759706A CA 2759706 A1 CA2759706 A1 CA 2759706A1
Authority
CA
Canada
Prior art keywords
compound
isobutyl
cyclohexylmethyl
phenyl
disorder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2759706A
Other languages
English (en)
Inventor
Christopher M. Flores
Marina I. Nelen
Erica L. Nulton
Stephen Prouty
Matthew Todd
Sui-Po Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of CA2759706A1 publication Critical patent/CA2759706A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
CA2759706A 2009-04-22 2010-04-22 Piperazinyl azetidinyl amides heteroaromatiques et aromatiques en tant qu'inhibiteurs de la monoacylglycerol lipase Abandoned CA2759706A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17166109P 2009-04-22 2009-04-22
US61/171,661 2009-04-22
PCT/US2010/032100 WO2010124122A1 (fr) 2009-04-22 2010-04-22 Pipérazinyl azétidinyl amides hétéroaromatiques et aromatiques en tant qu'inhibiteurs de la monoacylglycérol lipase

Publications (1)

Publication Number Publication Date
CA2759706A1 true CA2759706A1 (fr) 2010-10-28

Family

ID=42226535

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2759706A Abandoned CA2759706A1 (fr) 2009-04-22 2010-04-22 Piperazinyl azetidinyl amides heteroaromatiques et aromatiques en tant qu'inhibiteurs de la monoacylglycerol lipase

Country Status (11)

Country Link
EP (1) EP2421535A1 (fr)
JP (1) JP2012524810A (fr)
KR (1) KR20120005517A (fr)
CN (1) CN102458407B (fr)
AU (1) AU2010238746B2 (fr)
BR (1) BRPI1014874A2 (fr)
CA (1) CA2759706A1 (fr)
IL (1) IL215797A0 (fr)
RU (1) RU2011147201A (fr)
TW (1) TW201103914A (fr)
WO (1) WO2010124122A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2760450A1 (fr) * 2011-09-30 2014-08-06 Janssen Pharmaceutica, N.V. Inhibiteurs de monoacylglycérol lipase pour le traitement de maladies métaboliques et de troubles apparentés
EP2935294A4 (fr) 2012-12-21 2016-08-31 Univ California Méthodes et compositions pour le traitement de la toxicité du cyanure et de sulfure d'hydrogène
JP6454349B2 (ja) * 2013-12-26 2019-01-16 武田薬品工業株式会社 モノアシルグリセロールリパーゼ（ｍａｇｌ）阻害剤としての４−（ピペラジン−１−イル）−ピロリジン−２−オン化合物
WO2016158956A1 (fr) * 2015-03-30 2016-10-06 武田薬品工業株式会社 Composé hétérocyclique
US10463753B2 (en) 2016-02-19 2019-11-05 Lundbeck La Jolla Research Center, Inc. Radiolabeled monoacylglycerol lipase occupancy probe
BR112018068538B1 (pt) 2016-03-31 2023-12-12 Takeda Pharmaceutical Company Limited Composto, medicamento, e, uso de um composto
WO2017170830A1 (fr) 2016-03-31 2017-10-05 武田薬品工業株式会社 Composé hétérocyclique
MX2020007318A (es) 2017-09-29 2020-08-24 Takeda Pharmaceuticals Co Compuesto heterociclico.
EP3717477B1 (fr) 2017-11-28 2022-07-20 F. Hoffmann-La Roche AG Nouveaux composés hétérocycliques
TW201930300A (zh) * 2017-12-15 2019-08-01 瑞士商赫孚孟拉羅股份公司 新雜環化合物
EP3856178A1 (fr) * 2018-09-28 2021-08-04 Janssen Pharmaceutica NV Modulateurs de la monoacylglycérol lipase

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2915199B1 (fr) * 2007-04-18 2010-01-22 Sanofi Aventis Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique.
EP2180048B1 (fr) * 2008-10-09 2014-12-17 Janssen Pharmaceutica N.V. Forme cristalline alternative de la monoacylglycérol lipase (MGLL)

Also Published As

Publication number Publication date
CN102458407B (zh) 2014-03-05
KR20120005517A (ko) 2012-01-16
AU2010238746B2 (en) 2015-02-19
WO2010124122A1 (fr) 2010-10-28
CN102458407A (zh) 2012-05-16
IL215797A0 (en) 2012-01-31
JP2012524810A (ja) 2012-10-18
BRPI1014874A2 (pt) 2016-04-12
RU2011147201A (ru) 2013-05-27
AU2010238746A1 (en) 2011-11-10
EP2421535A1 (fr) 2012-02-29
TW201103914A (en) 2011-02-01

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20150421

FZDE Discontinued

Effective date: 20170712