RU2011139724A - Композиции и способы, используемые для ускорения заживления ран и регенерации тканей - Google Patents

Композиции и способы, используемые для ускорения заживления ран и регенерации тканей Download PDF

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RU2011139724A
RU2011139724A RU2011139724/15A RU2011139724A RU2011139724A RU 2011139724 A RU2011139724 A RU 2011139724A RU 2011139724/15 A RU2011139724/15 A RU 2011139724/15A RU 2011139724 A RU2011139724 A RU 2011139724A RU 2011139724 A RU2011139724 A RU 2011139724A
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seq
nucleic acid
isolated nucleic
connexin
composition
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Роберт ГОУРДИ
Гаутам ГХАТНЕКАР
Джейн ДЖОУРДАН
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Маск Фаундейшн Фор Рисерч Дивелопмент
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    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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Abstract

1. Выделенная нуклеиновая кислота, кодирующая полипептид состоящий из 4-30 последовательных аминокислот карбокси-конца белка альфа-коннексина, или его консервативный вариант, где указанный по меньшей мере один полипептид альфа-коннексина связан на своем амино-конце с переносчиком клеточной интернализации.2. Выделенная нуклеиновая кислота по п.1, где указанный белок альфа-коннексин представляет собой коннексин 37, коннексин 40, коннексин 43 или коннексин 45.3. Выделенная нуклеиновая кислота по п.1, где указанный полипептид содержит аминокислотную последовательность, выбранную из группы, состоящей из SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5 и SEQ ID NO:43.4. Выделенная нуклеиновая кислота по п.1, где указанный переносчик клеточной интернализации выбран из группы, состоящей из Antennapedia, TAT, HIV-Tat, Penetratin, Antp-3A, Buforin II, Transportan, модельного амфипатического пептида (MAP), K-FGF, Ku70, Prion, pVEC, Pep-I, SynBl, Pep-7 и HN-l.5. Выделенная нуклеиновая кислота по п.4, где указанная нуклеиновая кислота кодирует полипептид, содержащий аминокислотную последовательность, выбранную из группы, состоящей из SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:56, SEQ ID NO:57, SEQ ID NO:58, SEQ ID NO:59, SEQ ID NO:60, SEQ ID NO:61, SEQ ID NO:62, SEQ ID NO:63, SEQ ID NO:64, SEQ ID NO:65, SEQ ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:69 и SEQ ID NO:70.6. Выделенная нуклеиновая кислота по п.1, где указанная нуклеиновая кислота содержит последовательность, выбранную из группы, состоящей из SEQ ID NO:13, SEQ ID NO:85, SEQ ID NO:86, SEQ ID NO:87, SEQ ID NO:88, SEQ ID NO:89.7. Выделенная нуклеиновая кислота по п.1, где указанный по меньшей мере один полипептид состоит из 5-19 последовательных аминокислот карбокси-конца белка альфа-коннексина.8. Выделенная нуклеиновая кислота по п.1, где указанный по меньшей мере один �

Claims (22)

1. Выделенная нуклеиновая кислота, кодирующая полипептид состоящий из 4-30 последовательных аминокислот карбокси-конца белка альфа-коннексина, или его консервативный вариант, где указанный по меньшей мере один полипептид альфа-коннексина связан на своем амино-конце с переносчиком клеточной интернализации.
2. Выделенная нуклеиновая кислота по п.1, где указанный белок альфа-коннексин представляет собой коннексин 37, коннексин 40, коннексин 43 или коннексин 45.
3. Выделенная нуклеиновая кислота по п.1, где указанный полипептид содержит аминокислотную последовательность, выбранную из группы, состоящей из SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5 и SEQ ID NO:43.
4. Выделенная нуклеиновая кислота по п.1, где указанный переносчик клеточной интернализации выбран из группы, состоящей из Antennapedia, TAT, HIV-Tat, Penetratin, Antp-3A, Buforin II, Transportan, модельного амфипатического пептида (MAP), K-FGF, Ku70, Prion, pVEC, Pep-I, SynBl, Pep-7 и HN-l.
5. Выделенная нуклеиновая кислота по п.4, где указанная нуклеиновая кислота кодирует полипептид, содержащий аминокислотную последовательность, выбранную из группы, состоящей из SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:56, SEQ ID NO:57, SEQ ID NO:58, SEQ ID NO:59, SEQ ID NO:60, SEQ ID NO:61, SEQ ID NO:62, SEQ ID NO:63, SEQ ID NO:64, SEQ ID NO:65, SEQ ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:69 и SEQ ID NO:70.
6. Выделенная нуклеиновая кислота по п.1, где указанная нуклеиновая кислота содержит последовательность, выбранную из группы, состоящей из SEQ ID NO:13, SEQ ID NO:85, SEQ ID NO:86, SEQ ID NO:87, SEQ ID NO:88, SEQ ID NO:89.
7. Выделенная нуклеиновая кислота по п.1, где указанный по меньшей мере один полипептид состоит из 5-19 последовательных аминокислот карбокси-конца белка альфа-коннексина.
8. Выделенная нуклеиновая кислота по п.1, где указанный по меньшей мере один полипептид состоит из 9 последовательных аминокислот карбокси-конца белка альфа-коннексина.
9. Выделенная нуклеиновая кислота по п.1, где нуклеиновая кислота функционально связана с последовательностью, контролирующей экспрессию.
10. Вектор, содержащий нуклеиновую кислоту по п.9.
11. Вектор по п.10, где вектор представляет собой вирус.
12. Клетка, содержащая вектор по п.10.
13. Клетка по п.12, где клетка является эукариотической клеткой.
14. Состав для местного нанесения, содержащий выделенную нуклеиновую кислоту по п.1.
15. Состав по п.14, где указанная выделенная нуклеиновая кислота функционально связана с последовательностью, контролирующей экспрессию.
16. Состав по п.15, где указанная выделенная нуклеиновая кислота кодируется вирусным вектором.
17. Состав по п.14, где указанный состав представляет собой мазь, лосьон, спрей, крем или гель.
18. Состав по п.17, где указанный гель представляет собой гель плуроника.
19. Состав по п.17, где указанный гель является гидрогелем.
20. Состав по п.17, где указанный состав является полоксамером.
21. Состав по п.14, где указанный состав дополнительно содержит коллагеновый полимер.
22. Состав по п.14, где указанный состав дополнительно содержит антибиотик, стероидный препарат, анальгетик, противовоспалительное средство, антигистаминное средство, хемотерапевтический агент или другой терапевтический пептид или их сочетание.
RU2011139724/15A 2004-12-21 2011-09-29 Композиции и способы, используемые для ускорения заживления ран и регенерации тканей RU2582394C2 (ru)

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