RU2010135794A - Амиды 3-(4-фторфенил)-3-гидрокси-2-аминопропионовой кислоты и родственные соединения, обладающие обезболивающим действием - Google Patents
Амиды 3-(4-фторфенил)-3-гидрокси-2-аминопропионовой кислоты и родственные соединения, обладающие обезболивающим действием Download PDFInfo
- Publication number
- RU2010135794A RU2010135794A RU2010135794/04A RU2010135794A RU2010135794A RU 2010135794 A RU2010135794 A RU 2010135794A RU 2010135794/04 A RU2010135794/04 A RU 2010135794/04A RU 2010135794 A RU2010135794 A RU 2010135794A RU 2010135794 A RU2010135794 A RU 2010135794A
- Authority
- RU
- Russia
- Prior art keywords
- fluorophenyl
- hydrochloride
- amino
- hydroxy
- propan
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 31
- 150000001408 amides Chemical class 0.000 title claims abstract 3
- YSNNRQFRXBIYIZ-UHFFFAOYSA-N 2-amino-3-(4-fluorophenyl)-3-hydroxypropanoic acid Chemical compound OC(=O)C(N)C(O)C1=CC=C(F)C=C1 YSNNRQFRXBIYIZ-UHFFFAOYSA-N 0.000 title 1
- 230000000202 analgesic effect Effects 0.000 title 1
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical group O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims abstract 2
- 125000002252 acyl group Chemical group 0.000 claims abstract 2
- 150000001412 amines Chemical group 0.000 claims abstract 2
- 125000000565 sulfonamide group Chemical group 0.000 claims abstract 2
- LKWKASPCPQUHAJ-XNGOQOFYSA-N (2r,3s)-2-amino-3-(4-fluorophenyl)-1-[(3s)-3-fluoropyrrolidin-1-yl]-3-hydroxypropan-1-one;hydrochloride Chemical compound Cl.C1([C@H](O)[C@@H](N)C(=O)N2C[C@@H](F)CC2)=CC=C(F)C=C1 LKWKASPCPQUHAJ-XNGOQOFYSA-N 0.000 claims 1
- LKWKASPCPQUHAJ-AHBISNNASA-N (2s,3r)-2-amino-3-(4-fluorophenyl)-1-[(3s)-3-fluoropyrrolidin-1-yl]-3-hydroxypropan-1-one;hydrochloride Chemical compound Cl.C1([C@@H](O)[C@H](N)C(=O)N2C[C@@H](F)CC2)=CC=C(F)C=C1 LKWKASPCPQUHAJ-AHBISNNASA-N 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- BRZKIPCFDCUNEY-DFQHDRSWSA-N [(1s,2r)-2-amino-1-(4-fluorophenyl)-3-oxo-3-pyrrolidin-1-ylpropyl] acetate;hydrochloride Chemical compound Cl.O=C([C@H](N)[C@@H](OC(=O)C)C=1C=CC(F)=CC=1)N1CCCC1 BRZKIPCFDCUNEY-DFQHDRSWSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2617808P | 2008-02-05 | 2008-02-05 | |
| US61/026,178 | 2008-02-05 | ||
| US12/364,930 US8168631B2 (en) | 2008-02-05 | 2009-02-03 | 3-(4-fluorophenyl)-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic activity |
| US12/364,930 | 2009-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010135794A true RU2010135794A (ru) | 2012-03-20 |
Family
ID=40568212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010135794/04A RU2010135794A (ru) | 2008-02-05 | 2009-02-04 | Амиды 3-(4-фторфенил)-3-гидрокси-2-аминопропионовой кислоты и родственные соединения, обладающие обезболивающим действием |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8168631B2 (enExample) |
| EP (1) | EP2252583B1 (enExample) |
| JP (1) | JP2011512334A (enExample) |
| KR (1) | KR20100126345A (enExample) |
| CN (1) | CN101998950A (enExample) |
| AU (1) | AU2009212519A1 (enExample) |
| BR (1) | BRPI0907482A2 (enExample) |
| CA (1) | CA2714398A1 (enExample) |
| MX (1) | MX2010008586A (enExample) |
| RU (1) | RU2010135794A (enExample) |
| WO (1) | WO2009100095A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL383715A1 (pl) | 2005-01-26 | 2008-05-12 | Allergan, Inc. | Amidy kwasu 3-arylo-3-hydroksy-2-amino-propionowego, amidy kwasu 3-heteroarylo-3-hydroksy-2-amino-propionowego i ich związki pokrewne posiadające aktywność przeciwbólową i/lub pobudzającą odporność |
| BR112012006073A2 (pt) | 2009-09-16 | 2016-05-31 | Allergan Inc | composições e métodos para tratar espasticidade. |
| EP2477623A1 (en) * | 2009-09-16 | 2012-07-25 | Allergan, Inc. | Compositions and methods for treating disorders of gastrointestinal motility |
| JP2013505248A (ja) | 2009-09-16 | 2013-02-14 | アラーガン インコーポレイテッド | 発作性疾患を治療するための組成物及び方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916911A (en) * | 1995-09-20 | 1999-06-29 | The Regents Of The University Of Michigan | Amino ceramide--like compounds and therapeutic methods of use |
| DE60139728D1 (de) * | 2001-06-27 | 2009-10-08 | Siemens Ag | Verfahren, Vorrichtungen und Softwareprogramme zum Verarbeiten und/oder Bewerten von MMS-bezogenen Nachrichten |
| US6855830B2 (en) | 2001-07-16 | 2005-02-15 | Genzyme Corporation | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors |
| WO2003045928A1 (en) * | 2001-11-26 | 2003-06-05 | Genzyme Corporation | Diastereoselective synthesis of udp-glucose : n-acylsphingosine glucosyltransferase inhibitors |
| KR20060123344A (ko) * | 2003-12-19 | 2006-12-01 | 바스프 악티엔게젤샤프트 | 벤조일-치환된 페닐알라닌아미드 |
| PL383715A1 (pl) | 2005-01-26 | 2008-05-12 | Allergan, Inc. | Amidy kwasu 3-arylo-3-hydroksy-2-amino-propionowego, amidy kwasu 3-heteroarylo-3-hydroksy-2-amino-propionowego i ich związki pokrewne posiadające aktywność przeciwbólową i/lub pobudzającą odporność |
| WO2008011478A2 (en) | 2006-07-19 | 2008-01-24 | Allergan, Inc. | Methods for treating chronic pain using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds |
-
2009
- 2009-02-03 US US12/364,930 patent/US8168631B2/en active Active
- 2009-02-04 BR BRPI0907482A patent/BRPI0907482A2/pt not_active IP Right Cessation
- 2009-02-04 MX MX2010008586A patent/MX2010008586A/es active IP Right Grant
- 2009-02-04 KR KR1020107019698A patent/KR20100126345A/ko not_active Withdrawn
- 2009-02-04 CA CA2714398A patent/CA2714398A1/en not_active Abandoned
- 2009-02-04 CN CN2009801118205A patent/CN101998950A/zh active Pending
- 2009-02-04 AU AU2009212519A patent/AU2009212519A1/en not_active Abandoned
- 2009-02-04 RU RU2010135794/04A patent/RU2010135794A/ru not_active Application Discontinuation
- 2009-02-04 JP JP2010545959A patent/JP2011512334A/ja active Pending
- 2009-02-04 WO PCT/US2009/033014 patent/WO2009100095A1/en not_active Ceased
- 2009-02-04 EP EP09708345.5A patent/EP2252583B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011512334A (ja) | 2011-04-21 |
| CN101998950A (zh) | 2011-03-30 |
| AU2009212519A1 (en) | 2009-08-13 |
| US8168631B2 (en) | 2012-05-01 |
| CA2714398A1 (en) | 2009-08-13 |
| EP2252583A1 (en) | 2010-11-24 |
| MX2010008586A (es) | 2010-08-23 |
| KR20100126345A (ko) | 2010-12-01 |
| US20090281085A1 (en) | 2009-11-12 |
| EP2252583B1 (en) | 2014-04-23 |
| WO2009100095A1 (en) | 2009-08-13 |
| BRPI0907482A2 (pt) | 2017-05-30 |
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| Date | Code | Title | Description |
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| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
Effective date: 20140609 |