JP2011512334A5 - - Google Patents
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- Publication number
- JP2011512334A5 JP2011512334A5 JP2010545959A JP2010545959A JP2011512334A5 JP 2011512334 A5 JP2011512334 A5 JP 2011512334A5 JP 2010545959 A JP2010545959 A JP 2010545959A JP 2010545959 A JP2010545959 A JP 2010545959A JP 2011512334 A5 JP2011512334 A5 JP 2011512334A5
- Authority
- JP
- Japan
- Prior art keywords
- fluorophenyl
- hydrochloride
- amino
- threo
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 16
- LKWKASPCPQUHAJ-AHBISNNASA-N (2s,3r)-2-amino-3-(4-fluorophenyl)-1-[(3s)-3-fluoropyrrolidin-1-yl]-3-hydroxypropan-1-one;hydrochloride Chemical compound Cl.C1([C@@H](O)[C@H](N)C(=O)N2C[C@@H](F)CC2)=CC=C(F)C=C1 LKWKASPCPQUHAJ-AHBISNNASA-N 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical group O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims 1
- BRZKIPCFDCUNEY-DFQHDRSWSA-N [(1s,2r)-2-amino-1-(4-fluorophenyl)-3-oxo-3-pyrrolidin-1-ylpropyl] acetate;hydrochloride Chemical compound Cl.O=C([C@H](N)[C@@H](OC(=O)C)C=1C=CC(F)=CC=1)N1CCCC1 BRZKIPCFDCUNEY-DFQHDRSWSA-N 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 150000001412 amines Chemical group 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- GIZSHQYTTBQKOQ-UHFFFAOYSA-N threo-Syringoylglycerol Chemical compound COC1=CC(C(O)C(O)CO)=CC(OC)=C1O GIZSHQYTTBQKOQ-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2617808P | 2008-02-05 | 2008-02-05 | |
| US12/364,930 US8168631B2 (en) | 2008-02-05 | 2009-02-03 | 3-(4-fluorophenyl)-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic activity |
| PCT/US2009/033014 WO2009100095A1 (en) | 2008-02-05 | 2009-02-04 | 3-(4-fluorophenyl)-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011512334A JP2011512334A (ja) | 2011-04-21 |
| JP2011512334A5 true JP2011512334A5 (enExample) | 2012-03-22 |
Family
ID=40568212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545959A Pending JP2011512334A (ja) | 2008-02-05 | 2009-02-04 | ３‐（４‐フルオロフェニル）‐３‐ヒドロキシ‐２‐アミノ‐プロピオン酸アミドおよび鎮痛活性を有する関連化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8168631B2 (enExample) |
| EP (1) | EP2252583B1 (enExample) |
| JP (1) | JP2011512334A (enExample) |
| KR (1) | KR20100126345A (enExample) |
| CN (1) | CN101998950A (enExample) |
| AU (1) | AU2009212519A1 (enExample) |
| BR (1) | BRPI0907482A2 (enExample) |
| CA (1) | CA2714398A1 (enExample) |
| MX (1) | MX2010008586A (enExample) |
| RU (1) | RU2010135794A (enExample) |
| WO (1) | WO2009100095A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090088433A1 (en) | 2005-01-26 | 2009-04-02 | Bertrand Leblond | Methods of using as analgesics 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds |
| WO2011034912A1 (en) * | 2009-09-16 | 2011-03-24 | Allergan, Inc. | Compositions and methods for treating spasticity |
| US8242141B2 (en) | 2009-09-16 | 2012-08-14 | Allergan, Inc. | Compositions and methods for treating seizure disorders |
| JP2013505247A (ja) * | 2009-09-16 | 2013-02-14 | アラーガン インコーポレイテッド | 消化管運動障害を治療するための組成物および方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997010817A1 (en) * | 1995-09-20 | 1997-03-27 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| EP2101522B1 (en) * | 2001-06-27 | 2011-05-25 | Siemens Aktiengesellschaft | Displaying of multimedia messages |
| BR122015016313B8 (pt) | 2001-07-16 | 2021-05-25 | Genzyme Corp | composto semelhante à ceramida e método de preparar um composto |
| US6835831B2 (en) * | 2001-11-26 | 2004-12-28 | Genzyme Corporation | Diastereoselective synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors |
| CA2548442A1 (en) * | 2003-12-19 | 2005-07-07 | Basf Aktiengesellschaft | Benzoyl-substituted phenylalanine amides |
| US20090088433A1 (en) | 2005-01-26 | 2009-04-02 | Bertrand Leblond | Methods of using as analgesics 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds |
| WO2008011478A2 (en) | 2006-07-19 | 2008-01-24 | Allergan, Inc. | Methods for treating chronic pain using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds |
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2009
- 2009-02-03 US US12/364,930 patent/US8168631B2/en active Active
- 2009-02-04 EP EP09708345.5A patent/EP2252583B1/en not_active Not-in-force
- 2009-02-04 JP JP2010545959A patent/JP2011512334A/ja active Pending
- 2009-02-04 AU AU2009212519A patent/AU2009212519A1/en not_active Abandoned
- 2009-02-04 MX MX2010008586A patent/MX2010008586A/es active IP Right Grant
- 2009-02-04 CN CN2009801118205A patent/CN101998950A/zh active Pending
- 2009-02-04 KR KR1020107019698A patent/KR20100126345A/ko not_active Withdrawn
- 2009-02-04 BR BRPI0907482A patent/BRPI0907482A2/pt not_active IP Right Cessation
- 2009-02-04 RU RU2010135794/04A patent/RU2010135794A/ru not_active Application Discontinuation
- 2009-02-04 CA CA2714398A patent/CA2714398A1/en not_active Abandoned
- 2009-02-04 WO PCT/US2009/033014 patent/WO2009100095A1/en not_active Ceased