RU2009110152A - Генетически закодированная формула селективно-сульфатных белков в эубактерии - Google Patents
Генетически закодированная формула селективно-сульфатных белков в эубактерии Download PDFInfo
- Publication number
- RU2009110152A RU2009110152A RU2009110152/10A RU2009110152A RU2009110152A RU 2009110152 A RU2009110152 A RU 2009110152A RU 2009110152/10 A RU2009110152/10 A RU 2009110152/10A RU 2009110152 A RU2009110152 A RU 2009110152A RU 2009110152 A RU2009110152 A RU 2009110152A
- Authority
- RU
- Russia
- Prior art keywords
- trna
- translation system
- amino acid
- providing
- clause
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title claims abstract 10
- 108090000623 proteins and genes Proteins 0.000 title claims abstract 10
- 241000894006 Bacteria Species 0.000 title 1
- 229910021653 sulphate ion Inorganic materials 0.000 title 1
- 108091033319 polynucleotide Proteins 0.000 claims abstract 18
- 102000040430 polynucleotide Human genes 0.000 claims abstract 18
- 239000002157 polynucleotide Substances 0.000 claims abstract 18
- 150000001413 amino acids Chemical class 0.000 claims abstract 16
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims abstract 11
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims abstract 11
- 102000039446 nucleic acids Human genes 0.000 claims abstract 10
- 108020004707 nucleic acids Proteins 0.000 claims abstract 10
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 10
- 108020004705 Codon Proteins 0.000 claims abstract 8
- 241000203407 Methanocaldococcus jannaschii Species 0.000 claims abstract 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 7
- 108020005038 Terminator Codon Proteins 0.000 claims abstract 4
- 102000003960 Ligases Human genes 0.000 claims abstract 3
- 108090000364 Ligases Proteins 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims 20
- 241001112695 Clostridiales Species 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 241000588724 Escherichia coli Species 0.000 claims 2
- 101710146427 Probable tyrosine-tRNA ligase, cytoplasmic Proteins 0.000 claims 2
- 102000018378 Tyrosine-tRNA ligase Human genes 0.000 claims 2
- 101710107268 Tyrosine-tRNA ligase, mitochondrial Proteins 0.000 claims 2
- 238000002741 site-directed mutagenesis Methods 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84651906P | 2006-09-21 | 2006-09-21 | |
| US60/846,519 | 2006-09-21 | ||
| US85521006P | 2006-10-28 | 2006-10-28 | |
| US60/855,210 | 2006-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2009110152A true RU2009110152A (ru) | 2010-10-27 |
Family
ID=39201110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009110152/10A RU2009110152A (ru) | 2006-09-21 | 2007-09-20 | Генетически закодированная формула селективно-сульфатных белков в эубактерии |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8114652B2 (enExample) |
| EP (1) | EP2052083B1 (enExample) |
| JP (1) | JP5385143B2 (enExample) |
| KR (1) | KR20090074765A (enExample) |
| CN (1) | CN101516901B (enExample) |
| AU (1) | AU2007297610A1 (enExample) |
| BR (1) | BRPI0716963A2 (enExample) |
| CA (1) | CA2663052A1 (enExample) |
| ES (1) | ES2456331T3 (enExample) |
| IL (1) | IL197531A0 (enExample) |
| MX (1) | MX2009002987A (enExample) |
| PL (1) | PL2052083T3 (enExample) |
| PT (1) | PT2052083E (enExample) |
| RU (1) | RU2009110152A (enExample) |
| WO (1) | WO2008036392A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1490483B1 (en) * | 2001-04-19 | 2015-06-03 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| KR20050073559A (ko) * | 2002-10-16 | 2005-07-14 | 더 스크립스 리서치 인스티튜트 | 당단백질 합성 |
| CN103289960B (zh) | 2003-04-17 | 2017-04-26 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| DE602004011789T2 (de) * | 2003-07-07 | 2009-02-12 | The Scripps Research Institute, La Jolla | Zusammensetzungen der orthogonalen Lysyl-tRNA und Aminoacyl-tRNA Synthetase Paaren und ihre Verwendungen |
| BRPI0819092A2 (pt) * | 2007-11-02 | 2014-10-14 | Scripps Research Inst | Evolução direcionada usando proteínas que compreendem aminoácidos não naturais. |
| US8658394B2 (en) * | 2011-02-02 | 2014-02-25 | Waterstone Pharmaceuticals | Methods, cells and systems for incorporating non-canonical amino acids into proteins |
| CN102888387B (zh) * | 2011-07-21 | 2015-03-18 | 中国科学院生物物理研究所 | 3-氯代酪氨酸翻译系统及其应用 |
| CN103571804B (zh) * | 2012-08-10 | 2015-08-12 | 中国科学院生物物理研究所 | 3-吡唑基酪氨酸翻译系统及其应用 |
| WO2015120287A2 (en) | 2014-02-06 | 2015-08-13 | Yale University | Compositions and methods of use thereof for making polypeptides with many instances of nonstandard amino acids |
| WO2016073079A2 (en) | 2014-09-26 | 2016-05-12 | Yale University | Compositions and methods for biocontainment of microorganisms |
| CN110117580B (zh) * | 2018-02-05 | 2021-12-14 | 中国科学院生物物理研究所 | 硒代酪氨酸翻译系统及其应用 |
| IL280198B1 (en) * | 2018-07-18 | 2025-09-01 | Regenxbio Inc | Treatment of mucopolysaccharidosis I with fully glycosylated human iduronidase-alpha-L (idus) |
| US12371817B2 (en) * | 2019-03-04 | 2025-07-29 | The Texas A&M University System | Methods of making and utilizing amber-obligated phage display libraries |
| US11149280B2 (en) | 2019-10-29 | 2021-10-19 | Yale University | Engineering organisms resistant to viruses and horizontally transferred genetic elements |
| CN111304234A (zh) * | 2020-02-27 | 2020-06-19 | 江南大学 | 一种适用于枯草芽孢杆菌的非天然氨基酸利用工具 |
| CN113789335B (zh) * | 2021-11-16 | 2022-03-15 | 江苏省中国科学院植物研究所 | 一种水蛭酪氨酸磺酸转移酶基因及其应用 |
| CN118389493B (zh) * | 2024-05-10 | 2025-04-11 | 北京大学 | 一种定点修饰的工程化tRNA及其应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204016B1 (en) | 1998-01-29 | 2001-03-20 | The Board Of Regents Of The University Of Oklahoma | Tyrosylprotein sulfotransferases and methods of use thereof |
| EP1490483B1 (en) | 2001-04-19 | 2015-06-03 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| DK1578949T3 (da) * | 2002-10-16 | 2009-07-27 | Scripps Research Inst | Stedspecifik optagelse af keto-aminnosyrer hos proteiner |
| KR20050073559A (ko) | 2002-10-16 | 2005-07-14 | 더 스크립스 리서치 인스티튜트 | 당단백질 합성 |
| EP1583816A4 (en) | 2002-12-22 | 2007-06-13 | Scripps Research Inst | PROTEIN ARRAYS |
| CN103289960B (zh) | 2003-04-17 | 2017-04-26 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| WO2005003294A2 (en) | 2003-06-18 | 2005-01-13 | The Scripps Research Institute | Unnatural reactive amino acid genetic code additions |
| WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| DE602004011789T2 (de) | 2003-07-07 | 2009-02-12 | The Scripps Research Institute, La Jolla | Zusammensetzungen der orthogonalen Lysyl-tRNA und Aminoacyl-tRNA Synthetase Paaren und ihre Verwendungen |
| WO2005007870A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | COMPOSITIONS OF ORTHOGONAL LEUCYL-tRNA AND AMINOACYL-tRNA SYNTHETASE PAIRS AND USES THEREOF |
| WO2005038002A2 (en) | 2003-10-14 | 2005-04-28 | The Scripps Research Institute | Site-specific incorporation of redox active amino acids into proteins |
| BRPI0417801A (pt) | 2003-12-18 | 2007-04-10 | Scripps Research Inst | incorporação seletiva de 5-hidroxitriptofano em proteìnas de células mamìferas |
| AU2005248392A1 (en) | 2004-05-25 | 2005-12-08 | Irm, Llc | Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for crystal structure determination |
| EP1797177A4 (en) | 2004-09-21 | 2008-07-09 | Scripps Research Inst | ADDITION OF PHOTOREGULATED AMINO ACIDS TO THE GENETIC CODE |
| EP1794323B1 (en) | 2004-09-21 | 2014-08-06 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| JP2008513806A (ja) | 2004-09-22 | 2008-05-01 | ザ スクリップス リサーチ インスティテュート | Ｎｍｒ試験のための蛋白質の部位特異的標識 |
| EP1809758A4 (en) | 2004-10-20 | 2009-04-01 | Scripps Research Inst | LOCAL IN VIVO INSTALLATION OF N-ACETYLGALACTOSAMINE AMINO ACIDS IN EU BACTERIA |
| AU2005330514B2 (en) | 2004-10-27 | 2011-05-12 | The Scripps Research Institute | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
| CA2624290A1 (en) | 2005-10-12 | 2007-04-26 | Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| CA2638763A1 (en) | 2006-03-09 | 2007-09-13 | The Scripps Research Institute | System for the expression of orthogonal translation components in eubacterial host cells |
| JP5249194B2 (ja) | 2006-03-16 | 2013-07-31 | ザ スクリプス リサーチ インスティチュート | 非天然アミノ酸フェニルセレノシステインを含有するタンパク質の遺伝的にプログラムされた発現 |
-
2007
- 2007-09-20 CA CA002663052A patent/CA2663052A1/en not_active Abandoned
- 2007-09-20 RU RU2009110152/10A patent/RU2009110152A/ru not_active Application Discontinuation
- 2007-09-20 US US12/311,169 patent/US8114652B2/en active Active
- 2007-09-20 KR KR1020097007574A patent/KR20090074765A/ko not_active Ceased
- 2007-09-20 BR BRPI0716963-9A patent/BRPI0716963A2/pt not_active IP Right Cessation
- 2007-09-20 AU AU2007297610A patent/AU2007297610A1/en not_active Abandoned
- 2007-09-20 WO PCT/US2007/020459 patent/WO2008036392A2/en not_active Ceased
- 2007-09-20 EP EP07861356.9A patent/EP2052083B1/en not_active Not-in-force
- 2007-09-20 ES ES07861356.9T patent/ES2456331T3/es active Active
- 2007-09-20 JP JP2009529249A patent/JP5385143B2/ja not_active Expired - Fee Related
- 2007-09-20 PL PL07861356T patent/PL2052083T3/pl unknown
- 2007-09-20 PT PT78613569T patent/PT2052083E/pt unknown
- 2007-09-20 US US11/903,499 patent/US8114627B2/en active Active
- 2007-09-20 CN CN200780035189.6A patent/CN101516901B/zh not_active Expired - Fee Related
- 2007-09-20 MX MX2009002987A patent/MX2009002987A/es not_active Application Discontinuation
-
2009
- 2009-03-11 IL IL197531A patent/IL197531A0/en unknown
-
2011
- 2011-12-14 US US13/326,143 patent/US8361770B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8114652B2 (en) | 2012-02-14 |
| EP2052083A2 (en) | 2009-04-29 |
| US8114627B2 (en) | 2012-02-14 |
| MX2009002987A (es) | 2009-04-28 |
| EP2052083B1 (en) | 2014-01-08 |
| CN101516901A (zh) | 2009-08-26 |
| PT2052083E (pt) | 2014-04-10 |
| US8361770B2 (en) | 2013-01-29 |
| BRPI0716963A2 (pt) | 2013-11-05 |
| KR20090074765A (ko) | 2009-07-07 |
| CN101516901B (zh) | 2014-01-08 |
| PL2052083T3 (pl) | 2014-06-30 |
| ES2456331T3 (es) | 2014-04-22 |
| US20120184018A1 (en) | 2012-07-19 |
| CA2663052A1 (en) | 2008-03-27 |
| US20090286279A1 (en) | 2009-11-19 |
| US20080113407A1 (en) | 2008-05-15 |
| WO2008036392A2 (en) | 2008-03-27 |
| JP2010504096A (ja) | 2010-02-12 |
| EP2052083A4 (en) | 2010-03-24 |
| JP5385143B2 (ja) | 2014-01-08 |
| WO2008036392A9 (en) | 2008-05-22 |
| AU2007297610A1 (en) | 2008-03-27 |
| IL197531A0 (en) | 2009-12-24 |
| WO2008036392A3 (en) | 2008-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20120504 |