JP5385143B2 - 真正細菌における選択的に硫酸化された蛋白質の遺伝的にプログラムされた発現 - Google Patents
真正細菌における選択的に硫酸化された蛋白質の遺伝的にプログラムされた発現 Download PDFInfo
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/52—Genes encoding for enzymes or proenzymes
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/70—Vectors or expression systems specially adapted for E. coli
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
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| PCT/US2007/020459 WO2008036392A2 (en) | 2006-09-21 | 2007-09-20 | Genetically programmed expression of selectively sulfated proteins in eubacteria |
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| ES2464532T3 (es) * | 2001-04-19 | 2014-06-03 | The Scripps Research Institute | Métodos y composiciones para la producción de pares ortogonales de ARNt-aminoacil-ARNt sintetasa |
| EP1558747B1 (en) * | 2002-10-16 | 2009-10-14 | The Scripps Research Institute | Glycoprotein synthesis |
| JP5642916B2 (ja) | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| WO2005019415A2 (en) | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| US9150849B2 (en) * | 2007-11-02 | 2015-10-06 | The Scripps Research Institute | Directed evolution using proteins comprising unnatural amino acids |
| US8658394B2 (en) * | 2011-02-02 | 2014-02-25 | Waterstone Pharmaceuticals | Methods, cells and systems for incorporating non-canonical amino acids into proteins |
| CN102888387B (zh) * | 2011-07-21 | 2015-03-18 | 中国科学院生物物理研究所 | 3-氯代酪氨酸翻译系统及其应用 |
| CN103571804B (zh) * | 2012-08-10 | 2015-08-12 | 中国科学院生物物理研究所 | 3-吡唑基酪氨酸翻译系统及其应用 |
| WO2015120287A2 (en) * | 2014-02-06 | 2015-08-13 | Yale University | Compositions and methods of use thereof for making polypeptides with many instances of nonstandard amino acids |
| WO2016073079A2 (en) | 2014-09-26 | 2016-05-12 | Yale University | Compositions and methods for biocontainment of microorganisms |
| CN110117580B (zh) * | 2018-02-05 | 2021-12-14 | 中国科学院生物物理研究所 | 硒代酪氨酸翻译系统及其应用 |
| IL280198B2 (en) * | 2018-07-18 | 2026-01-01 | Regenxbio Inc | Treatment of mucopolysaccharidosis I with fully glycosylated human iduronidase-alpha-L (idus) |
| WO2020180971A1 (en) * | 2019-03-04 | 2020-09-10 | The Texas A&M University System | Methods of making and utilizing amber-obligated phage display libraries |
| WO2021086487A1 (en) | 2019-10-29 | 2021-05-06 | Yale University | Engineering organisms resistant to viruses and horizontally transferred genetic elements |
| CN111304234A (zh) * | 2020-02-27 | 2020-06-19 | 江南大学 | 一种适用于枯草芽孢杆菌的非天然氨基酸利用工具 |
| CN113789335B (zh) * | 2021-11-16 | 2022-03-15 | 江苏省中国科学院植物研究所 | 一种水蛭酪氨酸磺酸转移酶基因及其应用 |
| CN118389493B (zh) * | 2024-05-10 | 2025-04-11 | 北京大学 | 一种定点修饰的工程化tRNA及其应用 |
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| US6204016B1 (en) | 1998-01-29 | 2001-03-20 | The Board Of Regents Of The University Of Oklahoma | Tyrosylprotein sulfotransferases and methods of use thereof |
| ES2464532T3 (es) * | 2001-04-19 | 2014-06-03 | The Scripps Research Institute | Métodos y composiciones para la producción de pares ortogonales de ARNt-aminoacil-ARNt sintetasa |
| MXPA05003983A (es) * | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Incorporacion en sitio especifico de cetoaminoacidos en proteinas. |
| EP1558747B1 (en) | 2002-10-16 | 2009-10-14 | The Scripps Research Institute | Glycoprotein synthesis |
| EP1583816A4 (en) | 2002-12-22 | 2007-06-13 | Scripps Research Inst | PROTEIN ARRAYS |
| JP5642916B2 (ja) | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| JP5275566B2 (ja) | 2003-06-18 | 2013-08-28 | ザ スクリプス リサーチ インスティチュート | 反応性非天然アミノ酸遺伝コード付加 |
| WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| WO2005019415A2 (en) | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| EP1704242A4 (en) | 2003-07-07 | 2008-06-18 | Scripps Research Inst | COMPOSITIONS WITH PAIRS OF ORTHOGONAL LEUCYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF |
| CN101532046A (zh) | 2003-10-14 | 2009-09-16 | 斯克利普斯研究院 | 将氧化还原活性氨基酸位点特异地掺入蛋白质 |
| CA2549830A1 (en) | 2003-12-18 | 2006-01-05 | The Scripps Research Institute | Selective incorporation of 5-hyroxytryptophan into proteins in mammalian cells |
| CA2567624A1 (en) | 2004-05-25 | 2005-12-08 | The Scripps Research Institute | Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for crystal structure determination |
| US20090181858A1 (en) | 2004-09-21 | 2009-07-16 | The Scripps Research Institute | Adding photoregulated amino acids to the genetic code |
| MX2007003142A (es) | 2004-09-21 | 2007-07-04 | Scripps Research Inst | Incorporacion in vivo de alquinil aminoacidos a proteinas en eubacterias. |
| EP1794312A4 (en) | 2004-09-22 | 2009-08-12 | Scripps Research Inst | LOCAL LABELING OF PROTEINS FOR NMR STUDIES |
| WO2006045116A2 (en) | 2004-10-20 | 2006-04-27 | The Scripps Research Institute | In vivo site-specific incorporation of n-acetyl-galactosamine amino acids in eubacteria |
| MX2007004892A (es) | 2004-10-27 | 2007-08-16 | Scripps Research Inst | Componentes de traduccion ortogonales para la incorporacion in vivo de aminoacidos no naturales. |
| CA2624290A1 (en) | 2005-10-12 | 2007-04-26 | Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| MX2008011470A (es) | 2006-03-09 | 2008-09-24 | Scripps Research Inst | Sistemas para la expresion de componentes de traduccion ortogonales en celulas huesped eubacterianas. |
| US7790847B2 (en) | 2006-03-16 | 2010-09-07 | The Scripps Research Institute | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
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- 2007-09-20 US US11/903,499 patent/US8114627B2/en active Active
- 2007-09-20 PT PT78613569T patent/PT2052083E/pt unknown
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- 2007-09-20 CA CA002663052A patent/CA2663052A1/en not_active Abandoned
- 2007-09-20 EP EP07861356.9A patent/EP2052083B1/en not_active Not-in-force
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- 2007-09-20 PL PL07861356T patent/PL2052083T3/pl unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| RU2009110152A (ru) | 2010-10-27 |
| WO2008036392A3 (en) | 2008-12-31 |
| US20090286279A1 (en) | 2009-11-19 |
| AU2007297610A1 (en) | 2008-03-27 |
| CN101516901A (zh) | 2009-08-26 |
| EP2052083A4 (en) | 2010-03-24 |
| WO2008036392A2 (en) | 2008-03-27 |
| US20080113407A1 (en) | 2008-05-15 |
| CN101516901B (zh) | 2014-01-08 |
| US8361770B2 (en) | 2013-01-29 |
| US20120184018A1 (en) | 2012-07-19 |
| CA2663052A1 (en) | 2008-03-27 |
| PL2052083T3 (pl) | 2014-06-30 |
| US8114627B2 (en) | 2012-02-14 |
| EP2052083B1 (en) | 2014-01-08 |
| WO2008036392A9 (en) | 2008-05-22 |
| JP2010504096A (ja) | 2010-02-12 |
| EP2052083A2 (en) | 2009-04-29 |
| IL197531A0 (en) | 2009-12-24 |
| KR20090074765A (ko) | 2009-07-07 |
| US8114652B2 (en) | 2012-02-14 |
| PT2052083E (pt) | 2014-04-10 |
| ES2456331T3 (es) | 2014-04-22 |
| BRPI0716963A2 (pt) | 2013-11-05 |
| MX2009002987A (es) | 2009-04-28 |
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