RU2007132260A - Синтез арилпирролидонов - Google Patents
Синтез арилпирролидонов Download PDFInfo
- Publication number
- RU2007132260A RU2007132260A RU2007132260/04A RU2007132260A RU2007132260A RU 2007132260 A RU2007132260 A RU 2007132260A RU 2007132260/04 A RU2007132260/04 A RU 2007132260/04A RU 2007132260 A RU2007132260 A RU 2007132260A RU 2007132260 A RU2007132260 A RU 2007132260A
- Authority
- RU
- Russia
- Prior art keywords
- substituted
- unsubstituted
- group
- aryl
- heteroaryl
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title claims 4
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 37
- 125000003118 aryl group Chemical group 0.000 claims 35
- 125000001072 heteroaryl group Chemical group 0.000 claims 33
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 24
- 125000000753 cycloalkyl group Chemical group 0.000 claims 23
- 125000004404 heteroalkyl group Chemical group 0.000 claims 23
- 238000000034 method Methods 0.000 claims 22
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 150000002367 halogens Chemical class 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 150000001408 amides Chemical class 0.000 claims 4
- 125000002524 organometallic group Chemical group 0.000 claims 4
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 3
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims 3
- 125000006239 protecting group Chemical group 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims 2
- 238000006254 arylation reaction Methods 0.000 claims 2
- -1 benzoimidazolyl Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Natural products P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims 1
- 239000011717 all-trans-retinol Substances 0.000 claims 1
- 235000019169 all-trans-retinol Nutrition 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 238000004440 column chromatography Methods 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
- 150000003951 lactams Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 150000003003 phosphines Chemical class 0.000 claims 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 238000001953 recrystallisation Methods 0.000 claims 1
- 239000010802 sludge Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 0 Cc1c(*)c(*)c(*)c(B(O*)O*)c1* Chemical compound Cc1c(*)c(*)c(*)c(B(O*)O*)c1* 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64803905P | 2005-01-28 | 2005-01-28 | |
| US60/648,039 | 2005-01-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2007132260A true RU2007132260A (ru) | 2009-03-10 |
Family
ID=36741151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007132260/04A RU2007132260A (ru) | 2005-01-28 | 2006-01-30 | Синтез арилпирролидонов |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1841424A4 (enExample) |
| JP (1) | JP2008528625A (enExample) |
| KR (1) | KR100890696B1 (enExample) |
| CN (1) | CN101111246A (enExample) |
| AU (1) | AU2006209241B2 (enExample) |
| BR (1) | BRPI0607294A2 (enExample) |
| CA (1) | CA2593816A1 (enExample) |
| MX (1) | MX2007008974A (enExample) |
| RU (1) | RU2007132260A (enExample) |
| WO (1) | WO2006081562A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013526542A (ja) | 2010-05-12 | 2013-06-24 | アッヴィ・インコーポレイテッド | キナーゼのインダゾール阻害薬 |
| CN101979378B (zh) * | 2010-10-13 | 2012-06-27 | 中国科学院上海有机化学研究所 | 一种手性γ-内酰胺化合物的合成方法 |
| RU2485100C1 (ru) * | 2012-02-07 | 2013-06-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" | 1-арил-4-бензоил-3-гидрокси-5-метоксикарбонил-2,5-дигидро-1н-пиррол-2-оны, проявляющие анальгетическую активность, и способ их получения |
| AU2014357342B2 (en) | 2013-12-03 | 2019-01-17 | Fmc Corporation | Pyrrolidinones as herbicides |
| US11589583B2 (en) | 2013-12-03 | 2023-02-28 | Fmc Corporation | Pyrrolidinones herbicides |
| UA125012C2 (uk) | 2014-07-02 | 2021-12-29 | ЕфЕмСі КОРПОРЕЙШН | Піперидинонові гербіциди |
| BR112017009701B1 (pt) | 2014-12-08 | 2021-09-08 | Fmc Corporation | Composto e métodos de preparação de compostos |
| WO2016164201A1 (en) | 2015-04-10 | 2016-10-13 | E I Du Pont De Nemours And Company | Substituted cyclic amides as herbicides |
| BR112017020094B1 (pt) | 2015-04-27 | 2022-01-11 | Fmc Corporation | Composto, composições herbicidas, mistura de herbicida e método para controlar o crescimento de vegetação indesejada |
| RU2750293C2 (ru) | 2015-05-12 | 2021-06-25 | ЭфЭмСи Корпорейшн | Арилзамещенные бициклические соединения в качестве гербицидов |
| CN107690426B (zh) | 2015-05-29 | 2021-07-06 | Fmc公司 | 作为除草剂的取代的环酰胺 |
| RU2017142979A (ru) | 2015-06-02 | 2019-07-15 | ЭфЭмСи Корпорейшн | Замещенные циклические амиды и их применение в качестве гербицидов |
| RU2720994C2 (ru) | 2015-07-31 | 2020-05-15 | Е.И.Дюпон Де Немур Энд Компани | Новые соединения циклического n-карбоксамида, применяемые в качестве гербицидов |
| ES2958741T3 (es) | 2016-12-21 | 2024-02-14 | Fmc Corp | Herbicidas de nitrona |
| UA126576C2 (uk) | 2017-03-21 | 2022-11-02 | ЕфЕмСі КОРПОРЕЙШН | Гербіцидна суміш, композиція та спосіб |
| CN110691516B (zh) | 2017-03-21 | 2022-10-28 | Fmc公司 | 吡咯烷酮及其制备方法 |
| AR111967A1 (es) | 2017-05-30 | 2019-09-04 | Fmc Corp | Amidas herbicidas |
| AR111839A1 (es) | 2017-05-30 | 2019-08-21 | Fmc Corp | Lactamas 3-sustituidas herbicidas |
| CN116782894A (zh) * | 2020-10-06 | 2023-09-19 | D.E.肖研究有限责任公司 | 作为Kv1.3钾Shaker通道阻断剂的内酰胺化合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3058986A (en) * | 1962-10-16 | N-ammoalkyl-x-phenyl-x-lower alkyl-z- | ||
| US3956314A (en) * | 1970-07-24 | 1976-05-11 | U.C.B., Societe Anonyme | Derivatives of 2-pyrrolidinone |
| US3956914A (en) * | 1974-11-14 | 1976-05-18 | The Marison Company | Spin lathe |
| JP2002363160A (ja) * | 2001-06-05 | 2002-12-18 | Sumitomo Chem Co Ltd | 光学活性４−アリール−２−ピペリジノン類の製造方法 |
| AU2003285952A1 (en) * | 2002-10-21 | 2004-05-13 | Irm Llc | Pyrrolidones with anti-hiv activity |
| JP4351859B2 (ja) * | 2003-04-14 | 2009-10-28 | 三菱レイヨン株式会社 | 光学活性β−アリ−ル化合物の製造法 |
| KR100896889B1 (ko) * | 2005-01-28 | 2009-05-14 | 아이알엠 엘엘씨 | 페닐-치환 피롤리돈 |
-
2006
- 2006-01-30 MX MX2007008974A patent/MX2007008974A/es not_active Application Discontinuation
- 2006-01-30 WO PCT/US2006/003240 patent/WO2006081562A2/en not_active Ceased
- 2006-01-30 BR BRPI0607294-1A patent/BRPI0607294A2/pt not_active IP Right Cessation
- 2006-01-30 AU AU2006209241A patent/AU2006209241B2/en not_active Expired - Fee Related
- 2006-01-30 RU RU2007132260/04A patent/RU2007132260A/ru not_active Application Discontinuation
- 2006-01-30 EP EP06719887A patent/EP1841424A4/en not_active Withdrawn
- 2006-01-30 CN CNA2006800035536A patent/CN101111246A/zh active Pending
- 2006-01-30 JP JP2007553329A patent/JP2008528625A/ja active Pending
- 2006-01-30 CA CA002593816A patent/CA2593816A1/en not_active Abandoned
- 2006-01-30 KR KR1020077017460A patent/KR100890696B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR100890696B1 (ko) | 2009-03-26 |
| AU2006209241B2 (en) | 2009-10-22 |
| AU2006209241A1 (en) | 2006-08-03 |
| EP1841424A2 (en) | 2007-10-10 |
| MX2007008974A (es) | 2007-09-18 |
| CN101111246A (zh) | 2008-01-23 |
| JP2008528625A (ja) | 2008-07-31 |
| WO2006081562A3 (en) | 2006-10-19 |
| KR20070097555A (ko) | 2007-10-04 |
| CA2593816A1 (en) | 2006-08-03 |
| WO2006081562A2 (en) | 2006-08-03 |
| EP1841424A4 (en) | 2010-01-27 |
| BRPI0607294A2 (pt) | 2009-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
Effective date: 20101112 |