RU2007108896A - Биологически активные пептиды - Google Patents
Биологически активные пептиды Download PDFInfo
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- RU2007108896A RU2007108896A RU2007108896/13A RU2007108896A RU2007108896A RU 2007108896 A RU2007108896 A RU 2007108896A RU 2007108896/13 A RU2007108896/13 A RU 2007108896/13A RU 2007108896 A RU2007108896 A RU 2007108896A RU 2007108896 A RU2007108896 A RU 2007108896A
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- Prior art keywords
- immune response
- cancer
- specified
- pharmaceutical composition
- modulating
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4716—Muscle proteins, e.g. myosin, actin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- Heart & Thoracic Surgery (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Claims (20)
1. Выделенный пептид, стимулирующий противоопухолевый иммунный ответ, характеризующийся аминокислотной последовательностью, выбранной из группы, состоящей из SEQ ID No:1-15, 17-30.
2. Пептид по п.1, где указанный ответ происходит за счет модуляции иммунной активности у пациента.
3. Пептид по п.1, где указанный ответ модулирует развитие рака.
4. Пептид по п.3, где указанный рак представляет собой рак печени.
5. Пептид по п.3, где указанный рак представляет собой меланому.
6. Фармацевтическая композиция, стимулирующая противоопухолевый иммунный ответ, состоящая из эффективного количества пептида по п.1 и фармацевтически приемлемого носителя.
7. Фармацевтическая композиция по п.6, где указанный ответ происходит за счет модуляции иммунной активности у пациента.
8. Фармацевтическая композиция по п.6, где указанный ответ модулирует развитие рака.
9. Фармацевтическая композиция по п.8, где указанный рак представляет собой рак печени.
10. Фармацевтическая композиция по п.8, где указанный рак представляет собой меланому.
11. Способ лечения млекопитающего, страдающего заболеванием, при лечении которого необходима стимуляция противоопухолевого иммунного ответа, включающий введение фармацевтически эффективной дозы фармацевтической композиции по п.6.
12. Способ лечения по п. 11, где у указанного млекопитающего диагностирован рак.
13. Способ лечения по п. 11, где указанный рак представляет собой рак печени.
14. Способ лечения по п. 11, где указанный рак представляет собой меланому.
15. Способ модуляции иммунного ответа у млекопитающего, страдающего заболеванием, при лечении которого необходима стимуляция противоопухолевого иммунного ответа, включающий введение фармацевтически эффективной дозы фармацевтической композиции по п.6.
16. Способ модуляции иммунного ответа по п.15, где указанный иммунный ответ состоит в увеличении цитотоксической активности NK клеток.
17. Способ модуляции иммунного ответа по п.15, где указанный иммунный ответ состоит в усилении синтеза анти-SRBC антител при антигенной стимуляции.
18. Способ модуляции иммунного ответа по п.15, где указанный иммунный ответ состоит в усилении фагоцитарной активности моноядерных фагоцитов.
19. Способ модуляции иммунного ответа по п.15, где указанный иммунный ответ состоит в увеличении веса вилочковой железы.
20. Способ модуляции иммунного ответа по п.15, где указанный иммунный ответ состоит в снижении веса селезенки.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90449201A | 2001-07-13 | 2001-07-13 | |
| US09/904,492 | 2001-07-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004104335/13A Division RU2305107C2 (ru) | 2001-07-13 | 2002-07-11 | Пептид, стимулирующий противоопухолевый иммунный ответ, фармацевтическая композиция на его основе, способ лечения млекопитающего и способ модуляции иммунного ответа |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007108896A true RU2007108896A (ru) | 2008-09-20 |
| RU2425053C2 RU2425053C2 (ru) | 2011-07-27 |
Family
ID=25419251
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007108896/10A RU2425053C2 (ru) | 2001-07-13 | 2002-07-11 | Выделенный пептид, стимулирующий противоопухолевый иммунный ответ, фармацевтическая композиция на его основе, способ лечения млекопитающего и способ модуляции иммунного ответа |
| RU2004104335/13A RU2305107C2 (ru) | 2001-07-13 | 2002-07-11 | Пептид, стимулирующий противоопухолевый иммунный ответ, фармацевтическая композиция на его основе, способ лечения млекопитающего и способ модуляции иммунного ответа |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004104335/13A RU2305107C2 (ru) | 2001-07-13 | 2002-07-11 | Пептид, стимулирующий противоопухолевый иммунный ответ, фармацевтическая композиция на его основе, способ лечения млекопитающего и способ модуляции иммунного ответа |
Country Status (24)
| Country | Link |
|---|---|
| EP (3) | EP1790655B1 (ru) |
| JP (3) | JP4213581B2 (ru) |
| KR (2) | KR100889993B1 (ru) |
| AT (2) | ATE466871T1 (ru) |
| AU (1) | AU2002319423B2 (ru) |
| BR (1) | BR0210252A (ru) |
| CA (2) | CA2452417C (ru) |
| DE (2) | DE60229883D1 (ru) |
| DK (2) | DK1478659T3 (ru) |
| ES (2) | ES2345842T3 (ru) |
| HK (2) | HK1066552A1 (ru) |
| IL (2) | IL159827A0 (ru) |
| MX (1) | MXPA03011190A (ru) |
| MY (1) | MY138219A (ru) |
| NO (2) | NO332061B1 (ru) |
| NZ (3) | NZ553507A (ru) |
| PL (2) | PL208666B1 (ru) |
| PT (2) | PT1790655E (ru) |
| RU (2) | RU2425053C2 (ru) |
| SA (1) | SA04240478B1 (ru) |
| SG (2) | SG185137A1 (ru) |
| UA (1) | UA83989C2 (ru) |
| WO (1) | WO2003006492A2 (ru) |
| ZA (2) | ZA200401108B (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1216069C (zh) | 2001-07-13 | 2005-08-24 | 一泰医药研究（深圳）有限公司 | 序列号25的生物活性肽 |
| WO2004055042A1 (en) * | 2002-12-18 | 2004-07-01 | Pepharm R & D Limited | Biologically active peptide conjugates |
| TWI322815B (en) * | 2003-06-26 | 2010-04-01 | Cms Peptides Patent Holding Company Ltd | Biologically active peptide comprising tyrosyl-seryl-valine (ysv) |
| TWI353252B (en) * | 2004-04-28 | 2011-12-01 | Cms Peptides Patent Holding Company Ltd | Biologically active peptide vapeehptllteaplnpk der |
| CN1799623B (zh) * | 2005-01-05 | 2011-01-26 | 康哲医药研究(深圳)有限公司 | 生物活性肽在制备用于防治关节炎的药物中的用途 |
| US8586525B2 (en) | 2005-07-26 | 2013-11-19 | Cms Peptides Patent Holding Company Limited | Biologically active peptides and their new uses |
| GB0918579D0 (en) * | 2009-10-22 | 2009-12-09 | Imp Innovations Ltd | Gadd45beta targeting agents |
| RU2615908C1 (ru) * | 2016-05-16 | 2017-04-11 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ моделирования лимфогенного и гематогенного метастазирования мышиной меланомы В16 у белых нелинейных крыс |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5242821A (en) | 1989-07-10 | 1993-09-07 | Valio, Finnish Co-Operative Dairies' Association | Lactococcus promoter and signal sequences for expression in bacteria |
| IT1231156B (it) | 1989-07-19 | 1991-11-19 | Eniricerche Spa | Espressione e secrezione di interleuchina 1 beta umana matura in bacillus subtilis e mezzi e metodi per il suo ottenimento. |
| AU7142391A (en) * | 1989-12-22 | 1991-07-24 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Synthetic peptides as modulators of functional responses of intact cells |
| US5556744A (en) * | 1992-05-29 | 1996-09-17 | The Trustees Of The University Of Pennsylvania | Methods and compositions for diagnosing and treating certain HIV infected patients |
| WO1994029450A2 (en) | 1993-06-15 | 1994-12-22 | E.I. Du Pont De Nemours And Company | Novel, recombinantly produced spider silk analogs |
| JP3286420B2 (ja) | 1993-09-28 | 2002-05-27 | 株式会社ユニシアジェックス | 内燃機関の吸排気弁駆動制御装置 |
| JPH10503643A (ja) | 1994-06-17 | 1998-04-07 | ネーデルランセ オルハニサチエ フォール トゥーヘパスト−ナツールウェーテンシャッペルック オンデルズク テーエヌオー | 微生物中に遺伝物質を導入する方法およびその方法によってえられる形質転換体 |
| US6184208B1 (en) | 1994-06-29 | 2001-02-06 | Immunotech Developments Inc. | Peptide, a method for its preparation and a pharmaceutical composition containing the peptide |
| US5958416A (en) * | 1994-12-16 | 1999-09-28 | Regents Of The University Of Minnesota | Heat shock protein peptides and methods for modulating autoimmune central nervous system disease |
| IL115199A (en) | 1995-09-07 | 2005-05-17 | Opperbas Holding Bv | Composition comprising a polynucleic acid molecule in a liposome and method using said composition |
| DE69633133T2 (de) | 1995-10-24 | 2005-07-28 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | TFPI-verwandte Peptide die das Wachstums von glatten Muskelzellen inhibieren |
| GB9606016D0 (en) * | 1996-03-22 | 1996-05-22 | Smithkline Beecham Plc | Novel use |
| US5861483A (en) * | 1996-04-03 | 1999-01-19 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
| SE9603468D0 (sv) * | 1996-09-23 | 1996-09-23 | Astra Ab | New compounds |
| GB9710762D0 (en) * | 1997-05-23 | 1997-07-23 | Cancer Res Inst Royal | Binding complexes |
| EP1015612B1 (en) | 1997-05-27 | 2005-01-26 | Hanil Synthetic Fiber Co., Ltd. | Process for preparing recombinant proteins using highly efficient expression vector from saccharomyces cerevisiae |
| KR19990024297A (ko) | 1997-08-07 | 1999-04-06 | 오종석 | 인체 구강내 치태형성을 억제하는 신규한 유산균 |
| US6100388A (en) | 1998-03-16 | 2000-08-08 | Biogaia Biologies Ab | Lactobacilli harboring aggregation gene as a vaccine delivery vehicle |
| US6245427B1 (en) | 1998-07-06 | 2001-06-12 | DüZGüNES NEJAT | Non-ligand polypeptide and liposome complexes as intracellular delivery vehicles |
| US6653076B1 (en) * | 1998-08-31 | 2003-11-25 | The Regents Of The University Of Washington | Stable isotope metabolic labeling for analysis of biopolymers |
| US6413530B1 (en) * | 1999-04-21 | 2002-07-02 | University Of Florida Research Foundation, Inc. | Pesticidal peptides |
| FR2794370B1 (fr) * | 1999-06-03 | 2003-10-17 | Biovector Therapeutics | Fragments proteiques polyepitopiques, leur obtention et leurs utilisations notamment en vaccination |
| WO2001032853A1 (en) * | 1999-10-29 | 2001-05-10 | Institute For Applied Biomedicine | B cell clonal toxins and methods for using the same |
-
2002
- 2002-07-11 PL PL368059A patent/PL208666B1/pl unknown
- 2002-07-11 EP EP07000950A patent/EP1790655B1/en not_active Expired - Lifetime
- 2002-07-11 AT AT07000950T patent/ATE466871T1/de not_active IP Right Cessation
- 2002-07-11 PL PL383101A patent/PL211884B1/pl unknown
- 2002-07-11 AT AT02749008T patent/ATE414099T1/de not_active IP Right Cessation
- 2002-07-11 WO PCT/GB2002/003203 patent/WO2003006492A2/en active Application Filing
- 2002-07-11 NZ NZ553507A patent/NZ553507A/en not_active IP Right Cessation
- 2002-07-11 EP EP08005150A patent/EP1947109A3/en not_active Withdrawn
- 2002-07-11 NZ NZ529879A patent/NZ529879A/en not_active IP Right Cessation
- 2002-07-11 ES ES07000950T patent/ES2345842T3/es not_active Expired - Lifetime
- 2002-07-11 KR KR1020047000499A patent/KR100889993B1/ko not_active IP Right Cessation
- 2002-07-11 NZ NZ544079A patent/NZ544079A/en not_active IP Right Cessation
- 2002-07-11 JP JP2003512262A patent/JP4213581B2/ja not_active Expired - Fee Related
- 2002-07-11 ES ES02749008T patent/ES2316586T3/es not_active Expired - Lifetime
- 2002-07-11 BR BR0210252-8A patent/BR0210252A/pt active Search and Examination
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