RU2006146051A - Новые соединения, фармацевтические композиции на их основе и способы применения - Google Patents
Новые соединения, фармацевтические композиции на их основе и способы применения Download PDFInfo
- Publication number
- RU2006146051A RU2006146051A RU2006146051/04A RU2006146051A RU2006146051A RU 2006146051 A RU2006146051 A RU 2006146051A RU 2006146051/04 A RU2006146051/04 A RU 2006146051/04A RU 2006146051 A RU2006146051 A RU 2006146051A RU 2006146051 A RU2006146051 A RU 2006146051A
- Authority
- RU
- Russia
- Prior art keywords
- compound
- compound according
- pharmaceutical composition
- alkylaryl
- arylalkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 35
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 12
- 238000000034 method Methods 0.000 title claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 10
- 125000002877 alkyl aryl group Chemical group 0.000 claims abstract 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract 10
- 125000003118 aryl group Chemical group 0.000 claims abstract 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 10
- 125000005843 halogen group Chemical group 0.000 claims abstract 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 3
- 239000008024 pharmaceutical diluent Substances 0.000 claims abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 241001465754 Metazoa Species 0.000 claims 6
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 2
- 101150073133 Cpt1a gene Proteins 0.000 claims 1
- 102000015303 Fatty Acid Synthases Human genes 0.000 claims 1
- 108010039731 Fatty Acid Synthases Proteins 0.000 claims 1
- 101710151321 Melanostatin Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102400000064 Neuropeptide Y Human genes 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000005907 cancer growth Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- URPYMXQQVHTUDU-OFGSCBOVSA-N nucleopeptide y Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 URPYMXQQVHTUDU-OFGSCBOVSA-N 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
- 0 CC(*)(C(C1(CC=C)CC=C)=O)SC1=O Chemical compound CC(*)(C(C1(CC=C)CC=C)=O)SC1=O 0.000 description 1
- WNEZTBHQCUAWHR-UHFFFAOYSA-N CC(C)(C(C(C)(C)S1)=O)C1=O Chemical compound CC(C)(C(C(C)(C)S1)=O)C1=O WNEZTBHQCUAWHR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Child & Adolescent Psychology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57463904P | 2004-05-26 | 2004-05-26 | |
| US60/574,639 | 2004-05-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2006146051A true RU2006146051A (ru) | 2008-07-10 |
Family
ID=35463277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006146051/04A RU2006146051A (ru) | 2004-05-26 | 2005-05-25 | Новые соединения, фармацевтические композиции на их основе и способы применения |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20090005435A1 (https=) |
| EP (1) | EP1758577A4 (https=) |
| JP (1) | JP2008500363A (https=) |
| KR (1) | KR20070095754A (https=) |
| CN (1) | CN101022792A (https=) |
| AU (1) | AU2005249437A1 (https=) |
| BR (1) | BRPI0510397A (https=) |
| CA (1) | CA2568639A1 (https=) |
| IL (1) | IL179530A0 (https=) |
| MX (1) | MXPA06013687A (https=) |
| RU (1) | RU2006146051A (https=) |
| WO (1) | WO2005117590A2 (https=) |
| ZA (1) | ZA200700024B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007014248A2 (en) * | 2005-07-26 | 2007-02-01 | Johns Hopkins University | Method of reducing food intake |
| JP5489333B2 (ja) * | 2006-09-22 | 2014-05-14 | メルク・シャープ・アンド・ドーム・コーポレーション | 脂肪酸合成阻害剤を用いた治療の方法 |
| ES2660690T3 (es) * | 2007-10-05 | 2018-03-23 | Genzyme Corporation | Método para tratar poliquistosis renales con derivados de ceramida |
| WO2010118324A2 (en) | 2009-04-09 | 2010-10-14 | Nuclea Biotechnologies, LLC | Antibodies against fatty acid synthase |
| JP6285442B2 (ja) * | 2012-09-07 | 2018-02-28 | ヤンセン ファーマシューティカ エヌ．ベー． | がん治療用の脂肪酸合成酵素（ｆａｓｎ）阻害剤として有用なイミダゾリン−５−オン誘導体 |
| WO2016079317A1 (en) | 2014-11-20 | 2016-05-26 | Vib Vzw | Means and methods for treatment of early-onset parkinson's disease |
| MX2022009078A (es) | 2020-01-23 | 2022-08-15 | Basf Se | Formulaciones de ppo que contienen sulfatos de eter. |
| JP2023547434A (ja) | 2020-10-27 | 2023-11-10 | ビーエーエスエフ ソシエタス・ヨーロピア | 有害生物防除用マイクロエマルジョン組成物 |
| CR20230380A (es) | 2021-02-05 | 2023-10-12 | Basf Se | Composiciones herbicidas liquidas |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3427847A1 (de) * | 1983-12-09 | 1985-06-13 | Bayer Ag, 5090 Leverkusen | Thiolan-2,4-dion-3-carboxamide |
| US5759837A (en) * | 1989-01-17 | 1998-06-02 | John Hopkins University | Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway |
| US5614551A (en) * | 1994-01-24 | 1997-03-25 | The Johns Hopkins University | Inhibitors of fatty acid synthesis as antimicrobial agents |
| US5981575A (en) * | 1996-11-15 | 1999-11-09 | Johns Hopkins University, The | Inhibition of fatty acid synthase as a means to reduce adipocyte mass |
| EP1471906A4 (en) * | 2002-02-08 | 2006-02-01 | Univ Johns Hopkins Med | STIMULATION OF CPT-1 TO REDUCE BODY WEIGHT |
| EP2386551A1 (en) * | 2002-07-09 | 2011-11-16 | Fasgen Inc. | Novel compounds, pharmaceutical compositions containing same, and methods of use for same |
-
2005
- 2005-05-25 CN CNA2005800233119A patent/CN101022792A/zh active Pending
- 2005-05-25 AU AU2005249437A patent/AU2005249437A1/en not_active Abandoned
- 2005-05-25 CA CA002568639A patent/CA2568639A1/en not_active Abandoned
- 2005-05-25 ZA ZA200700024A patent/ZA200700024B/en unknown
- 2005-05-25 MX MXPA06013687A patent/MXPA06013687A/es not_active Application Discontinuation
- 2005-05-25 US US11/597,538 patent/US20090005435A1/en not_active Abandoned
- 2005-05-25 JP JP2007515318A patent/JP2008500363A/ja active Pending
- 2005-05-25 BR BRPI0510397-5A patent/BRPI0510397A/pt not_active IP Right Cessation
- 2005-05-25 WO PCT/US2005/018443 patent/WO2005117590A2/en not_active Ceased
- 2005-05-25 EP EP05754100A patent/EP1758577A4/en not_active Withdrawn
- 2005-05-25 KR KR1020067026941A patent/KR20070095754A/ko not_active Withdrawn
- 2005-05-25 RU RU2006146051/04A patent/RU2006146051A/ru not_active Application Discontinuation
-
2006
- 2006-11-23 IL IL179530A patent/IL179530A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL179530A0 (en) | 2007-05-15 |
| WO2005117590A2 (en) | 2005-12-15 |
| ZA200700024B (en) | 2008-06-25 |
| JP2008500363A (ja) | 2008-01-10 |
| BRPI0510397A (pt) | 2007-11-13 |
| AU2005249437A1 (en) | 2005-12-15 |
| EP1758577A4 (en) | 2010-05-05 |
| EP1758577A2 (en) | 2007-03-07 |
| US20090005435A1 (en) | 2009-01-01 |
| KR20070095754A (ko) | 2007-10-01 |
| CN101022792A (zh) | 2007-08-22 |
| WO2005117590A3 (en) | 2006-07-27 |
| CA2568639A1 (en) | 2005-12-15 |
| MXPA06013687A (es) | 2007-10-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
Effective date: 20110516 |