RU2005123794A - Способ определения концентрации исследуемого вещества в физиологической пробе - Google Patents
Способ определения концентрации исследуемого вещества в физиологической пробе Download PDFInfo
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- RU2005123794A RU2005123794A RU2005123794/28A RU2005123794A RU2005123794A RU 2005123794 A RU2005123794 A RU 2005123794A RU 2005123794/28 A RU2005123794/28 A RU 2005123794/28A RU 2005123794 A RU2005123794 A RU 2005123794A RU 2005123794 A RU2005123794 A RU 2005123794A
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
Claims (3)
1. Способ определения концентрации исследуемого вещества в физиологической пробе, включающий в себя:
(a) введение упомянутой физиологической пробы в электрохимическую ячейку, содержащую:
(i) отстоящие друг от друга рабочий электрод и электрод сравнения; и
(ii) систему окислительно-восстановительных реактивов, содержащую фермент и медиатор;
(b) приложение к упомянутой электрохимической ячейке первого электрического потенциала, имеющего первую полярность, и измерение тока в ячейке как функции времени для получения первой переходной характеристики время-ток;
(c) приложение к упомянутой электрохимической ячейке второго электрического потенциала, имеющего вторую полярность, противоположную упомянутой первой полярности, и измерение тока в ячейке как функции времени для получения второй переходной характеристики время-ток;
(d) выведение предварительной концентрации исследуемого вещества на основании упомянутых первой и/или второй переходных характеристик время-ток; и
(е) умножение упомянутой предварительной концентрации исследуемого вещества за вычетом значения фона на коэффициент поправки для выведения скорректированной концентрации исследуемого вещества в упомянутой пробе;
посредством чего определяют скорректированную концентрацию упомянутого исследуемого вещества в упомянутой пробе.
2. Способ по п.1, в котором упомянутая физиологическая проба представляет собой цельную кровь или ее производное.
3. Способ по п.1, в котором упомянутое исследуемое вещество представляет собой глюкозу.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/497,304 US6475372B1 (en) | 2000-02-02 | 2000-02-02 | Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations |
US09/497,304 | 2000-02-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2005123794A true RU2005123794A (ru) | 2007-02-10 |
Family
ID=23976305
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2002116217/14A RU2262890C2 (ru) | 2000-02-02 | 2001-01-25 | Электрохимический способ и устройства, предназначенные для применения при определении концентраций исследуемых веществ с поправкой на гематокритное число |
RU2005123794/28A RU2005123794A (ru) | 2000-02-02 | 2005-07-26 | Способ определения концентрации исследуемого вещества в физиологической пробе |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2002116217/14A RU2262890C2 (ru) | 2000-02-02 | 2001-01-25 | Электрохимический способ и устройства, предназначенные для применения при определении концентраций исследуемых веществ с поправкой на гематокритное число |
Country Status (21)
Country | Link |
---|---|
US (3) | US6475372B1 (ru) |
EP (2) | EP1645876A3 (ru) |
JP (1) | JP2003521708A (ru) |
KR (1) | KR20020077409A (ru) |
CN (1) | CN1193228C (ru) |
AR (1) | AR027345A1 (ru) |
AT (1) | ATE313794T1 (ru) |
AU (1) | AU783311B2 (ru) |
CA (1) | CA2398203A1 (ru) |
CZ (1) | CZ20021298A3 (ru) |
DE (1) | DE60116056T2 (ru) |
DK (1) | DK1252514T3 (ru) |
ES (1) | ES2254368T3 (ru) |
HK (1) | HK1049881B (ru) |
IL (1) | IL149662A (ru) |
MX (1) | MXPA02005797A (ru) |
MY (1) | MY127335A (ru) |
PL (1) | PL358492A1 (ru) |
RU (2) | RU2262890C2 (ru) |
TW (1) | TW520439B (ru) |
WO (1) | WO2001057510A2 (ru) |
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-
2004
- 2004-11-01 US US10/979,054 patent/US20050176153A1/en not_active Abandoned
-
2005
- 2005-07-26 RU RU2005123794/28A patent/RU2005123794A/ru not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL149662A (en) | 2005-07-25 |
IL149662A0 (en) | 2002-11-10 |
CA2398203A1 (en) | 2001-08-09 |
EP1252514A2 (en) | 2002-10-30 |
CZ20021298A3 (cs) | 2003-05-14 |
WO2001057510A3 (en) | 2002-02-21 |
RU2002116217A (ru) | 2004-01-20 |
DK1252514T3 (da) | 2006-05-01 |
DE60116056T2 (de) | 2006-08-10 |
EP1645876A2 (en) | 2006-04-12 |
ATE313794T1 (de) | 2006-01-15 |
PL358492A1 (en) | 2004-08-09 |
EP1645876A3 (en) | 2008-03-05 |
EP1252514B1 (en) | 2005-12-21 |
US6890421B2 (en) | 2005-05-10 |
DE60116056D1 (de) | 2006-01-26 |
US20050176153A1 (en) | 2005-08-11 |
AR027345A1 (es) | 2003-03-26 |
HK1049881B (zh) | 2006-09-08 |
JP2003521708A (ja) | 2003-07-15 |
ES2254368T3 (es) | 2006-06-16 |
AU783311B2 (en) | 2005-10-13 |
AU3297401A (en) | 2001-08-14 |
CN1193228C (zh) | 2005-03-16 |
RU2262890C2 (ru) | 2005-10-27 |
HK1049881A1 (en) | 2003-05-30 |
TW520439B (en) | 2003-02-11 |
WO2001057510A2 (en) | 2001-08-09 |
KR20020077409A (ko) | 2002-10-11 |
MXPA02005797A (es) | 2003-10-14 |
US20020125145A1 (en) | 2002-09-12 |
US6475372B1 (en) | 2002-11-05 |
CN1394280A (zh) | 2003-01-29 |
MY127335A (en) | 2006-11-30 |
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