RU2004118247A - Бензимидазол-или индоламиноацетонитрильные производные для борьбы с паразитами - Google Patents
Бензимидазол-или индоламиноацетонитрильные производные для борьбы с паразитами Download PDFInfo
- Publication number
- RU2004118247A RU2004118247A RU2004118247/04A RU2004118247A RU2004118247A RU 2004118247 A RU2004118247 A RU 2004118247A RU 2004118247/04 A RU2004118247/04 A RU 2004118247/04A RU 2004118247 A RU2004118247 A RU 2004118247A RU 2004118247 A RU2004118247 A RU 2004118247A
- Authority
- RU
- Russia
- Prior art keywords
- group
- halo
- alkyl
- unsubstituted
- mono
- Prior art date
Links
- 244000045947 parasite Species 0.000 title claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 48
- 150000001875 compounds Chemical class 0.000 claims 45
- 229910052736 halogen Inorganic materials 0.000 claims 45
- 150000002367 halogens Chemical class 0.000 claims 45
- 125000004093 cyano group Chemical group *C#N 0.000 claims 40
- 229910052739 hydrogen Inorganic materials 0.000 claims 37
- 239000001257 hydrogen Substances 0.000 claims 37
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 34
- 125000003545 alkoxy group Chemical group 0.000 claims 32
- 150000002431 hydrogen Chemical class 0.000 claims 32
- 125000001424 substituent group Chemical group 0.000 claims 31
- 125000004414 alkyl thio group Chemical group 0.000 claims 14
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 12
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 12
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 12
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 9
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 9
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 8
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 8
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 8
- 125000003277 amino group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000004104 aryloxy group Chemical group 0.000 claims 7
- 125000001475 halogen functional group Chemical group 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 6
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 5
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 5
- 125000005554 pyridyloxy group Chemical group 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 4
- 125000004970 halomethyl group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000003320 C2-C6 alkenyloxy group Chemical group 0.000 claims 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 3
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 3
- 125000005493 quinolyl group Chemical group 0.000 claims 3
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 2
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 claims 1
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 1
- 125000005947 C1-C6 alkylsulfonyloxy group Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- UEXCJVNBTNXOEH-UHFFFAOYSA-N Ethynylbenzene Chemical group C#CC1=CC=CC=C1 UEXCJVNBTNXOEH-UHFFFAOYSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 1
- 125000005199 aryl carbonyloxy group Chemical group 0.000 claims 1
- 125000004657 aryl sulfonyl amino group Chemical group 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 239000002270 dispersing agent Substances 0.000 claims 1
- -1 monosubstituted naphthyl Chemical group 0.000 claims 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/10—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH21032001 | 2001-11-14 | ||
| CH2103/01 | 2001-11-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2004118247A true RU2004118247A (ru) | 2006-01-10 |
Family
ID=4567523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004118247/04A RU2004118247A (ru) | 2001-11-14 | 2002-11-13 | Бензимидазол-или индоламиноацетонитрильные производные для борьбы с паразитами |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7279495B2 (enExample) |
| EP (1) | EP1446386A1 (enExample) |
| JP (1) | JP2005518351A (enExample) |
| KR (1) | KR20050044451A (enExample) |
| CN (1) | CN1304378C (enExample) |
| AR (1) | AR037363A1 (enExample) |
| AU (1) | AU2002351995B2 (enExample) |
| BR (1) | BR0214151A (enExample) |
| CA (1) | CA2466971A1 (enExample) |
| CO (1) | CO5390082A1 (enExample) |
| MX (1) | MXPA04004605A (enExample) |
| NZ (1) | NZ532864A (enExample) |
| RU (1) | RU2004118247A (enExample) |
| TW (1) | TW200300140A (enExample) |
| WO (1) | WO2003042184A1 (enExample) |
| ZA (1) | ZA200403459B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200409760A (en) | 2002-09-11 | 2004-06-16 | Novartis Ag | Organic compounds |
| US20040192738A1 (en) * | 2003-03-18 | 2004-09-30 | Aventis Pharma Deutschland Gmbh | 2-(Butyl-1-sulfonylamino)-N-[1(R)-(6-methoxypyridin-3-yl)propyl] benzamide, its use as a medicament, and pharmaceutical preparations comprising it |
| GB0402677D0 (en) * | 2003-11-06 | 2004-03-10 | Novartis Ag | Organic compounds |
| WO2006043654A1 (ja) * | 2004-10-22 | 2006-04-27 | Nihon Nohyaku Co., Ltd. | アセトニトリル誘導体及び有害生物防除剤並びにその使用方法 |
| EP1904473A1 (en) * | 2005-07-12 | 2008-04-02 | Bayer CropScience S.A. | Benzoheterocyclylethylcarboxamide derivatives |
| PE20070335A1 (es) | 2005-08-30 | 2007-04-21 | Novartis Ag | Benzimidazoles sustituidos y metodos para su preparacion |
| PT3088384T (pt) * | 2007-05-15 | 2019-03-22 | Aventis Agriculture | Compostos de ariloazol-2-il-cianoetilamino, método de fabrico e seu método de utilização |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| KR101782311B1 (ko) | 2008-10-21 | 2017-09-27 | 메리얼 인코포레이티드 | 티오아미드 화합물, 이의 제조 방법 및 사용 방법 |
| AR074024A1 (es) | 2008-11-14 | 2010-12-15 | Merial Ltd | Compuesto de arilazol-2-il-cianoetilamino enantiomericamente enriquecidos, composicion plaguicida y su uso para prevenir la infeccion parasitaria |
| GB0905365D0 (en) | 2009-03-27 | 2009-05-13 | Norbrook Lab Ltd | A topical parasiticide composition |
| US20100307542A1 (en) * | 2009-06-05 | 2010-12-09 | Kraft Foods Global Brands Llc | Method of Reducing Surface Oil on Encapsulated Material |
| US8859003B2 (en) * | 2009-06-05 | 2014-10-14 | Intercontinental Great Brands Llc | Preparation of an enteric release system |
| US20100310726A1 (en) | 2009-06-05 | 2010-12-09 | Kraft Foods Global Brands Llc | Novel Preparation of an Enteric Release System |
| US9968564B2 (en) | 2009-06-05 | 2018-05-15 | Intercontinental Great Brands Llc | Delivery of functional compounds |
| CA2870956C (en) * | 2012-04-20 | 2020-03-31 | Merial Limited | Parasiticidal compositions comprising benzimidazole derivatives, methods and uses thereof |
| US8822689B2 (en) | 2012-09-19 | 2014-09-02 | Merial Limited | Aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof |
| US8859005B2 (en) | 2012-12-03 | 2014-10-14 | Intercontinental Great Brands Llc | Enteric delivery of functional ingredients suitable for hot comestible applications |
| EP3141592B1 (en) * | 2014-05-08 | 2020-03-11 | Osaka University | Heat convection-generating chip and liquid-weighing instrument |
| ES2723969T3 (es) | 2014-06-19 | 2019-09-04 | Merial Inc | Composiciones parasiticidas que comprenden derivados de indol, procedimientos y usos de las mismas |
| US20200385398A1 (en) | 2019-06-07 | 2020-12-10 | Elanco Tiergesundheit Ag | New bicyclic derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6239077B1 (en) | 1998-05-01 | 2001-05-29 | Nihon Nohyaku Co., Ltd. | Aminoacetonitrile derivative agricultural and horticultural insecticide containing the same and use thereof |
-
2002
- 2002-11-12 TW TW091133121A patent/TW200300140A/zh unknown
- 2002-11-13 CA CA002466971A patent/CA2466971A1/en not_active Abandoned
- 2002-11-13 MX MXPA04004605A patent/MXPA04004605A/es unknown
- 2002-11-13 BR BR0214151-5A patent/BR0214151A/pt not_active IP Right Cessation
- 2002-11-13 WO PCT/EP2002/012709 patent/WO2003042184A1/en not_active Ceased
- 2002-11-13 CN CNB028241053A patent/CN1304378C/zh not_active Expired - Fee Related
- 2002-11-13 KR KR1020047007293A patent/KR20050044451A/ko not_active Withdrawn
- 2002-11-13 JP JP2003544020A patent/JP2005518351A/ja not_active Withdrawn
- 2002-11-13 EP EP02787667A patent/EP1446386A1/en not_active Withdrawn
- 2002-11-13 AR ARP020104355A patent/AR037363A1/es not_active Application Discontinuation
- 2002-11-13 AU AU2002351995A patent/AU2002351995B2/en not_active Ceased
- 2002-11-13 NZ NZ532864A patent/NZ532864A/xx unknown
- 2002-11-13 RU RU2004118247/04A patent/RU2004118247A/ru not_active Application Discontinuation
- 2002-11-13 US US10/494,897 patent/US7279495B2/en not_active Expired - Fee Related
- 2002-11-14 CO CO02103446A patent/CO5390082A1/es not_active Application Discontinuation
-
2004
- 2004-05-06 ZA ZA200403459A patent/ZA200403459B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200403459B (en) | 2006-11-29 |
| AR037363A1 (es) | 2004-11-03 |
| CA2466971A1 (en) | 2003-05-22 |
| US20050026972A1 (en) | 2005-02-03 |
| WO2003042184A1 (en) | 2003-05-22 |
| US7279495B2 (en) | 2007-10-09 |
| TW200300140A (en) | 2003-05-16 |
| AU2002351995B2 (en) | 2006-08-10 |
| CN1304378C (zh) | 2007-03-14 |
| CN1599725A (zh) | 2005-03-23 |
| KR20050044451A (ko) | 2005-05-12 |
| NZ532864A (en) | 2005-11-25 |
| CO5390082A1 (es) | 2004-04-30 |
| EP1446386A1 (en) | 2004-08-18 |
| MXPA04004605A (es) | 2005-03-07 |
| BR0214151A (pt) | 2004-09-14 |
| JP2005518351A (ja) | 2005-06-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2005110918A (ru) | Органические соединения | |
| RU2003122196A (ru) | Органические соединения | |
| RU2004139033A (ru) | Индазоламиноацетонитрильные производные, обладающие особой пестицидной активностью | |
| JP2005518351A5 (enExample) | ||
| RU2004114240A (ru) | Органические соединения | |
| RU2003124076A (ru) | Фармацевтическая композиция, содержащая производные аминоацетонитрида, и ее применение в приготовлении фармацевтической композиции для обработки эндопаразитарных вредителей у животных | |
| JP2004521097A5 (enExample) | ||
| RU2409576C2 (ru) | Системы, содержащие имидазольное кольцо с заместителями, и способы их получения | |
| RU2445312C2 (ru) | ПРОИЗВОДНЫЕ 2-МЕТИЛМОРФОЛИН ПИРИДО-, ПИРАЗО- И ПИРИМИДО-ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ mTOR | |
| TR200503847T1 (tr) | Metoksi akrilik asit metil ester bileşiği içeren fungusitler. | |
| AR037363A1 (es) | Derivados de indolil- y benzimidazolil-aminoacetonitrilo, composiciones para controlar parasitos y el uso de dichos compuestos para la preparacion de una composicion farmaceutica | |
| EA200901186A1 (ru) | S-ТРИАЗОЛИЛ-α-МЕРКАПТОАЦЕТАНИЛИДЫ КАК ИНГИБИТОРЫ ОБРАТНОЙ ТРАНСКРИПТАЗЫ ВИЧ | |
| RU2007114124A (ru) | Бициклические маиды, как ингибиторы киназы | |
| RU2221778C2 (ru) | N-сульфонилглициналкинилоксифенэтиламидные производные, обладающие бактерицидной активностью | |
| RU2004120790A (ru) | Аминоацетонитрильные производные и их применение для борьбы с паразитами | |
| RU2002116224A (ru) | N-гетероарил-альфа-алкоксиминокарбосамиды, обладающие пестицидной активнотью | |
| RU2003137564A (ru) | Применение аминоацетонитрильных соединений для борьбы с эндопаразитами | |
| RU2006100484A (ru) | Соединения, обладающие ингибирующей активностью в отношении фосфатидилинозит-3-киназы, фармацевтическая композиция, способ определения эффективности этих соединений, способ лечения нарушений (варианты) и способ изменения передачи сигнала в клетках | |
| RU2005101203A (ru) | N-сульфониламиноацетонитрилы, обладающие пестицидными свойствами | |
| RU2004125858A (ru) | Амидоацетонитрильные производные | |
| RU2203891C2 (ru) | Антивирусные производные пиримидиндиона, способ их получения и фармацевтическая композиция на их основе | |
| RU2001132322A (ru) | Производные триазина, обладающие пестицидной активностью | |
| EP1465488A4 (en) | ARYLAMINES AS INHIBITORS OF THE BINDING OF CHEMOKINE A US28 | |
| RU2004137655A (ru) | N-ациламиноацетонитрильные производные и их применение для борьбы с паразитами | |
| RU2005101201A (ru) | Аминоацетонитрилбные производные, пригодные для борьбы с паразитами |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20070202 |