RU2003137596A - Карбаматы 2-гетероциклил-1,2-этандиолов - Google Patents

Карбаматы 2-гетероциклил-1,2-этандиолов Download PDF

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RU2003137596A
RU2003137596A RU2003137596/04A RU2003137596A RU2003137596A RU 2003137596 A RU2003137596 A RU 2003137596A RU 2003137596/04 A RU2003137596/04 A RU 2003137596/04A RU 2003137596 A RU2003137596 A RU 2003137596A RU 2003137596 A RU2003137596 A RU 2003137596A
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compound according
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aryl
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oxocarboxamide
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RU2298552C2 (ru
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Йонг-Моон ЧОЙ (US)
Йонг-Моон ЧОЙ
Ки-Хо ЛИ (KR)
Ки-Хо ЛИ
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Ск Корпорейшн (Kr)
СК Корпорейшн
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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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Claims (17)

1. Карбаматы 2-гетероциклил-1,2-этандиолов формулы
Figure 00000001
где А обозначает гетероциклический фрагмент, необязательно замещенный одним или более заместителей, выбираемых из группы, состоящей из алкила, арила, галогена, тригалогенметила, тригалогенметокси, триалкилсилила, S(O)R, SO2R, SO2NRR’, SO3R, SR, NO2, NRR’, OR, CN, C(O)R, OC(O)R, NHC(O)R, CO2R и CONRR’, где R и R’, независимо, обозначают водород, алкил или арил;
B1 и В2, независимо, обозначают гидрокси или OCONR1R2, при условии, что B1 и В2 не одновременно обозначают гидрокси, и R1 и R2, независимо, выбирают из группы, состоящей из водорода, гидрокси, алкила, алкокси, алкиларила, арилалкила, арила и арилокси и их энантиомеров, их энантиомерные смеси,
и их фармацевтически приемлемые соли.
2. Соединение по п.1, отличающееся тем, что указанное соединение представляет собой чистый энантиомер или энантиомерную смесь, в которой один энантиомер преобладает.
3. Соединение по п.1, отличающееся тем, что B1 и В2 обозначают OCONH2.
4. Соединение по п.1, отличающееся тем, что только один из B1 и В2 обозначает OCONH2.
5. Соединение по п.1, отличающееся тем, что А выбирают из группы, состоящей из
Figure 00000002
Figure 00000003
где каждый из R3, R4 и R5, независимо, выбирают из группы, состоящей из водорода, алкила и арила, а Х выбирают из серы, кислорода и азота.
6. Соединение по п.5, отличающееся тем, что А обозначает
Figure 00000004
где каждый из R3, R4 и R5, независимо, выбирают из группы, состоящей из водорода, алкила и арила, а Х выбирают из серы, кислорода и азота.
7. Соединение по п.6, отличающееся тем, что А обозначает
Figure 00000005
где каждый из R3, R4 и R5, независимо, выбирают из группы, состоящей из водорода, алкила и арила.
8. Соединение по п.1, которое представляет собой (±)-(2-(5-хлор-2-тиенил)-2-карбамоилоксиэтил)оксокарбоксамид.
9. Соединение по п.1, которое представляет собой (+)-(2R)-(2-(5-хлор-2-тиенил)-2-карбамоилоксиэтил)оксокарбоксамид.
10. Соединение по п.1, которое представляет собой (-)-(2S)-(2-(5-хлор-2-тиенил)-2-карбамоилоксиэтил)оксокарбоксамид.
11. Соединение по п.1, которое представляет собой (2-(5-трифторметил-2-тиенил)-2-карбамоилоксиэтил)оксокарбоксамид.
12. Соединение по п.1, которое представляет собой (2-(5-бром-2-тиенил)-2-карбамоилоксиэтил)оксокарбоксамид.
13. Фармацевтическая композиция для лечения расстройств центральной нервной системы, содержащая эффективное количество соединения по п.1.
14. Фармацевтическая композиция по п.13, отличающаяся тем, что подлежащее лечению расстройство центральной нервной системы выбирают из группы, состоящей из судорог, эпилепсии, удара, нейрогенных болей и мышечного спазма.
15. Фармацевтическая композиция по п.13, отличающаяся тем, что указанное соединение представляет собой чистый энантиомер или энантиомерную смесь, в которой преобладает один энантиомер.
16. Способ лечения расстройства центральной нервной системы, который заключается во введении больному, нуждающемуся в таком лечении, эффективного количества соединения по п.1.
17. Способ по п.16, отличающийся тем, что указанное соединение представляет собой чистый энантиомер или энантиомерную смесь, в которой преобладает один энантиомер.
RU2003137596/04A 2001-06-25 2002-06-18 Карбаматы 2-гетероциклил-1,2-этандиолов RU2298552C2 (ru)

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US7598279B2 (en) * 2005-04-22 2009-10-06 Sk Holdings Co., Ltd. Neurotherapeutic azole compounds
EP2590936B1 (en) * 2010-07-02 2018-12-12 Bio-Pharm Solutions Co., Ltd. Phenylcarbamate compound and muscle relaxant containing the same
US9018253B2 (en) 2010-07-02 2015-04-28 Bio-Pharm Solutions Co., Ltd. Phenylcarbamate compound and muscle relaxant containing the same
ES2710902T3 (es) 2011-12-27 2019-04-29 Bio Pharm Solutions Co Ltd Compuesto derivado de carbamatos de fenilalquilo y composición farmacéutica que contiene el mismo

Family Cites Families (8)

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US2884444A (en) 1956-01-13 1959-04-28 Carter Prod Inc 2-phenyl-1,3 propane diol dicarbamate
US2937119A (en) 1959-06-11 1960-05-17 Carter Prod Inc Nu-monosubstituted-2, 2-dialkyl-1, 3-propanediol dicarbamates
US5484727A (en) * 1992-10-14 1996-01-16 Trustees Of Dartmouth College Cloned gene encoding acylcoenzyme A: cholesterol acyltransferase (ACAT)
US6274590B1 (en) * 1993-01-15 2001-08-14 G. D. Searle & Co. Method of treating skin related conditions
DE4425098A1 (de) * 1994-07-15 1996-01-18 Forsch Borstel Inst Fuer Exper 7-0-Carbamoyl-Heptose-Derivate, Verfahren zu deren Herstellung und deren Verwendung sowie Screening-Verfahren zu deren Bestimmung
US5698588A (en) * 1996-01-16 1997-12-16 Yukong Limited Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol
US5973043A (en) * 1997-11-26 1999-10-26 Milliken & Company Carbamoyl substituted acetals and compositions containing the same
US6414013B1 (en) * 2000-06-19 2002-07-02 Pharmacia & Upjohn S.P.A. Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention

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US6841569B2 (en) 2005-01-11
KR100912521B1 (ko) 2009-08-18
CA2451151C (en) 2011-08-09
ATE373475T1 (de) 2007-10-15
DE60222552D1 (de) 2007-10-31
CA2451151A1 (en) 2003-01-03
US20050065193A1 (en) 2005-03-24
RU2298552C2 (ru) 2007-05-10
JP4378616B2 (ja) 2009-12-09
BR0210678A (pt) 2004-09-21
WO2003000247A1 (en) 2003-01-03
CN1536992A (zh) 2004-10-13
EP1406605A1 (en) 2004-04-14
ES2294140T3 (es) 2008-04-01
JP2005502609A (ja) 2005-01-27
EP1406605B1 (en) 2007-09-19
US20030078235A1 (en) 2003-04-24
EP1406605A4 (en) 2005-10-26
MXPA04000008A (es) 2004-05-21
KR20040018271A (ko) 2004-03-02
CN100338055C (zh) 2007-09-19
DE60222552T2 (de) 2008-06-26

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