RU2002132381A - СПОСОБ ОБНАРУЖЕНИЯ α-ОКСОАЛЬДЕГИДОВ В ЦЕЛЬНОЙ КРОВИ, ПЛАЗМЕ КРОВИ И/ИЛИ СЫВОРОТКЕ ПАЦИЕНТА - Google Patents
СПОСОБ ОБНАРУЖЕНИЯ α-ОКСОАЛЬДЕГИДОВ В ЦЕЛЬНОЙ КРОВИ, ПЛАЗМЕ КРОВИ И/ИЛИ СЫВОРОТКЕ ПАЦИЕНТА Download PDFInfo
- Publication number
- RU2002132381A RU2002132381A RU2002132381/15A RU2002132381A RU2002132381A RU 2002132381 A RU2002132381 A RU 2002132381A RU 2002132381/15 A RU2002132381/15 A RU 2002132381/15A RU 2002132381 A RU2002132381 A RU 2002132381A RU 2002132381 A RU2002132381 A RU 2002132381A
- Authority
- RU
- Russia
- Prior art keywords
- oxoaldehydes
- sample
- inhaled
- exhaled air
- serum
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 12
- 210000004369 blood Anatomy 0.000 title claims abstract 6
- 239000008280 blood Substances 0.000 title claims abstract 6
- 210000002381 plasma Anatomy 0.000 title claims abstract 6
- 210000002966 serum Anatomy 0.000 title claims abstract 6
- 238000004458 analytical method Methods 0.000 claims abstract 2
- AIJULSRZWUXGPQ-UHFFFAOYSA-N Methylglyoxal Chemical compound CC(=O)C=O AIJULSRZWUXGPQ-UHFFFAOYSA-N 0.000 claims 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 2
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 claims 2
- 229930189936 Glyoxalase Natural products 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 229940015043 glyoxal Drugs 0.000 claims 1
- 230000000984 immunochemical effect Effects 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Physiology (AREA)
- Medical Informatics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Claims (9)
1. Способ обнаружения α-оксоальдегидов в цельной крови, плазме крови и/или сыворотке пациента, при котором анализируют образец вдыхаемого и выдыхаемого воздуха на наличие по меньшей мере одного α-оксоальдегида и делают вывод о наличии α-оксоальдегидов в цельной крови, плазме крови и/или сыворотке пациента на основании результатов этого анализа.
2. Способ по п.1, при котором определяют концентрацию α-оксоальдегидов в образце вдыхаемого и выдыхаемого воздуха и делают вывод о концентрации α-оксоальдегидов в цельной крови, плазме крови и/или сыворотке пациента на основании этого определения.
3. Способ по п.1 или 2, при котором в качестве α-оксоальдегидов определяют метилглиоксаль, глиоксаль и/или 3-дезоксиглюкурон.
4. Способ по любому из пп.1-3, при котором образец вдыхаемого и выдыхаемого воздуха заключают в мешок для образца и/или в подходящий контейнер для образца и/или направляют через импинджер.
5. Способ по любому из пп.1-4, при котором α-оксоальдегиды в образце вдыхаемого и выдыхаемого воздуха преобразуют с помощью среды преобразования и определяют полученные в результате производные.
6. Способ по п.5, при котором производные обнаруживают флюорометрическим, фотометрическим и/или хроматографическим путем.
7. Способ по любому из пп.1-4, при котором α-оксоальдегиды в образце вдыхаемого и выдыхаемого воздуха определяют на основании α-оксоальдегидов, обнаруженных электрохимическим, спектрометрическим, ферментативным и/или иммунохимическим путем.
8. Способ по любому из пп.1-4, при котором α-оксоальдегиды в образце вдыхаемого и выдыхаемого воздуха определяют масс-спектрометрическим путем.
9. Способ по любому из пп.1-4, при котором метилглиоксаль, который содержится в образце вдыхаемого и выдыхаемого воздуха, превращают в лактат с помощью глиоксалазы, а затем обнаруживают лактат с помощью датчика.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10028548A DE10028548C1 (de) | 2000-06-09 | 2000-06-09 | Verfahren zum Nachweis von alpha-Oxoaldehyden in Vollblut, Blutplasma und/oder Serum eines Patienten |
| DE10028548.1 | 2000-06-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2002132381A true RU2002132381A (ru) | 2004-04-27 |
Family
ID=7645215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002132381/15A RU2002132381A (ru) | 2000-06-09 | 2001-05-29 | СПОСОБ ОБНАРУЖЕНИЯ α-ОКСОАЛЬДЕГИДОВ В ЦЕЛЬНОЙ КРОВИ, ПЛАЗМЕ КРОВИ И/ИЛИ СЫВОРОТКЕ ПАЦИЕНТА |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6884223B2 (ru) |
| EP (1) | EP1287356B1 (ru) |
| JP (1) | JP2004501366A (ru) |
| KR (1) | KR20030014691A (ru) |
| AT (1) | ATE262179T1 (ru) |
| AU (1) | AU2001263943A1 (ru) |
| DE (2) | DE10028548C1 (ru) |
| RU (1) | RU2002132381A (ru) |
| WO (1) | WO2001094942A1 (ru) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10134568C2 (de) * | 2001-07-16 | 2003-07-24 | Inst Chemo Biosensorik | Verfahren zur quantitativen Bestimmung von alpha-Oxoaldehyd |
| DE10202893A1 (de) * | 2002-01-25 | 2003-08-07 | Inst Chemo Biosensorik | Verfahren zur spezifischen Bestimmung von Methylglyoxal in flüssigen und/oder gasförmigen Proben |
| FR2888128B1 (fr) * | 2005-07-11 | 2007-10-12 | Maintenance Securite Installat | Procede de controle du taux de fuite des filtres a charbon actif |
| AT14763U1 (de) * | 2008-10-16 | 2016-05-15 | Darwin Gmbh | Set und Verfahren zur Gewinnung einer Atemluftprobe |
| US9626650B2 (en) | 2011-04-14 | 2017-04-18 | Elwha Llc | Cost-effective resource apportionment technologies suitable for facilitating therapies |
| US10445846B2 (en) | 2011-04-14 | 2019-10-15 | Elwha Llc | Cost-effective resource apportionment technologies suitable for facilitating therapies |
| US8599009B2 (en) | 2011-08-16 | 2013-12-03 | Elwha Llc | Systematic distillation of status data relating to regimen compliance |
| RU2476873C1 (ru) * | 2011-08-22 | 2013-02-27 | Открытое акционерное общество "Нижегородский химико-фармацевтический завод" | Способ определения содержания эстрогена и декспантенола в двухкомпонентном лекарственном препарате методом вэжх |
| RU2475733C1 (ru) * | 2011-08-22 | 2013-02-20 | Открытое акционерное общество "Нижегородский химико-фармацевтический завод" | Способ определения содержания троксерутина, декспантенола, бензокаина и метилпарагидроксибензоата в лекарственном препарате методом вэжх |
| RU2517761C1 (ru) * | 2012-11-08 | 2014-05-27 | Открытое акционерное общество "Нижегородский химико-фармацевтический завод" | Способ определения содержания гидроксиметилхиноксилиндиоксида и его примесей методом вэжх |
| CN111398460A (zh) * | 2020-04-02 | 2020-07-10 | 必睿思(杭州)科技有限公司 | 一种人体呼出气中醛酮类物质含量的检测方法 |
| CN112255354B (zh) * | 2020-09-11 | 2021-09-10 | 广州医科大学附属第一医院 | 马尔尼菲篮状菌病诊断的特征物及其筛选方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3792272A (en) * | 1973-01-12 | 1974-02-12 | Omicron Syst Corp | Breath test device for organic components, including alcohol |
| DD219287A1 (de) * | 1983-11-02 | 1985-02-27 | Adw Ddr | Messgeraet zur kontrolle von blutzucker |
| US5174959A (en) * | 1986-12-22 | 1992-12-29 | Abbott Laboratories | Breath component monitoring device |
| US5370114A (en) * | 1992-03-12 | 1994-12-06 | Wong; Jacob Y. | Non-invasive blood chemistry measurement by stimulated infrared relaxation emission |
| JP2727289B2 (ja) * | 1993-09-29 | 1998-03-11 | 呉羽化学工業株式会社 | ３−デオキシグルコソン誘導体及びその定量法 |
| US5494562A (en) * | 1994-06-27 | 1996-02-27 | Ciba Corning Diagnostics Corp. | Electrochemical sensors |
| GB9704676D0 (en) * | 1997-03-06 | 1997-04-23 | Aromascan Plc | Condition indicator |
| WO1998057145A1 (en) * | 1997-06-10 | 1998-12-17 | Quadrivium, L.L.C. | System and method for detection of a biological condition |
| GB9711994D0 (en) | 1997-06-11 | 1997-08-06 | Glaxo Group Ltd | Chemical compounds |
| WO1999056790A2 (en) * | 1998-05-06 | 1999-11-11 | Isotechnika, Inc. | 13c glucose breath test for the diagnosis of diabetes |
| WO1999066304A1 (en) * | 1998-06-19 | 1999-12-23 | California Institute Of Technology | Trace level detection of analytes using artificial olfactometry |
| DE10202893A1 (de) * | 2002-01-25 | 2003-08-07 | Inst Chemo Biosensorik | Verfahren zur spezifischen Bestimmung von Methylglyoxal in flüssigen und/oder gasförmigen Proben |
-
2000
- 2000-06-09 DE DE10028548A patent/DE10028548C1/de not_active Expired - Fee Related
-
2001
- 2001-05-29 KR KR1020027016648A patent/KR20030014691A/ko not_active Application Discontinuation
- 2001-05-29 EP EP01938242A patent/EP1287356B1/de not_active Expired - Lifetime
- 2001-05-29 US US10/297,424 patent/US6884223B2/en not_active Expired - Fee Related
- 2001-05-29 AT AT01938242T patent/ATE262179T1/de not_active IP Right Cessation
- 2001-05-29 WO PCT/EP2001/006101 patent/WO2001094942A1/de active IP Right Grant
- 2001-05-29 AU AU2001263943A patent/AU2001263943A1/en not_active Abandoned
- 2001-05-29 DE DE50101715T patent/DE50101715D1/de not_active Expired - Fee Related
- 2001-05-29 RU RU2002132381/15A patent/RU2002132381A/ru not_active Application Discontinuation
- 2001-05-29 JP JP2002502440A patent/JP2004501366A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20030014691A (ko) | 2003-02-19 |
| JP2004501366A (ja) | 2004-01-15 |
| EP1287356A1 (de) | 2003-03-05 |
| DE10028548C1 (de) | 2001-08-30 |
| ATE262179T1 (de) | 2004-04-15 |
| US6884223B2 (en) | 2005-04-26 |
| EP1287356B1 (de) | 2004-03-17 |
| AU2001263943A1 (en) | 2001-12-17 |
| WO2001094942A1 (de) | 2001-12-13 |
| US20030176805A1 (en) | 2003-09-18 |
| DE50101715D1 (de) | 2004-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20050111 |