RU2002127733A - Способ лечения или профилактики повышенного глазного давления и глаукомы, фармацевтическая композиция и способ получения соединения простагландинов - Google Patents
Способ лечения или профилактики повышенного глазного давления и глаукомы, фармацевтическая композиция и способ получения соединения простагландиновInfo
- Publication number
- RU2002127733A RU2002127733A RU2002127733/15A RU2002127733A RU2002127733A RU 2002127733 A RU2002127733 A RU 2002127733A RU 2002127733/15 A RU2002127733/15 A RU 2002127733/15A RU 2002127733 A RU2002127733 A RU 2002127733A RU 2002127733 A RU2002127733 A RU 2002127733A
- Authority
- RU
- Russia
- Prior art keywords
- group
- compound
- aryl
- prostaglandins
- substituted
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 40
- 150000001875 compounds Chemical class 0.000 title claims 39
- 230000002265 prevention Effects 0.000 title claims 8
- 239000008194 pharmaceutical composition Substances 0.000 title claims 7
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 125000003118 aryl group Chemical group 0.000 claims 33
- 125000000217 alkyl group Chemical group 0.000 claims 31
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 30
- 150000003180 prostaglandins Chemical class 0.000 claims 26
- 239000000203 mixture Substances 0.000 claims 25
- 125000000623 heterocyclic group Chemical group 0.000 claims 24
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims 24
- 125000005843 halogen group Chemical group 0.000 claims 21
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 21
- 125000003545 alkoxy group Chemical group 0.000 claims 18
- 125000004043 oxo group Chemical group O=* 0.000 claims 18
- 125000001931 aliphatic group Chemical group 0.000 claims 12
- 150000001408 amides Chemical class 0.000 claims 12
- 229910052799 carbon Inorganic materials 0.000 claims 12
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 12
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 12
- 229920006395 saturated elastomer Polymers 0.000 claims 12
- 208000010412 Glaucoma Diseases 0.000 claims 9
- 238000011866 long-term treatment Methods 0.000 claims 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 6
- 125000004423 acyloxy group Chemical group 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 6
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 6
- 125000004104 aryloxy group Chemical group 0.000 claims 6
- 150000001721 carbon Chemical group 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 6
- 150000002148 esters Chemical class 0.000 claims 6
- 150000002170 ethers Chemical class 0.000 claims 6
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 6
- 125000004430 oxygen atom Chemical group O* 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 230000002035 prolonged effect Effects 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 238000011200 topical administration Methods 0.000 claims 4
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 claims 3
- 150000002026 docosanoids Chemical class 0.000 claims 3
- 230000019612 pigmentation Effects 0.000 claims 3
- DKYCMQSMHPIBBZ-VIZYZFHWSA-N propan-2-yl (z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]hept-5-enoate Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(=O)CCC1=CC=CC=C1 DKYCMQSMHPIBBZ-VIZYZFHWSA-N 0.000 claims 3
- TVHAZVBUYQMHBC-SNHXEXRGSA-N unoprostone Chemical compound CCCCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O TVHAZVBUYQMHBC-SNHXEXRGSA-N 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 230000007423 decrease Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
- A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52757300A | 2000-03-16 | 2000-03-16 | |
| US09/527.573 | 2000-03-16 | ||
| US09/730.830 | 2000-12-07 | ||
| US09/730,830 US20010034355A1 (en) | 2000-03-16 | 2000-12-07 | Treatment of ocular hypertension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2002127733A true RU2002127733A (ru) | 2004-03-27 |
Family
ID=27062443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002127733/15A RU2002127733A (ru) | 2000-03-16 | 2001-03-15 | Способ лечения или профилактики повышенного глазного давления и глаукомы, фармацевтическая композиция и способ получения соединения простагландинов |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20010056104A1 (enExample) |
| EP (1) | EP1272194A2 (enExample) |
| JP (1) | JP2003526660A (enExample) |
| KR (1) | KR20080012407A (enExample) |
| CN (1) | CN100506232C (enExample) |
| AR (1) | AR029818A1 (enExample) |
| AU (2) | AU4114301A (enExample) |
| BR (1) | BR0109192A (enExample) |
| CA (1) | CA2402597C (enExample) |
| CZ (1) | CZ20023092A3 (enExample) |
| HU (1) | HUP0300391A3 (enExample) |
| IL (1) | IL151683A0 (enExample) |
| MX (1) | MXPA02008967A (enExample) |
| NO (1) | NO20024381L (enExample) |
| NZ (1) | NZ521325A (enExample) |
| RU (1) | RU2002127733A (enExample) |
| TW (1) | TWI286932B (enExample) |
| WO (1) | WO2001068072A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997022689A1 (en) † | 1995-12-18 | 1997-06-26 | Myriad Genetics, Inc. | Chromosome 13-linked breast cancer susceptibility gene |
| US20020035148A1 (en) * | 2000-07-20 | 2002-03-21 | Ryuji Ueno | Treatment of ocular hypertension |
| US6713268B2 (en) * | 2001-06-26 | 2004-03-30 | Allergan, Inc. | Methods of identifying ocular hypotensive compounds having reduced hyperpigmentation |
| EP1411950A2 (en) * | 2001-07-31 | 2004-04-28 | Sucampo AG | Treatment of ocular hypertension and glaucoma |
| AU2003215820A1 (en) * | 2002-03-28 | 2003-10-13 | Sucampo Ag | Method for treating ocular hypertension and glaucoma |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3876050T2 (de) * | 1987-09-18 | 1993-03-25 | Ueno Seiyaku Oyo Kenkyujo Kk | Okulare hypotensivagenzien. |
| ES2213504T1 (es) * | 1988-09-06 | 2004-09-01 | Pfizer Health Ab | Derivados de prostaglandina para el tratamiento del glaucoma o hipertension ocular. |
| US5321128A (en) * | 1988-09-06 | 1994-06-14 | Kabi Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| CA2039420C (en) * | 1990-04-04 | 1996-12-10 | Ryuji Ueno | Treatment of cataract with 15-keto-prostaglandin compounds |
| AU687906B2 (en) * | 1993-12-15 | 1998-03-05 | Alcon Laboratories, Inc. | Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension |
| US6011062A (en) * | 1994-12-22 | 2000-01-04 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| WO1997023225A1 (en) * | 1995-12-22 | 1997-07-03 | Alcon Laboratories, Inc. | Combinations of dp and fp type prostaglandins for lowering iop |
| US6232344B1 (en) * | 1997-12-22 | 2001-05-15 | Alcon Laboratories, Inc. | 13-Oxa prostaglandins for the treatment of glaucoma and ocular hypertension |
| ATE245451T1 (de) * | 1998-04-07 | 2003-08-15 | Alcon Lab Inc | Xanthangummi enthaltende gelbildende ophthalmische zusammensetzungen |
-
2001
- 2001-03-15 HU HU0300391A patent/HUP0300391A3/hu unknown
- 2001-03-15 CA CA2402597A patent/CA2402597C/en not_active Expired - Fee Related
- 2001-03-15 AU AU4114301A patent/AU4114301A/xx active Pending
- 2001-03-15 AU AU2001241143A patent/AU2001241143B2/en not_active Ceased
- 2001-03-15 BR BR0109192-1A patent/BR0109192A/pt not_active Application Discontinuation
- 2001-03-15 CZ CZ20023092A patent/CZ20023092A3/cs unknown
- 2001-03-15 CN CNB018093396A patent/CN100506232C/zh not_active Expired - Fee Related
- 2001-03-15 RU RU2002127733/15A patent/RU2002127733A/ru unknown
- 2001-03-15 JP JP2001566636A patent/JP2003526660A/ja active Pending
- 2001-03-15 NZ NZ521325A patent/NZ521325A/en not_active IP Right Cessation
- 2001-03-15 IL IL15168301A patent/IL151683A0/xx not_active IP Right Cessation
- 2001-03-15 EP EP01912374A patent/EP1272194A2/en not_active Ceased
- 2001-03-15 MX MXPA02008967A patent/MXPA02008967A/es active IP Right Grant
- 2001-03-15 WO PCT/JP2001/002035 patent/WO2001068072A2/en not_active Ceased
- 2001-03-15 KR KR1020087002403A patent/KR20080012407A/ko not_active Ceased
- 2001-03-16 AR ARP010101231A patent/AR029818A1/es unknown
- 2001-03-16 TW TW090106162A patent/TWI286932B/zh not_active IP Right Cessation
- 2001-03-27 US US09/817,046 patent/US20010056104A1/en not_active Abandoned
-
2002
- 2002-09-13 NO NO20024381A patent/NO20024381L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU4114301A (en) | 2001-09-24 |
| KR20080012407A (ko) | 2008-02-11 |
| NO20024381L (no) | 2002-11-15 |
| TWI286932B (en) | 2007-09-21 |
| HUP0300391A3 (en) | 2008-05-28 |
| IL151683A0 (en) | 2003-04-10 |
| HUP0300391A2 (hu) | 2003-06-28 |
| CA2402597A1 (en) | 2001-09-20 |
| CN100506232C (zh) | 2009-07-01 |
| CA2402597C (en) | 2011-04-26 |
| CN1429112A (zh) | 2003-07-09 |
| EP1272194A2 (en) | 2003-01-08 |
| CZ20023092A3 (cs) | 2003-05-14 |
| WO2001068072A3 (en) | 2002-06-06 |
| NZ521325A (en) | 2004-05-28 |
| MXPA02008967A (es) | 2003-02-12 |
| WO2001068072A2 (en) | 2001-09-20 |
| US20010056104A1 (en) | 2001-12-27 |
| JP2003526660A (ja) | 2003-09-09 |
| NO20024381D0 (no) | 2002-09-13 |
| BR0109192A (pt) | 2003-05-27 |
| AR029818A1 (es) | 2003-07-16 |
| AU2001241143B2 (en) | 2005-08-25 |
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