RU2001107005A - Биофлавоноиды в качестве агента, снижающего уровень глюкозы в крови - Google Patents
Биофлавоноиды в качестве агента, снижающего уровень глюкозы в кровиInfo
- Publication number
- RU2001107005A RU2001107005A RU2001107005/14A RU2001107005A RU2001107005A RU 2001107005 A RU2001107005 A RU 2001107005A RU 2001107005/14 A RU2001107005/14 A RU 2001107005/14A RU 2001107005 A RU2001107005 A RU 2001107005A RU 2001107005 A RU2001107005 A RU 2001107005A
- Authority
- RU
- Russia
- Prior art keywords
- group
- bioflavonoid
- alkoxy
- hydroxy
- aryloxy
- Prior art date
Links
- 210000004369 Blood Anatomy 0.000 title claims 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims 3
- 239000008280 blood Substances 0.000 title claims 3
- 239000008103 glucose Substances 0.000 title claims 3
- 229940083828 Bioflavonoid drugs for capillary stabilizing Drugs 0.000 title 1
- 229940093797 Bioflavonoids Drugs 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000004104 aryloxy group Chemical group 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 239000000419 plant extract Substances 0.000 claims 4
- 125000003368 amide group Chemical group 0.000 claims 3
- 239000000284 extract Substances 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical group 0.000 claims 3
- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 claims 2
- AIONOLUJZLIMTK-AWEZNQCLSA-N Hesperetin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O)=CC(O)=C2C(=O)C1 AIONOLUJZLIMTK-AWEZNQCLSA-N 0.000 claims 2
- FTVWIRXFELQLPI-ZDUSSCGKSA-N Naringenin Chemical compound C1=CC(O)=CC=C1[C@H]1OC2=CC(O)=CC(O)=C2C(=O)C1 FTVWIRXFELQLPI-ZDUSSCGKSA-N 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 235000013311 vegetables Nutrition 0.000 claims 2
- GZSOSUNBTXMUFQ-NJGQXECBSA-N 5,7,3'-Trihydroxy-4'-methoxyflavone 7-O-rutinoside Natural products O(C[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](Oc2cc(O)c3C(=O)C=C(c4cc(O)c(OC)cc4)Oc3c2)O1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](C)O1 GZSOSUNBTXMUFQ-NJGQXECBSA-N 0.000 claims 1
- 239000001606 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)chroman-4-one Substances 0.000 claims 1
- 241000219051 Fagopyrum Species 0.000 claims 1
- 235000009419 Fagopyrum esculentum Nutrition 0.000 claims 1
- 229940025878 Hesperidin Drugs 0.000 claims 1
- QUQPHWDTPGMPEX-YEDPJISVSA-N Hesperidin Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](Oc2cc(O)c3C(=O)C[C@@H](c4cc(O)c(OC)cc4)Oc3c2)O1)[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](C)O1 QUQPHWDTPGMPEX-YEDPJISVSA-N 0.000 claims 1
- DFPMSGMNTNDNHN-OHXUDFEXSA-N Naringin Natural products O([C@@H]1[C@@H](O)[C@H](O)[C@H](CO)O[C@H]1Oc1cc(O)c2C(=O)C[C@@H](c3ccc(O)cc3)Oc2c1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](C)O1 DFPMSGMNTNDNHN-OHXUDFEXSA-N 0.000 claims 1
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims 1
- 229960001285 Quercetin Drugs 0.000 claims 1
- 229940081967 Rutin Drugs 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive Effects 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000005201 cycloalkylcarbonyloxy group Chemical group 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- GZSOSUNBTXMUFQ-YFAPSIMESA-N diosmin Chemical compound C1=C(O)C(OC)=CC=C1C(OC1=C2)=CC(=O)C1=C(O)C=C2O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)O1 GZSOSUNBTXMUFQ-YFAPSIMESA-N 0.000 claims 1
- 229960004352 diosmin Drugs 0.000 claims 1
- 235000013399 edible fruits Nutrition 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 235000010209 hesperetin Nutrition 0.000 claims 1
- 229960001587 hesperetin Drugs 0.000 claims 1
- QUQPHWDTPGMPEX-QJBIFVCTSA-N hesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-QJBIFVCTSA-N 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 235000007625 naringenin Nutrition 0.000 claims 1
- 229940117954 naringenin Drugs 0.000 claims 1
- DFPMSGMNTNDNHN-ZPHOTFPESA-N naringin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC=2C=C3O[C@@H](CC(=O)C3=C(O)C=2)C=2C=CC(O)=CC=2)O[C@H](CO)[C@@H](O)[C@@H]1O DFPMSGMNTNDNHN-ZPHOTFPESA-N 0.000 claims 1
- 229940052490 naringin Drugs 0.000 claims 1
- ITVGXXMINPYUHD-CUVHLRMHSA-N neohesperidin dihydrochalcone Chemical compound C1=C(O)C(OC)=CC=C1CCC(=O)C(C(=C1)O)=C(O)C=C1O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ITVGXXMINPYUHD-CUVHLRMHSA-N 0.000 claims 1
- 239000000879 neohesperidine DC Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229930002344 quercetin Natural products 0.000 claims 1
- 235000005875 quercetin Nutrition 0.000 claims 1
- 229930002876 rutin Natural products 0.000 claims 1
- 235000005493 rutin Nutrition 0.000 claims 1
- 229960004555 rutoside Drugs 0.000 claims 1
Claims (11)
1. Применение биофлавоноида формулы (I) или растительного экстракта, содержащего биофлавоноид, для снижения уровня глюкозы в крови у млекопитающего
где каждый R1, R2, R3, R4, R5, R6, R7, R8 и R9 независимо каждый представляет водород; гидроксигруппу; C1-9 алкоксигруппу, необязательно замещенную одним или более заместителями, выбранными из группы, состоящей из гидрокси, С1-5алкокси, арилокси и фенильной группы, замещенной 1-3 заместителями, выбранными из группы, состоящей из гидрокси, алкокси, арилокси, галогена, нитро и амидогруппы; C5-9 циклоалкилоксигруппу, замещенную 1-3 заместителями, выбранными из группы, состоящей из гидрокси, алкокси, арилокси, галогена, нитро и амидогруппы; C5-9 циклоалкилкарбонилоксигруппу, замещенную 1-3 заместителями, выбранными из группы, состоящей из гидрокси, алкокси, арилокси, галогена, нитро и амидогруппы; C2-10 или C16-18 ацилоксигруппу, необязательно замещенную одним или более заместителями, выбранными из группы, состоящей из гидрокси, С1-5алкокси, арилокси и фенильной группы, замещенной 1-3 заместителями, выбранными из группы, состоящей из гидрокси, алкокси, арилокси, галогена, нитрогруппы; рутинозильную группу; или раминозильную группу; и
Х представляет простую или двойную связь.
2. Применение по п.1, где указанным млекопитающим является человек.
3. Применение по п.2, где эффективное количество биофлавоноида изменяется от 0,1 до 500 мг/кг массы тела в день.
4. Применение по п.1, где биофлавоноидом является гесперидин, гесперетин, нарингин, нарингенин, диосмин, рутин, кверцетин или их смесь.
5. Применение по п.1, где растительным экстрактом является овощной или фруктовый экстракт.
6. Применение по п.5, где овощным экстрактом является экстракт из побегов, семян, стеблей, листьев или цветков гречихи.
7. Применение по п.1, где биофлавоноид или растительный экстракт вводят в виде фармацевтической композиции.
8. Применение по п.1, где биофлавоноид или растительный экстракт вводят в виде добавки или диетической добавки в пищевой продукт или напиток.
9. Применение по п.8, где количество биофлавоноида в пищевом продукте составляет в пределах от 0,01 до 50 мас.%.
10. Применение по п.8, где количество биофлавоноида в напитке составляет от 200 до 1000 мг на 1000 мл напитка.
11. Применение для снижения уровня глюкозы в крови у млекопитающего, предусматривающее введение этому млекопитающему эффективного количества неогесперидиндигидрохалкона формулы (II)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1998/37958 | 1998-09-15 | ||
| KR1019980037958A KR20000019716A (ko) | 1998-09-15 | 1998-09-15 | 바이오플라보노이드 화합물을 포함하는 혈당 강하용 조성물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2203050C2 RU2203050C2 (ru) | 2003-04-27 |
| RU2001107005A true RU2001107005A (ru) | 2003-07-27 |
Family
ID=19550601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001107005/14A RU2203050C2 (ru) | 1998-09-15 | 1998-10-20 | Биофлавоноиды в качестве агента, снижающего уровень глюкозы в крови |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6096364A (ru) |
| EP (1) | EP1113791A2 (ru) |
| JP (1) | JP2002524480A (ru) |
| KR (1) | KR20000019716A (ru) |
| CN (1) | CN1322132A (ru) |
| CA (1) | CA2342608A1 (ru) |
| RU (1) | RU2203050C2 (ru) |
| WO (1) | WO2000015174A2 (ru) |
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1998
- 1998-09-15 KR KR1019980037958A patent/KR20000019716A/ko not_active Application Discontinuation
- 1998-10-20 CN CN98814241A patent/CN1322132A/zh active Pending
- 1998-10-20 JP JP2000569759A patent/JP2002524480A/ja active Pending
- 1998-10-20 CA CA002342608A patent/CA2342608A1/en not_active Abandoned
- 1998-10-20 WO PCT/KR1998/000325 patent/WO2000015174A2/en not_active Application Discontinuation
- 1998-10-20 RU RU2001107005/14A patent/RU2203050C2/ru not_active IP Right Cessation
- 1998-10-20 EP EP98951778A patent/EP1113791A2/en not_active Withdrawn
- 1998-10-22 US US09/177,463 patent/US6096364A/en not_active Expired - Lifetime
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