RU1831479C - Способ получени замещенных имидазолов или их нетоксичных фармакологически приемлемых солей - Google Patents

Способ получени замещенных имидазолов или их нетоксичных фармакологически приемлемых солей

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Publication number
RU1831479C
RU1831479C SU4742612A SU4742612A RU1831479C RU 1831479 C RU1831479 C RU 1831479C SU 4742612 A SU4742612 A SU 4742612A SU 4742612 A SU4742612 A SU 4742612A RU 1831479 C RU1831479 C RU 1831479C
Authority
RU
Russia
Prior art keywords
substituted
imidazols
production
acceptable salts
pharmacologically acceptable
Prior art date
Application number
SU4742612A
Other languages
English (en)
Inventor
Йоханнес Карьялайнен Арто
Эйнари Виртанен Раймо
Леена Карьялайнен Арья
Original Assignee
Фармос-Ихтюмя Ой
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармос-Ихтюмя Ой filed Critical Фармос-Ихтюмя Ой
Application granted granted Critical
Publication of RU1831479C publication Critical patent/RU1831479C/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Использование: в качестве антагонистов од-адренорецепторов. Сущность изобретени - ПРОДУКТ общей формулы Ri ч/ CM -В Р 4УГГЧ N А, где X - СН2 или С О. Ri - Ci - s-алкил, либо бензил, который может быть замещенным или незамещенным, R2 - Н, Ci - 4-алкил, ОН или Ci-з-алкокси, Яз-Н, СНз, СН2СНз, ОСНз или Hal. RA - Н, СНз, СНа СНз, JCHs или Hal, Hal-галоген, причем, когда R2-H или Ci - з-алкил. RI не может быть водорбдом и когда R2 - ОН или Ci - з-алкокси, X не может быть С О. Реагент I: продукт общей формулы: . N ч-нО N Н где R2, Rs, R4 имеют вышеуказанные значени . Реагент II: алкил или аралкилгалогенид формулы: R Y, Ci -s-алкил, либо незамещенный бензил , Y-галоген. З табл. w V |ё

Description

Таблица 1
Номер
14- (2-этил-2,3-дигидро-1 Н-инкент2-ил) -1 -метил-111-имидазол
21 -Этил-4- (2-этил-2,3-л.игидро-1 И-инден-2-ил)-1 Н-имидазол
(2-этил-2,3-дигидро- 1Н-инден-2-ил)-1-н-пропил-111-имидазол k}-бензип-1 - (2-этил-2 3-лигидро-1П-инден-2-ил)-1П-имидазол
5 2Чэтил-2-(1-метил-1Н-имидазол- -ил)-1-инданон
7k(2,3-дигидро-2-метоксиметил-1И-инден-2-ил)-1-метил-1Н-имидазол
81-этил-(-(2,3-дигидро-/2-н-пропил-1 1-ин/-,ен-2-ил)-1М-инидазол
(2,3-дигидро-2-н-пропил-1п-инден-2-ил)-1-метил-111-имидазол
10(2)-1-этил-1Н-имидазол- -ил(-2,3-дигидро-111-инден-2-ил)метанол
111-этил- -(2,3-дигилро-2-метоксиметил-1М-инлен-2-ил)-1Н-имилазол
122-ЭТИЛ-2-(1-этил-1Н-имидааол- -ил)-1-инданон
Название
Таблица 2
Таблица 3
SU4742612A 1988-12-09 1989-12-08 Способ получени замещенных имидазолов или их нетоксичных фармакологически приемлемых солей RU1831479C (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8828831A GB2225782A (en) 1988-12-09 1988-12-09 Imidazole derivatives useful for treatment of diabetes

Publications (1)

Publication Number Publication Date
RU1831479C true RU1831479C (ru) 1993-07-30

Family

ID=10648267

Family Applications (2)

Application Number Title Priority Date Filing Date
SU4742612A RU1831479C (ru) 1988-12-09 1989-12-08 Способ получени замещенных имидазолов или их нетоксичных фармакологически приемлемых солей
SU91A RU1833375C (en) 1988-12-09 1991-01-08 Method of synthesis of substituted derivatives of imidazole or their nontoxic pharmacology acceptable salts

Family Applications After (1)

Application Number Title Priority Date Filing Date
SU91A RU1833375C (en) 1988-12-09 1991-01-08 Method of synthesis of substituted derivatives of imidazole or their nontoxic pharmacology acceptable salts

Country Status (22)

Country Link
US (1) US5292887A (ru)
EP (1) EP0372954B1 (ru)
JP (1) JP2868813B2 (ru)
KR (1) KR900009605A (ru)
CN (1) CN1023219C (ru)
AT (1) ATE102608T1 (ru)
AU (1) AU619928B2 (ru)
CA (1) CA2004799A1 (ru)
DD (1) DD290880A5 (ru)
DE (1) DE68913673T2 (ru)
DK (1) DK603789A (ru)
ES (1) ES2052937T3 (ru)
FI (1) FI96026C (ru)
GB (1) GB2225782A (ru)
HU (1) HU205086B (ru)
IE (1) IE61870B1 (ru)
IL (1) IL92609A0 (ru)
NO (1) NO177138C (ru)
NZ (1) NZ231649A (ru)
PT (1) PT92515B (ru)
RU (2) RU1831479C (ru)
ZA (1) ZA899366B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI862039A0 (fi) * 1986-05-15 1986-05-15 Farmos Oy Nytt foerfarande foer framstaellning av 4(5)-substituerade imidazolderivat.
GB9127050D0 (en) * 1991-12-20 1992-02-19 Orion Yhtymae Oy Substituted imidazole derivatives and their preparation and use
GB9312669D0 (en) 1993-06-18 1993-08-04 Orion Yhtymae Oy New opticla isomers
FR2735776B1 (fr) * 1995-06-22 1997-07-18 Synthelabo Derives de 2,3-dihydro-1h-indole, leur preparation et leur application en therapeutique
JP2002534511A (ja) * 1999-01-18 2002-10-15 ノボ ノルディスク アクティーゼルスカブ 置換型イミダゾール、それらの調製及び使用
FI20000073A0 (fi) * 2000-01-14 2000-01-14 Orion Yhtymae Oy Uusia imidatsolijohdannaisia
US6388090B2 (en) 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
IL152401A0 (en) 2000-05-08 2003-05-29 Orion Corp New polycyclic indanylimidazoles with alpha2 adrenergic activity
FR2839719B1 (fr) * 2002-05-16 2004-08-06 Pf Medicament Nouveaux composes imidazoliques, leur procede de preparation et leur utilisation a titre de medicaments
US8188126B2 (en) 2002-05-16 2012-05-29 Pierre Fabre Medicament Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
GB0226076D0 (en) * 2002-11-08 2002-12-18 Rp Scherer Technologies Inc Improved formulations containing substituted imidazole derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2167408B (en) * 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
FI81092C (fi) * 1986-05-15 1990-09-10 Farmos Oy Foerfarande foer framstaellning av terapeutiskt aktiva 4(5)-(2,3-dihydro-1h-inden-2-yl)-imidazolderivat.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Эльдерфилд Р. Гетероциклические соединени , т. 5, М.: И.Л.. 1954, с. 167. *

Also Published As

Publication number Publication date
FI96026B (fi) 1996-01-15
GB8828831D0 (en) 1989-01-18
HU205086B (en) 1992-03-30
NO177138B (no) 1995-04-18
GB2225782A (en) 1990-06-13
IE893926L (en) 1990-06-09
IE61870B1 (en) 1994-11-30
RU1833375C (en) 1993-08-07
CN1043128A (zh) 1990-06-20
DK603789D0 (da) 1989-11-30
NO177138C (no) 1995-07-26
JPH02202874A (ja) 1990-08-10
ES2052937T3 (es) 1994-07-16
PT92515A (pt) 1990-06-29
DK603789A (da) 1990-06-10
EP0372954B1 (en) 1994-03-09
FI895325A0 (fi) 1989-11-09
CN1023219C (zh) 1993-12-22
DE68913673T2 (de) 1994-07-14
US5292887A (en) 1994-03-08
AU4599289A (en) 1990-08-16
FI96026C (fi) 1996-04-25
PT92515B (pt) 1995-08-09
DE68913673D1 (de) 1994-04-14
HUT52065A (en) 1990-06-28
AU619928B2 (en) 1992-02-06
EP0372954A1 (en) 1990-06-13
KR900009605A (ko) 1990-07-05
NZ231649A (en) 1991-09-25
NO894563D0 (no) 1989-11-16
ATE102608T1 (de) 1994-03-15
ZA899366B (en) 1991-03-27
IL92609A0 (en) 1990-08-31
DD290880A5 (de) 1991-06-13
CA2004799A1 (en) 1990-06-09
NO894563L (no) 1990-06-11
JP2868813B2 (ja) 1999-03-10

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