RS65543B1 - Diazabiciklični supstituisani imidazopirimidini i njihova primena za lečenje poremećaja disanja - Google Patents

Diazabiciklični supstituisani imidazopirimidini i njihova primena za lečenje poremećaja disanja

Info

Publication number
RS65543B1
RS65543B1 RS20240581A RSP20240581A RS65543B1 RS 65543 B1 RS65543 B1 RS 65543B1 RS 20240581 A RS20240581 A RS 20240581A RS P20240581 A RSP20240581 A RS P20240581A RS 65543 B1 RS65543 B1 RS 65543B1
Authority
RS
Serbia
Prior art keywords
diazabicyclic
treatment
breathing disorders
substituted imidazopyrimidines
imidazopyrimidines
Prior art date
Application number
RS20240581A
Other languages
English (en)
Serbian (sr)
Inventor
Martina Delbeck
Michael Hahn
Thomas Müller
Klemens Lustig
Karl Collins
Niels Lindner
Janine Nicolai
Moritz Beck-Broichsitter
Udo Albus
Doris Gehring
Björn Rosenstein
Original Assignee
Bayer Ag
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Bayer Pharma AG filed Critical Bayer Ag
Publication of RS65543B1 publication Critical patent/RS65543B1/sr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995Pyrazines or piperazines forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53861,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RS20240581A 2017-06-14 2018-06-07 Diazabiciklični supstituisani imidazopirimidini i njihova primena za lečenje poremećaja disanja RS65543B1 (sr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP17176046 2017-06-14
EP17193252 2017-09-26
PCT/EP2018/064977 WO2018228907A1 (de) 2017-06-14 2018-06-07 Diazabicyclisch substituierte imidazopyrimidine und ihre verwendung zur behandlung von atemstörungen
EP18728646.3A EP3638675B1 (de) 2017-06-14 2018-06-07 Diazabicyclisch substituierte imidazopyrimidine und ihre verwendung zur behandlung von atemstörungen

Publications (1)

Publication Number Publication Date
RS65543B1 true RS65543B1 (sr) 2024-06-28

Family

ID=62492660

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20240581A RS65543B1 (sr) 2017-06-14 2018-06-07 Diazabiciklični supstituisani imidazopirimidini i njihova primena za lečenje poremećaja disanja

Country Status (30)

Country Link
US (2) US11098063B2 (pt-PT)
EP (1) EP3638675B1 (pt-PT)
JP (2) JP6896113B2 (pt-PT)
KR (1) KR102364134B1 (pt-PT)
CN (4) CN115554299A (pt-PT)
AR (1) AR112099A1 (pt-PT)
AU (1) AU2018283331B2 (pt-PT)
BR (1) BR112019026450A2 (pt-PT)
CA (1) CA3066942A1 (pt-PT)
CL (1) CL2019003650A1 (pt-PT)
CO (1) CO2019014047A2 (pt-PT)
CR (1) CR20190563A (pt-PT)
CU (1) CU24603B1 (pt-PT)
DO (1) DOP2019000308A (pt-PT)
EA (1) EA202090043A1 (pt-PT)
EC (1) ECSP19088492A (pt-PT)
GE (1) GEP20227366B (pt-PT)
IL (1) IL271117B (pt-PT)
JO (1) JOP20190284A1 (pt-PT)
MA (1) MA49368A (pt-PT)
MX (2) MX2019014983A (pt-PT)
NI (1) NI201900126A (pt-PT)
PE (1) PE20200016A1 (pt-PT)
PH (1) PH12019502828A1 (pt-PT)
RS (1) RS65543B1 (pt-PT)
SG (1) SG11201911508XA (pt-PT)
TW (1) TWI801388B (pt-PT)
UA (1) UA125186C2 (pt-PT)
UY (1) UY37773A (pt-PT)
WO (1) WO2018228907A1 (pt-PT)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112018011783A2 (pt) 2015-12-10 2018-12-04 Bayer Pharma Aktiengesellschaft derivados de 2-fenil-3-(piperazinometil)imidazo[1,2-a]piridina, como bloqueadores dos canais de task-1 e task-2 para o tratamento de transtornos respiratórios relacionados ao sono
JOP20190284A1 (ar) * 2017-06-14 2019-12-11 Bayer Pharma AG مركبات إيميدازوبيريميدين مستبدلة بديازا ثنائي الحلقة واستخدامها للمعالجة من اضطرابات التنفس
WO2018227427A1 (en) 2017-06-14 2018-12-20 Bayer Aktiengesellschaft Substituted bridged diazepane derivatives and use thereof
EP3965766A1 (en) * 2019-05-09 2022-03-16 Bayer Aktiengesellschaft Combination of an ?2-adrenoceptor subtype c (alpha-2c) antagonists with a task1/3 channel blocker for the treatment of sleep apnea
CA3139298A1 (en) 2019-05-09 2020-11-12 Bayer Aktiengesellschaft Combination of an a2-adrenoceptor subtype c (alpha-2c) antagonists with a task1/3 channel blocker for the treatment of sleep apnea
MX2022005414A (es) 2019-11-06 2022-05-26 Bayer Ag Inhibidores de adrenoreceptor adrac2.
CN116057057A (zh) 2020-07-06 2023-05-02 拜耳公司 用于治疗睡眠呼吸暂停的α2-肾上腺素受体亚型C(α-2C)拮抗剂与TASK1/3通道阻断剂的结合物
GB202101734D0 (en) * 2021-02-08 2021-03-24 Cerevance Inc Novel Compounds
WO2023118102A1 (en) 2021-12-22 2023-06-29 Bayer Aktiengesellschaft Combination of a task1/3 channel blocker with a muscarinic receptor antagonist for the treatment of sleep apnea
AU2022422284A1 (en) 2021-12-22 2024-07-04 Bayer Aktiengesellschaft Combination of a task1/3 channel blocker with a norepinephrine reuptake inhibitor for the treatment of sleep apnea
WO2023118122A1 (en) 2021-12-22 2023-06-29 Bayer Aktiengesellschaft Combination of a task1/3 channel blocker with a p2x3 receptor antagonist for the treatment of sleep apnea
WO2023131640A1 (en) 2022-01-07 2023-07-13 Bayer Aktiengesellschaft α2-ADRENOCEPTOR SUBTYPE C ANTAGONISTS FOR THE TREATMENT OF SLEEP APNEA
WO2023131638A1 (en) 2022-01-07 2023-07-13 Bayer Aktiengesellschaft 2,3-dihydrobenzo [b][1, 4]dioxin-2-ylmethyl)piperazin-1-yl derivates for the treatment of sleep apnea

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19943636A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943634A1 (de) 1999-09-13 2001-04-12 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943639A1 (de) 1999-09-13 2001-03-15 Bayer Ag Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
MY125533A (en) * 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
WO2002002557A2 (en) 2000-06-30 2002-01-10 Neurogen Corporation 2-phenylimidazo[1,2-a]pyridine derivatives: a new class of gaba brain receptor ligands
GB0017256D0 (en) 2000-07-13 2000-08-30 Merck Sharp & Dohme Therapeutic agents
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
SE0100568D0 (sv) 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
DE10110749A1 (de) 2001-03-07 2002-09-12 Bayer Ag Substituierte Aminodicarbonsäurederivate
DE10110750A1 (de) 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
DE10247269A1 (de) 2002-10-10 2004-04-22 Grünenthal GmbH Substituierte C-Imidazo[1,2-a]pyridin-3-yl-methylamine
US7855194B2 (en) * 2006-03-27 2010-12-21 Hoffmann-La Roche Inc. Pyrimidine, quinazoline, pteridine and triazine derivatives
AU2007245891B2 (en) * 2006-04-27 2012-10-18 Sanofi-Aventis Deutschland Gmbh Inhibitors of the TASK-1 and TASK-3 ion channel
EP2049110B1 (en) * 2006-07-14 2014-08-20 Merck Sharp & Dohme Corp. Bridged diazepan orexin receptor antagonists
EP1974729A1 (en) 2007-03-28 2008-10-01 Santhera Pharmaceuticals (Schweiz) AG Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists
EP2300470A2 (en) 2008-05-19 2011-03-30 Sepracor Inc. Imidazo[1,2-a]pyridine compounds as gaba-a receptor modulators
WO2011115804A1 (en) 2010-03-17 2011-09-22 Ironwood Pharmaceuticals, Inc. Sgc stimulators
SG10201502109VA (en) 2010-03-18 2015-05-28 Pasteur Institut Korea Anti-infective compounds
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
CN103097387B (zh) 2010-07-09 2016-11-02 拜耳知识产权有限责任公司 环稠合的嘧啶和三嗪以及其用于治疗和/或预防心血管疾病的用途
DE102010040233A1 (de) 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Bicyclische Aza-Heterocyclen und ihre Verwendung
DE102010043379A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung
CN103298468A (zh) 2011-02-01 2013-09-11 协和发酵麒麟株式会社 稠环杂环衍生物
WO2012130322A1 (en) 2011-03-31 2012-10-04 Elara Pharmaceuticals Gmbh Imidazo [1,2-a]pyridine compounds for use in therapy
KR102104125B1 (ko) 2011-04-21 2020-05-29 재단법인 한국파스퇴르연구소 소염 화합물
EA023648B1 (ru) 2011-09-12 2016-06-30 Санофи ИНДАНИЛЗАМЕЩЕННЫЕ 4,5,6,7-ТЕТРАГИДРО-1H-ПИРАЗОЛО[4,3-с]ПИРИДИНЫ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННОГО СРЕДСТВА И СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ ПРЕПАРАТЫ
ES2559450T3 (es) 2011-09-16 2016-02-12 Sanofi 4,5,6,7-Tetrahidro-1H-pirazolo[4,3-c]piridinas sustituidas, su uso como medicamento, y preparaciones farmacéuticas que las comprenden
WO2013037914A1 (en) * 2011-09-16 2013-03-21 Sanofi Substituted 4,5,6,7-tetrahydro-1h-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them
KR102017362B1 (ko) 2012-02-03 2019-09-02 사노피 축합 피롤디카복사미드 및 약제로서의 그의 용도
JP2016527184A (ja) * 2013-05-24 2016-09-08 イオメット ファーマ リミテッド Slc2a輸送体阻害剤
DK3122750T3 (da) 2014-03-26 2019-11-04 Hoffmann La Roche Bicykliske forbindelser som autotaxin (ATX)- og lysofosfatidsyre (LPA)-produktionshæmmere
JP2018012645A (ja) 2014-11-26 2018-01-25 持田製薬株式会社 新規ジアザビシクロ誘導体
US10000499B2 (en) 2014-11-26 2018-06-19 Merck Sharp & Dohme Corp. Methyl diazepane orexin receptor antagonists
TWI585785B (zh) * 2014-11-26 2017-06-01 Murata Manufacturing Co Electronic parts manufacturing methods, electronic components and electronic devices
US9994570B2 (en) 2014-11-26 2018-06-12 Merck Sharp & Dohme Corp. Bridged diazepane orexin receptor antagonists
JP2018016544A (ja) 2014-12-03 2018-02-01 持田製薬株式会社 新規ジアザビシクロ[2.2.2]オクタン誘導体
BR112018006024A2 (pt) 2015-09-24 2020-05-12 F. Hoffmann-La Roche Ag Compostos bicíclicos como inibidores de atx
BR112018011783A2 (pt) 2015-12-10 2018-12-04 Bayer Pharma Aktiengesellschaft derivados de 2-fenil-3-(piperazinometil)imidazo[1,2-a]piridina, como bloqueadores dos canais de task-1 e task-2 para o tratamento de transtornos respiratórios relacionados ao sono
JP2018538296A (ja) * 2015-12-10 2018-12-27 バイエル・ファルマ・アクティエンゲゼルシャフト 置換ペルヒドロピロロ[3,4−c]ピロール誘導体およびその使用
JOP20190005A1 (ar) 2016-07-20 2019-01-20 Bayer Ag مركبات ديازاهيترو ثنائية الحلقة مستبدلة واستخداماتها
JOP20190148A1 (ar) 2016-12-21 2019-06-18 Bayer Pharma AG أشكال جرعات صيدلية تحتوي على مثبطات قنوات task-1 و task-3 واستخدامها لمعالجة الاضطرابات التنفسية
JOP20190141A1 (ar) 2016-12-21 2019-06-12 Bayer Pharma AG أشكال جرعات صيدلية تحتوي على مثبطات لقناة task-1 و task-3 واستخدامها في معالجة اضطراب تنفسي
JOP20190284A1 (ar) * 2017-06-14 2019-12-11 Bayer Pharma AG مركبات إيميدازوبيريميدين مستبدلة بديازا ثنائي الحلقة واستخدامها للمعالجة من اضطرابات التنفس
WO2018227427A1 (en) 2017-06-14 2018-12-20 Bayer Aktiengesellschaft Substituted bridged diazepane derivatives and use thereof
EP3965766A1 (en) 2019-05-09 2022-03-16 Bayer Aktiengesellschaft Combination of an ?2-adrenoceptor subtype c (alpha-2c) antagonists with a task1/3 channel blocker for the treatment of sleep apnea
CA3139298A1 (en) 2019-05-09 2020-11-12 Bayer Aktiengesellschaft Combination of an a2-adrenoceptor subtype c (alpha-2c) antagonists with a task1/3 channel blocker for the treatment of sleep apnea

Also Published As

Publication number Publication date
IL271117A (en) 2020-01-30
TW201919638A (zh) 2019-06-01
CN110719911B (zh) 2022-10-21
SG11201911508XA (en) 2020-01-30
ECSP19088492A (es) 2019-12-27
TWI801388B (zh) 2023-05-11
WO2018228907A1 (de) 2018-12-20
EP3638675A1 (de) 2020-04-22
CO2019014047A2 (es) 2020-01-17
CA3066942A1 (en) 2018-12-20
CN115583959A (zh) 2023-01-10
EA202090043A1 (ru) 2020-04-02
GEP20227366B (en) 2022-03-25
CL2019003650A1 (es) 2020-07-10
CN115583959B (zh) 2024-04-26
PH12019502828A1 (en) 2020-10-26
US20200109155A1 (en) 2020-04-09
CN110719911A (zh) 2020-01-21
UY37773A (es) 2019-01-02
AR112099A1 (es) 2019-09-18
CU20190101A7 (es) 2020-10-20
BR112019026450A2 (pt) 2020-07-14
EP3638675B1 (de) 2024-04-17
MX2022012716A (es) 2022-11-07
JOP20190284A1 (ar) 2019-12-11
US11098063B2 (en) 2021-08-24
CN115554300A (zh) 2023-01-03
DOP2019000308A (es) 2020-01-31
KR20200014915A (ko) 2020-02-11
CU24603B1 (es) 2022-06-06
CN115554299A (zh) 2023-01-03
UA125186C2 (uk) 2022-01-26
PE20200016A1 (es) 2020-01-06
MX2019014983A (es) 2020-02-24
AU2018283331A1 (en) 2019-12-19
JP2021127346A (ja) 2021-09-02
MA49368A (fr) 2021-04-14
NI201900126A (es) 2020-04-02
KR102364134B1 (ko) 2022-02-18
EP3638675C0 (de) 2024-04-17
IL271117B (en) 2022-03-01
AU2018283331B2 (en) 2022-08-04
JP2020523388A (ja) 2020-08-06
JP6896113B2 (ja) 2021-06-30
US20220017540A1 (en) 2022-01-20
CR20190563A (es) 2020-04-22

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