NI201900126A - Imidazopirimidinas diazabicíclicas sustituidas y su uso para el tratamiento de trastornos respiratorios - Google Patents

Imidazopirimidinas diazabicíclicas sustituidas y su uso para el tratamiento de trastornos respiratorios

Info

Publication number
NI201900126A
NI201900126A NI201900126A NI201900126A NI201900126A NI 201900126 A NI201900126 A NI 201900126A NI 201900126 A NI201900126 A NI 201900126A NI 201900126 A NI201900126 A NI 201900126A NI 201900126 A NI201900126 A NI 201900126A
Authority
NI
Nicaragua
Prior art keywords
treatment
respiratory disorders
diazabicyclic
imidazopyrimidines
substitute
Prior art date
Application number
NI201900126A
Other languages
English (en)
Inventor
Delbeck Martina
Hahn Michael
Müller Thomas
Lustig Klemens
Collins Karl
Lindner Niels
Nicolai Janine
Beck-Broichsitter Moritz
Albus Udo
Gehring Doris
ROSENSTEIN Björn
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NI201900126A publication Critical patent/NI201900126A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente solicitud se refiere a nuevos derivados de imidazo[1,2-a] pirimidina diazabicíclicos sustituidos, procedimientos para su preparación, a su uso solos o en combinaciones para el tratamiento y/o prevención de enfermedades y su uso para la preparación de medicamentos para el tratamiento y/o prevención de enfermedades, en particular para el tratamiento y/o prevención de trastornos respiratorios, incluyendo trastornos respiratorios relacionados con el sueño, tales como la apnea obstructiva y la apnea central del sueño y el ronquido.
NI201900126A 2017-06-14 2019-12-12 Imidazopirimidinas diazabicíclicas sustituidas y su uso para el tratamiento de trastornos respiratorios NI201900126A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17176046 2017-06-14
EP17193252 2017-09-26

Publications (1)

Publication Number Publication Date
NI201900126A true NI201900126A (es) 2020-04-02

Family

ID=62492660

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201900126A NI201900126A (es) 2017-06-14 2019-12-12 Imidazopirimidinas diazabicíclicas sustituidas y su uso para el tratamiento de trastornos respiratorios

Country Status (29)

Country Link
US (2) US11098063B2 (es)
EP (1) EP3638675B1 (es)
JP (2) JP6896113B2 (es)
KR (1) KR102364134B1 (es)
CN (4) CN115554300A (es)
AR (1) AR112099A1 (es)
AU (1) AU2018283331B2 (es)
BR (1) BR112019026450A2 (es)
CA (1) CA3066942A1 (es)
CL (1) CL2019003650A1 (es)
CO (1) CO2019014047A2 (es)
CR (1) CR20190563A (es)
CU (1) CU24603B1 (es)
DO (1) DOP2019000308A (es)
EA (1) EA202090043A1 (es)
EC (1) ECSP19088492A (es)
GE (1) GEP20227366B (es)
IL (1) IL271117B (es)
JO (1) JOP20190284A1 (es)
MA (1) MA49368A (es)
MX (2) MX2019014983A (es)
NI (1) NI201900126A (es)
PE (1) PE20200016A1 (es)
PH (1) PH12019502828A1 (es)
SG (1) SG11201911508XA (es)
TW (1) TWI801388B (es)
UA (1) UA125186C2 (es)
UY (1) UY37773A (es)
WO (1) WO2018228907A1 (es)

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Also Published As

Publication number Publication date
AU2018283331A1 (en) 2019-12-19
EP3638675C0 (de) 2024-04-17
JP2021127346A (ja) 2021-09-02
TWI801388B (zh) 2023-05-11
CR20190563A (es) 2020-04-22
JP2020523388A (ja) 2020-08-06
MA49368A (fr) 2021-04-14
JOP20190284A1 (ar) 2019-12-11
CO2019014047A2 (es) 2020-01-17
CL2019003650A1 (es) 2020-07-10
CA3066942A1 (en) 2018-12-20
CN110719911A (zh) 2020-01-21
CN115583959A (zh) 2023-01-10
PE20200016A1 (es) 2020-01-06
ECSP19088492A (es) 2019-12-27
AU2018283331B2 (en) 2022-08-04
CU24603B1 (es) 2022-06-06
CN115554299A (zh) 2023-01-03
US20220017540A1 (en) 2022-01-20
IL271117A (en) 2020-01-30
CN110719911B (zh) 2022-10-21
IL271117B (en) 2022-03-01
KR20200014915A (ko) 2020-02-11
US20200109155A1 (en) 2020-04-09
AR112099A1 (es) 2019-09-18
WO2018228907A1 (de) 2018-12-20
CN115554300A (zh) 2023-01-03
EP3638675A1 (de) 2020-04-22
PH12019502828A1 (en) 2020-10-26
BR112019026450A2 (pt) 2020-07-14
EP3638675B1 (de) 2024-04-17
JP6896113B2 (ja) 2021-06-30
CU20190101A7 (es) 2020-10-20
MX2022012716A (es) 2022-11-07
TW201919638A (zh) 2019-06-01
EA202090043A1 (ru) 2020-04-02
GEP20227366B (en) 2022-03-25
MX2019014983A (es) 2020-02-24
KR102364134B1 (ko) 2022-02-18
UA125186C2 (uk) 2022-01-26
SG11201911508XA (en) 2020-01-30
DOP2019000308A (es) 2020-01-31
UY37773A (es) 2019-01-02
CN115583959B (zh) 2024-04-26
US11098063B2 (en) 2021-08-24

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