RS65016B1 - Kristalni oblik magl inhibitora - Google Patents

Kristalni oblik magl inhibitora

Info

Publication number
RS65016B1
RS65016B1 RS20231263A RSP20231263A RS65016B1 RS 65016 B1 RS65016 B1 RS 65016B1 RS 20231263 A RS20231263 A RS 20231263A RS P20231263 A RSP20231263 A RS P20231263A RS 65016 B1 RS65016 B1 RS 65016B1
Authority
RS
Serbia
Prior art keywords
compound
crystalline
theta
patient
pyrrolidin
Prior art date
Application number
RS20231263A
Other languages
English (en)
Serbian (sr)
Inventor
Cheryl A Grice
Todd K Jones
Kurt G Grimm
Jacqueline Lorayne Blankman
Channing Rodney Beals
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of RS65016B1 publication Critical patent/RS65016B1/sr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205Radicals derived from carbonic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13Dicarboxylic acids
    • C07C57/15Fumaric acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
RS20231263A 2016-11-16 2017-11-15 Kristalni oblik magl inhibitora RS65016B1 (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662423126P 2016-11-16 2016-11-16
EP21199077.5A EP3964503B1 (en) 2016-11-16 2017-11-15 A crystalline form of a magl inhibitor

Publications (1)

Publication Number Publication Date
RS65016B1 true RS65016B1 (sr) 2024-01-31

Family

ID=62145805

Family Applications (2)

Application Number Title Priority Date Filing Date
RS20231263A RS65016B1 (sr) 2016-11-16 2017-11-15 Kristalni oblik magl inhibitora
RS20211501A RS62665B1 (sr) 2016-11-16 2017-11-15 Kristalni oblik magl inhibitora

Family Applications After (1)

Application Number Title Priority Date Filing Date
RS20211501A RS62665B1 (sr) 2016-11-16 2017-11-15 Kristalni oblik magl inhibitora

Country Status (38)

Country Link
US (2) US11142517B2 (enExample)
EP (2) EP3964503B1 (enExample)
JP (2) JP7042548B2 (enExample)
KR (1) KR102508739B1 (enExample)
CN (2) CN115093382A (enExample)
AU (1) AU2017361257B2 (enExample)
BR (1) BR112019010003A2 (enExample)
CA (1) CA3043610A1 (enExample)
CL (1) CL2019001340A1 (enExample)
CO (1) CO2019005045A2 (enExample)
CR (1) CR20190242A (enExample)
CY (2) CY1124870T1 (enExample)
DK (1) DK3541807T3 (enExample)
DO (1) DOP2019000120A (enExample)
EA (1) EA201991086A1 (enExample)
EC (1) ECSP19035171A (enExample)
ES (2) ES2900016T3 (enExample)
GE (2) GEAP202315091A (enExample)
HR (2) HRP20211863T1 (enExample)
HU (2) HUE064559T2 (enExample)
IL (1) IL266548A (enExample)
JO (1) JOP20190109B1 (enExample)
LT (1) LT3541807T (enExample)
MA (2) MA46866B1 (enExample)
MX (2) MX389459B (enExample)
MY (1) MY199386A (enExample)
NI (1) NI201900053A (enExample)
PE (1) PE20191239A1 (enExample)
PH (1) PH12019501068A1 (enExample)
PL (2) PL3541807T3 (enExample)
PT (1) PT3541807T (enExample)
RS (2) RS65016B1 (enExample)
SI (1) SI3541807T1 (enExample)
SM (2) SMT202100675T1 (enExample)
TN (1) TN2019000151A1 (enExample)
UA (1) UA124585C2 (enExample)
WO (1) WO2018093953A1 (enExample)
ZA (1) ZA201903093B (enExample)

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JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
AU2017361254B2 (en) 2016-11-16 2021-09-23 H. Lundbeck A/S. Pharmaceutical formulations
PE20191239A1 (es) 2016-11-16 2019-09-16 Abide Therapeutics Inc Formas cristalinas de un inhibidor de magl
US10927105B1 (en) 2017-05-23 2021-02-23 Lundbeck La Jolla Research Center, Inc. Pyrazole MAGL inhibitors
DK3630744T3 (da) 2017-05-23 2023-03-06 H Lundbeck As Pyrazol-magl-inhibitorer
UA126685C2 (uk) 2017-08-29 2023-01-11 Луннбек Ла-Холья Рісьоч Сенте, Інк. Сполуки, які є модуляторами magl, і способи їх отримання і застосування
EP3793547A4 (en) 2018-05-15 2021-11-17 H. Lundbeck A/S MAGL INHIBITORS
MX2021000549A (es) * 2018-07-19 2021-03-25 Pfizer Compuestos espiro heterociclicos como inhibidores de magl.
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EP3914589A4 (en) * 2019-01-25 2022-11-30 H. Lundbeck A/S Methods of treating disease with magl inhibitors
WO2021097107A1 (en) * 2019-11-15 2021-05-20 Lundbeck La Jolla Research Center, Inc. Crystalline forms of a magl inhibitor
AU2021259496A1 (en) 2020-04-21 2022-11-10 H. Lundbeck A/S Synthesis of a monoacylglycerol lipase inhibitor
WO2023092079A1 (en) * 2021-11-19 2023-05-25 Bryant Cynthia W Use of cannabinoid compounds to treat gastrointestinal disorders
IL313987A (en) 2021-12-29 2024-08-01 Psy Therapeutics Inc Inhibiting monoacylglycerol lipase (magl)
IL316302A (en) 2022-05-04 2024-12-01 H Lundbeck As Crystalline form of 111333-hexafluoropro s-1-pyridazin-3-ylca azaspiro2.5octane-6- as a monoacylglycerol lipase inhibitor
CN117665187B (zh) * 2023-11-23 2024-08-16 宁波大红鹰药业股份有限公司 一种舒林酸中间体杂质的测定方法

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PE20191239A1 (es) 2016-11-16 2019-09-16 Abide Therapeutics Inc Formas cristalinas de un inhibidor de magl
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Also Published As

Publication number Publication date
ES2900016T3 (es) 2022-03-15
JP2022084717A (ja) 2022-06-07
RU2019116689A3 (enExample) 2021-02-26
MA46866B1 (fr) 2021-11-30
WO2018093953A1 (en) 2018-05-24
SMT202300494T1 (it) 2024-01-10
SMT202100675T1 (it) 2022-01-10
MX389459B (es) 2025-03-20
CY1124870T1 (el) 2022-11-25
GEAP202315091A (en) 2023-05-10
MX2019005767A (es) 2019-12-05
EP3964503C0 (en) 2023-11-08
PL3541807T3 (pl) 2022-01-17
JOP20190109B1 (ar) 2022-09-15
EA201991086A1 (ru) 2019-11-29
CN110291083A (zh) 2019-09-27
CN110291083B (zh) 2022-06-17
HRP20231697T1 (hr) 2024-03-15
AU2017361257A1 (en) 2019-05-30
RU2019116689A (ru) 2020-12-17
KR20190077561A (ko) 2019-07-03
US20200190063A1 (en) 2020-06-18
HRP20211863T1 (hr) 2022-03-04
CY1126586T1 (el) 2026-02-25
ES2966939T3 (es) 2024-04-25
RS62665B1 (sr) 2021-12-31
MA58133B1 (fr) 2024-02-29
PH12019501068A1 (en) 2019-08-19
UA124585C2 (uk) 2021-10-13
MA46866A (fr) 2021-06-02
MX2022000249A (es) 2022-02-03
ZA201903093B (en) 2020-11-25
DOP2019000120A (es) 2019-09-30
SI3541807T1 (sl) 2022-01-31
EP3541807A1 (en) 2019-09-25
HUE056973T2 (hu) 2022-04-28
TN2019000151A1 (en) 2020-10-05
HUE064559T2 (hu) 2024-03-28
EP3964503A1 (en) 2022-03-09
NZ753241A (en) 2021-06-25
ECSP19035171A (es) 2019-05-31
EP3964503B1 (en) 2023-11-08
GEP20237559B (en) 2023-10-25
BR112019010003A2 (pt) 2019-08-20
JP7042548B2 (ja) 2022-03-28
MY199386A (en) 2023-10-25
CR20190242A (es) 2019-07-09
CN115093382A (zh) 2022-09-23
US11993588B2 (en) 2024-05-28
CL2019001340A1 (es) 2019-10-04
EP3541807A4 (en) 2020-04-22
EP3541807B1 (en) 2021-09-29
KR102508739B1 (ko) 2023-03-09
CA3043610A1 (en) 2018-05-24
JP2019537596A (ja) 2019-12-26
AU2017361257B2 (en) 2022-02-10
PL3964503T3 (pl) 2024-04-02
JP7350117B2 (ja) 2023-09-25
LT3541807T (lt) 2021-12-27
DK3541807T3 (da) 2021-12-06
JOP20190109A1 (ar) 2019-05-09
PE20191239A1 (es) 2019-09-16
US11142517B2 (en) 2021-10-12
PT3541807T (pt) 2021-12-09
IL266548A (en) 2019-07-31
CO2019005045A2 (es) 2019-05-31
NI201900053A (es) 2019-10-30
US20220235037A1 (en) 2022-07-28

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