RS57899B1 - Glukagon/glp-1 agonisti za tretman gojaznosti - Google Patents

Glukagon/glp-1 agonisti za tretman gojaznosti

Info

Publication number
RS57899B1
RS57899B1 RS20181267A RSP20181267A RS57899B1 RS 57899 B1 RS57899 B1 RS 57899B1 RS 20181267 A RS20181267 A RS 20181267A RS P20181267 A RSP20181267 A RS P20181267A RS 57899 B1 RS57899 B1 RS 57899B1
Authority
RS
Serbia
Prior art keywords
polyoxyethylene sorbitan
agents
shoots
aqueous solution
growth
Prior art date
Application number
RS20181267A
Other languages
English (en)
Serbian (sr)
Inventor
Balaji Agoram
Madeleine Antonsson
Maria Bednarek
Nicole Burmeister
Lambertus Benthem
David Fairman
Maria Fritsch-Fredin
Ronald Jackson
Rasmus Jansson Lofmark
Jacqueline Metcalfe
Original Assignee
Medimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Ltd filed Critical Medimmune Ltd
Publication of RS57899B1 publication Critical patent/RS57899B1/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Child & Adolescent Psychology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
RS20181267A 2012-12-11 2013-12-10 Glukagon/glp-1 agonisti za tretman gojaznosti RS57899B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261735823P 2012-12-11 2012-12-11
PCT/IB2013/003191 WO2014091316A2 (en) 2012-12-11 2013-12-10 Glucagon/glp-1 agonists for the treatment of obesity
EP13849992.6A EP2931745B1 (en) 2012-12-11 2013-12-10 Glucagon/glp-1 agonists for the treatment of obesity

Publications (1)

Publication Number Publication Date
RS57899B1 true RS57899B1 (sr) 2019-01-31

Family

ID=50588751

Family Applications (2)

Application Number Title Priority Date Filing Date
RS20181267A RS57899B1 (sr) 2012-12-11 2013-12-10 Glukagon/glp-1 agonisti za tretman gojaznosti
RS20220574A RS63305B1 (sr) 2012-12-11 2013-12-10 Ko-agonisti glukagona i glp-1 za lečenje gojaznosti

Family Applications After (1)

Application Number Title Priority Date Filing Date
RS20220574A RS63305B1 (sr) 2012-12-11 2013-12-10 Ko-agonisti glukagona i glp-1 za lečenje gojaznosti

Country Status (26)

Country Link
US (4) US9765130B2 (enExample)
EP (2) EP3495380B1 (enExample)
JP (1) JP6490011B2 (enExample)
KR (1) KR102080366B1 (enExample)
CN (2) CN109776670A (enExample)
AR (1) AR093903A1 (enExample)
AU (3) AU2013356934C1 (enExample)
BR (1) BR112015012238B1 (enExample)
CA (1) CA2893445C (enExample)
CY (2) CY1121114T1 (enExample)
DK (2) DK2931745T3 (enExample)
ES (2) ES2926713T3 (enExample)
HR (2) HRP20181678T1 (enExample)
HU (1) HUE039952T2 (enExample)
LT (2) LT2931745T (enExample)
MX (2) MX365458B (enExample)
PL (2) PL2931745T3 (enExample)
PT (2) PT2931745T (enExample)
RS (2) RS57899B1 (enExample)
RU (2) RU2018137842A (enExample)
SG (2) SG11201503230XA (enExample)
SI (2) SI3495380T1 (enExample)
SM (2) SMT202200266T1 (enExample)
TR (1) TR201815172T4 (enExample)
TW (2) TWI674270B (enExample)
WO (1) WO2014091316A2 (enExample)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
TWI674270B (zh) * 2012-12-11 2019-10-11 英商梅迪繆思有限公司 用於治療肥胖之升糖素與glp-1共促效劑
MX362190B (es) 2012-12-21 2019-01-08 Sanofi Sa Agonistas duales de glp1/gip o trigonales de glp1/gip/glucagon.
AU2014230472A1 (en) * 2013-03-14 2015-10-01 Medimmune Limited Pegylated glucagon and GLP-1 co-agonists for the treatment of obesity
WO2015086729A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/gip receptor agonists
WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
TW201609796A (zh) 2013-12-13 2016-03-16 賽諾菲公司 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
CN106519015B (zh) * 2014-09-23 2020-04-17 深圳市图微安创科技开发有限公司 胃泌酸调节素类似物
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
WO2016198624A1 (en) 2015-06-12 2016-12-15 Sanofi Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists
WO2016198628A1 (en) 2015-06-12 2016-12-15 Sanofi Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists
TW201706291A (zh) 2015-07-10 2017-02-16 賽諾菲公司 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物
TWI622596B (zh) * 2015-10-26 2018-05-01 美國禮來大藥廠 升糖素受體促效劑
CN113546159B (zh) * 2015-12-29 2023-09-08 派格生物医药(苏州)股份有限公司 包含glp-1受体激动剂和胰高血糖素受体激动剂的组合物及其用途
KR102460198B1 (ko) * 2016-03-10 2022-10-31 메디뮨 리미티드 비만 치료를 위한 글루카곤 및 glp-1 공동-작용제
WO2017210099A1 (en) * 2016-06-02 2017-12-07 Indiana University Research And Technology Corporation Glucagon-t3 conjugates
CN107281471A (zh) * 2017-06-26 2017-10-24 中国药科大学 一种改构的胰高血糖素样肽－1及其修饰物的应用
CN111278853B (zh) * 2017-11-06 2022-06-21 深圳市图微安创科技开发有限公司 基于胃泌酸调节素类似物glp-1r/gcgr双靶点激动剂多肽治疗胆汁性肝硬化
TWI770085B (zh) * 2017-11-21 2022-07-11 日商武田藥品工業股份有限公司 胜肽化合物
DK3774862T3 (da) 2018-04-05 2022-09-05 Sun Pharmaceutical Ind Ltd Nye GLP-1-analoger
CN111171134B (zh) * 2018-11-12 2023-08-15 天津药物研究院有限公司 胰高血糖素衍生肽及其用途
JP2022533674A (ja) 2019-05-21 2022-07-25 メディミューン リミテッド シクロデキストリンをベースとするｓｇｌｔ２阻害剤及びインクレチンペプチドの注射用共製剤
JP2022539200A (ja) 2019-07-01 2022-09-07 メドイミューン・リミテッド グルカゴン及びｇｌｐ－１コアゴニストペプチドのための医薬組成物
CN110845601B (zh) * 2019-10-12 2021-01-19 广东药科大学 不同构型的glp-1类似肽修饰二聚体及其制备方法在治疗ii型糖尿病中的应用
KR20220110506A (ko) * 2019-12-03 2022-08-08 메디뮨 엘엘씨 비만 치료를 위한 글루카곤 및 glp-1 공동-작용제를 사용하는 조합 치료법
TW202140061A (zh) 2020-01-10 2021-11-01 英商梅迪繆思有限公司 用於治療２型糖尿病中的慢性腎病和糖尿病性腎病的升糖素及ｇｌｐ－１協同促效劑
CN113493503B (zh) * 2020-04-08 2022-08-05 浙江道尔生物科技有限公司 一种肠促胰岛素类似物及其制备方法和用途
CN120737188A (zh) 2020-04-24 2025-10-03 勃林格殷格翰国际有限公司 作为长效glp-1/升糖素受体激动剂以治疗脂肪肝疾病及脂肪肝炎的升糖素类似物
TW202313974A (zh) 2021-06-08 2023-04-01 瑞典商阿斯特捷利康公司 用於治療肝病之組合療法
CA3226846A1 (en) 2021-07-30 2023-02-02 Boehringer Ingelheim International Gmbh Dose regimen for long-acting glp1/glucagon receptor agonists
TW202346323A (zh) 2022-02-07 2023-12-01 英商梅迪繆思有限公司 具有改善的生物穩定性的ｇｌｐ—１及升糖素雙重激動肽
EP4611736A1 (en) * 2022-11-03 2025-09-10 Efil Bioscience Inc. Composition comprising glp-1 receptor agonist and acat inhibitor
WO2024123812A1 (en) * 2022-12-05 2024-06-13 Shattuck Labs, Inc. Fusion proteins for the treatment of cardiometabolic diseases
WO2024165571A2 (en) 2023-02-06 2024-08-15 E-Therapeutics Plc Inhibitors of expression and/or function
CN115975057B (zh) * 2023-03-16 2023-05-16 杭州信海医药科技有限公司 一种可妥度肽的固相合成方法
WO2024252366A1 (en) 2023-06-09 2024-12-12 Sun Pharmaceutical Industries Limited Glp-1/gip dual, glp-1/gcg dual and glp-1/gip/gcg triple receptor agonists
WO2025024788A1 (en) * 2023-07-27 2025-01-30 Biomedit, Llc Stabilized glp-1 peptides and dual agonist peptides against glp-1r and gipr and methods of use thereof
WO2025125576A2 (en) 2023-12-15 2025-06-19 E-Therapeutics Plc Inhibitors of expression and/or function
WO2025133348A1 (en) 2023-12-22 2025-06-26 E-Therapeutics Plc Inhibitors of expression and/or function
WO2025196502A1 (en) 2024-03-20 2025-09-25 North Carolina Agricultural & Technical State University Choline kinase inhibitors as a therapeutic treatment for obesity
WO2025242620A1 (en) 2024-05-20 2025-11-27 Medimmune Limited Polypeptide combinations and uses thereof
CN118787658B (zh) * 2024-06-14 2025-01-21 中国农业大学 一种胰高血糖素样肽-1受体特异性核酸适配体在代谢疾病干预中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US30326A (en) * 1860-10-09 Steam-g-eneratob
DE3572982D1 (en) 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
CA2006596C (en) 1988-12-22 2000-09-05 Rika Ishikawa Chemically-modified g-csf
EP1539210A4 (en) * 2002-09-06 2006-06-07 Bayer Pharmaceuticals Corp GLP-1 RECEPTOR MODIFIED AGONISTS AND THEIR PHARMACOLOGICAL METHODS OF USE
CN1938334A (zh) * 2004-01-30 2007-03-28 瓦拉塔药品公司 Glp－1激动剂和胃泌素化合物的联合使用
DE102004043153B4 (de) * 2004-09-03 2013-11-21 Philipps-Universität Marburg Erfindung betreffend GLP-1 und Exendin
MX2008002028A (es) * 2005-08-11 2008-03-27 Amylin Pharmaceuticals Inc Polipeptidos hibridos con propiedades de seleccion.
CN1935846A (zh) * 2005-09-14 2007-03-28 王庆华 一种用于治疗糖尿病的融合蛋白及其制备方法和应用
PL2173890T3 (pl) 2007-06-21 2011-07-29 Univ Muenchen Tech Białka czynne biologicznie o zwiększonej stabilności in vivo i (lub) in vitro
WO2009058734A1 (en) * 2007-10-30 2009-05-07 Indiana University Research And Technology Corporation Compounds exhibiting glucagon antagonist and glp-1 agonist activity
BRPI1014508A2 (pt) 2009-06-16 2016-04-05 Univ Indiana Res & Tech Corp análogos de peptídeo de glucagon, dimer de dois peptídeos de glucagon, composição farmacêutica deles derivada e métodos para seu uso"
JP6121323B2 (ja) * 2010-05-13 2017-05-10 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ 核内ホルモン受容体の活性を示すグルカゴンスーパーファミリーのペプチド
TWI674270B (zh) * 2012-12-11 2019-10-11 英商梅迪繆思有限公司 用於治療肥胖之升糖素與glp-1共促效劑

Also Published As

Publication number Publication date
US9765130B2 (en) 2017-09-19
HUE039952T2 (hu) 2019-02-28
EP2931745A2 (en) 2015-10-21
US20200115431A1 (en) 2020-04-16
EP3495380B1 (en) 2022-03-30
TWI617574B (zh) 2018-03-11
DK3495380T3 (da) 2022-06-20
CY1121114T1 (el) 2019-12-11
CN109776670A (zh) 2019-05-21
MX365458B (es) 2019-06-04
AU2013356934A1 (en) 2015-05-21
CN104822699A (zh) 2015-08-05
CA2893445A1 (en) 2014-06-19
TWI674270B (zh) 2019-10-11
HK1216179A1 (en) 2016-10-21
TW201427993A (zh) 2014-07-16
PL3495380T3 (pl) 2022-08-01
AR093903A1 (es) 2015-06-24
KR102080366B1 (ko) 2020-02-21
MX2015006568A (es) 2015-08-05
CA2893445C (en) 2020-06-02
EP3495380A1 (en) 2019-06-12
US10556939B2 (en) 2020-02-11
JP2016501256A (ja) 2016-01-18
RU2015127780A (ru) 2017-01-19
US20170342121A1 (en) 2017-11-30
PT2931745T (pt) 2018-11-29
SMT202200266T1 (it) 2022-07-21
TW201829452A (zh) 2018-08-16
PT3495380T (pt) 2022-06-28
AU2019272054A1 (en) 2020-01-02
US20150307579A1 (en) 2015-10-29
WO2014091316A2 (en) 2014-06-19
SI3495380T1 (sl) 2022-08-31
WO2014091316A3 (en) 2014-10-30
SI2931745T1 (sl) 2018-11-30
MX2019006260A (es) 2019-08-14
KR20150093167A (ko) 2015-08-17
RU2671088C2 (ru) 2018-10-29
TR201815172T4 (tr) 2018-11-21
RU2018137842A (ru) 2018-12-13
US20220098265A1 (en) 2022-03-31
BR112015012238A2 (enExample) 2017-08-15
AU2017261505C1 (en) 2020-07-30
SMT201800611T1 (it) 2019-01-11
HRP20181678T1 (hr) 2019-03-08
SG11201503230XA (en) 2015-06-29
AU2017261505B2 (en) 2019-10-10
AU2013356934C1 (en) 2018-07-05
MX388904B (es) 2025-03-20
AU2013356934B2 (en) 2017-08-17
LT3495380T (lt) 2022-06-27
PL2931745T3 (pl) 2019-04-30
CN104822699B (zh) 2019-03-01
RS63305B1 (sr) 2022-07-29
BR112015012238B1 (pt) 2022-03-29
JP6490011B2 (ja) 2019-03-27
US11230584B2 (en) 2022-01-25
SG10201801159WA (en) 2018-03-28
AU2017261505A1 (en) 2017-12-07
ES2698329T3 (es) 2019-02-04
ES2926713T3 (es) 2022-10-27
LT2931745T (lt) 2018-11-12
CY1125302T1 (el) 2025-03-28
EP2931745B1 (en) 2018-08-22
RU2018137842A3 (enExample) 2022-04-01
DK2931745T3 (en) 2018-12-10
HRP20220734T1 (hr) 2022-09-02

Similar Documents

Publication Publication Date Title
RS57899B1 (sr) Glukagon/glp-1 agonisti za tretman gojaznosti
Peluso et al. 32P‐postlabeling detection of DNA adducts in mice treated with the herbicide roundup
Cao et al. Assessment of potential dermal and inhalation exposure of workers to the insecticide imidacloprid using whole-body dosimetry in China
US11039623B2 (en) Arthropod control formulations and methods
Purkait et al. Formulation of plant based insecticides, their bio-efficacy evaluation and chemical characterization
DE3044220A1 (de) Feste, pheromone enthaltende mischungen
CN103814932A (zh) 一种农药组合物及其应用
CN104126602A (zh) 一种含有吡蚜酮和呋虫胺的可分散油悬浮剂
CN114287450A (zh) 一种防治甘蔗蓟马的农药组合物
CN104304269A (zh) 一种水稻田除草组合物
Baricevic et al. Insecticidal effect of oregano (Origanum vulgare L. ssp. hirtum Ietswaart) on bean weevil (Acanthoscelides obtectus Say)
CN102113496A (zh) 一种含有环虫腈和灭多威的杀虫组合物
CN114467967A (zh) 一种含喹诺酮类化合物和铜制剂的增效杀菌组合物
CN106359440A (zh) 一种呋虫胺可分散油悬浮剂及其制备方法
Van Ginkel et al. Allergic contact dermatitis from the newly introduced fungicide fluazinam
AU2020102528A4 (en) Tank Mix Adjuvant and Preparation Method Thereof
CN105432629A (zh) 一种丙炔噁草酮和噁草酮复配乳油及其制备方法
CN112237187B (zh) 酚类化合物在作为杀线虫剂的应用
CN116762805B (zh) 3-十五烷基苯酚在驱避红火蚁中的应用
CN115500364B (zh) 包含丁香花油和百里香油的水基产品及其灭螨应用
AU7384398A (en) Chemical pinching method and composition
CN114680130B (zh) 一种草甘膦异丙胺盐可溶液剂及其制备方法
CN105340920A (zh) 一种除草组合物
US2777762A (en) Method and composition for the control of undesirable vegetation
US6245712B1 (en) Chemical pinching method and composition