RS57624B1 - Nova sukcinatna jedinjenja koja prodiru u ćelije - Google Patents

Nova sukcinatna jedinjenja koja prodiru u ćelije

Info

Publication number
RS57624B1
RS57624B1 RS20180921A RSP20180921A RS57624B1 RS 57624 B1 RS57624 B1 RS 57624B1 RS 20180921 A RS20180921 A RS 20180921A RS P20180921 A RSP20180921 A RS P20180921A RS 57624 B1 RS57624 B1 RS 57624B1
Authority
RS
Serbia
Prior art keywords
novel cell
succinate compounds
permeable succinate
permeable
compounds
Prior art date
Application number
RS20180921A
Other languages
English (en)
Inventor
Eskil Elmér
Magnus Joakim Hansson
Karl Henrik Johannes Ehinger
Steven Moss
Original Assignee
Neurovive Pharmaceutical Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58804197&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS57624(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Neurovive Pharmaceutical Ab filed Critical Neurovive Pharmaceutical Ab
Publication of RS57624B1 publication Critical patent/RS57624B1/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/28—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C07C327/34—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/18—Eight-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
RS20180921A 2014-04-08 2015-04-08 Nova sukcinatna jedinjenja koja prodiru u ćelije RS57624B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201470190 2014-04-08
EP15714820.6A EP3129016B1 (en) 2014-04-08 2015-04-08 Novel cell-permeable succinate compounds
PCT/EP2015/057606 WO2015155231A1 (en) 2014-04-08 2015-04-08 Novel cell-permeable succinate compounds

Publications (1)

Publication Number Publication Date
RS57624B1 true RS57624B1 (sr) 2018-11-30

Family

ID=58804197

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20180921A RS57624B1 (sr) 2014-04-08 2015-04-08 Nova sukcinatna jedinjenja koja prodiru u ćelije

Country Status (25)

Country Link
US (2) US11147789B2 (sr)
EP (2) EP3391941B1 (sr)
JP (4) JP7082861B6 (sr)
KR (1) KR102322543B1 (sr)
CN (1) CN106458957B (sr)
AU (2) AU2015243346C9 (sr)
CA (1) CA2944565C (sr)
CY (1) CY1120650T1 (sr)
DK (1) DK3129016T3 (sr)
EA (1) EA035678B1 (sr)
ES (2) ES2683860T3 (sr)
HK (1) HK1255109A1 (sr)
HR (1) HRP20181126T1 (sr)
IL (1) IL247904B (sr)
LT (2) LT3391941T (sr)
MA (2) MA39855B1 (sr)
MX (1) MX2016012691A (sr)
PL (1) PL3129016T3 (sr)
PT (2) PT3129016T (sr)
RS (1) RS57624B1 (sr)
SG (1) SG11201607907PA (sr)
SI (1) SI3129016T1 (sr)
TR (1) TR201810411T4 (sr)
WO (1) WO2015155231A1 (sr)
ZA (1) ZA201606608B (sr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7082861B6 (ja) * 2014-04-08 2023-12-22 アブリバ エービー 新規な細胞透過性サクシネート化合物
MA39857A (fr) 2014-04-08 2017-02-15 Neurovive Pharmaceutical Ab Promédicaments à base de succinate destinés à être utilisés dans le traitement de l'acidose lactique ou d'effets secondaires induits par un médicament dus à une déficience liée au complexe i de la phosphorylation oxydative mitochondriale
JP2017518960A (ja) * 2014-04-08 2017-07-13 ネウロビベ プハルマセウトイカル エービー Ａｔｐ産生を増加するためのコハク酸のプロドラッグ
WO2017060422A1 (en) * 2015-10-07 2017-04-13 Neurovive Pharmaceutical Ab Protected carboxylic acid-based metabolites for the treatment of mitochondrial disorders
WO2017060420A1 (en) * 2015-10-07 2017-04-13 Neurovive Pharmaceutical Ab Protected fumaric acid-based metabolites for the treatment of autoimmune diseases
WO2017060418A1 (en) * 2015-10-07 2017-04-13 Neurovive Pharmaceutical Ab Protected carboxylic acid-based metabolites for the treatment of mitochondria-related diseases
WO2017096270A1 (en) 2015-12-03 2017-06-08 The Regents Of The University Of California Methods for treating mitochondrial diseases
CA3113071A1 (en) * 2018-10-11 2020-04-16 Imbria Pharmaceuticals, Inc. Tca cycle intermediates and methods of use thereof
KR20210076041A (ko) * 2018-10-11 2021-06-23 임브리아 파마슈티칼스, 인크. 레베르 유전성 시신경병증의 치료 및 예방을 위한 조성물 및 방법
CN109675037B (zh) * 2019-01-25 2021-09-14 南方医科大学 Atp及其受体在制备治疗自闭症药物中的应用
EP4360708A2 (en) 2019-06-19 2024-05-01 Abliva AB Succinate prodrug, compositions containing the succinate prodrug and uses thereof

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JP2002525026A (ja) * 1998-07-02 2002-08-13 ザ ボード オブ リージェンツ オブ ザ レランド スタンフォード ジュニア ユニバーシティ ポリケチドを作製するための方法
AUPR059400A0 (en) * 2000-10-06 2000-11-02 Bar-Ilan University Formaldehyde-releasing prodrugs
EP1401850A1 (en) * 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
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KR100791844B1 (ko) 2006-06-30 2008-01-07 주식회사유한양행 메트포르민 또는 그의 염을 함유하는 서방성 제제 및 그의제조방법
KR101069502B1 (ko) 2006-10-31 2011-09-30 (주)아모레퍼시픽 비만 및 당뇨병 개선용 경구용 조성물
US20120308646A1 (en) * 2007-01-18 2012-12-06 Hesheng Zhang Tetracyclic anthraquinones possessing anti-cancer properties
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JP2014024772A (ja) 2012-07-25 2014-02-06 Univ Of Tokyo ミトコンドリアのａｔｐ産生能昂進剤
WO2014053857A1 (en) 2012-10-05 2014-04-10 Mitopharm Ltd Protected succinates for enhancing mitochondrial atp-production
JP7082861B6 (ja) * 2014-04-08 2023-12-22 アブリバ エービー 新規な細胞透過性サクシネート化合物
MA39857A (fr) 2014-04-08 2017-02-15 Neurovive Pharmaceutical Ab Promédicaments à base de succinate destinés à être utilisés dans le traitement de l'acidose lactique ou d'effets secondaires induits par un médicament dus à une déficience liée au complexe i de la phosphorylation oxydative mitochondriale
JP2017518960A (ja) 2014-04-08 2017-07-13 ネウロビベ プハルマセウトイカル エービー Ａｔｐ産生を増加するためのコハク酸のプロドラッグ

Also Published As

Publication number Publication date
KR20160142861A (ko) 2016-12-13
CN106458957B (zh) 2020-08-18
PT3391941T (pt) 2023-08-24
DK3129016T3 (en) 2018-09-03
AU2018282308B2 (en) 2020-04-30
AU2015243346C9 (en) 2019-03-07
TR201810411T4 (tr) 2018-08-27
EA201692017A1 (ru) 2017-02-28
AU2015243346C1 (en) 2019-02-07
ZA201606608B (en) 2022-10-26
CA2944565C (en) 2022-11-29
BR112016023086A2 (pt) 2017-08-15
HRP20181126T1 (hr) 2018-10-05
CY1120650T1 (el) 2019-12-11
JP7229189B2 (ja) 2023-02-27
US20170105961A1 (en) 2017-04-20
JP2021169518A (ja) 2021-10-28
PL3129016T3 (pl) 2018-10-31
EP3391941A1 (en) 2018-10-24
MX2016012691A (es) 2016-12-16
EP3391941B1 (en) 2023-06-07
BR112016023086A8 (pt) 2021-06-29
US20210401792A1 (en) 2021-12-30
EP3129016A1 (en) 2017-02-15
MA39855A (fr) 2018-10-24
AU2015243346B2 (en) 2018-10-18
WO2015155231A1 (en) 2015-10-15
US11147789B2 (en) 2021-10-19
IL247904B (en) 2020-08-31
EP3129016B1 (en) 2018-06-06
ES2953522T3 (es) 2023-11-14
EA035678B1 (ru) 2020-07-24
LT3129016T (lt) 2018-09-10
SI3129016T1 (sl) 2018-10-30
KR102322543B1 (ko) 2021-11-04
MA44092B1 (fr) 2023-08-31
CA2944565A1 (en) 2015-10-15
PT3129016T (pt) 2018-10-01
SG11201607907PA (en) 2016-10-28
MA39855B1 (fr) 2018-10-31
HK1255109A1 (zh) 2019-08-02
JP7082861B6 (ja) 2023-12-22
IL247904A0 (en) 2016-11-30
JP2020100628A (ja) 2020-07-02
JP2017513829A (ja) 2017-06-01
AU2018282308A1 (en) 2019-01-17
CN106458957A (zh) 2017-02-22
ES2683860T3 (es) 2018-09-28
JP2021169519A (ja) 2021-10-28
JP7082861B2 (ja) 2022-06-09
LT3391941T (lt) 2023-11-10
AU2015243346A1 (en) 2016-10-13

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