MA39855A - Nouveaux composés de succinate perméables à travers les cellules - Google Patents
Nouveaux composés de succinate perméables à travers les cellulesInfo
- Publication number
- MA39855A MA39855A MA039855A MA39855A MA39855A MA 39855 A MA39855 A MA 39855A MA 039855 A MA039855 A MA 039855A MA 39855 A MA39855 A MA 39855A MA 39855 A MA39855 A MA 39855A
- Authority
- MA
- Morocco
- Prior art keywords
- permeable
- cell
- cells
- succinates
- atp
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/28—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C07C327/34—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/18—Eight-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La présente invention concerne de nouveaux succinates perméables aux cellules et des précurseurs perméables aux cellules du succinate destinés à augmenter la production d'atp dans les mitochondries. La majeure partie de l'atp produite et utilisée dans la cellule eucaryote provient de la phosphorylation oxydative mitochondriale, processus auquel le cycle de kreb fournit des électrons de haute énergie. Tous les intermédiaires du cycle de kreb ne sont pas facilement perméables à la membrane cellulaire, l'un d'entre eux étant le succinate. La fourniture des nouveaux succinates perméables aux cellules est envisagée pour permettre le passage sur la membrane cellulaire et ainsi les succinates perméables aux cellules peuvent être utilisés pour améliorer la sortie d'atp mitochondrial.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201470190 | 2014-04-08 | ||
PCT/EP2015/057606 WO2015155231A1 (fr) | 2014-04-08 | 2015-04-08 | Nouveaux composés de succinate perméables à travers les cellules |
EP15714820.6A EP3129016B1 (fr) | 2014-04-08 | 2015-04-08 | Nouveaux composés de succinate perméables à travers les cellules |
Publications (2)
Publication Number | Publication Date |
---|---|
MA39855A true MA39855A (fr) | 2018-10-24 |
MA39855B1 MA39855B1 (fr) | 2018-10-31 |
Family
ID=58804197
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA39855A MA39855B1 (fr) | 2014-04-08 | 2015-04-08 | Nouveaux composés de succinate perméables à travers les cellules |
MA44092A MA44092B1 (fr) | 2014-04-08 | 2015-04-08 | Nouveaux composés de succinate perméables à travers les cellules |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA44092A MA44092B1 (fr) | 2014-04-08 | 2015-04-08 | Nouveaux composés de succinate perméables à travers les cellules |
Country Status (25)
Country | Link |
---|---|
US (2) | US11147789B2 (fr) |
EP (2) | EP3129016B1 (fr) |
JP (4) | JP7082861B6 (fr) |
KR (1) | KR102322543B1 (fr) |
CN (1) | CN106458957B (fr) |
AU (2) | AU2015243346C9 (fr) |
CA (1) | CA2944565C (fr) |
CY (1) | CY1120650T1 (fr) |
DK (1) | DK3129016T3 (fr) |
EA (1) | EA035678B1 (fr) |
ES (2) | ES2683860T3 (fr) |
HK (1) | HK1255109A1 (fr) |
HR (1) | HRP20181126T1 (fr) |
IL (1) | IL247904B (fr) |
LT (2) | LT3391941T (fr) |
MA (2) | MA39855B1 (fr) |
MX (1) | MX2016012691A (fr) |
PL (1) | PL3129016T3 (fr) |
PT (2) | PT3391941T (fr) |
RS (1) | RS57624B1 (fr) |
SG (1) | SG11201607907PA (fr) |
SI (1) | SI3129016T1 (fr) |
TR (1) | TR201810411T4 (fr) |
WO (1) | WO2015155231A1 (fr) |
ZA (1) | ZA201606608B (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106255509A (zh) | 2014-04-08 | 2016-12-21 | 纽维制药有限公司 | 用于在归因于线粒体氧化磷酸化的复合体i相关损伤的乳酸性酸中毒或药物诱导的副作用的治疗中应用的琥珀酸酯前药 |
CA2944565C (fr) * | 2014-04-08 | 2022-11-29 | Neurovive Pharmaceutical Ab | Nouveaux composes de succinate permeables a travers les cellules |
KR20160143731A (ko) * | 2014-04-08 | 2016-12-14 | 뉴로바이브 파마슈티컬 에이비 | Atp 생산을 증가시키기 위한 숙신산 프로드러그 |
WO2017060400A1 (fr) * | 2015-10-07 | 2017-04-13 | Neurovive Pharmaceutical Ab | Métabolites protégés à base d'acide carboxylique pour le traitement des maladies liées à des dysfonctions mitochondriales |
WO2017060418A1 (fr) * | 2015-10-07 | 2017-04-13 | Neurovive Pharmaceutical Ab | Métabolites protégés à base d'acide carboxylique pour le traitement des maladies liées aux mitochondries |
WO2017060422A1 (fr) * | 2015-10-07 | 2017-04-13 | Neurovive Pharmaceutical Ab | Métabolites protégés à base d'acide carboxylique pour le traitement des troubles mitochondriaux |
WO2017096270A1 (fr) * | 2015-12-03 | 2017-06-08 | The Regents Of The University Of California | Méthodes de traitement de maladies mitochondriales |
WO2020077106A1 (fr) * | 2018-10-11 | 2020-04-16 | Imbria Pharmaceuticals, Inc. | Compositions et procédés de traitement et de prévention de la neuropathie optique héréditaire de leber |
EP3863624A4 (fr) * | 2018-10-11 | 2022-08-31 | Imbria Pharmaceuticals, Inc. | Intermédiaires de cycle de tca et leur procédé d'utilisation |
CN109675037B (zh) * | 2019-01-25 | 2021-09-14 | 南方医科大学 | Atp及其受体在制备治疗自闭症药物中的应用 |
CA3143112A1 (fr) * | 2019-06-19 | 2020-12-24 | Abliva Ab | Promedicamenta base de succinate, compositions contenant le promedicament de succinate et utilisations associees |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB756422A (en) * | 1950-09-14 | 1956-09-05 | Saint Gobain | Esters of urethanes of glycols and the manufacture thereof |
NL6806584A (fr) * | 1965-09-20 | 1968-11-12 | ||
FR2265355B1 (fr) | 1974-03-28 | 1977-11-04 | Blum Jean | |
US5112953A (en) * | 1989-12-29 | 1992-05-12 | Neorx Corporation | Radiolabeled proteins for diagnostic or therapeutic use |
DE4101158C2 (de) * | 1991-01-14 | 1994-06-23 | Dainippon Ink & Chemicals | Wärmehärtbare Reaktionsharzgemische, Verwendung der erfindungsgemäßen Reaktionsharze zur Herstellung von Formkörpern und Beschichtungen |
EP0583480A4 (fr) | 1992-02-07 | 1994-03-18 | Tsumura & Co | Agent d'attenuation des effets secondaires. |
JPH07331262A (ja) | 1994-05-31 | 1995-12-19 | Tonen Corp | パティキュレート低減用添加剤及び該添加剤を用いたディーゼルエンジン用燃料組成物 |
GB9612331D0 (en) * | 1996-06-13 | 1996-08-14 | Leo Pharm Prod Ltd | Chemical compounds |
CN1222139A (zh) * | 1996-06-13 | 1999-07-07 | 里奥药物制品有限公司 | 多元醇琥珀酸酯及其药物制剂 |
EP1100927A2 (fr) * | 1998-07-02 | 2001-05-23 | The Board Of Trustees Of The Leland Stanford Junior University | Procedes permettant de fabriquer des polycetides |
AUPR059400A0 (en) * | 2000-10-06 | 2000-11-02 | Bar-Ilan University | Formaldehyde-releasing prodrugs |
EP1401850A1 (fr) * | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Derives nucleosidiques pour elaboration de bibliotheque combinatoire |
US7468383B2 (en) * | 2005-02-11 | 2008-12-23 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
KR100791844B1 (ko) | 2006-06-30 | 2008-01-07 | 주식회사유한양행 | 메트포르민 또는 그의 염을 함유하는 서방성 제제 및 그의제조방법 |
KR101069502B1 (ko) | 2006-10-31 | 2011-09-30 | (주)아모레퍼시픽 | 비만 및 당뇨병 개선용 경구용 조성물 |
US20120308646A1 (en) * | 2007-01-18 | 2012-12-06 | Hesheng Zhang | Tetracyclic anthraquinones possessing anti-cancer properties |
US8252840B2 (en) | 2007-03-26 | 2012-08-28 | Salutria Pharmaceuticals Llc | Methods of derivatives of probucol for the treatment of type II diabetes |
US8410139B2 (en) * | 2009-10-07 | 2013-04-02 | Bristol-Myers Squibb Company | Prodrugs of a piperidinyl derivative as modulators of chemokine receptor activity |
IT1406068B1 (it) | 2010-07-22 | 2014-02-06 | Medestea Int Spa | Polidesossiribonucleotidi (pdrn) per l'impiego nel trattamento di condizioni di acidosi e composizioni a base di polidesossiribonucleotidi per il suddetto impiego |
JP2014024772A (ja) | 2012-07-25 | 2014-02-06 | Univ Of Tokyo | ミトコンドリアのatp産生能昂進剤 |
ES2661009T3 (es) * | 2012-10-05 | 2018-03-27 | Neurovive Pharmaceutical Ab | Succinatos protegidos para mejorar la producción de ATP mitocondrial |
CA2944565C (fr) * | 2014-04-08 | 2022-11-29 | Neurovive Pharmaceutical Ab | Nouveaux composes de succinate permeables a travers les cellules |
CN106255509A (zh) | 2014-04-08 | 2016-12-21 | 纽维制药有限公司 | 用于在归因于线粒体氧化磷酸化的复合体i相关损伤的乳酸性酸中毒或药物诱导的副作用的治疗中应用的琥珀酸酯前药 |
KR20160143731A (ko) | 2014-04-08 | 2016-12-14 | 뉴로바이브 파마슈티컬 에이비 | Atp 생산을 증가시키기 위한 숙신산 프로드러그 |
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2015
- 2015-04-08 CA CA2944565A patent/CA2944565C/fr active Active
- 2015-04-08 LT LTEP18175718.8T patent/LT3391941T/lt unknown
- 2015-04-08 MA MA39855A patent/MA39855B1/fr unknown
- 2015-04-08 US US15/128,480 patent/US11147789B2/en active Active
- 2015-04-08 DK DK15714820.6T patent/DK3129016T3/en active
- 2015-04-08 PT PT181757188T patent/PT3391941T/pt unknown
- 2015-04-08 MA MA44092A patent/MA44092B1/fr unknown
- 2015-04-08 EP EP15714820.6A patent/EP3129016B1/fr active Active
- 2015-04-08 EP EP18175718.8A patent/EP3391941B1/fr active Active
- 2015-04-08 CN CN201580021727.0A patent/CN106458957B/zh active Active
- 2015-04-08 RS RS20180921A patent/RS57624B1/sr unknown
- 2015-04-08 WO PCT/EP2015/057606 patent/WO2015155231A1/fr active Application Filing
- 2015-04-08 TR TR2018/10411T patent/TR201810411T4/tr unknown
- 2015-04-08 JP JP2016561677A patent/JP7082861B6/ja active Active
- 2015-04-08 PT PT15714820T patent/PT3129016T/pt unknown
- 2015-04-08 LT LTEP15714820.6T patent/LT3129016T/lt unknown
- 2015-04-08 KR KR1020167030753A patent/KR102322543B1/ko active IP Right Grant
- 2015-04-08 MX MX2016012691A patent/MX2016012691A/es unknown
- 2015-04-08 EA EA201692017A patent/EA035678B1/ru not_active IP Right Cessation
- 2015-04-08 AU AU2015243346A patent/AU2015243346C9/en active Active
- 2015-04-08 ES ES15714820.6T patent/ES2683860T3/es active Active
- 2015-04-08 SG SG11201607907PA patent/SG11201607907PA/en unknown
- 2015-04-08 PL PL15714820T patent/PL3129016T3/pl unknown
- 2015-04-08 ES ES18175718T patent/ES2953522T3/es active Active
- 2015-04-08 SI SI201530356T patent/SI3129016T1/sl unknown
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2016
- 2016-09-19 IL IL247904A patent/IL247904B/en active IP Right Grant
- 2016-09-23 ZA ZA2016/06608A patent/ZA201606608B/en unknown
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2018
- 2018-07-16 HR HRP20181126TT patent/HRP20181126T1/hr unknown
- 2018-08-27 CY CY181100892T patent/CY1120650T1/el unknown
- 2018-11-08 HK HK18114264.0A patent/HK1255109A1/zh unknown
- 2018-12-19 AU AU2018282308A patent/AU2018282308B2/en active Active
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2020
- 2020-02-06 JP JP2020018467A patent/JP7229189B2/ja active Active
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2021
- 2021-07-20 JP JP2021119885A patent/JP2021169519A/ja active Pending
- 2021-07-20 JP JP2021119813A patent/JP2021169518A/ja active Pending
- 2021-09-14 US US17/474,482 patent/US20210401792A1/en active Pending
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