MA44092B1 - Nouveaux composés de succinate perméables à travers les cellules - Google Patents

Nouveaux composés de succinate perméables à travers les cellules

Info

Publication number
MA44092B1
MA44092B1 MA44092A MA44092A MA44092B1 MA 44092 B1 MA44092 B1 MA 44092B1 MA 44092 A MA44092 A MA 44092A MA 44092 A MA44092 A MA 44092A MA 44092 B1 MA44092 B1 MA 44092B1
Authority
MA
Morocco
Prior art keywords
permeable
cell
cells
succinates
succinate
Prior art date
Application number
MA44092A
Other languages
English (en)
Inventor
Eskil Elmér
Magnus Joakim Hansson
Karl Henrik Johannes Ehinger
Steven Moss
Original Assignee
Abliva Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58804197&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA44092(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abliva Ab filed Critical Abliva Ab
Publication of MA44092B1 publication Critical patent/MA44092B1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C07C327/34—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/28—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/18—Eight-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

La présente invention concerne de nouveaux succinates perméables aux cellules et des précurseurs de succinate perméables aux cellules destinés à augmenter la production d'atp dans les mitochondries. La majeure partie de l'atp produit et utilisé dans la cellule eucaryote provient de la phosphorylation oxydative mitochondriale, un processus auquel des électrons de haute énergie sont fournis par le cycle de kreb. Tous les intermédiaires du cycle de kreb ne sont pas facilement perméables à la membrane cellulaire, l'un d'eux étant le succinate. La fourniture des nouveaux succinates perméables aux cellules est envisagée pour permettre le passage sur la membrane cellulaire et ainsi les succinates perméables aux cellules peuvent être utilisés pour améliorer la production d'atp mitochondriale.
MA44092A 2014-04-08 2015-04-08 Nouveaux composés de succinate perméables à travers les cellules MA44092B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA201470190 2014-04-08

Publications (1)

Publication Number Publication Date
MA44092B1 true MA44092B1 (fr) 2023-08-31

Family

ID=58804197

Family Applications (2)

Application Number Title Priority Date Filing Date
MA39855A MA39855B1 (fr) 2014-04-08 2015-04-08 Nouveaux composés de succinate perméables à travers les cellules
MA44092A MA44092B1 (fr) 2014-04-08 2015-04-08 Nouveaux composés de succinate perméables à travers les cellules

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA39855A MA39855B1 (fr) 2014-04-08 2015-04-08 Nouveaux composés de succinate perméables à travers les cellules

Country Status (25)

Country Link
US (2) US11147789B2 (fr)
EP (2) EP3391941B1 (fr)
JP (4) JP7082861B6 (fr)
KR (1) KR102322543B1 (fr)
CN (1) CN106458957B (fr)
AU (2) AU2015243346C9 (fr)
CA (1) CA2944565C (fr)
CY (1) CY1120650T1 (fr)
DK (1) DK3129016T3 (fr)
EA (1) EA035678B1 (fr)
ES (2) ES2683860T3 (fr)
HK (1) HK1255109A1 (fr)
HR (1) HRP20181126T1 (fr)
IL (1) IL247904B (fr)
LT (2) LT3391941T (fr)
MA (2) MA39855B1 (fr)
MX (1) MX2016012691A (fr)
PL (1) PL3129016T3 (fr)
PT (2) PT3129016T (fr)
RS (1) RS57624B1 (fr)
SG (1) SG11201607907PA (fr)
SI (1) SI3129016T1 (fr)
TR (1) TR201810411T4 (fr)
WO (1) WO2015155231A1 (fr)
ZA (1) ZA201606608B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3129364A1 (fr) * 2014-04-08 2017-02-15 Neurovive Pharmaceutical AB Promédicaments d'acide succinique pour augmenter la production d'atp
RS57624B1 (sr) * 2014-04-08 2018-11-30 Neurovive Pharmaceutical Ab Nova sukcinatna jedinjenja koja prodiru u ćelije
US10307389B2 (en) 2014-04-08 2019-06-04 Neurovive Pharmaceutical Ab Succinate prodrugs for use in the treatment of lactic acidosis or drug-induced side-effects due to Complex I-related impairment of mitochondrial oxidative phosphorylation
WO2017060400A1 (fr) * 2015-10-07 2017-04-13 Neurovive Pharmaceutical Ab Métabolites protégés à base d'acide carboxylique pour le traitement des maladies liées à des dysfonctions mitochondriales
WO2017060418A1 (fr) * 2015-10-07 2017-04-13 Neurovive Pharmaceutical Ab Métabolites protégés à base d'acide carboxylique pour le traitement des maladies liées aux mitochondries
WO2017060422A1 (fr) * 2015-10-07 2017-04-13 Neurovive Pharmaceutical Ab Métabolites protégés à base d'acide carboxylique pour le traitement des troubles mitochondriaux
WO2017096270A1 (fr) * 2015-12-03 2017-06-08 The Regents Of The University Of California Méthodes de traitement de maladies mitochondriales
JP2022504584A (ja) * 2018-10-11 2022-01-13 インブリア ファーマシューティカルズ， インコーポレイテッド Ｔｃａ回路中間体およびその使用方法
EP3863596A4 (fr) * 2018-10-11 2022-08-10 Imbria Pharmaceuticals, Inc. Compositions et procédés de traitement et de prévention de la neuropathie optique héréditaire de leber
CN109675037B (zh) * 2019-01-25 2021-09-14 南方医科大学 Atp及其受体在制备治疗自闭症药物中的应用
MA56506A (fr) * 2019-06-19 2022-04-27 Abliva Ab Promédicamentà base de succinate, compositions contenant le promédicament de succinate et utilisations associées

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KR101069502B1 (ko) 2006-10-31 2011-09-30 (주)아모레퍼시픽 비만 및 당뇨병 개선용 경구용 조성물
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ES2661009T3 (es) * 2012-10-05 2018-03-27 Neurovive Pharmaceutical Ab Succinatos protegidos para mejorar la producción de ATP mitocondrial
RS57624B1 (sr) * 2014-04-08 2018-11-30 Neurovive Pharmaceutical Ab Nova sukcinatna jedinjenja koja prodiru u ćelije
EP3129364A1 (fr) 2014-04-08 2017-02-15 Neurovive Pharmaceutical AB Promédicaments d'acide succinique pour augmenter la production d'atp
US10307389B2 (en) 2014-04-08 2019-06-04 Neurovive Pharmaceutical Ab Succinate prodrugs for use in the treatment of lactic acidosis or drug-induced side-effects due to Complex I-related impairment of mitochondrial oxidative phosphorylation

Also Published As

Publication number Publication date
RS57624B1 (sr) 2018-11-30
US20170105961A1 (en) 2017-04-20
MX2016012691A (es) 2016-12-16
EP3129016B1 (fr) 2018-06-06
JP2017513829A (ja) 2017-06-01
AU2018282308B2 (en) 2020-04-30
LT3129016T (lt) 2018-09-10
EP3391941B1 (fr) 2023-06-07
AU2015243346A1 (en) 2016-10-13
AU2015243346C9 (en) 2019-03-07
JP2021169518A (ja) 2021-10-28
PT3391941T (pt) 2023-08-24
US11147789B2 (en) 2021-10-19
SG11201607907PA (en) 2016-10-28
LT3391941T (lt) 2023-11-10
IL247904B (en) 2020-08-31
MA39855A (fr) 2018-10-24
ES2683860T3 (es) 2018-09-28
ES2953522T3 (es) 2023-11-14
BR112016023086A2 (pt) 2017-08-15
ZA201606608B (en) 2022-10-26
AU2015243346C1 (en) 2019-02-07
KR102322543B1 (ko) 2021-11-04
EP3129016A1 (fr) 2017-02-15
JP7229189B2 (ja) 2023-02-27
HRP20181126T1 (hr) 2018-10-05
US20210401792A1 (en) 2021-12-30
WO2015155231A1 (fr) 2015-10-15
EA201692017A1 (ru) 2017-02-28
KR20160142861A (ko) 2016-12-13
CN106458957A (zh) 2017-02-22
PT3129016T (pt) 2018-10-01
CY1120650T1 (el) 2019-12-11
JP7082861B6 (ja) 2023-12-22
IL247904A0 (en) 2016-11-30
SI3129016T1 (sl) 2018-10-30
CA2944565A1 (fr) 2015-10-15
JP7082861B2 (ja) 2022-06-09
JP2020100628A (ja) 2020-07-02
TR201810411T4 (tr) 2018-08-27
BR112016023086A8 (pt) 2021-06-29
EP3391941A1 (fr) 2018-10-24
AU2015243346B2 (en) 2018-10-18
CA2944565C (fr) 2022-11-29
CN106458957B (zh) 2020-08-18
DK3129016T3 (en) 2018-09-03
EA035678B1 (ru) 2020-07-24
JP2021169519A (ja) 2021-10-28
AU2018282308A1 (en) 2019-01-17
HK1255109A1 (zh) 2019-08-02
MA39855B1 (fr) 2018-10-31
PL3129016T3 (pl) 2018-10-31

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