RS55539B1 - Antitelo koje prepoznaje humani inhibitorni faktor leukemije (lif) i primena anti-lif antitela u lečenju bolesti povezanih sa neželjenom proliferacijom ćelija - Google Patents

Antitelo koje prepoznaje humani inhibitorni faktor leukemije (lif) i primena anti-lif antitela u lečenju bolesti povezanih sa neželjenom proliferacijom ćelija

Info

Publication number
RS55539B1
RS55539B1 RS20161123A RSP20161123A RS55539B1 RS 55539 B1 RS55539 B1 RS 55539B1 RS 20161123 A RS20161123 A RS 20161123A RS P20161123 A RSP20161123 A RS P20161123A RS 55539 B1 RS55539 B1 RS 55539B1
Authority
RS
Serbia
Prior art keywords
lif
treatment
cell proliferation
diseases associated
inhibitory factor
Prior art date
Application number
RS20161123A
Other languages
English (en)
Inventor
Suarez Joan Seoane
Folgueira Judit Anido
Borderias Andrea Saez
Original Assignee
Fund Privada Inst D'investigacio Oncologica De Vall D'hebron (Vhio)
Fundació Privada Institució Catalana De Recerca I Estudis Avançants
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fund Privada Inst D'investigacio Oncologica De Vall D'hebron (Vhio), Fundació Privada Institució Catalana De Recerca I Estudis Avançants filed Critical Fund Privada Inst D'investigacio Oncologica De Vall D'hebron (Vhio)
Publication of RS55539B1 publication Critical patent/RS55539B1/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5415—Leukaemia inhibitory factor [LIF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Radiology & Medical Imaging (AREA)
RS20161123A 2010-04-05 2011-04-05 Antitelo koje prepoznaje humani inhibitorni faktor leukemije (lif) i primena anti-lif antitela u lečenju bolesti povezanih sa neželjenom proliferacijom ćelija RS55539B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10380049A EP2371860A1 (en) 2010-04-05 2010-04-05 Antibody recognising human leukemia inhibitory factor (LIF) and use of anti-LIF antibodies in the treatment of diseases associated with unwanted cell proliferation
EP11715676.0A EP2556091B1 (en) 2010-04-05 2011-04-05 Antibody recognising human leukemia inhibitory factor (LIF) and use of anti-LIF antibodies in the treatment of diseases associated with unwanted cell proliferation
PCT/EP2011/055253 WO2011124566A1 (en) 2010-04-05 2011-04-05 Antibody recognizing human leukemia inhibitory factor (lif) and use of anti-lif antibodies in the treatment of diseases associated with unwanted cell proliferation

Publications (1)

Publication Number Publication Date
RS55539B1 true RS55539B1 (sr) 2017-05-31

Family

ID=42338260

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20161123A RS55539B1 (sr) 2010-04-05 2011-04-05 Antitelo koje prepoznaje humani inhibitorni faktor leukemije (lif) i primena anti-lif antitela u lečenju bolesti povezanih sa neželjenom proliferacijom ćelija

Country Status (25)

Country Link
US (3) US8926956B2 (sr)
EP (3) EP2371860A1 (sr)
JP (2) JP6289906B2 (sr)
KR (5) KR20130121679A (sr)
CN (2) CN103797031A (sr)
AU (1) AU2011237922B2 (sr)
BR (1) BR112012025517B1 (sr)
CA (1) CA2797257A1 (sr)
CY (1) CY1119451T1 (sr)
DK (1) DK2556091T3 (sr)
EA (2) EA202092276A3 (sr)
ES (1) ES2608699T3 (sr)
HK (3) HK1180702A1 (sr)
HR (1) HRP20161736T1 (sr)
HU (1) HUE030578T2 (sr)
IL (3) IL222270A (sr)
LT (1) LT2556091T (sr)
MX (2) MX365054B (sr)
PL (1) PL2556091T3 (sr)
PT (1) PT2556091T (sr)
RS (1) RS55539B1 (sr)
SG (1) SG184429A1 (sr)
SI (1) SI2556091T1 (sr)
SM (1) SMT201600468T1 (sr)
WO (1) WO2011124566A1 (sr)

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US20160237158A1 (en) * 2013-09-23 2016-08-18 Institut National De La Santé Et Da La Recherche Médicale (Inserm) Methods and Compositions for Targeting Tumor Microenvironment and for preventing Metastasis
TWI486172B (zh) * 2013-11-08 2015-06-01 Univ Chang Gung 鼻咽癌治療的醫藥
US20170247446A1 (en) * 2014-09-10 2017-08-31 The Regents Of The University Of California TARGETING K-RAS-MEDIATED SIGNALING PATHWAYS AND MALIGNANCY BY ANTI-hLIF ANTIBODIES
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WO2018167283A1 (en) 2017-03-17 2018-09-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma associated neural remodeling
KR20210021287A (ko) 2018-04-12 2021-02-25 메디뮨 리미티드 암을 치료하는 데 사용하기 위한 lif 억제제와 pd-1 축 억제제의 조합
MA52021A (fr) * 2018-05-14 2021-03-24 Fundacio Privada Inst Catalana De Recerca I Estudis Avancats Anticorps anti-lif et leurs formes galéniques
SG11202012619WA (en) * 2018-06-18 2021-01-28 Medimmune Ltd Methods for improving response to anti-lif antibody treatment in individuals with cancer
EA202092964A1 (ru) * 2018-06-18 2021-03-30 Медиммун Лимитед Комбинация ингибиторов lif и антинеопластических средств на основе платины для применения в лечении рака
MX2022003762A (es) * 2019-09-29 2022-06-24 Jacobio Pharmaceuticals Co Ltd Molécula de unión específica para el factor inhibidor de la leucemia (lif) y uso de la misma.
CN111020030A (zh) * 2019-12-03 2020-04-17 中山大学 一种骨肉瘤干细胞标志物及其应用、试剂盒
CN111378036B (zh) * 2020-01-09 2021-08-10 北京浩古元方生物医药科技有限公司 一种抗人白血病抑制因子单克隆抗体的制备方法及其应用
CN112294812B (zh) * 2020-11-18 2022-08-16 新乡医学院 一种小分子抑制剂在制备抗肿瘤药物方面的应用
CN114672460B (zh) * 2021-12-21 2023-06-23 中国人民解放军军事科学院军事医学研究院 一种靶向cd44的异质型cic细胞模型的制备方法及应用

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TWI486172B (zh) 2013-11-08 2015-06-01 Univ Chang Gung 鼻咽癌治療的醫藥

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IL222270A0 (en) 2012-12-31
EA036698B1 (ru) 2020-12-09
KR102294207B1 (ko) 2021-08-26
EA202092276A2 (ru) 2021-01-29
HK1180702A1 (zh) 2013-10-25
JP2013523796A (ja) 2013-06-17
CY1119451T1 (el) 2018-03-07
US20150139989A1 (en) 2015-05-21
SI2556091T1 (sl) 2017-02-28
IL254664A0 (en) 2017-11-30
EA036698B9 (ru) 2021-02-25
JP6289906B2 (ja) 2018-03-07
CA2797257A1 (en) 2011-10-13
PL2556091T3 (pl) 2017-04-28
DK2556091T3 (en) 2017-01-16
IL222270A (en) 2016-06-30
HK1208469A1 (en) 2016-03-04
EP2371860A1 (en) 2011-10-05
EP3045473A1 (en) 2016-07-20
LT2556091T (lt) 2016-12-27
IL241952A (en) 2017-10-31
BR112012025517A2 (pt) 2017-11-28
KR20170125137A (ko) 2017-11-13
ES2608699T3 (es) 2017-04-12
HK1223384A1 (zh) 2017-07-28
US8926956B2 (en) 2015-01-06
MX2012011636A (es) 2013-04-03
HUE030578T2 (en) 2017-06-28
US20130142808A1 (en) 2013-06-06
CN103797031A (zh) 2014-05-14
SMT201600468T1 (it) 2017-03-08
BR112012025517B1 (pt) 2021-08-31
AU2011237922B2 (en) 2014-07-10
JP2017019775A (ja) 2017-01-26
US10968273B2 (en) 2021-04-06
JP6483059B2 (ja) 2019-03-13
US20190119373A1 (en) 2019-04-25
AU2011237922A1 (en) 2012-11-01
EP2556091B1 (en) 2016-09-28
KR20130121679A (ko) 2013-11-06
SG184429A1 (en) 2012-11-29
KR20180078352A (ko) 2018-07-09
EA201201373A1 (ru) 2013-04-30
EP2556091A1 (en) 2013-02-13
CN109320609A (zh) 2019-02-12
MX365054B (es) 2019-05-21
HRP20161736T1 (hr) 2017-02-10
KR20190061098A (ko) 2019-06-04
PT2556091T (pt) 2017-01-03
KR20200119344A (ko) 2020-10-19
EA202092276A3 (ru) 2021-04-30
IL254664B (en) 2022-03-01
WO2011124566A1 (en) 2011-10-13

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