RS53788B1 - Jedinjenje za inhibiciju mitotičke progresije - Google Patents

Jedinjenje za inhibiciju mitotičke progresije

Info

Publication number
RS53788B1
RS53788B1 RS20150047A RSP20150047A RS53788B1 RS 53788 B1 RS53788 B1 RS 53788B1 RS 20150047 A RS20150047 A RS 20150047A RS P20150047 A RSP20150047 A RS P20150047A RS 53788 B1 RS53788 B1 RS 53788B1
Authority
RS
Serbia
Prior art keywords
cancer
compound
group
heteroaryl
proliferative disorder
Prior art date
Application number
RS20150047A
Other languages
English (en)
Serbian (sr)
Inventor
Christopher F. Claiborne
Todd B. Sells
Stephen G. Stroud
Original Assignee
Millennium Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39315133&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS53788(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharmaceuticals Inc. filed Critical Millennium Pharmaceuticals Inc.
Publication of RS53788B1 publication Critical patent/RS53788B1/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RS20150047A 2006-11-16 2007-11-14 Jedinjenje za inhibiciju mitotičke progresije RS53788B1 (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85934006P 2006-11-16 2006-11-16

Publications (1)

Publication Number Publication Date
RS53788B1 true RS53788B1 (sr) 2015-06-30

Family

ID=39315133

Family Applications (2)

Application Number Title Priority Date Filing Date
RS20150047A RS53788B1 (sr) 2006-11-16 2007-11-14 Jedinjenje za inhibiciju mitotičke progresije
RS20120247A RS52313B (sr) 2006-11-16 2007-11-14 Jedinjenja za inhibiciju napredovanja mitoze

Family Applications After (1)

Application Number Title Priority Date Filing Date
RS20120247A RS52313B (sr) 2006-11-16 2007-11-14 Jedinjenja za inhibiciju napredovanja mitoze

Country Status (34)

Country Link
US (7) US8026246B2 (cg-RX-API-DMAC7.html)
EP (4) EP2086981B1 (cg-RX-API-DMAC7.html)
JP (3) JP5102839B2 (cg-RX-API-DMAC7.html)
KR (2) KR101110458B1 (cg-RX-API-DMAC7.html)
CN (2) CN101547924B (cg-RX-API-DMAC7.html)
AR (1) AR064246A1 (cg-RX-API-DMAC7.html)
AT (1) ATE556076T1 (cg-RX-API-DMAC7.html)
AU (1) AU2007322046B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0718803B8 (cg-RX-API-DMAC7.html)
CA (1) CA2669680C (cg-RX-API-DMAC7.html)
CL (1) CL2007003244A1 (cg-RX-API-DMAC7.html)
CR (3) CR10782A (cg-RX-API-DMAC7.html)
CY (1) CY1112828T1 (cg-RX-API-DMAC7.html)
DK (2) DK2086981T3 (cg-RX-API-DMAC7.html)
EA (1) EA015779B1 (cg-RX-API-DMAC7.html)
ES (3) ES2384123T3 (cg-RX-API-DMAC7.html)
GE (1) GEP20125459B (cg-RX-API-DMAC7.html)
HR (2) HRP20120490T1 (cg-RX-API-DMAC7.html)
IL (1) IL198690A0 (cg-RX-API-DMAC7.html)
MA (1) MA30988B1 (cg-RX-API-DMAC7.html)
MX (3) MX348568B (cg-RX-API-DMAC7.html)
MY (1) MY153243A (cg-RX-API-DMAC7.html)
NO (1) NO343338B1 (cg-RX-API-DMAC7.html)
NZ (3) NZ577042A (cg-RX-API-DMAC7.html)
PH (1) PH12012502057B1 (cg-RX-API-DMAC7.html)
PL (2) PL2086981T3 (cg-RX-API-DMAC7.html)
PT (2) PT2497772E (cg-RX-API-DMAC7.html)
RS (2) RS53788B1 (cg-RX-API-DMAC7.html)
SG (2) SG10201503350TA (cg-RX-API-DMAC7.html)
SI (2) SI2086981T1 (cg-RX-API-DMAC7.html)
TW (1) TWI401255B (cg-RX-API-DMAC7.html)
UA (1) UA94129C2 (cg-RX-API-DMAC7.html)
WO (1) WO2008063525A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200903279B (cg-RX-API-DMAC7.html)

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DE602005003951T4 (de) 2004-05-14 2012-10-11 Millennium Pharmaceuticals, Inc. Verbindungen und verfahren zur inhibierung der mitotischen progression durch hemmung von aurorakinase
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EP2373657B1 (en) * 2008-12-05 2016-09-14 Millennium Pharmaceuticals, Inc. 5,7-dihydro-6h-pyrimido[5,4-d][1]benzazepin-6-thiones as plk inhibitors
RU2535032C2 (ru) * 2008-12-22 2014-12-10 Милленниум Фармасьютикалз, Инк. Сочетание ингибиторов аврора киназы и анти-cd 20 антител
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
JO3434B1 (ar) * 2009-07-31 2019-10-20 Millennium Pharm Inc مركبات صيدلانية لمعالجة السرطان وامراض واضطرابات اخري
CN104031049A (zh) * 2010-02-19 2014-09-10 米伦纽姆医药公司 极光激酶抑制剂的结晶形式
US20120107304A1 (en) 2010-04-27 2012-05-03 Boehringer Ingelheim International Gmbh Combination therapy in treatment of oncological and fibrotic diseases
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UY34114A (es) * 2011-06-03 2013-01-03 Millennium Pharm Inc Combinación de inhibidores de mek e inhibidores selectivos de la quiinasa aurora a
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
CN103772391A (zh) * 2012-10-23 2014-05-07 杨子娇 一类治疗房角狭窄的化合物及其用途
JP6360881B2 (ja) * 2013-03-22 2018-07-18 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 触媒的ｍｔｏｒｃ１／２阻害薬及びオーロラａキナーゼの選択的阻害薬の組合せ
US10335494B2 (en) 2013-12-06 2019-07-02 Millennium Pharmaceuticals, Inc. Combination of aurora kinase inhibitors and anti-CD30 antibodies
EP3236948A4 (en) * 2014-12-23 2018-10-03 Millennium Pharmaceuticals, Inc. Combination of raf inhibitors and aurora kinase inhibitors
US20180207173A1 (en) 2015-07-21 2018-07-26 Millennium Pharmaceuticals, Inc. Administration of aurora kinase inhibitor and chemotherapeutic agents
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CN108349943A (zh) 2015-09-09 2018-07-31 西奈山伊坎医学院 杂环受限三环磺酰胺作为抗癌试剂
WO2017146253A1 (ja) 2016-02-26 2017-08-31 公益財団法人がん研究会 Ｈｐ１の機能に着目した抗癌剤のスクリーニング方法及び評価系
JP7158023B2 (ja) 2016-03-15 2022-10-21 オリソン ヘノミクス エセ． アー． 固形腫瘍の治療における使用のための、ｌｓｄ１阻害剤の組合せ
JP6188986B1 (ja) * 2017-03-23 2017-08-30 株式会社ノエビア 時計遺伝子発現量調整剤及びエラスチン産生促進剤
WO2019195658A1 (en) 2018-04-05 2019-10-10 Dana-Farber Cancer Institute, Inc. Sting levels as a biomarker for cancer immunotherapy
WO2020049208A1 (es) 2018-09-09 2020-03-12 Fundacio Privada Institut De Recerca De La Sida - Caixa Aurora cinasa como diana para tratar, prevenir o curar una infección por vih o sida
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WO2025245045A1 (en) 2024-05-21 2025-11-27 The Regents Of The University Of California Methods of treating lung cancer

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JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها

Also Published As

Publication number Publication date
SI2086981T1 (sl) 2012-12-31
ES2528793T3 (es) 2015-02-12
CN101547924A (zh) 2009-09-30
MX348568B (es) 2017-06-20
ES2384123T3 (es) 2012-06-29
KR101342014B1 (ko) 2013-12-19
TW200829589A (en) 2008-07-16
US8026246B2 (en) 2011-09-27
US9765076B2 (en) 2017-09-19
AR064246A1 (es) 2009-03-25
EP2497773A1 (en) 2012-09-12
US20210214361A1 (en) 2021-07-15
CA2669680A1 (en) 2008-05-29
EP2086981A1 (en) 2009-08-12
GEP20125459B (en) 2012-03-26
US9988384B2 (en) 2018-06-05
EP2497772A1 (en) 2012-09-12
DK2086981T3 (da) 2012-08-06
KR20110113210A (ko) 2011-10-14
CR10782A (es) 2009-06-24
PH12012502057A1 (en) 2015-09-14
SI2497772T1 (sl) 2015-03-31
PL2497772T3 (pl) 2015-05-29
EP2497772B1 (en) 2014-10-29
HK1175777A1 (en) 2013-07-12
SG176443A1 (en) 2011-12-29
ATE556076T1 (de) 2012-05-15
CY1112828T1 (el) 2016-02-10
NZ597252A (en) 2013-06-28
US20110312943A1 (en) 2011-12-22
US20190031662A1 (en) 2019-01-31
MA30988B1 (fr) 2009-12-01
JP2010510215A (ja) 2010-04-02
ZA200903279B (en) 2010-07-28
CL2007003244A1 (es) 2008-04-04
KR20090091173A (ko) 2009-08-26
WO2008063525A1 (en) 2008-05-29
EP2497773B1 (en) 2015-02-25
HRP20150047T1 (en) 2015-03-13
PT2497772E (pt) 2015-02-05
AU2007322046A1 (en) 2008-05-29
CR20140154A (es) 2014-07-23
US11958855B2 (en) 2024-04-16
US20110312942A1 (en) 2011-12-22
HK1134672A1 (en) 2010-05-07
US20150166545A1 (en) 2015-06-18
US10836766B2 (en) 2020-11-17
CN103483343A (zh) 2014-01-01
DK2497772T3 (en) 2015-01-19
AU2007322046B2 (en) 2012-04-05
KR101110458B1 (ko) 2012-03-13
NO343338B1 (no) 2019-02-04
BRPI0718803B8 (pt) 2021-05-25
JP5452811B2 (ja) 2014-03-26
PL2086981T3 (pl) 2012-09-28
NZ611898A (en) 2015-01-30
BRPI0718803B1 (pt) 2020-11-17
EA015779B1 (ru) 2011-12-30
MX343391B (es) 2016-11-04
CN103483343B (zh) 2016-06-01
NZ577042A (en) 2012-03-30
HRP20120490T1 (hr) 2012-07-31
CR20140544A (es) 2015-01-12
CA2669680C (en) 2012-04-10
SG10201503350TA (en) 2015-06-29
HK1217699A1 (en) 2017-01-20
IL198690A0 (en) 2010-02-17
EP2086981B1 (en) 2012-05-02
JP5102839B2 (ja) 2012-12-19
NO20091864L (no) 2009-06-15
EP2944639B1 (en) 2017-01-04
JP2012006965A (ja) 2012-01-12
RS52313B (sr) 2012-12-31
CN101547924B (zh) 2013-09-25
EA200970486A1 (ru) 2009-10-30
US20080167292A1 (en) 2008-07-10
ES2537451T3 (es) 2015-06-08
US20240400567A1 (en) 2024-12-05
MX2009004670A (es) 2009-05-15
PT2086981E (pt) 2012-06-20
JP2014055166A (ja) 2014-03-27
HK1175778A1 (en) 2013-07-12
BRPI0718803A2 (pt) 2013-12-03
EP2944639A1 (en) 2015-11-18
PH12012502057B1 (en) 2018-10-24
TWI401255B (zh) 2013-07-11
UA94129C2 (ru) 2011-04-11
MY153243A (en) 2015-01-29

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