RS50886B - Nova jedinjenja koja su jaki inhibitori mehanizma za izmenu na+/ca2+ i korisni su kod lečenja aritmija - Google Patents
Nova jedinjenja koja su jaki inhibitori mehanizma za izmenu na+/ca2+ i korisni su kod lečenja aritmijaInfo
- Publication number
- RS50886B RS50886B YUP-6/04A YUP604A RS50886B RS 50886 B RS50886 B RS 50886B YU P604 A YUP604 A YU P604A RS 50886 B RS50886 B RS 50886B
- Authority
- RS
- Serbia
- Prior art keywords
- yloxy
- chroman
- compound
- phenylchroman
- nmr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
- C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
- C07C217/90—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. amino-diphenylethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20011507A FI20011507A0 (fi) | 2001-07-10 | 2001-07-10 | Uusia yhdisteitä |
| PCT/FI2002/000621 WO2003006452A1 (en) | 2001-07-10 | 2002-07-10 | New compounds, which are potent inhibitors of na+/ca2+ exchange mechanism and are useful in the treatment of arrhythmias |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RS604A RS604A (sr) | 2006-12-15 |
| RS50886B true RS50886B (sr) | 2010-08-31 |
Family
ID=8561628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YUP-6/04A RS50886B (sr) | 2001-07-10 | 2002-07-10 | Nova jedinjenja koja su jaki inhibitori mehanizma za izmenu na+/ca2+ i korisni su kod lečenja aritmija |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7425568B2 (OSRAM) |
| EP (1) | EP1412343B1 (OSRAM) |
| JP (1) | JP4113839B2 (OSRAM) |
| KR (1) | KR20040025697A (OSRAM) |
| CN (1) | CN1281597C (OSRAM) |
| AR (1) | AR036236A1 (OSRAM) |
| AT (1) | ATE338038T1 (OSRAM) |
| AU (1) | AU2002321339B2 (OSRAM) |
| BR (1) | BR0211070A (OSRAM) |
| CA (1) | CA2452918C (OSRAM) |
| DE (1) | DE60214388T2 (OSRAM) |
| DK (1) | DK1412343T3 (OSRAM) |
| EA (1) | EA006580B1 (OSRAM) |
| ES (1) | ES2269746T3 (OSRAM) |
| FI (1) | FI20011507A0 (OSRAM) |
| HR (1) | HRP20040133A2 (OSRAM) |
| HU (1) | HUP0400391A3 (OSRAM) |
| IL (2) | IL159647A0 (OSRAM) |
| MX (1) | MXPA04000267A (OSRAM) |
| NO (1) | NO20035821L (OSRAM) |
| NZ (1) | NZ530490A (OSRAM) |
| PL (1) | PL367958A1 (OSRAM) |
| PT (1) | PT1412343E (OSRAM) |
| RS (1) | RS50886B (OSRAM) |
| UA (1) | UA76168C2 (OSRAM) |
| WO (1) | WO2003006452A1 (OSRAM) |
| ZA (1) | ZA200400145B (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI20030030A0 (fi) * | 2003-01-09 | 2003-01-09 | Orion Corp | Uusia yhdisteitä |
| JP5380069B2 (ja) | 2005-03-11 | 2014-01-08 | ハワード フローリー インスティチュート | フラボノイド化合物およびその使用 |
| US8912224B2 (en) | 2011-09-12 | 2014-12-16 | Sanofi | Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals |
| JP5941637B2 (ja) * | 2011-09-12 | 2016-06-29 | サノフイ | 置換２−（クロマン−６−イルオキシ）−チアゾール及び医薬としてのその使用 |
| ES2528143T3 (es) | 2011-09-12 | 2015-02-04 | Sanofi | 2-(croman-6-iloxi)-tiazoles sustituidos y su uso como productos farmacéuticos |
| CA2846347C (en) * | 2011-09-12 | 2019-05-21 | Sanofi | Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals |
| CN102993195B (zh) * | 2011-09-14 | 2017-05-17 | 赛诺菲 | 取代的2‑(色满‑6‑基氧基)噻唑及其作为药物的用途 |
| CN103030646B (zh) * | 2011-09-29 | 2016-08-24 | 上海恒瑞医药有限公司 | 苯并二氧六环类衍生物、其制备方法及其在医药上的应用 |
| TWI633095B (zh) * | 2013-03-08 | 2018-08-21 | 賽諾菲公司 | 經取代－６－基氧基－環烷類及其作為醫藥品之用途 |
| GB201416186D0 (en) | 2014-09-12 | 2014-10-29 | Redx Pharma Ltd | Compounds |
| WO2019175464A1 (en) | 2018-03-14 | 2019-09-19 | Orion Corporation | Compounds useful as inhibitors of sodium-calcium exchanger (ncx) |
| WO2022023447A2 (en) | 2020-07-28 | 2022-02-03 | Jazz Pharmaceuticals Ireland Limited | Fused bicyclic raf inhibitors and methods for use thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2820817A (en) * | 1954-02-04 | 1958-01-21 | Mcneilab Inc | Oxygenated indan compounds and method of making the same |
| BE650081A (OSRAM) * | 1963-07-03 | |||
| US3862232A (en) * | 1963-07-03 | 1975-01-21 | Upjohn Co | 1-(p-hydroxyphenyl)-2-phenyl-6-(2-diethylaminoethoxy)-3,4-dihydronaphthalene and the salts thereof |
| GB1154119A (en) * | 1968-05-20 | 1969-06-04 | Merck Ag E | 3-Alkyl-Flavanones |
| FR2733685B1 (fr) | 1995-05-05 | 1997-05-30 | Adir | Utilisation des derives du benzopyrane pour l'obtention de compositions pharmaceutiques destinees au traitement des pathologies liees a l'echangeur c1-/hc03-, na+ independant |
| JPH0967336A (ja) | 1995-09-04 | 1997-03-11 | Kanebo Ltd | 新規なイソチオウレア誘導体 |
| WO1998043943A1 (fr) | 1997-03-27 | 1998-10-08 | Taisho Pharmaceutical Co., Ltd. | Derives de 2-phenoxyaniline |
| JPH1149752A (ja) | 1997-08-05 | 1999-02-23 | Taisho Pharmaceut Co Ltd | フェノキシピリジン誘導体 |
| DE19742508A1 (de) | 1997-09-26 | 1999-04-01 | Hoechst Marion Roussel De Gmbh | Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
| US6162832A (en) | 1997-10-20 | 2000-12-19 | Taisho Pharmaceutical Co., Inc. | 2-Phenoxyaniline derivatives |
| JPH11302235A (ja) * | 1998-04-15 | 1999-11-02 | Taisho Pharmaceut Co Ltd | フェノキシアルキルアミン誘導体 |
| JP2002542291A (ja) | 1999-04-23 | 2002-12-10 | ブリストル−マイヤーズ スクイブ カンパニー | ジ環式アシルグアニジン・ナトリウム／プロトン交換抑制剤および方法 |
| US6589983B1 (en) | 1999-09-17 | 2003-07-08 | Nissan Chemical Industries, Ltd. | Benzopyran derivative |
| FI20030030A0 (fi) | 2003-01-09 | 2003-01-09 | Orion Corp | Uusia yhdisteitä |
-
2001
- 2001-07-10 FI FI20011507A patent/FI20011507A0/fi unknown
-
2002
- 2002-07-10 DK DK02755036T patent/DK1412343T3/da active
- 2002-07-10 PT PT02755036T patent/PT1412343E/pt unknown
- 2002-07-10 CN CNB028138635A patent/CN1281597C/zh not_active Expired - Fee Related
- 2002-07-10 JP JP2003512224A patent/JP4113839B2/ja not_active Expired - Fee Related
- 2002-07-10 IL IL15964702A patent/IL159647A0/xx active IP Right Grant
- 2002-07-10 PL PL02367958A patent/PL367958A1/xx unknown
- 2002-07-10 US US10/482,396 patent/US7425568B2/en not_active Expired - Fee Related
- 2002-07-10 NZ NZ530490A patent/NZ530490A/en not_active IP Right Cessation
- 2002-07-10 WO PCT/FI2002/000621 patent/WO2003006452A1/en not_active Ceased
- 2002-07-10 KR KR10-2004-7000332A patent/KR20040025697A/ko not_active Ceased
- 2002-07-10 MX MXPA04000267A patent/MXPA04000267A/es active IP Right Grant
- 2002-07-10 EP EP02755036A patent/EP1412343B1/en not_active Expired - Lifetime
- 2002-07-10 HU HU0400391A patent/HUP0400391A3/hu unknown
- 2002-07-10 RS YUP-6/04A patent/RS50886B/sr unknown
- 2002-07-10 AU AU2002321339A patent/AU2002321339B2/en not_active Ceased
- 2002-07-10 AT AT02755036T patent/ATE338038T1/de not_active IP Right Cessation
- 2002-07-10 AR ARP020102586A patent/AR036236A1/es unknown
- 2002-07-10 EA EA200400161A patent/EA006580B1/ru not_active IP Right Cessation
- 2002-07-10 HR HR20040133A patent/HRP20040133A2/hr not_active Application Discontinuation
- 2002-07-10 DE DE60214388T patent/DE60214388T2/de not_active Expired - Fee Related
- 2002-07-10 ES ES02755036T patent/ES2269746T3/es not_active Expired - Lifetime
- 2002-07-10 BR BR0211070-9A patent/BR0211070A/pt not_active IP Right Cessation
- 2002-07-10 CA CA2452918A patent/CA2452918C/en not_active Expired - Fee Related
- 2002-10-07 UA UA2004020928A patent/UA76168C2/uk unknown
-
2003
- 2003-12-23 NO NO20035821A patent/NO20035821L/no not_active Application Discontinuation
- 2003-12-30 IL IL159647A patent/IL159647A/en not_active IP Right Cessation
-
2004
- 2004-01-08 ZA ZA200400145A patent/ZA200400145B/en unknown
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