RS50832B2 - Agens oleogela sa sadržajem triterpena, oleogel sa sadržajem triterpena i postupak za proizvodnju oleogela sa sadržajem triterpena - Google Patents
Agens oleogela sa sadržajem triterpena, oleogel sa sadržajem triterpena i postupak za proizvodnju oleogela sa sadržajem triterpenaInfo
- Publication number
- RS50832B2 RS50832B2 RS20090188A RSP20090188A RS50832B2 RS 50832 B2 RS50832 B2 RS 50832B2 RS 20090188 A RS20090188 A RS 20090188A RS P20090188 A RSP20090188 A RS P20090188A RS 50832 B2 RS50832 B2 RS 50832B2
- Authority
- RS
- Serbia
- Prior art keywords
- triterpene
- weight
- oleogel
- proportion
- particle size
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
- C07C35/37—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with a hydroxy group on a condensed system having three rings
- C07C35/42—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with a hydroxy group on a condensed system having three rings derived from the phenanthrene skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Measuring Volume Flow (AREA)
- Colloid Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Claims (42)
1. Primena barem jednog visoko disperzivnog triterpena sa česticama srednje veličine manje od 50 μm kao agensa oleogela u oleogelu.
2. Primena u skladu sa zahtevom 1 kod kojeg srednja veličina čestica barem jednog triterpena iznosi manje od 10 μm.
3. Primena u skladu sa jednim od prethodnih zahteva kod koga jedan udeo u sekundarnim aglomeratima, barem jednog triterpena, iznosi manje od 20 % težine.
4. Primena u skladu sa zahtevom 3 kod koga barem jedan triterpen ima homogenu raspodelu veličine čestica.
5. Primena u skladu sa jednim od prethodnih zahteva kod koga specifična površina barem jednog triterpena iznosi između 1m2 /g i 500 m2 /g.
6. Primena u skladu sa zahtevom 5. kod kojeg specifična površina barem jednog triterpena iznosi između 10 m2 /g i 100 m2 /g.
7. Primena u skladu sa zahtevom 6. kod kojeg specifična površina barem jednog triterpena iznosi između 20 m2 /g i 50 m2 /g.
8. Primena u skladu sa jednim od prethodnih zahteva kod kojeg barem jedan triterpen ima udela više od 80 % težine betulina.
9. Oleogel koji sadrži sledeće sastojke:
- nepolarnu tečnost sa udelom između 80% težine i 99 % težine u pogledu ukupne težine gela.
- barem jedan visoko disperzivni triterpen kao agens oleogela koji prikazuje srednju veličinu čestica manje od 50 μm sa udelom između 1% težine i 20 % težine u pogledu ukupne težine gela.
10. Oleogel u skladu sa zahtevom 9. kod kojeg srednja veličina čestica barem jednog triterpena iznosi manje od 10 μm.
11. Oleogel u skladu sa zahtevom 9. ili 10. kod kojih udeo u sekundarnim aglomeratima barem jednog triterpena iznosi manje od 20 % težine.
12. Oleogel u skladu sa zahtevom 11. kod kojeg barem jedan triterpen ima homogenu raspodelu veličine čestica.
13. Oleogel u skladu sa zahtevima 9. do 12. kod kojeg specifična površina barem jednog triterpena iznosi između 1m2 /g i 500 m2 /g.
14. Oleogel u skladu sa zahtevom 13. kod koga specifična površina barem jednog triterpena iznosi između 10 m2 /g i 100 m2 /g.
15. Oleogel u skladu sa zahtevom 14. kod koga specičična površina barem jednog triterpena iznosi između 20 m2 /g i 50 m2 /g.
16. Oleogel u skladu sa zahtevima 9. do 15. kod kojeg barem jedan triterpen ima udela više od 80 % težine betulina.
17. Oleogel u skladu sa zahtevima 9. do 16. kod kojeg udeo oleogela iznosi između 3% težine i 15% težine.
18. Oleogel u skladu sa zahtevom 17. Kod kojeg udeo nepolarne tečnosti iznosi između 88% težine i 94% težine a udeo agensa oleogela između 6% težine i 12% težine.
19. Oleogel u skladu sa zahtevima 9 do 18 kod kojeg je nepolarna tečnost biljno, životinjsko, mineralno ili sintetičko ulje.
20. Oleogel u skladu sa zahtevom 19. kod kojeg je ulje jedno od sledećih biljnih ulja ili mešavina sledećih biljnih ulja: suncokretovog ulja, maslinovog ulja, avokado ulja, bademovog ulja.
21. Oleogel u skladu sa zahtevima 9 do 18 kod kojeg je nepolarna tečnost vosak ili parafin.
22. Postupak za proizvodnju oleogela koji obuhvata mešanje samo sledećih sastojaka:
- nepolarnu tečnost sa udelom između 80% težine i 99 % težine u pogledu ukupne težine gela.
- barem jedan visoko disperzivni triterpen kao agens oleogela koji prikazuje srednju veličinu čestica manje od 50 μm sa udelom između 1% težine i 20 % težine u pogledu ukupne težine gela.
23. Postupak u skladu sa zahtevom 22 kod kojeg je srednja veličina čestica barem jednog triterpena manja od 10 μm.
24. Postupak u skladu sa jednim od zahteva 22 ili 23 kod kojeg udeo u sekundarnim aglomeratima barem jednog triterpena iznosi manje od 20% težine.
25. Postupak u skladu sa zahtevom 24 kod kojeg barem jedan triterpen ima homogenu raspodelu veličine čestice.
26. Postupak u skladu sa jednim od zahteva 22 do 25 kod kojeg specifična površina barem jednog triterpena iznosi između 1m2 /g i 500 m2 /g.
27. Postupak u skladu sa zahtevom 26 kod kojeg specifična površina barem jednog triterpena iznosi između 10m2 /g i 100 m2 /g.
28. Postupak u skladu sa zahtevom 27 kod kojeg specifična površina barem jednog triterpena iznosi između 20m2 /g i 50 m2 /g.
29. Postupak u skladu sa zahtevima 22 do 28 kod kojeg barem jedan triterpen obuhvata udeo veći od 80% težine betulina.
30. Postupak u skladu sa zahtevima 22 do 29 kod kojeg udeo agensa oleogela iznosi između 3% težine i 15% težine.
31. Postupak u skladu sa zahtevom 30 kod kojeg udeo nepolarne tečnosti iznosi između 88% težine i 94% težine i udeo agensa oleogela između 6% težine i 12% težine.
32. Postupak u skladu sa zahtevima 22 do 31 kod kojeg je nepolarna tečnost biljno, životinjsko ili sintetičko ulje.
33. Postupak u skladu sa zahtevom 32 kod kojeg je ulje jedno od sledećih ili mešavina sledećih biljnih ulja: suncokretovo ulje, maslinovo ulje, avokado ulje, bademovo ulje.
34. Postupak u skladu sa jedim od zahteva 22 do 29 ili 31 kod kojeg je nepolarna tečnost vosak ili parafin.
35. Primena visoko disperzivnog triterpena srednje veličine čestica manje od 50 μm kao sredstvo za zgušnjavanje u nepolarnoj tečnosti tako što se triterpen u tečnosti primenjuje u koncentraciji ispod granice koja je data za triterpen i stvaranje želatina.
36. Primena u skladu sa zahtevom 35 kod kojeg srednja veličina čestica barem jednog triterpena iznosi 10 μm.
37. Primena u skladu sa jednim od zahteva 35 ili 36 kod kojeg jedan udeo u sekundarnim aglomeratima barem jednog triterpena iznosi manje od 205 teže.
38. Primena u skladu sa zahtevom 37 kod kojeg barem jedan triterpen ima homogenu raspodelu veličine čestica.
39. Primena u skladu sa jednim od zahteva 35 do 38 kod kojeg specifična površina barem jednog triterpena iznosi između 1m2 /g i 500 m2 /g.
40. Primena u skladu sa zahtevom 39 kod kojeg specifična površina barem jednog triterpena iznosi između 10m2 /g i 100 m2 /g.
41. Primena u skladu sa zahtevom 40 kod kojeg specifična površina barem jednog triterpena iznosi između 20m2 /g i 50 m2 /g.
42. Primena u skladu sa jednim od zahteva 35 ili 41 kod kojeg barem jedan triterpen ima udeo veći od 80% težine betulina.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004030044A DE102004030044A1 (de) | 2004-06-22 | 2004-06-22 | Triterpenhaltiger Oleogelbildner, triterpenhaltiges Oleogel und Verfahren zur Herstellung eines triterpenhaltigen Oleogels |
| PCT/EP2005/006710 WO2005123037A1 (de) | 2004-06-22 | 2005-06-21 | Triterpenhaltiger oleogelbildner, triterpenhaltiges oleogel und verfahren zur herstellung eines triterpenhaltigen oleogels |
| EP05756084A EP1758555B2 (de) | 2004-06-22 | 2005-06-21 | Triterpenhaltiger oleogelbildner, triterpenhaltiges oleogel und verfahren zur herstellung eines triterpenhaltigen oleogels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RS50832B RS50832B (sr) | 2010-08-31 |
| RS50832B2 true RS50832B2 (sr) | 2018-09-28 |
Family
ID=34971468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20090188A RS50832B2 (sr) | 2004-06-22 | 2005-06-21 | Agens oleogela sa sadržajem triterpena, oleogel sa sadržajem triterpena i postupak za proizvodnju oleogela sa sadržajem triterpena |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US8536380B2 (sr) |
| EP (1) | EP1758555B2 (sr) |
| JP (1) | JP4468987B2 (sr) |
| KR (1) | KR101162991B1 (sr) |
| CN (1) | CN1972668B (sr) |
| AT (1) | ATE423546T1 (sr) |
| AU (1) | AU2005253732C1 (sr) |
| BE (1) | BE2016C035I2 (sr) |
| BR (1) | BRPI0512288B8 (sr) |
| CA (1) | CA2571606C (sr) |
| CY (2) | CY1109066T1 (sr) |
| DE (2) | DE102004030044A1 (sr) |
| DK (1) | DK1758555T4 (sr) |
| ES (1) | ES2323082T5 (sr) |
| FR (1) | FR16C1003I2 (sr) |
| HU (1) | HUS1600032I1 (sr) |
| IL (1) | IL180057A (sr) |
| LT (1) | LTC1758555I2 (sr) |
| LU (1) | LU93142I2 (sr) |
| MX (1) | MXPA06015233A (sr) |
| NL (1) | NL300823I2 (sr) |
| NO (2) | NO336747B1 (sr) |
| NZ (1) | NZ552280A (sr) |
| PL (1) | PL1758555T5 (sr) |
| PT (1) | PT1758555E (sr) |
| RS (1) | RS50832B2 (sr) |
| RU (1) | RU2430717C2 (sr) |
| SI (1) | SI1758555T2 (sr) |
| UA (1) | UA88308C2 (sr) |
| WO (1) | WO2005123037A1 (sr) |
| ZA (1) | ZA200610304B (sr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2332525A1 (en) | 2009-11-23 | 2011-06-15 | Novaliq GmbH | Pharmaceutical composition comprising propofol |
| DE102009047092A1 (de) * | 2009-11-24 | 2011-05-26 | Birken Gmbh | Verwendung eines triterpenhaltigen Oleogels zur Wundheilung |
| ES2537151T3 (es) | 2009-12-10 | 2015-06-02 | Neubourg Skin Care Gmbh & Co. Kg | Formulaciones de espuma estabilizadas con polímeros, libres de emulsionantes |
| PL2363108T3 (pl) | 2010-03-02 | 2018-04-30 | Neubourg Skin Care Gmbh & Co. Kg | Formulacje piankowe zawierające co najmniej jeden triterpenoid |
| KR101723272B1 (ko) | 2011-06-21 | 2017-04-18 | 비브이더블유 홀딩 에이쥐 | 보스웰릭산을 포함하는 메디컬 디바이스 |
| HRP20250066T1 (hr) * | 2016-05-12 | 2025-03-14 | Rudjer Boskovic Institute | Organski gelatori biljnog ulja niske molekularne težine |
| EP3484434A4 (en) * | 2016-07-18 | 2020-01-08 | Amryt Research Limited | BETULINE-CONTAINING WATER-IN-OIL FOAMS AND COMPOSITIONS THEREOF |
| US20180258277A1 (en) * | 2017-03-10 | 2018-09-13 | Kraton Polymers U.S. Llc | Fusible oil gel compositions and methods of making and using same |
| KR102692754B1 (ko) | 2017-08-31 | 2024-08-08 | (주)아모레퍼시픽 | 병풀 추출물 또는 이로부터 유래한 트리테르펜을 고함량으로 포함하는 화장료 조성물 및 이의 제조 방법 |
| CA3081436A1 (en) | 2017-10-31 | 2019-05-09 | Western Oncolytics Ltd. | Platform oncolytic vector for systemic delivery |
| AU2019205091B2 (en) | 2018-01-04 | 2024-07-25 | Amryt Pharmaceuticals Designated Activity Company | Betulin-containing birch bark extracts and their formulation |
| CA3117842A1 (en) | 2018-10-26 | 2020-04-30 | Viramal Limited | Mucoadhesive gel composition |
| EP3659583B1 (en) | 2018-11-30 | 2023-06-07 | Viramal Limited | A method of preparing a gelling agent, the gelling agent obtained thereby, and the use of said gelling agent |
| CN109512780A (zh) * | 2019-01-09 | 2019-03-26 | 河南省医药科学研究院 | 一种凝胶药膏及其制备方法和应用 |
| GR1010072B (el) * | 2019-05-15 | 2021-09-15 | Αριστοτελειο Πανεπιστημιο Θεσσαλονικης - Ειδικος Λογαριασμος Κονδυλιων Ερευνας | Βρωσιμα κτηνιατρικα σκευασματα ενδομαστικης προστασιας θηλαστικων και μεθοδος για την παρασκευη τους |
| TW202227621A (zh) | 2020-11-19 | 2022-07-16 | 美商凱立凡爾免疫治療股份有限公司 | 重塑腫瘤微環境的溶瘤免疫療法 |
| WO2022232375A1 (en) | 2021-04-30 | 2022-11-03 | Kalivir Immunotherapeutics, Inc. | Oncolytic viruses for modified mhc expression |
| DE102024116319B3 (de) | 2024-06-11 | 2025-10-30 | Fuchs SE | Schmierfett-Zusammensetzungen enthaltend pentacyclische Triterpene als Co-Verdicker, deren Verwendung und Verfahren zu deren Herstellung |
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| LU83173A1 (fr) * | 1981-02-27 | 1981-06-05 | Oreal | Nouvelles compositions cosmetiques pour le traitement des cheveux et de la peau contenant une poudre resultant de la pulverisation d'au moins une plante et un agent de cohesion |
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2004
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