RO85814B - Procedeu pentru prepararea unor derivati de 1-(arilciclohexil)-piperidina - Google Patents

Procedeu pentru prepararea unor derivati de 1-(arilciclohexil)-piperidina

Info

Publication number
RO85814B
RO85814B RO110666A RO11066681A RO85814B RO 85814 B RO85814 B RO 85814B RO 110666 A RO110666 A RO 110666A RO 11066681 A RO11066681 A RO 11066681A RO 85814 B RO85814 B RO 85814B
Authority
RO
Romania
Prior art keywords
lower alkyl
general formula
formula
substituents
carbon atoms
Prior art date
Application number
RO110666A
Other languages
English (en)
Other versions
RO85814A (ro
Inventor
Raymond Antoine Stokbroekx
Joannes Josephus Maria Willems
Marcel Gerebernus Maria Luyckx
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/222,091 external-priority patent/US4329353A/en
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of RO85814A publication Critical patent/RO85814A/ro
Publication of RO85814B publication Critical patent/RO85814B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor derivati de 1-(acrilciclohexil)-piperidina, cu formula generala I: (vezi formula) în care substituentul R reprezinta alchil inferior cu 1...4 atomi de carbon, cianalchil inferior cu 1...4 atomi de carbon, metilalcoxiinferior, fenilcarbonil sau un radical cu formula: -CnH2n(Q)-CO-(Y)m-R1 în care n reprezinta 0 sau un numar întreg cuprins între 1 si 4 inclusiv, p este 0 sau 1, m este 0 sa 1, Q reprezinta gruparea -NH, Y reprezinta oxigen sau NH si R1 reprezinta hidrogen alchil inferior sau dialchil inferior, substituentii Ar1 si Ar2 pot fi identici sau diferiti si reprezinta fenil sau fenil substituit cu haligen, constînd din aceea ca un derivat de piperidina cu formula generala II: (vezi formula) în care substituentii Ar1 si Ar2 au semnificatiile de mai sus, se N-alchileaza, prin tratare cu un compus cu formula generala R -W în care R are semnificatiile de mai sus, iar W este un radical reactiv, ales dintre clor, brom, iod, metilsulfoniloxi sau metilfenilsulfoniloxi, reactia avînd loc la o temperatura cuprinsa între temperatura camerei si temperatura de reflux, într-un solvent, ales dintre dimetilsulfoxid, dimetilformamida si 4-metil-2-pentatona si în prezenta unui hidroxid sau carbonat de metal alcalin ca acceptor de acid, dupa care compusii cu formula I pot fi, eventual, transformati, prin metode în sine cunoscute, în saruri de aditie acceptabile farmaceutic.
RO110666A 1980-03-10 1981-03-09 Procedeu pentru prepararea unor derivati de 1-(arilciclohexil)-piperidina RO85814B (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12870580A 1980-03-10 1980-03-10
US19914280A 1980-10-22 1980-10-22
US06/222,091 US4329353A (en) 1980-10-22 1981-01-09 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof

Publications (2)

Publication Number Publication Date
RO85814A RO85814A (ro) 1984-11-25
RO85814B true RO85814B (ro) 1984-11-30

Family

ID=27383775

Family Applications (2)

Application Number Title Priority Date Filing Date
RO81103622A RO81938A (ro) 1980-03-10 1981-03-09 Procedeu pentru prepararea unor derivati de 1-(arilciclohexil)-piperidina
RO110666A RO85814B (ro) 1980-03-10 1981-03-09 Procedeu pentru prepararea unor derivati de 1-(arilciclohexil)-piperidina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RO81103622A RO81938A (ro) 1980-03-10 1981-03-09 Procedeu pentru prepararea unor derivati de 1-(arilciclohexil)-piperidina

Country Status (20)

Country Link
EP (1) EP0035902B1 (ro)
KR (1) KR850000026B1 (ro)
AU (1) AU538147B2 (ro)
BG (1) BG35898A3 (ro)
CA (1) CA1161438A (ro)
DE (1) DE3166892D1 (ro)
DK (1) DK107181A (ro)
ES (1) ES500251A0 (ro)
FI (1) FI73428C (ro)
GR (1) GR73633B (ro)
HU (1) HU187362B (ro)
IE (1) IE51080B1 (ro)
IL (1) IL62320A (ro)
NO (1) NO159793C (ro)
NZ (1) NZ196441A (ro)
PH (1) PH16661A (ro)
PL (1) PL130480B1 (ro)
PT (1) PT72641B (ro)
RO (2) RO81938A (ro)
YU (1) YU42236B (ro)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK139684A (da) * 1983-04-11 1984-10-12 Janssen Pharmaceutica Nv N-aryl-alpha-amino-carboxamider
US4975445A (en) * 1989-12-06 1990-12-04 Warner-Lambert Company Substituted cyclohexenes as central nervous system agents
US5047406A (en) * 1989-12-06 1991-09-10 Warner-Lambert Co. Substituted cyclohexanols as central nervous system agents
ZA929008B (en) * 1991-12-13 1993-05-21 Bristol Myers Squibb Co Piperazinyl- and piperidinyl-cyclohexanols.
CA2091204C (en) * 1992-03-11 1997-04-08 Ronald J. Mattson Antiischemic-piperazinyl and piperidinyl-cyclohexanes
CN1047594C (zh) * 1993-01-02 1999-12-22 布里斯托尔-迈尔斯斯奎布公司 哌嗪基或哌啶基环己醇、其制法和用途
ES2170446T3 (es) * 1997-12-05 2002-08-01 Hoffmann La Roche Derivados de 1,3,8-triaza-espiro(4,5)decan-4-ona.
SI0921125T1 (en) * 1997-12-05 2002-04-30 F. Hoffmann-La Roche Ag 1,3,8-Triazaspiro(4,5)decan-4-on derivatives
WO1999032489A1 (en) * 1997-12-23 1999-07-01 Alcon Laboratories, Inc. Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
AU2206499A (en) * 1997-12-23 1999-07-12 Alcon Laboratories, Inc. Muscarinic agents and use thereof to treat glaucoma, myopia, and various other conditions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3712897A (en) * 1970-06-10 1973-01-23 Lepetit Spa Triazaspirodecanedithiones
CH572460A5 (ro) * 1972-07-28 1976-02-13 Ciba Geigy Ag
US4048058A (en) * 1975-08-13 1977-09-13 Standard Oil Company (Indiana) Methods to be used in reforming processes employing multi-metallic catalysts
US4051248A (en) * 1975-07-14 1977-09-27 E. R. Squibb & Sons, Inc. 1,3,8-triazaspiro(4.5)decan-4-one derivatives
US4076821A (en) * 1976-02-27 1978-02-28 Yoshitomi Pharmaceutical Industries, Ltd. 4,4-Diphenylcycloalkylpiperidines and psychotropic compositions thereof

Also Published As

Publication number Publication date
ES8300743A1 (es) 1982-11-01
CA1161438A (en) 1984-01-31
FI73428C (fi) 1987-10-09
YU42236B (en) 1988-06-30
EP0035902B1 (en) 1984-10-31
NO159793C (no) 1989-02-08
PT72641B (en) 1982-11-15
EP0035902A1 (en) 1981-09-16
IE810506L (en) 1981-09-10
KR830005200A (ko) 1983-08-03
AU6809281A (en) 1981-09-17
RO81938B (ro) 1983-05-30
GR73633B (ro) 1984-03-26
IL62320A0 (en) 1981-05-20
FI73428B (fi) 1987-06-30
ES500251A0 (es) 1982-11-01
NO810793L (no) 1981-09-11
BG35898A3 (en) 1984-07-16
FI810727L (fi) 1981-09-11
KR850000026B1 (ko) 1985-02-11
PH16661A (en) 1983-12-13
AU538147B2 (en) 1984-08-02
IL62320A (en) 1984-06-29
PT72641A (en) 1981-04-01
PL230073A1 (en) 1983-04-11
DE3166892D1 (de) 1984-12-06
NO159793B (no) 1988-10-31
RO81938A (ro) 1983-06-01
DK107181A (da) 1981-09-11
YU62081A (en) 1983-12-31
IE51080B1 (en) 1986-10-01
RO85814A (ro) 1984-11-25
PL130480B1 (en) 1984-08-31
HU187362B (en) 1985-12-28
NZ196441A (en) 1984-07-06

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