RO81174B - PROCEDEU DE PREPARARE A COMPLEXULUI FORMAT îNTRE BETA-DIETILAMINOETILAMIDA ACIDULUI P-CLORFENOXIACETIC CU 4-N-BUTIL-3, 5-DICETI-1, 2-DIFENOLPIREZOLIDINA - Google Patents

PROCEDEU DE PREPARARE A COMPLEXULUI FORMAT îNTRE BETA-DIETILAMINOETILAMIDA ACIDULUI P-CLORFENOXIACETIC CU 4-N-BUTIL-3, 5-DICETI-1, 2-DIFENOLPIREZOLIDINA

Info

Publication number
RO81174B
RO81174B RO102656A RO10265680A RO81174B RO 81174 B RO81174 B RO 81174B RO 102656 A RO102656 A RO 102656A RO 10265680 A RO10265680 A RO 10265680A RO 81174 B RO81174 B RO 81174B
Authority
RO
Romania
Prior art keywords
beta
complex formed
butyl
diphenylpyrezolidine
diceti
Prior art date
Application number
RO102656A
Other languages
English (en)
Other versions
RO81174A (ro
Inventor
Jan Bogusz
Lucina Lemiesz
Jerzy Luszczewski
Jerzy Pzcholczyk
Original Assignee
Lodzkic Zaklandy Fermacontyczne "Polfa"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lodzkic Zaklandy Fermacontyczne "Polfa" filed Critical Lodzkic Zaklandy Fermacontyczne "Polfa"
Publication of RO81174A publication Critical patent/RO81174A/ro
Publication of RO81174B publication Critical patent/RO81174B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/28—Two oxygen or sulfur atoms
    • C07D231/30—Two oxygen or sulfur atoms attached in positions 3 and 5
    • C07D231/32—Oxygen atoms
    • C07D231/34—Oxygen atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unui complex format între beta-dietilamino acetic cu 4-n-butil-3,5-diceto-1,2-difenil-pirazolidina cu formula:(vezi form. in desc.)Procedeul consta în aceea ca acidul p-clorfenoxiacetic se trateaza cu beta-dietilamino-etilamina în prezenta 4-n-butil-3,5-diceto-1,2-difenilpirazolidinei, folosind cantitîti stoichiometrice sau un exces nesemnificativ de beta-dietilaminoetilamina, în mediu de toluen sau xilen la temperatura de 107....148 degree C, dupa care complexul format este izolat si purificat prin tratare la 60 degree C cu o solutie apoasa 80% acetona în apa dupa racire cristalizînd complexul format cu 2 mol apa.
RO102656A 1979-11-26 1980-11-21 PROCEDEU DE PREPARARE A COMPLEXULUI FORMAT îNTRE BETA-DIETILAMINOETILAMIDA ACIDULUI P-CLORFENOXIACETIC CU 4-N-BUTIL-3, 5-DICETI-1, 2-DIFENOLPIREZOLIDINA RO81174B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL1979219874A PL122256B1 (en) 1979-11-26 1979-11-26 Process for preparing molecular compound of beta-diethylaminoethylamide of p-chlorophenoxyacetic acid with 4-n-butyl-3,5-diketo-1,2-diphenylpyrazolidin

Publications (2)

Publication Number Publication Date
RO81174A RO81174A (ro) 1983-04-29
RO81174B true RO81174B (ro) 1983-04-30

Family

ID=19999619

Family Applications (1)

Application Number Title Priority Date Filing Date
RO102656A RO81174B (ro) 1979-11-26 1980-11-21 PROCEDEU DE PREPARARE A COMPLEXULUI FORMAT îNTRE BETA-DIETILAMINOETILAMIDA ACIDULUI P-CLORFENOXIACETIC CU 4-N-BUTIL-3, 5-DICETI-1, 2-DIFENOLPIREZOLIDINA

Country Status (8)

Country Link
JP (1) JPS5687567A (ro)
CS (1) CS212286B2 (ro)
DD (1) DD154817A5 (ro)
GB (1) GB2064522B (ro)
HU (1) HU185287B (ro)
PL (1) PL122256B1 (ro)
RO (1) RO81174B (ro)
SU (1) SU1034605A3 (ro)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU203538B (en) * 1988-03-10 1991-08-28 Richter Gedeon Vegyeszet Process for producing 1,2-diphenyl-3,5-dioxy-4-butyl-pirazolidin-sodium-monohydrate
IT1282693B1 (it) * 1996-02-27 1998-03-31 Dompe Spa Acidi carbossilici geminali e loro esteri;preparazioni farmaceutiche che li contengono utili nel trattamento del dismetabolismo osseo
MX2019014773A (es) 2017-06-13 2020-02-07 Afecta Pharmaceuticals Inc Inhibidores de ccl2.

Also Published As

Publication number Publication date
JPS5687567A (en) 1981-07-16
PL219874A1 (ro) 1981-06-05
PL122256B1 (en) 1982-07-31
HU185287B (en) 1984-12-28
SU1034605A3 (ru) 1983-08-07
DD154817A5 (de) 1982-04-21
GB2064522A (en) 1981-06-17
RO81174A (ro) 1983-04-29
GB2064522B (en) 1983-05-11
CS212286B2 (en) 1982-03-26

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