RO80266B - Procedeu pentru prepararea unor derivati de 1-amino-2-propanol - Google Patents
Procedeu pentru prepararea unor derivati de 1-amino-2-propanolInfo
- Publication number
- RO80266B RO80266B RO102863A RO10286380A RO80266B RO 80266 B RO80266 B RO 80266B RO 102863 A RO102863 A RO 102863A RO 10286380 A RO10286380 A RO 10286380A RO 80266 B RO80266 B RO 80266B
- Authority
- RO
- Romania
- Prior art keywords
- carbon atoms
- temperature
- solvent
- amino
- amine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C07D333/80—Seven-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor derivati de 1-amino-2-propanol, izomeri cu formulele generale Ia si Ib: (vezi form. in desc.)în care R1 si R2 înseamna un atom de hidrogen, o grupa alchil lineara sau ramificata avînd de la 1 la 10 atomi de carbon cicloalchil monociclic cu 1 la 12 atomi de carbon, sau adamantil, alfa alfa-dialchilpropinil cu 1...4 atomi de carbon, fenilalchil cu 1...4 atomi de carbon sau R1 si R2 formeaza cu atomul de azot un radical pirolidino morfolino, piperidino sau piperazino, compusi cu aplicare în medicina umana si veterinara, prin condensarea oximelor corespunzatoare cu epihalohidrina într-un solvent inert ales dintre dimetilformamida metanol si etanol în prezenta de carbonat de metal alcalin ca baza la o temperatura cuprinsa între 10 degree C si punctul de fierbere al solventului, obtinîndu-se compusii cu formulele generale III-a si IIIb; care se condenseaza cu o amina într-un alcool inferior ca solvent inert în prezenta unui exces de amina la o temperatura cuprinsa între 10 degree C si temperatura de fierbere a solventului.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7931402A FR2471980A1 (fr) | 1979-12-21 | 1979-12-21 | Nouveaux derives de l'amino-1 propanol-2, leur procede de preparation et leur application therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO80266A RO80266A (ro) | 1983-04-29 |
| RO80266B true RO80266B (ro) | 1983-04-30 |
Family
ID=9233060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO102863A RO80266B (ro) | 1979-12-21 | 1980-12-16 | Procedeu pentru prepararea unor derivati de 1-amino-2-propanol |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4339450A (ro) |
| EP (1) | EP0031266B1 (ro) |
| JP (1) | JPS5699472A (ro) |
| AR (1) | AR225937A1 (ro) |
| AU (1) | AU541684B2 (ro) |
| BE (1) | BE886471A (ro) |
| BG (1) | BG35047A3 (ro) |
| CA (1) | CA1158643A (ro) |
| CH (1) | CH646165A5 (ro) |
| CS (1) | CS228143B2 (ro) |
| DE (1) | DE3061928D1 (ro) |
| DK (1) | DK536180A (ro) |
| ES (1) | ES8200886A1 (ro) |
| FR (1) | FR2471980A1 (ro) |
| GB (1) | GB2066808B (ro) |
| GR (1) | GR72831B (ro) |
| HU (1) | HU181774B (ro) |
| IE (1) | IE50546B1 (ro) |
| IL (1) | IL61602A (ro) |
| IN (1) | IN150867B (ro) |
| IT (1) | IT1141642B (ro) |
| LU (1) | LU83021A1 (ro) |
| NZ (1) | NZ195786A (ro) |
| PL (1) | PL127009B1 (ro) |
| PT (1) | PT72247B (ro) |
| RO (1) | RO80266B (ro) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3704604A1 (de) * | 1987-02-13 | 1988-08-25 | Mack Chem Pharm | Oximether von 2,6-dioxabicyclo(3.3.0)octanonen, herstellungsverfahren und anwendung als arzneimittel |
| US4803286A (en) * | 1987-08-19 | 1989-02-07 | Merck & Co., Inc. | Amino-2-hydroxypropyloximinoheterocycle α-blockers |
| EP0347378A1 (de) * | 1988-06-13 | 1989-12-20 | Ciba-Geigy Ag | Imidazol-Derivate |
| IL103106A (en) * | 1991-09-25 | 1998-06-15 | Sanofi Elf | Sites of tynocyclopentanone oximes, their preparation and pharmaceutical preparations containing them |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3398161A (en) * | 1965-06-30 | 1968-08-20 | Ici Ltd | Benzo (b) thiophen derivatives which have beta-adrenergic blocking activity |
| NL6810133A (ro) * | 1968-07-18 | 1970-01-20 |
-
1979
- 1979-12-21 FR FR7931402A patent/FR2471980A1/fr active Granted
-
1980
- 1980-11-15 GR GR63372A patent/GR72831B/el unknown
- 1980-11-18 GB GB8036920A patent/GB2066808B/en not_active Expired
- 1980-12-01 IL IL8061602A patent/IL61602A/xx unknown
- 1980-12-01 DE DE8080401713T patent/DE3061928D1/de not_active Expired
- 1980-12-01 EP EP80401713A patent/EP0031266B1/fr not_active Expired
- 1980-12-02 CH CH893680A patent/CH646165A5/fr not_active IP Right Cessation
- 1980-12-03 BE BE0/203024A patent/BE886471A/fr not_active IP Right Cessation
- 1980-12-04 IE IE2535/80A patent/IE50546B1/en unknown
- 1980-12-09 NZ NZ195786A patent/NZ195786A/xx unknown
- 1980-12-10 ES ES497563A patent/ES8200886A1/es not_active Expired
- 1980-12-12 BG BG049969A patent/BG35047A3/xx unknown
- 1980-12-16 RO RO102863A patent/RO80266B/ro unknown
- 1980-12-17 DK DK536180A patent/DK536180A/da not_active Application Discontinuation
- 1980-12-17 AR AR283678A patent/AR225937A1/es active
- 1980-12-18 CA CA000367082A patent/CA1158643A/en not_active Expired
- 1980-12-18 IT IT68942/80A patent/IT1141642B/it active
- 1980-12-19 HU HU803060A patent/HU181774B/hu unknown
- 1980-12-19 PL PL1980228606A patent/PL127009B1/pl unknown
- 1980-12-19 CS CS809065A patent/CS228143B2/cs unknown
- 1980-12-19 PT PT72247A patent/PT72247B/pt unknown
- 1980-12-19 AU AU65587/80A patent/AU541684B2/en not_active Ceased
- 1980-12-19 LU LU83021A patent/LU83021A1/fr unknown
- 1980-12-22 US US06/219,213 patent/US4339450A/en not_active Expired - Fee Related
- 1980-12-22 JP JP18180280A patent/JPS5699472A/ja active Pending
-
1981
- 1981-01-17 IN IN54/CAL/81A patent/IN150867B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IT8068942A0 (it) | 1980-12-18 |
| CH646165A5 (fr) | 1984-11-15 |
| DE3061928D1 (en) | 1983-03-17 |
| EP0031266A1 (fr) | 1981-07-01 |
| CA1158643A (en) | 1983-12-13 |
| IE50546B1 (en) | 1986-05-14 |
| GR72831B (ro) | 1983-12-06 |
| GB2066808B (en) | 1983-07-06 |
| HU181774B (en) | 1983-11-28 |
| GB2066808A (en) | 1981-07-15 |
| ES497563A0 (es) | 1981-11-16 |
| EP0031266B1 (fr) | 1983-02-09 |
| BG35047A3 (en) | 1984-01-16 |
| IE802535L (en) | 1981-06-21 |
| AR225937A1 (es) | 1982-05-14 |
| ES8200886A1 (es) | 1981-11-16 |
| IN150867B (ro) | 1983-01-01 |
| IL61602A (en) | 1984-05-31 |
| PL228606A1 (ro) | 1981-08-21 |
| JPS5699472A (en) | 1981-08-10 |
| RO80266A (ro) | 1983-04-29 |
| CS228143B2 (en) | 1984-05-14 |
| NZ195786A (en) | 1982-09-14 |
| LU83021A1 (fr) | 1981-03-27 |
| FR2471980A1 (fr) | 1981-06-26 |
| AU541684B2 (en) | 1985-01-17 |
| PT72247B (fr) | 1981-11-05 |
| US4339450A (en) | 1982-07-13 |
| PT72247A (fr) | 1981-01-01 |
| DK536180A (da) | 1981-06-22 |
| IT1141642B (it) | 1986-10-01 |
| IL61602A0 (en) | 1981-09-13 |
| FR2471980B1 (ro) | 1982-07-30 |
| BE886471A (fr) | 1981-04-01 |
| AU6558780A (en) | 1981-06-25 |
| PL127009B1 (en) | 1983-09-30 |
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