GB1122756A - Amino-substituted naphthalene derivatives - Google Patents
Amino-substituted naphthalene derivativesInfo
- Publication number
- GB1122756A GB1122756A GB3404567A GB3404567A GB1122756A GB 1122756 A GB1122756 A GB 1122756A GB 3404567 A GB3404567 A GB 3404567A GB 3404567 A GB3404567 A GB 3404567A GB 1122756 A GB1122756 A GB 1122756A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- formula
- substituted
- tertiary amino
- amino group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N39/00—Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or, e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises amino-substituted naphthalene derivatives of the general formula <FORM:1122756/C2/1> in which R1 and R2, which may be the same or different, are hydrogen, halogen, nitro, alkyl, alkoxy or trifluoromethyl; X is a straight- or branched-chain alkylene or alkenylene radical which may be substituted by an oxo or hydroxyl group; and -A-Y is a straight- or branched-chain alkyl radical substituted by a tertiary amino group; and the acid addition salts and quaternary ammonium compounds thereof. The tertiary amino group (Y) may be, for example, an alkylated amino group or the radical of a nitrogen-containing heterocyclic compound such as a pyrrolidino, piperidino, morpholino, piperazino, or imidazolino radical. The new compounds may be prepared by (a) reacting a naphthol derivative of the formula <FORM:1122756/C2/2> with a compound of formula U-A-Z in which U is a hydroxyl group or a hydroxyl group esterified with a hydrogen halide or an organic sulphonic acid, and Z is a tertiary amino group or a group which can be converted into a tertiary amino group; and converting the group Z if necessary to a tertiary amino group; (b) by condensing an amino-alkoxy naphthalene of the formula <FORM:1122756/C2/3> with a compound of the formula <FORM:1122756/C2/4> if the group X contains an oxo group it may be reduced to a hydroxyl group, dehydrated to give an alkenylene group and reduced to give an alkylene group, if desired; (c) by reacting the naphthol derivative of method (a) with compounds of formula U-A-U or the corresponding alkylene oxides to get intermediates of formula <FORM:1122756/C2/5> which can be converted to the required compounds by reaction with a base HY. The basic compounds obtained may be reacted with inorganic or organic acids to give acid addition salts or with quaternizing agents to give quaternary ammonium compounds.ALSO:Amino-substituted naphthalene derivatives of the general formula <FORM:1122756/A5-A6/1> in which R1 and R2, which may be the same or different, are hydrogen, halogen, nitro, alkyl, alkoxy or trifluoromethyl; X is a straight- or branched-chain alkylene or alkenylene radical which may be substituted by an oxo or hydroxyl group; and -A-y is a straight- or branched-chain alkyl radical substituted by a tertiary amino group and their acid addition salts and quaternary ammonium compounds may be used as fungicides and for bactericides.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEB0088200 | 1966-07-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1122756A true GB1122756A (en) | 1968-08-07 |
Family
ID=6984173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3404567A Expired GB1122756A (en) | 1966-07-27 | 1967-07-25 | Amino-substituted naphthalene derivatives |
Country Status (5)
| Country | Link |
|---|---|
| AT (2) | AT274797B (en) |
| CH (1) | CH502303A (en) |
| FR (1) | FR1550139A (en) |
| GB (1) | GB1122756A (en) |
| NL (2) | NL6710300A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2387213A2 (en) * | 1977-04-12 | 1978-11-10 | Nattermann A & Cie | Smooth-muscle relaxant quat. ammonium salts - derived from aminoalkoxy-di:phenyl-propiolophenone derivs. |
| WO2004043458A1 (en) * | 2002-11-12 | 2004-05-27 | Abbott Laboratories | Bicyclic-substituted amines as histamine-3 receptor ligands |
| WO2005007631A1 (en) * | 2003-07-10 | 2005-01-27 | Osi Pharmaceuticals, Inc. | Naphthylene derivatives as cytochrome p450 inhibitors |
| US7098222B2 (en) | 2004-05-12 | 2006-08-29 | Abbott Laboratories | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| US7145005B2 (en) | 2004-05-12 | 2006-12-05 | Abbott Laboratories | 2-(6-{2-[(2R)-2-Methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one salts and their preparation |
| US7153889B2 (en) | 2002-11-12 | 2006-12-26 | Abbott Laboratories | Bicyclic-substituted amines as histamine-3 receptor ligands |
| US7205316B2 (en) | 2004-05-12 | 2007-04-17 | Abbott Laboratories | Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands |
| US7662844B2 (en) | 2004-07-12 | 2010-02-16 | Osi Pharmaceuticals, Inc. | Naphthylene derivatives as cytochrome P450 inhibitors |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4536503A (en) * | 1981-12-14 | 1985-08-20 | Syntex (U.S.A.) Inc. | Naphthoxyalkylamines and related compounds as antiinflammatory agents |
-
0
- NL NL131915D patent/NL131915C/xx active
-
1967
- 1967-07-25 GB GB3404567A patent/GB1122756A/en not_active Expired
- 1967-07-25 CH CH1053167A patent/CH502303A/en not_active IP Right Cessation
- 1967-07-26 AT AT1007468A patent/AT274797B/en active
- 1967-07-26 NL NL6710300A patent/NL6710300A/xx unknown
- 1967-07-26 AT AT696167A patent/AT275507B/en active
- 1967-07-27 FR FR1550139D patent/FR1550139A/fr not_active Expired
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2387213A2 (en) * | 1977-04-12 | 1978-11-10 | Nattermann A & Cie | Smooth-muscle relaxant quat. ammonium salts - derived from aminoalkoxy-di:phenyl-propiolophenone derivs. |
| WO2004043458A1 (en) * | 2002-11-12 | 2004-05-27 | Abbott Laboratories | Bicyclic-substituted amines as histamine-3 receptor ligands |
| US7153889B2 (en) | 2002-11-12 | 2006-12-26 | Abbott Laboratories | Bicyclic-substituted amines as histamine-3 receptor ligands |
| US7456196B2 (en) | 2002-11-12 | 2008-11-25 | Abbott Laboratories | Bicyclic-substituted amines as histamine-3 receptor ligands |
| US7947711B2 (en) | 2002-11-12 | 2011-05-24 | Abbott Laboratories | Bicyclic-substituted amines as histamine-3 receptor ligands |
| US8273767B2 (en) | 2002-11-12 | 2012-09-25 | Abbott Laboratories | Bicyclic-substituted amines as histamine-3 receptor ligands |
| WO2005007631A1 (en) * | 2003-07-10 | 2005-01-27 | Osi Pharmaceuticals, Inc. | Naphthylene derivatives as cytochrome p450 inhibitors |
| US7098222B2 (en) | 2004-05-12 | 2006-08-29 | Abbott Laboratories | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| US7145005B2 (en) | 2004-05-12 | 2006-12-05 | Abbott Laboratories | 2-(6-{2-[(2R)-2-Methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one salts and their preparation |
| US7205316B2 (en) | 2004-05-12 | 2007-04-17 | Abbott Laboratories | Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands |
| US7662844B2 (en) | 2004-07-12 | 2010-02-16 | Osi Pharmaceuticals, Inc. | Naphthylene derivatives as cytochrome P450 inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| NL6710300A (en) | 1968-01-29 |
| NL131915C (en) | |
| AT274797B (en) | 1969-09-25 |
| FR1550139A (en) | 1968-12-20 |
| CH502303A (en) | 1971-01-31 |
| AT275507B (en) | 1969-10-27 |
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