GB863552A - 3-mercapto-phenthiazine derivatives and salts thereof - Google Patents
3-mercapto-phenthiazine derivatives and salts thereofInfo
- Publication number
- GB863552A GB863552A GB22979/60A GB2297960A GB863552A GB 863552 A GB863552 A GB 863552A GB 22979/60 A GB22979/60 A GB 22979/60A GB 2297960 A GB2297960 A GB 2297960A GB 863552 A GB863552 A GB 863552A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- acid addition
- group
- specifications
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
The invention comprises compounds of the general formula: <FORM:0863552/IV (b)/1> and their acid addition salts, wherein R1 is a methyl group, R2 is a hydrogen atom or an alkyl group (C1-4) and R3 + R4 is a trimethylene or tetramethylene group, thus forming a 5 or 6 membered ring with the carbon and the nitrogen atoms adjacent R4 and R3 respectively, and the preparation thereof by condensing a phenthiazine of the general formula: <FORM:0863552/IV (b)/2> with a haloalkyl amine of the general formula: <FORM:0863552/IV (b)/3> wherein X is a chlorine or bromine atom, if desired in the presence of an alkaline condensation agent and a solvent, and further if desired converting the base into an acid addition salt. 2-(N-Methyl-pyrrodidyl-21)-1- chlorolthaneis prepared from the corresponding ethanol by reaction with thionyl chloride. Specifications 802,726 and 863,547 also are referred to.ALSO:Pharmaceutical compositions comprise an inert diluent and compounds of the general formula <FORM:0863552/VI/1> or an acid addition salt thereof, wherein R1 is a methyl group, R2 is a hydrogen atom or a C1-4 alkyl group and R3 and R4 is a tri- or a tetramethylene group, thus forming a 5- or 6-membered ring with the carbon and the nitrogen atoms adjacent to R4 and R3, respectively. Compositions include tablets and solutions for both parenteral and local use. Acid addition salts include the hydrochlorides, hydrobromides, sulphates, citrates, tartrates, succinates, maleates, acetates, benzoates and hexahydrobenzoates. Specifications 802,726 and 863,547 also are referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH863552X | 1956-04-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB863552A true GB863552A (en) | 1961-03-22 |
Family
ID=4543391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB22979/60A Expired GB863552A (en) | 1956-04-19 | 1957-04-04 | 3-mercapto-phenthiazine derivatives and salts thereof |
Country Status (3)
Country | Link |
---|---|
CY (1) | CY276A (en) |
GB (1) | GB863552A (en) |
MY (1) | MY6600139A (en) |
-
1957
- 1957-04-04 GB GB22979/60A patent/GB863552A/en not_active Expired
-
1964
- 1964-02-12 CY CY27664A patent/CY276A/en unknown
-
1966
- 1966-12-31 MY MY1966139A patent/MY6600139A/en unknown
Also Published As
Publication number | Publication date |
---|---|
MY6600139A (en) | 1966-12-31 |
CY276A (en) | 1964-02-12 |
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