GB863552A - 3-mercapto-phenthiazine derivatives and salts thereof - Google Patents

3-mercapto-phenthiazine derivatives and salts thereof

Info

Publication number
GB863552A
GB863552A GB22979/60A GB2297960A GB863552A GB 863552 A GB863552 A GB 863552A GB 22979/60 A GB22979/60 A GB 22979/60A GB 2297960 A GB2297960 A GB 2297960A GB 863552 A GB863552 A GB 863552A
Authority
GB
United Kingdom
Prior art keywords
general formula
acid addition
group
specifications
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB22979/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB863552A publication Critical patent/GB863552A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention comprises compounds of the general formula: <FORM:0863552/IV (b)/1> and their acid addition salts, wherein R1 is a methyl group, R2 is a hydrogen atom or an alkyl group (C1-4) and R3 + R4 is a trimethylene or tetramethylene group, thus forming a 5 or 6 membered ring with the carbon and the nitrogen atoms adjacent R4 and R3 respectively, and the preparation thereof by condensing a phenthiazine of the general formula: <FORM:0863552/IV (b)/2> with a haloalkyl amine of the general formula: <FORM:0863552/IV (b)/3> wherein X is a chlorine or bromine atom, if desired in the presence of an alkaline condensation agent and a solvent, and further if desired converting the base into an acid addition salt. 2-(N-Methyl-pyrrodidyl-21)-1- chlorolthaneis prepared from the corresponding ethanol by reaction with thionyl chloride. Specifications 802,726 and 863,547 also are referred to.ALSO:Pharmaceutical compositions comprise an inert diluent and compounds of the general formula <FORM:0863552/VI/1> or an acid addition salt thereof, wherein R1 is a methyl group, R2 is a hydrogen atom or a C1-4 alkyl group and R3 and R4 is a tri- or a tetramethylene group, thus forming a 5- or 6-membered ring with the carbon and the nitrogen atoms adjacent to R4 and R3, respectively. Compositions include tablets and solutions for both parenteral and local use. Acid addition salts include the hydrochlorides, hydrobromides, sulphates, citrates, tartrates, succinates, maleates, acetates, benzoates and hexahydrobenzoates. Specifications 802,726 and 863,547 also are referred to.
GB22979/60A 1956-04-19 1957-04-04 3-mercapto-phenthiazine derivatives and salts thereof Expired GB863552A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH863552X 1956-04-19

Publications (1)

Publication Number Publication Date
GB863552A true GB863552A (en) 1961-03-22

Family

ID=4543391

Family Applications (1)

Application Number Title Priority Date Filing Date
GB22979/60A Expired GB863552A (en) 1956-04-19 1957-04-04 3-mercapto-phenthiazine derivatives and salts thereof

Country Status (3)

Country Link
CY (1) CY276A (en)
GB (1) GB863552A (en)
MY (1) MY6600139A (en)

Also Published As

Publication number Publication date
MY6600139A (en) 1966-12-31
CY276A (en) 1964-02-12

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