RO72900A - Procede pour la preparation des cis-4a-phenyloctahydro-1h-2-pyrindines - Google Patents

Procede pour la preparation des cis-4a-phenyloctahydro-1h-2-pyrindines

Info

Publication number
RO72900A
RO72900A RO7792007A RO9200777A RO72900A RO 72900 A RO72900 A RO 72900A RO 7792007 A RO7792007 A RO 7792007A RO 9200777 A RO9200777 A RO 9200777A RO 72900 A RO72900 A RO 72900A
Authority
RO
Romania
Prior art keywords
pyrindines
phenyloctahydro
cis
preparation
Prior art date
Application number
RO7792007A
Other languages
English (en)
Romanian (ro)
Inventor
Dennis M Zimmerman
Original Assignee
Eli Lilly And Co,Us
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co,Us filed Critical Eli Lilly And Co,Us
Publication of RO72900A publication Critical patent/RO72900A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757—Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
RO7792007A 1976-11-02 1977-11-02 Procede pour la preparation des cis-4a-phenyloctahydro-1h-2-pyrindines RO72900A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73795876A 1976-11-02 1976-11-02

Publications (1)

Publication Number Publication Date
RO72900A true RO72900A (fr) 1981-11-04

Family

ID=24965981

Family Applications (3)

Application Number Title Priority Date Filing Date
RO7799435A RO77935A (fr) 1976-11-02 1977-11-02 Procede pour la preparation des cis-4a-arylo tahydro-1h-2-pyrinidine s
RO7799434A RO78300A (fr) 1976-11-02 1977-11-02 Procede pour la preparation des cis-4a-aryloctahydro-1h-2-pyrimidines
RO7792007A RO72900A (fr) 1976-11-02 1977-11-02 Procede pour la preparation des cis-4a-phenyloctahydro-1h-2-pyrindines

Family Applications Before (2)

Application Number Title Priority Date Filing Date
RO7799435A RO77935A (fr) 1976-11-02 1977-11-02 Procede pour la preparation des cis-4a-arylo tahydro-1h-2-pyrinidine s
RO7799434A RO78300A (fr) 1976-11-02 1977-11-02 Procede pour la preparation des cis-4a-aryloctahydro-1h-2-pyrimidines

Country Status (26)

Country Link
JP (1) JPS5356669A (fr)
AR (1) AR223454A1 (fr)
AT (1) ATA782177A (fr)
AU (1) AU513679B2 (fr)
BE (1) BE860314A (fr)
CA (1) CA1100136A (fr)
CS (1) CS211380B2 (fr)
DD (1) DD133795A5 (fr)
DE (1) DE2748466A1 (fr)
DK (1) DK485277A (fr)
ES (3) ES463784A1 (fr)
FR (1) FR2369267A1 (fr)
GB (1) GB1590155A (fr)
GR (1) GR70053B (fr)
HU (1) HU176231B (fr)
IE (1) IE45901B1 (fr)
IL (1) IL53236A0 (fr)
NL (1) NL7712053A (fr)
NZ (1) NZ185539A (fr)
PH (1) PH12590A (fr)
PL (3) PL108466B1 (fr)
PT (1) PT67194B (fr)
RO (3) RO77935A (fr)
SE (3) SE7712218L (fr)
SU (3) SU812174A3 (fr)
ZA (1) ZA776497B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ189230A (en) * 1977-12-27 1981-05-15 Lilly Co Eli Trans-4a-aryl-2-substituted-octahydro-1h-2-pyrindines
US4277608A (en) * 1979-06-21 1981-07-07 Eli Lilly And Company Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines
US4236009A (en) * 1979-06-21 1980-11-25 Eli Lilly And Company Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
ZA9510829B (en) * 1994-12-23 1996-07-03 Smithkline Beecham Corp 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds
CA2812526A1 (fr) 2010-05-06 2011-11-10 Vertex Pharmaceuticals Incorporated Amides de chromene heterocyclique-piperidine spirocyclique utiles comme modulateurs des canaux ioniques
BR112013019211A2 (pt) 2011-02-02 2021-07-06 Vertex Pharma amidas de piperidina espirocíclicas de pirrolopirazina como moduladores de canais de íon
CN103443105A (zh) 2011-02-18 2013-12-11 沃泰克斯药物股份有限公司 作为离子通道调节剂的苯并二氢吡喃-螺环哌啶酰胺
US8828996B2 (en) 2011-03-14 2014-09-09 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels

Also Published As

Publication number Publication date
JPS5356669A (en) 1978-05-23
SU845777A3 (ru) 1981-07-07
AU3023577A (en) 1979-05-10
PL108466B1 (en) 1980-04-30
SU812174A3 (ru) 1981-03-07
PL201885A1 (pl) 1978-12-04
AR223454A1 (es) 1981-08-31
PT67194A (en) 1977-11-01
DD133795A5 (de) 1979-01-24
ES472276A1 (es) 1979-10-01
HU176231B (en) 1981-01-28
FR2369267B1 (fr) 1980-05-16
BE860314A (fr) 1978-04-28
RO78300A (fr) 1982-04-12
NZ185539A (en) 1979-12-11
AU513679B2 (en) 1980-12-18
CA1100136A (fr) 1981-04-28
ES463784A1 (es) 1978-06-16
ES463783A1 (es) 1979-07-16
RO77935A (fr) 1981-12-25
DE2748466A1 (de) 1978-05-03
IE45901B1 (en) 1982-12-29
GR70053B (fr) 1982-07-26
ATA782177A (de) 1981-10-15
CS211380B2 (en) 1982-02-26
DK485277A (da) 1978-05-03
PL109690B1 (en) 1980-06-30
PH12590A (en) 1979-06-27
SE7712218L (sv) 1978-05-03
IE45901L (en) 1978-05-02
PT67194B (en) 1979-03-23
NL7712053A (nl) 1978-05-05
FR2369267A1 (fr) 1978-05-26
ZA776497B (en) 1979-06-27
SE8103107L (sv) 1981-05-18
GB1590155A (en) 1981-05-28
IL53236A0 (en) 1977-12-30
PL108610B1 (en) 1980-04-30
SU913941A3 (en) 1982-03-15
SE8103106L (sv) 1981-05-18

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