PY2018652A - Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb) - Google Patents

Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb)

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Publication number
PY2018652A
PY2018652A PY202002018652A PY2018652A PY2018652A PY 2018652 A PY2018652 A PY 2018652A PY 202002018652 A PY202002018652 A PY 202002018652A PY 2018652 A PY2018652 A PY 2018652A PY 2018652 A PY2018652 A PY 2018652A
Authority
PY
Paraguay
Prior art keywords
hbv
virus
piperazines
oxalyl
new
Prior art date
Application number
PY202002018652A
Other languages
English (en)
Inventor
Alastair Donald Dr
Andreas Urban Dr
Thomas Goldner Dr
DETTA Elena
Alza Barrios Esther
Raumond Justine
Ángel Pericás Brondo Miquel
Bonsmann Susanne
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of PY2018652A publication Critical patent/PY2018652A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere generalmente a nuevos agentes antivirales. Específicamente, la presente invención se refiere a compuestos que pueden inhibir la(s) proteína(s) codificadas por el virus de la hepatitis B (VHB) o interferir con la función del ciclo de replicación del VHB, composiciones que comprenden tales compuestos, métodos para inhibir la replicación viral del VHB, métodos para tratar o prevenir la infección por VHB, y procesos e intermedios para fabricar los compuestos.
PY202002018652A 2019-04-30 2020-05-06 Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb) PY2018652A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19172008 2019-04-30
EP19172402 2019-05-02

Publications (1)

Publication Number Publication Date
PY2018652A true PY2018652A (es) 2021-07-05

Family

ID=70456795

Family Applications (1)

Application Number Title Priority Date Filing Date
PY202002018652A PY2018652A (es) 2019-04-30 2020-05-06 Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb)

Country Status (19)

Country Link
US (1) US20220227737A1 (es)
EP (1) EP3962909B1 (es)
JP (1) JP2022533008A (es)
KR (1) KR20220003023A (es)
CN (1) CN113748111A (es)
AU (1) AU2020266258A1 (es)
BR (1) BR112021021652A2 (es)
CA (1) CA3138380A1 (es)
CL (1) CL2021002798A1 (es)
CU (1) CU20210090A7 (es)
EC (1) ECSP21080338A (es)
IL (1) IL287269A (es)
MX (1) MX2021013105A (es)
PH (1) PH12021552755A1 (es)
PY (1) PY2018652A (es)
SG (1) SG11202111493WA (es)
TW (1) TWI753418B (es)
UY (1) UY38684A (es)
WO (1) WO2020221811A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116396204B (zh) * 2023-03-29 2024-09-24 无锡科华生物科技有限公司 一种4,6,7-三氟-1h-吲哚-2-羧酸的制备方法

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Also Published As

Publication number Publication date
CU20210090A7 (es) 2022-06-06
JP2022533008A (ja) 2022-07-21
EP3962909A1 (en) 2022-03-09
ECSP21080338A (es) 2021-12-30
BR112021021652A2 (pt) 2021-12-21
EP3962909B1 (en) 2023-10-04
TW202106678A (zh) 2021-02-16
IL287269A (en) 2021-12-01
AU2020266258A2 (en) 2022-05-05
CA3138380A1 (en) 2020-11-05
PH12021552755A1 (en) 2022-07-04
AU2020266258A1 (en) 2021-12-23
UY38684A (es) 2020-11-30
CN113748111A (zh) 2021-12-03
WO2020221811A1 (en) 2020-11-05
US20220227737A1 (en) 2022-07-21
CL2021002798A1 (es) 2022-06-10
MX2021013105A (es) 2021-11-17
KR20220003023A (ko) 2022-01-07
TWI753418B (zh) 2022-01-21
SG11202111493WA (en) 2021-11-29

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