PT99212A - Processo para a preparacao de acidos hidroxialquilquinolina saturados uteis como antagonistas do leucotrieno - Google Patents
Processo para a preparacao de acidos hidroxialquilquinolina saturados uteis como antagonistas do leucotrienoInfo
- Publication number
- PT99212A PT99212A PT99212A PT9921291A PT99212A PT 99212 A PT99212 A PT 99212A PT 99212 A PT99212 A PT 99212A PT 9921291 A PT9921291 A PT 9921291A PT 99212 A PT99212 A PT 99212A
- Authority
- PT
- Portugal
- Prior art keywords
- hydroxylochlquinolin
- acids
- preparation
- used saturated
- leucotriene antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59684490A | 1990-10-12 | 1990-10-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT99212A true PT99212A (pt) | 1992-09-30 |
| PT99212B PT99212B (pt) | 1999-04-30 |
Family
ID=24388953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99212A PT99212B (pt) | 1990-10-12 | 1991-10-11 | Processo para a preparacao de acidos hidroxialquilquinolina saturados uteis como antagonistas do leucotrieno |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5428033A (pt) |
| EP (1) | EP0480716A1 (pt) |
| JP (1) | JP2538155B2 (pt) |
| KR (1) | KR920008004A (pt) |
| CN (1) | CN1061408A (pt) |
| AU (1) | AU639611B2 (pt) |
| CA (1) | CA2053216C (pt) |
| CS (1) | CS309391A3 (pt) |
| FI (1) | FI914797A (pt) |
| HU (1) | HUT61980A (pt) |
| IE (1) | IE913611A1 (pt) |
| IL (1) | IL99725A0 (pt) |
| MX (1) | MX9101557A (pt) |
| NO (1) | NO914002L (pt) |
| PT (1) | PT99212B (pt) |
| ZA (1) | ZA918120B (pt) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5856322A (en) * | 1990-10-12 | 1999-01-05 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
| US5472964A (en) * | 1992-12-22 | 1995-12-05 | Merck Frosst Canada, Inc. | Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists |
| CA2111372C (en) * | 1992-12-22 | 2007-01-16 | Robert N. Young | Diaryl 5,6-fusedheterocyclic acids as leukotriene antagonists |
| US5438141A (en) * | 1993-05-21 | 1995-08-01 | Merck Frosst Canada, Inc. | Heteroaryl and haloaryl quinoline derivatives of cyclopropaneacetic acid as leukotriene antagonists |
| ES2080656B1 (es) * | 1993-07-19 | 1996-10-16 | Merck Frosst Canada Inc | Acidos de hidroxialquilquinolina fluorados como antagonistas del leucotrieno. |
| TW416948B (en) * | 1993-12-28 | 2001-01-01 | Merck & Co Inc | Process for the preparation of leukotriene antagonists |
| US5750539A (en) * | 1995-06-07 | 1998-05-12 | Merck Frosst Canada | Heteroaryl diol acids as leukotriene antagonists |
| US6696466B1 (en) * | 2000-09-07 | 2004-02-24 | Leslie Joe Dunaway | Methods of treating select neuronal inflammatory disorders using hydroxyalkylquinolines |
| CN101596191B (zh) * | 2001-01-26 | 2011-06-15 | 中外制药株式会社 | 用作代谢调节剂的丙二酰基辅酶a脱羧酶抑制剂 |
| ES2284817T3 (es) | 2001-01-26 | 2007-11-16 | Chugai Seiyaku Kabushiki Kaisha | Procedimientos para el tratamiento de enfermedades con inhibidores de la malonil coa descarboxilasa. |
| ES2274005T3 (es) * | 2001-01-26 | 2007-05-16 | Chugai Seiyaku Kabushiki Kaisha | Inhibidores de malonyl-coa decarboxilasa usados como moduladores metabolicos. |
| BR0207408A (pt) | 2001-02-20 | 2004-02-25 | Chugai Pharmaceutical Co Ltd | Azóis como inibidores de malonil-coa decarboxilase úteis como moduladores metabólicos |
| US7709510B2 (en) * | 2001-02-20 | 2010-05-04 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
| ATE400272T1 (de) * | 2003-08-01 | 2008-07-15 | Chugai Pharmaceutical Co Ltd | Piperidin-verbindungen als malonyl-coa decarboxylase-hemmer |
| EP1658071B1 (en) * | 2003-08-01 | 2008-09-10 | Chugai Seiyaku Kabushiki Kaisha | Cyanoguanidine-based azole compounds useful as malonyl-coa decarboxylase inhibitors |
| ES2353306T3 (es) * | 2003-08-01 | 2011-03-01 | Chugai Seiyaku Kabushiki Kaisha | Compuestos heterocíclicos útiles como inhibidores de la malonil-coa-descarboxilasa. |
| JP4727579B2 (ja) * | 2003-08-01 | 2011-07-20 | 中外製薬株式会社 | マロニル−ＣｏＡデカルボキシラーゼ阻害剤として有用なシアノアミド化合物 |
| PT1678139E (pt) * | 2003-10-10 | 2011-11-28 | Synhton B V | Montelucaste em estado sólido |
| EP1708708A1 (en) * | 2004-01-30 | 2006-10-11 | Teva Pharmaceutical Industries Ltd. | Montelukast free acid polymorphs |
| WO2005075427A2 (en) * | 2004-01-30 | 2005-08-18 | Teva Pharmaceutical Industries Ltd. | Montelukast sodium polymorphs |
| MXPA06012220A (es) * | 2004-04-21 | 2007-07-18 | Teva Pharma | Procesos para preparar sodio de montelukast. |
| KR20090015186A (ko) * | 2005-07-05 | 2009-02-11 | 테바 파마슈티컬 인더스트리즈 리미티드 | 몬테루카스트의 정제 |
| AR057908A1 (es) * | 2005-11-18 | 2007-12-26 | Synthon Bv | Proceso para preparar montelukast e intermediarios del mismo |
| WO2009001374A2 (en) * | 2007-06-25 | 2008-12-31 | Aptuit Laurus Pvt Ltd | Preparation of ethyl-3'-[((7-chloro-2-quinolinyl)ethenyl)phenyl]-3-oxopropanoate, a key intermediate for montelukast sodium |
| CN102046602A (zh) * | 2008-04-25 | 2011-05-04 | 斯索恩有限公司 | 制备孟鲁司特中间体的方法 |
| WO2013051024A2 (en) * | 2011-07-26 | 2013-04-11 | Sun Pharma Advanced Research Company Ltd. | Cysteinyl leukotriene antagonists |
| JP2022516729A (ja) * | 2019-01-10 | 2022-03-02 | ジャンイン ムコケア ファーマシューティカル カンパニー，リミテッド | ロイコトリエン受容体アンタゴニストを含有する新たな製剤 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1144905A (en) | 1965-03-25 | 1969-03-12 | Fisons Pharmaceuticals Ltd | Substituted bis-(2-carboxy-chromonyl-oxy) derivatives and preparation and pharmaceutical compositions thereof |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3630200A (en) | 1969-06-09 | 1971-12-28 | Alza Corp | Ocular insert |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4325961A (en) | 1977-06-01 | 1982-04-20 | Merck & Co., Inc. | Fluorinated amino acids |
| PT68303A (en) | 1977-07-26 | 1978-08-01 | Merck & Co Inc | Process for the preparation of dibenzo/b,f/thiepin |
| SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| JPS6056143B2 (ja) | 1979-08-02 | 1985-12-09 | 山之内製薬株式会社 | アミジン誘導体ならびにその製造法 |
| PH16099A (en) | 1979-03-06 | 1983-06-24 | Yamanouchi Pharma Co Ltd | Guanidinothiazole compounds,process for preparing them and medical composition containing them |
| GB2058785B (en) | 1979-09-05 | 1983-05-25 | Glaxo Group Ltd | Phenol derivatives |
| US4237160A (en) | 1979-11-27 | 1980-12-02 | Merck Sharp & Dohme (I.A.) Corp. | 3-Hydroxymethyldibenzo[b,f]thiepins as prostaglandin antagonists |
| DE3175201D1 (en) | 1980-04-30 | 1986-10-02 | Merck & Co Inc | Aminothiadiazoles as gastric secretion inhibitors |
| US4394508A (en) | 1980-06-07 | 1983-07-19 | Bristol-Myers Company | Chemical compounds |
| EP0056172B1 (en) | 1981-01-09 | 1985-04-03 | FISONS plc | Phenoxy- and thiophenoxy compounds, methods for their preparation and pharmaceutical formulations containing them |
| DE3265715D1 (en) | 1981-03-24 | 1985-10-03 | Fisons Plc | Anti srs-a carboxylic acid derivatives, processes for their production and pharmaceutical formulations containing them |
| NZ205559A (en) | 1982-09-23 | 1987-08-31 | Merck Frosst Canada Inc | Leukotriene antagonists, pharmaceutical compositions, and intermediates |
| EP0106565B1 (en) | 1982-09-30 | 1986-09-10 | Merck Frosst Canada Inc. | Leukotriene antagonists, their production, and compositions containing them |
| NZ206795A (en) | 1983-01-21 | 1987-08-31 | Merck Frosst Canada Inc | Phenothiazines, analogues and pharmaceutical compositions |
| DE3479397D1 (en) | 1983-10-05 | 1989-09-21 | Merck Frosst Canada Inc | Benzoûa¨phenothiazines and hydro-derivatives and pharmaceutical compositions containing them |
| DE3484745D1 (de) | 1983-10-05 | 1991-08-01 | Merck Frosst Canada Inc | Inhibitoren fuer die leukotrien-biosynthese. |
| ES537162A0 (es) | 1983-10-31 | 1985-12-01 | Merck Frosst Canada Inc | Una composicion farmaceutica |
| IE861607L (en) * | 1985-06-18 | 1986-12-18 | Bunce Roger A | 2-substituted quinolines |
| US4851409A (en) * | 1986-02-14 | 1989-07-25 | Merck Frosst Canada Inc. | 2-substituted quinoline dioic acids and pharmaceutical compositions |
| IE59889B1 (en) * | 1986-02-14 | 1994-04-20 | Merck Frosst Canada Inc | 2-substituted quinoline dioic acids |
| EP0271287A3 (en) | 1986-12-11 | 1990-06-13 | Merck Frosst Canada Inc. | Quinoline dioic acids and amides |
| DE3700732A1 (de) * | 1987-01-13 | 1988-07-21 | Boehringer Mannheim Gmbh | Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| US4920132A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
| US4920131A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
| IL88433A0 (en) * | 1987-11-25 | 1989-06-30 | Merck Frosst Canada Inc | Diarylstyrylquinoline diacids and pharmaceutical compositions containing them |
| US5104882A (en) * | 1987-11-25 | 1992-04-14 | Merck Frosst Canada, Inc. | Diarylstrylquinoline diacids and pharmaceutical compositions thereof |
| NZ233752A (en) * | 1989-05-24 | 1993-05-26 | Merck Frosst Canada Inc | Substituted quinoline derivatives, preparation and pharmaceutical compositions thereof |
-
1991
- 1991-10-10 HU HU913216A patent/HUT61980A/hu unknown
- 1991-10-10 CA CA002053216A patent/CA2053216C/en not_active Expired - Fee Related
- 1991-10-10 US US07/774,396 patent/US5428033A/en not_active Expired - Fee Related
- 1991-10-10 EP EP91309305A patent/EP0480716A1/en not_active Withdrawn
- 1991-10-11 NO NO91914002A patent/NO914002L/no unknown
- 1991-10-11 MX MX9101557A patent/MX9101557A/es unknown
- 1991-10-11 CS CS913093A patent/CS309391A3/cs unknown
- 1991-10-11 AU AU85796/91A patent/AU639611B2/en not_active Ceased
- 1991-10-11 FI FI914797A patent/FI914797A/fi not_active Application Discontinuation
- 1991-10-11 PT PT99212A patent/PT99212B/pt not_active IP Right Cessation
- 1991-10-11 CN CN91110823A patent/CN1061408A/zh active Pending
- 1991-10-11 ZA ZA918120A patent/ZA918120B/xx unknown
- 1991-10-12 KR KR1019910017951A patent/KR920008004A/ko not_active Application Discontinuation
- 1991-10-13 IL IL99725A patent/IL99725A0/xx unknown
- 1991-10-14 JP JP3331111A patent/JP2538155B2/ja not_active Expired - Lifetime
- 1991-10-16 IE IE361191A patent/IE913611A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2053216C (en) | 2003-04-08 |
| HUT61980A (en) | 1993-03-29 |
| IL99725A0 (en) | 1992-08-18 |
| AU639611B2 (en) | 1993-07-29 |
| NO914002D0 (no) | 1991-10-11 |
| IE913611A1 (en) | 1992-04-22 |
| FI914797A0 (fi) | 1991-10-11 |
| CS309391A3 (en) | 1992-05-13 |
| MX9101557A (es) | 1994-05-31 |
| HU913216D0 (en) | 1992-01-28 |
| JP2538155B2 (ja) | 1996-09-25 |
| KR920008004A (ko) | 1992-05-27 |
| NO914002L (no) | 1992-04-13 |
| EP0480716A1 (en) | 1992-04-15 |
| AU8579691A (en) | 1992-04-16 |
| FI914797A (fi) | 1992-04-13 |
| ZA918120B (en) | 1992-06-24 |
| CA2053216A1 (en) | 1992-04-13 |
| JPH06206868A (ja) | 1994-07-26 |
| CN1061408A (zh) | 1992-05-27 |
| PT99212B (pt) | 1999-04-30 |
| US5428033A (en) | 1995-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19920427 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19990114 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20020731 Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20020731 |