PT97931A - Processo para a preparacao de analogos heterociclicos de antraciclinona e antracilina e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de analogos heterociclicos de antraciclinona e antracilina e de composicoes farmaceuticas que os contem Download PDF

Info

Publication number
PT97931A
PT97931A PT97931A PT9793191A PT97931A PT 97931 A PT97931 A PT 97931A PT 97931 A PT97931 A PT 97931A PT 9793191 A PT9793191 A PT 9793191A PT 97931 A PT97931 A PT 97931A
Authority
PT
Portugal
Prior art keywords
formula
preparation
compound
general formula
group
Prior art date
Application number
PT97931A
Other languages
English (en)
Portuguese (pt)
Inventor
Giorgio Attardo
Bernard Belleau
Yao Chang Xu
Jean-Francois Lavallee
Rabindra N Rej
Original Assignee
Iaf Biochem Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Publication of PT97931A publication Critical patent/PT97931A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/244—Anthraquinone radicals, e.g. sennosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Forms Removed On Construction Sites Or Auxiliary Members Thereof (AREA)
PT97931A 1990-06-11 1991-06-11 Processo para a preparacao de analogos heterociclicos de antraciclinona e antracilina e de composicoes farmaceuticas que os contem PT97931A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53610790A 1990-06-11 1990-06-11

Publications (1)

Publication Number Publication Date
PT97931A true PT97931A (pt) 1992-03-31

Family

ID=24137175

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97931A PT97931A (pt) 1990-06-11 1991-06-11 Processo para a preparacao de analogos heterociclicos de antraciclinona e antracilina e de composicoes farmaceuticas que os contem

Country Status (18)

Country Link
EP (1) EP0533744A1 (ja)
JP (1) JPH06504034A (ja)
CN (1) CN1058781A (ja)
AP (1) AP340A (ja)
AU (1) AU653348B2 (ja)
CA (1) CA2085120A1 (ja)
CS (1) CS178691A3 (ja)
FI (1) FI925611A0 (ja)
HU (1) HU9203720D0 (ja)
IE (1) IE911965A1 (ja)
IL (1) IL98460A0 (ja)
MA (1) MA22178A1 (ja)
NZ (1) NZ238490A (ja)
PL (1) PL297164A1 (ja)
PT (1) PT97931A (ja)
WO (1) WO1991019725A2 (ja)
YU (1) YU103391A (ja)
ZA (1) ZA914452B (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0659190A1 (en) * 1992-11-09 1995-06-28 Biochem Pharma Inc Antineoplastic heteronaphthoquinones
US5736523A (en) * 1992-11-09 1998-04-07 Biochem Pharma Inc. Antineoplastic heteronapthoquinones
US5606037A (en) * 1992-11-09 1997-02-25 Biochem Pharma Inc. Processes antineoplastic heteronaphthoquinones
AU6672794A (en) * 1993-11-05 1995-05-23 Biochem Pharma Inc. Antineoplastic heteronaphthoquinones
IT1271689B (it) * 1994-08-04 1997-06-04 Menarini Farma Ind 8-fluoro-antracicline, loro processi di preparazione e composizioni farmaceutiche che le contengono
CN112638944A (zh) 2018-08-23 2021-04-09 西进公司 抗tigit抗体
CN111087377B (zh) * 2020-03-19 2020-06-26 广东省微生物研究所（广东省微生物分析检测中心） 苯并异色满醌类化合物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52148088A (en) * 1976-06-01 1977-12-08 Richardson Merrell Inc 111aminoalkylmorphansridinee 111ols
JPS6030315B2 (ja) * 1976-06-01 1985-07-16 三井東圧化学株式会社 ４−ハロゲノメチルイソクマリン誘導体の製造法
GB2067552B (en) * 1980-01-16 1984-02-29 Erba Farmitalia Anthracyline derivatives
JPS60142976A (ja) * 1983-12-28 1985-07-29 Yoshinori Asakawa イソクマリン誘導体
CA1330560C (en) * 1986-05-21 1994-07-05 Maurits E. A. Vandewalle Di- and tetrahydroisoquinoline derivatives
JPH01238579A (ja) * 1988-03-18 1989-09-22 Yamanouchi Pharmaceut Co Ltd Ｙ−０５４６０ｍ−ａ物質及びその製造法
JPH08112310A (ja) * 1994-10-18 1996-05-07 New Oji Paper Co Ltd 使いすておむつ

Also Published As

Publication number Publication date
CN1058781A (zh) 1992-02-19
MA22178A1 (fr) 1991-12-31
FI925611A (fi) 1992-12-10
AU653348B2 (en) 1994-09-29
IL98460A0 (en) 1992-07-15
WO1991019725A2 (en) 1991-12-26
AP340A (en) 1994-05-13
NZ238490A (en) 1994-03-25
AP9100278A0 (en) 1991-07-31
HU9203720D0 (en) 1993-03-29
IE911965A1 (en) 1991-12-18
EP0533744A1 (en) 1993-03-31
AU8097391A (en) 1992-01-07
WO1991019725A3 (en) 1992-04-30
PL297164A1 (ja) 1992-10-05
JPH06504034A (ja) 1994-05-12
CA2085120A1 (en) 1991-12-12
FI925611A0 (fi) 1992-12-10
ZA914452B (en) 1992-06-24
YU103391A (sh) 1994-04-05
CS178691A3 (en) 1992-01-15

Similar Documents

Publication Publication Date Title
AP1A (en) Polycyclic aromatic compounds
US5593970A (en) Heterocyclic anthracycline analogs
JP3908270B2 (ja) アシルフルベン類似体およびその医薬組成物
US4719046A (en) Crysene derivatives
PT97931A (pt) Processo para a preparacao de analogos heterociclicos de antraciclinona e antracilina e de composicoes farmaceuticas que os contem
Batova et al. Synthesis and evaluation of caged Garcinia xanthones
Torii et al. Alicyclic terpenoids from cyclocitryl phenyl sulfides. 11. Stereoselective synthesis of (.+-.)-irones
FI75833C (fi) Foerfarande foer framstaellning av nya antracyklinglykosider.
Cimino et al. Minor C-21 furanoterpenes from the sponges Spongia officinalis and Hippospongia communis
Coxon et al. Macrobicyclic polyethers with bridgehead carbon atoms
JPH04503679A (ja) ドキソルビシンのモルホリニル誘導体及びそれらの製造方法
US4697005A (en) 1-fluoro, 4-fluoro, and 1,4-difluoro anthracycline anticancer antibiotics
Valenti et al. Benzo-y-pyrone analogues of geiparvarin: synthesis and biological evaluation against
HUT74174A (en) Use of natural products and related synthetic compounds for producing pharmaceutical compositions for the treatment of cardiovascular disease
US5348946A (en) Heteroanthracycline antitumor analogs
JPH07100713B2 (ja) １４−フルオロアントラサイクリン誘導体
Ayres et al. Modification of the pendant ring of podophyllotoxin
HU206700B (en) Process for producing new 4'-epi-4'-amino-antracyclines and pharmaceutical compositions containing them
Natori et al. The structure of mompain, a naphthoquinone from Helicobasidium mompa Tanaka, and its relation to spinochrome A (M)
US4663445A (en) 1-fluoro, 4-fluoro, and 1,4-difluoro-2'-halo anthracycline antibiotics
US20230130823A1 (en) Process for the production of antitumour pharmaceutical compositions using push-pull butadienes, compounds and uses thereof
Tririya Synthesis of anthracyclinone precursor, and, Syntheses and synthetic uses of anthracyne
Basavaiah et al. Synthesis and evaluation of antimitotic activity of N-phenyl tetralones
UMESHA et al. Synthesis and Bioevaluation Study of Benzofuran Linked Tetralones as Antimitotic Agent
US4808632A (en) Fluoranthene derivatives

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19911205

FC3A Refusal

Effective date: 19981202