AP340A - Heterocyclic anathracyclinone and anathracycline analogs - Google Patents

Heterocyclic anathracyclinone and anathracycline analogs Download PDF

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Publication number
AP340A
AP340A APAP/P/1991/000278A AP9100278A AP340A AP 340 A AP340 A AP 340A AP 9100278 A AP9100278 A AP 9100278A AP 340 A AP340 A AP 340A
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AP
ARIPO
Prior art keywords
compound
formula
group
pyran
bad original
Prior art date
Application number
APAP/P/1991/000278A
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English (en)
Other versions
AP9100278A0 (en
Inventor
Giorgio Attardo
Bernard Belleau
Yao Chang Xu
Jean-Francoise Lavallee
Rabindra N Rej
Original Assignee
Iaf Biochem Int
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Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Publication of AP9100278A0 publication Critical patent/AP9100278A0/xx
Application granted granted Critical
Publication of AP340A publication Critical patent/AP340A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/244—Anthraquinone radicals, e.g. sennosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Forms Removed On Construction Sites Or Auxiliary Members Thereof (AREA)
APAP/P/1991/000278A 1990-06-11 1991-06-10 Heterocyclic anathracyclinone and anathracycline analogs AP340A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53610790A 1990-06-11 1990-06-11

Publications (2)

Publication Number Publication Date
AP9100278A0 AP9100278A0 (en) 1991-07-31
AP340A true AP340A (en) 1994-05-13

Family

ID=24137175

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1991/000278A AP340A (en) 1990-06-11 1991-06-10 Heterocyclic anathracyclinone and anathracycline analogs

Country Status (18)

Country Link
EP (1) EP0533744A1 (ja)
JP (1) JPH06504034A (ja)
CN (1) CN1058781A (ja)
AP (1) AP340A (ja)
AU (1) AU653348B2 (ja)
CA (1) CA2085120A1 (ja)
CS (1) CS178691A3 (ja)
FI (1) FI925611A0 (ja)
HU (1) HU9203720D0 (ja)
IE (1) IE911965A1 (ja)
IL (1) IL98460A0 (ja)
MA (1) MA22178A1 (ja)
NZ (1) NZ238490A (ja)
PL (1) PL297164A1 (ja)
PT (1) PT97931A (ja)
WO (1) WO1991019725A2 (ja)
YU (1) YU103391A (ja)
ZA (1) ZA914452B (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5736523A (en) * 1992-11-09 1998-04-07 Biochem Pharma Inc. Antineoplastic heteronapthoquinones
AU5414094A (en) * 1992-11-09 1994-06-08 Biochem Pharma Inc. Antineoplastic heteronaphthoquinones
US5606037A (en) * 1992-11-09 1997-02-25 Biochem Pharma Inc. Processes antineoplastic heteronaphthoquinones
WO1995012588A1 (en) * 1993-11-05 1995-05-11 Biochem Pharma Inc. Antineoplastic heteronaphthoquinones
IT1271689B (it) * 1994-08-04 1997-06-04 Menarini Farma Ind 8-fluoro-antracicline, loro processi di preparazione e composizioni farmaceutiche che le contengono
BR112021003156A2 (pt) 2018-08-23 2021-05-11 Seagen, Inc. composição, anticorpo que se liga ao tigit humano, formulação farmacêutica, polinucleotídeo isolado, vetor, célula hospedeira, métodos para a produção de um anticorpo que se liga ao tigit humano e de anticorpos afucosilados que se ligam a tigit e para o tratamento de um câncer, e, kit.
CN111087377B (zh) * 2020-03-19 2020-06-26 广东省微生物研究所（广东省微生物分析检测中心） 苯并异色满醌类化合物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52148079A (en) * 1976-06-01 1977-12-08 Mitsui Toatsu Chem Inc Preparation of 4-halogenomethylisocoumarin derivatives
JPS52148088A (en) * 1976-06-01 1977-12-08 Richardson Merrell Inc 111aminoalkylmorphansridinee 111ols

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2067552B (en) * 1980-01-16 1984-02-29 Erba Farmitalia Anthracyline derivatives
JPS60142976A (ja) * 1983-12-28 1985-07-29 Yoshinori Asakawa イソクマリン誘導体
CA1330560C (en) * 1986-05-21 1994-07-05 Maurits E. A. Vandewalle Di- and tetrahydroisoquinoline derivatives
JPH01238579A (ja) * 1988-03-18 1989-09-22 Yamanouchi Pharmaceut Co Ltd Ｙ−０５４６０ｍ−ａ物質及びその製造法
JPH08112310A (ja) * 1994-10-18 1996-05-07 New Oji Paper Co Ltd 使いすておむつ

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52148079A (en) * 1976-06-01 1977-12-08 Mitsui Toatsu Chem Inc Preparation of 4-halogenomethylisocoumarin derivatives
JPS52148088A (en) * 1976-06-01 1977-12-08 Richardson Merrell Inc 111aminoalkylmorphansridinee 111ols

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts vol. 113, 1990, 115652 *

Also Published As

Publication number Publication date
CS178691A3 (en) 1992-01-15
ZA914452B (en) 1992-06-24
PL297164A1 (ja) 1992-10-05
MA22178A1 (fr) 1991-12-31
AP9100278A0 (en) 1991-07-31
WO1991019725A2 (en) 1991-12-26
FI925611A (fi) 1992-12-10
WO1991019725A3 (en) 1992-04-30
CN1058781A (zh) 1992-02-19
IL98460A0 (en) 1992-07-15
FI925611A0 (fi) 1992-12-10
CA2085120A1 (en) 1991-12-12
JPH06504034A (ja) 1994-05-12
PT97931A (pt) 1992-03-31
IE911965A1 (en) 1991-12-18
NZ238490A (en) 1994-03-25
EP0533744A1 (en) 1993-03-31
AU8097391A (en) 1992-01-07
YU103391A (sh) 1994-04-05
AU653348B2 (en) 1994-09-29
HU9203720D0 (en) 1993-03-29

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