PT96385A - Processo para a preparacao de um polipeptido anticoagulante da familia das anexinas e de meios de diagnostico que o contem - Google Patents
Processo para a preparacao de um polipeptido anticoagulante da familia das anexinas e de meios de diagnostico que o contemInfo
- Publication number
- PT96385A PT96385A PT96385A PT9638590A PT96385A PT 96385 A PT96385 A PT 96385A PT 96385 A PT96385 A PT 96385A PT 9638590 A PT9638590 A PT 9638590A PT 96385 A PT96385 A PT 96385A
- Authority
- PT
- Portugal
- Prior art keywords
- anticoagulant
- esp
- family
- polyepeptide
- annexes
- Prior art date
Links
- 239000003146 anticoagulant agent Substances 0.000 title abstract 3
- 229940127219 anticoagulant drug Drugs 0.000 title abstract 3
- 102000000412 Annexin Human genes 0.000 abstract 1
- 108050008874 Annexin Proteins 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002506 anticoagulant protein Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 230000005298 paramagnetic effect Effects 0.000 abstract 1
- 239000008363 phosphate buffer Substances 0.000 abstract 1
- 239000002504 physiological saline solution Substances 0.000 abstract 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 229920000053 polysorbate 80 Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
- A61K49/0043—Fluorescein, used in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/087—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being an annexin, e.g. annexin V
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4721—Lipocortins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4718—Lipocortins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
- G01N2405/04—Phospholipids, i.e. phosphoglycerides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Dental Preparations (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3942988 | 1989-12-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT96385A true PT96385A (pt) | 1991-10-31 |
| PT96385B PT96385B (pt) | 1998-06-30 |
Family
ID=6396455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96385A PT96385B (pt) | 1989-12-27 | 1990-12-27 | Processo para a preparacao de um polipeptido anticoagulante da familia das anexinas e de meios de diagnostico que o contem |
Country Status (15)
| Country | Link |
|---|---|
| EP (2) | EP0806670B1 (pt) |
| JP (1) | JP3135261B2 (pt) |
| KR (1) | KR0181520B1 (pt) |
| AT (2) | ATE164083T1 (pt) |
| AU (1) | AU642202B2 (pt) |
| CA (1) | CA2070647C (pt) |
| DE (3) | DE4040817A1 (pt) |
| ES (1) | ES2113372T3 (pt) |
| FI (1) | FI107586B (pt) |
| HU (2) | HUT61491A (pt) |
| NO (1) | NO305276B1 (pt) |
| NZ (1) | NZ236620A (pt) |
| PT (1) | PT96385B (pt) |
| WO (1) | WO1991009628A1 (pt) |
| ZA (1) | ZA9010319B (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5627036A (en) * | 1989-12-27 | 1997-05-06 | Boehringer Ingelheim International Gmbh | Use of an anticoagulant as a diagnostic agent |
| ATE210464T1 (de) * | 1992-06-09 | 2001-12-15 | Neorx Corp | BIOTIN-DOTA KONJUGATE UND DEREN VERWENDUNG IN ßPRETARGETINGß VERFAHREN |
| WO1995014788A1 (en) * | 1993-11-24 | 1995-06-01 | University Of Washington | Blood coagulation retardants and devices |
| US20030220233A1 (en) | 1994-01-24 | 2003-11-27 | Neorx Corporation | Radiolabeled annexins |
| CA2180555C (en) * | 1994-01-24 | 2004-12-14 | Sudhakar Kasina | Radiolabeled annexins |
| US5968477A (en) | 1994-01-24 | 1999-10-19 | Neorx Corporation | Radiolabeled annexin conjugates with hexose and a chelator |
| JP3812680B2 (ja) * | 1994-03-16 | 2006-08-23 | マリンクロッド・インコーポレイテッド | 放射性医薬用途のペプチド類およびタンパク質類の安定化 |
| JP2824155B2 (ja) * | 1994-04-11 | 1998-11-11 | ネクシンズ・リサーチ・ベー・ブイ | 試料中の又は試料からアポトーシス細胞を検出し及び／又は場合により定量し及び／又は分離するための方法 |
| WO1995034315A1 (en) * | 1994-06-16 | 1995-12-21 | Neorx Corporation | Radiolabeled annexin-galactose conjugates |
| ATE240749T1 (de) * | 1994-06-16 | 2003-06-15 | Neorx Corp | Radioaktivmarkierte annexin-galaktose konjugate |
| JPH10512852A (ja) * | 1994-12-07 | 1998-12-08 | ネオルクス コーポレイション | 放射性標識化アネキシン−ガラクトースクラスター複合体 |
| US5886143A (en) * | 1994-12-07 | 1999-03-23 | Neorx Corporation | Hepatic-directed compounds and reagents for preparation thereof |
| EP0799050B1 (en) * | 1994-12-07 | 2004-08-11 | Neorx Corporation | Radiolabeled annexin-galactose cluster conjugates |
| US5955605A (en) * | 1995-02-21 | 1999-09-21 | Neorx Corporation | Biotinidase resistant biotin-DOTA conjugates |
| FR2736197B1 (fr) * | 1995-06-29 | 1997-09-12 | Univ Paris Curie | Nanoparticules magnetiques couplees a de l'annexine et leur utilisation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4427646A (en) * | 1981-04-02 | 1984-01-24 | Research Corporation | Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo |
| US4455290A (en) * | 1981-04-02 | 1984-06-19 | Research Corporation | Inhibition of fibrin polymerization by a peptide isolated from fibrin Fragment D1 |
| US4820505A (en) * | 1985-04-04 | 1989-04-11 | Scripps Clinic And Research Foundation | Detection of activated platelets with antibodies to thrombospondin |
| PT87083B (pt) * | 1987-03-28 | 1992-07-31 | Boehringer Ingelheim Int | Processo para a preparacao de uma proteina anticoagulante vascular, de adn que codifica para esta proteina e de composicoes farmaceuticas que a contem |
| DE3810331A1 (de) * | 1988-03-26 | 1989-10-05 | Boehringer Ingelheim Int | Monoklonale vac-antikoerper |
-
1990
- 1990-12-19 JP JP03502409A patent/JP3135261B2/ja not_active Expired - Lifetime
- 1990-12-19 AT AT91902118T patent/ATE164083T1/de not_active IP Right Cessation
- 1990-12-19 CA CA002070647A patent/CA2070647C/en not_active Expired - Lifetime
- 1990-12-19 DE DE4040817A patent/DE4040817A1/de not_active Withdrawn
- 1990-12-19 ES ES91902118T patent/ES2113372T3/es not_active Expired - Lifetime
- 1990-12-19 EP EP97113801A patent/EP0806670B1/de not_active Expired - Lifetime
- 1990-12-19 DE DE59010946T patent/DE59010946D1/de not_active Expired - Lifetime
- 1990-12-19 WO PCT/EP1990/002257 patent/WO1991009628A1/de active IP Right Grant
- 1990-12-19 HU HU9202149A patent/HUT61491A/hu unknown
- 1990-12-19 KR KR1019920701497A patent/KR0181520B1/ko not_active IP Right Cessation
- 1990-12-19 AT AT97113801T patent/ATE429644T1/de not_active IP Right Cessation
- 1990-12-19 AU AU70711/91A patent/AU642202B2/en not_active Expired
- 1990-12-19 HU HU9202149A patent/HU209650B/hu unknown
- 1990-12-19 EP EP91902118A patent/EP0509026B1/de not_active Expired - Lifetime
- 1990-12-19 DE DE59010815T patent/DE59010815D1/de not_active Expired - Lifetime
- 1990-12-21 NZ NZ236620A patent/NZ236620A/en unknown
- 1990-12-21 ZA ZA9010319A patent/ZA9010319B/xx unknown
- 1990-12-27 PT PT96385A patent/PT96385B/pt not_active IP Right Cessation
-
1992
- 1992-06-12 FI FI922719A patent/FI107586B/fi active
- 1992-06-26 NO NO922528A patent/NO305276B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR920703121A (ko) | 1992-12-17 |
| HU9202149D0 (en) | 1992-10-28 |
| EP0806670A2 (de) | 1997-11-12 |
| WO1991009628A1 (de) | 1991-07-11 |
| CA2070647C (en) | 2001-04-10 |
| KR0181520B1 (ko) | 1999-05-01 |
| NO305276B1 (no) | 1999-05-03 |
| AU642202B2 (en) | 1993-10-14 |
| NO922528D0 (no) | 1992-06-26 |
| NZ236620A (en) | 1997-03-24 |
| FI107586B (fi) | 2001-09-14 |
| EP0509026A1 (de) | 1992-10-21 |
| DE59010815D1 (de) | 1998-04-23 |
| FI922719A0 (fi) | 1992-06-12 |
| EP0509026B1 (de) | 1998-03-18 |
| PT96385B (pt) | 1998-06-30 |
| EP0806670B1 (de) | 2009-04-22 |
| ATE164083T1 (de) | 1998-04-15 |
| AU7071191A (en) | 1991-07-24 |
| ES2113372T3 (es) | 1998-05-01 |
| HU209650B (en) | 1994-09-28 |
| ATE429644T1 (de) | 2009-05-15 |
| DE4040817A1 (de) | 1991-07-04 |
| EP0806670A3 (de) | 1997-12-10 |
| JP3135261B2 (ja) | 2001-02-13 |
| JPH05502877A (ja) | 1993-05-20 |
| ZA9010319B (en) | 1992-08-26 |
| DE59010946D1 (de) | 2009-06-04 |
| CA2070647A1 (en) | 1991-06-28 |
| NO922528L (no) | 1992-08-26 |
| HUT61491A (en) | 1993-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19910627 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19980327 |
|
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20130327 |