PT94674A - Processo para a purificacao de anexinas - Google Patents

Processo para a purificacao de anexinas

Info

Publication number
PT94674A
PT94674A PT94674A PT9467490A PT94674A PT 94674 A PT94674 A PT 94674A PT 94674 A PT94674 A PT 94674A PT 9467490 A PT9467490 A PT 9467490A PT 94674 A PT94674 A PT 94674A
Authority
PT
Portugal
Prior art keywords
annexines
cell residue
chelating agent
homogenized
washing
Prior art date
Application number
PT94674A
Other languages
English (en)
Other versions
PT94674B (pt
Inventor
Gerhard Bodo
Christian Reutelingsperger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PT94674A publication Critical patent/PT94674A/pt
Publication of PT94674B publication Critical patent/PT94674B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721—Lipocortins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Detergent Compositions (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
  • Amplifiers (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT94674A 1989-07-15 1990-07-12 Processo para a purificacao de anexinas PT94674B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3923501 1989-07-15

Publications (2)

Publication Number Publication Date
PT94674A true PT94674A (pt) 1991-04-18
PT94674B PT94674B (pt) 1997-03-31

Family

ID=6385155

Family Applications (1)

Application Number Title Priority Date Filing Date
PT94674A PT94674B (pt) 1989-07-15 1990-07-12 Processo para a purificacao de anexinas

Country Status (18)

Country Link
US (1) US5258497A (pt)
EP (1) EP0409053B1 (pt)
JP (1) JPH03175992A (pt)
KR (1) KR0159275B1 (pt)
AT (1) ATE95189T1 (pt)
AU (1) AU628604B2 (pt)
CA (1) CA2021147A1 (pt)
DD (1) DD297977A5 (pt)
DE (2) DE59002895D1 (pt)
DK (1) DK0409053T3 (pt)
ES (1) ES2045669T3 (pt)
FI (1) FI95136C (pt)
IE (1) IE65195B1 (pt)
IL (1) IL95082A (pt)
NO (1) NO177787C (pt)
NZ (1) NZ234492A (pt)
PT (1) PT94674B (pt)
ZA (1) ZA905490B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE89169T1 (de) * 1989-07-15 1993-05-15 Boehringer Ingelheim Int Antikoagulanz enthaltendes mittel.
US5627036A (en) * 1989-12-27 1997-05-06 Boehringer Ingelheim International Gmbh Use of an anticoagulant as a diagnostic agent
DE9110757U1 (de) * 1991-08-30 1992-02-13 Klein, Rainer, 5840 Schwerte Integriert-optischer Stoffsensor
WO1993006230A1 (en) * 1991-09-23 1993-04-01 The General Hospital Corporation Annexin xi
US5968477A (en) 1994-01-24 1999-10-19 Neorx Corporation Radiolabeled annexin conjugates with hexose and a chelator
JP3664727B2 (ja) * 1994-01-24 2005-06-29 ネオルクス コーポレイション 放射標識したアネキシン
US20030220233A1 (en) 1994-01-24 2003-11-27 Neorx Corporation Radiolabeled annexins
DE69533366T2 (de) * 1994-12-07 2005-08-04 Neorx Corp., Seattle Radioaktivmarkierte annexin-galaktose-cluster konjugate
US6204035B1 (en) 1996-04-02 2001-03-20 The Blood Center Research Foundation Methods and compositions to alter the cell surface expression of phosphatidylserine and other clot-promoting plasma membrane phospholipids
US6172210B1 (en) 1996-04-02 2001-01-09 Blood Center Research Foundation DNA encoding phospholipid scramblase
KR100841599B1 (ko) * 2000-07-21 2008-06-26 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 칼슘 이온-결합 단백질의 정제 방법
US20050222030A1 (en) * 2001-02-21 2005-10-06 Anthony Allison Modified annexin proteins and methods for preventing thrombosis
US20090291086A1 (en) * 2001-02-21 2009-11-26 Alavita Pharmaceuticals, Inc. Compositions and Methods for Treating Cerebral Thrombosis and Global Cerebral Ischemia
US7635680B2 (en) * 2001-02-21 2009-12-22 Alavita Pharmaceuticals, Inc. Attenuation of reperfusion injury
US7635676B2 (en) * 2001-02-21 2009-12-22 Alavita Pharmaccuticals, Inc. Modified annexin proteins and methods for their use in organ transplantation
ES2286247T3 (es) * 2001-02-21 2007-12-01 Alavita Pharmaceuticals, Inc. Proteinas anexinicas modificacdas y tratamiento de la trombosis.
US7645739B2 (en) * 2001-02-21 2010-01-12 Alavita Pharmaceuticals, Inc. Modified annexin compositions and methods of using same
DE10162434A1 (de) * 2001-12-18 2003-09-25 November Ag Molekulare Medizin Expressionsvektor und Verfahren zur Herstellung eines Expressionsvektors
AU2003237870A1 (en) * 2002-06-07 2003-12-22 The Brigham & Women's Hospital, Inc. Method and composition for inhibing or slowing blood coagulation
WO2005005954A2 (en) * 2003-06-30 2005-01-20 The Brigham & Women's Hospital, Inc. Method, composition and kit for detecting phosphatidylserine (ps) on cell membranes
KR102597544B1 (ko) * 2021-04-02 2023-11-03 주식회사 디에스시동탄 시트용 서포트 구동부 및 이를 포함하는 서포트 어셈블리

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3315000A1 (de) * 1983-04-26 1984-10-31 Behringwerke Ag, 3550 Marburg Gewebeprotein pp(pfeil abwaerts)4(pfeil abwaerts), verfahren zu seiner gewinnung sowie seine verwendung
KR930007434B1 (ko) * 1984-09-21 1993-08-10 베링거 잉겔하임 인터내셔날 게엠베하 혈액응고 억제 단백질 제조방법
US4683294A (en) * 1985-04-03 1987-07-28 Smith Kline Rit, S.A. Process for the extraction and purification of proteins from culture media producing them
US4937324A (en) * 1987-02-06 1990-06-26 Zymogenetics, Inc. Chromatographic purification of human proteins having anticoagulant and anti-inflammatory activity

Also Published As

Publication number Publication date
IE902563A1 (en) 1991-02-27
NO903149D0 (no) 1990-07-13
NO903149L (no) 1991-01-16
PT94674B (pt) 1997-03-31
KR0159275B1 (ko) 1998-11-16
CA2021147A1 (en) 1991-01-16
DE59002895D1 (de) 1993-11-04
IL95082A0 (en) 1991-06-10
EP0409053B1 (de) 1993-09-29
US5258497A (en) 1993-11-02
AU628604B2 (en) 1992-09-17
IE65195B1 (en) 1995-10-04
DD297977A5 (de) 1992-01-30
FI903508A0 (fi) 1990-07-11
ATE95189T1 (de) 1993-10-15
NO177787C (no) 1995-11-22
AU5901590A (en) 1991-01-17
NO177787B (no) 1995-08-14
EP0409053A1 (de) 1991-01-23
ZA905490B (en) 1992-03-25
IL95082A (en) 1995-03-30
KR910002893A (ko) 1991-02-26
FI95136C (fi) 1995-12-27
NZ234492A (en) 1991-10-25
ES2045669T3 (es) 1994-01-16
DK0409053T3 (da) 1993-11-08
DE4021979A1 (de) 1991-01-31
JPH03175992A (ja) 1991-07-31
FI95136B (fi) 1995-09-15

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19910208

FG3A Patent granted, date of granting

Effective date: 19961223

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20111223