PT93424B - Processo para a preparacao de uma composicao contendo d-cicloserina e d- -alanina para melhoria de memoria e de aprendizagem ou para tratamento de doencas psicoticas ou cognitivas - Google Patents
Processo para a preparacao de uma composicao contendo d-cicloserina e d- -alanina para melhoria de memoria e de aprendizagem ou para tratamento de doencas psicoticas ou cognitivas Download PDFInfo
- Publication number
- PT93424B PT93424B PT93424A PT9342490A PT93424B PT 93424 B PT93424 B PT 93424B PT 93424 A PT93424 A PT 93424A PT 9342490 A PT9342490 A PT 9342490A PT 93424 B PT93424 B PT 93424B
- Authority
- PT
- Portugal
- Prior art keywords
- cycloserine
- therapeutically effective
- alanine
- effective amount
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Hydrogenated Pyridines (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Detergent Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32427989A | 1989-03-15 | 1989-03-15 | |
| US07/473,241 US5061721A (en) | 1989-03-15 | 1990-02-06 | Composition containing d-cycloserine and d-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT93424A PT93424A (pt) | 1990-11-07 |
| PT93424B true PT93424B (pt) | 1996-08-30 |
Family
ID=26984373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT93424A PT93424B (pt) | 1989-03-15 | 1990-03-14 | Processo para a preparacao de uma composicao contendo d-cicloserina e d- -alanina para melhoria de memoria e de aprendizagem ou para tratamento de doencas psicoticas ou cognitivas |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5061721A (enExample) |
| EP (1) | EP0387867B1 (enExample) |
| JP (1) | JP2963720B2 (enExample) |
| KR (1) | KR900013961A (enExample) |
| AT (1) | ATE88890T1 (enExample) |
| AU (1) | AU624917B2 (enExample) |
| CA (1) | CA2010635C (enExample) |
| DE (1) | DE69001503T2 (enExample) |
| DK (1) | DK0387867T3 (enExample) |
| ES (1) | ES2055197T3 (enExample) |
| FI (1) | FI901289A7 (enExample) |
| GR (1) | GR3008225T3 (enExample) |
| IE (1) | IE64130B1 (enExample) |
| IL (1) | IL93562A (enExample) |
| NO (1) | NO901198L (enExample) |
| NZ (1) | NZ232809A (enExample) |
| PT (1) | PT93424B (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5153193A (en) * | 1991-10-01 | 1992-10-06 | Hoechst-Roussel Pharmaceuticals Incorporated | Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs |
| US5854217A (en) | 1992-09-28 | 1998-12-29 | Bearsden Bio, Inc. | Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function |
| JPH07505908A (ja) * | 1992-09-28 | 1995-06-29 | マックセチーニ、マリア ルイザ | Nmda受容体のアロステリックモジュレーター |
| US5302609A (en) * | 1992-12-16 | 1994-04-12 | The Regents Of The University Of Michigan | Treatment of diabetic nephropathy |
| US20040208875A1 (en) | 1995-03-15 | 2004-10-21 | Queen's University At Kingston | Method for treating amyloidosis |
| WO1994022437A2 (en) * | 1993-03-29 | 1994-10-13 | Queen's University At Kingston | Method for treating amyloidosis |
| US5523323A (en) * | 1993-09-14 | 1996-06-04 | Maccecchini; Maria-Luisa | Use of partial agonists of the NMDA receptor to reduce opiate induced tolerance and dependence |
| WO1996015788A1 (en) * | 1994-11-23 | 1996-05-30 | G.D. Searle & Co. | Use of amino-isoxazolidone compounds for improvement of implicit memory |
| JPH11501619A (ja) * | 1995-02-15 | 1999-02-09 | ベアーズデン バイオ,インコーポレイテッド | アルキルカルボキシアミノ酸−カイネートレセプターのモジュレーター |
| EP0956292A4 (en) | 1996-07-22 | 2003-07-30 | Univ Utah Res Found | CONANTOKINES |
| US6277825B1 (en) | 1996-07-22 | 2001-08-21 | University Of Utah Research Foundation | Use of conantokins for treating pain |
| AU735389B2 (en) | 1996-07-22 | 2001-07-05 | Cognetix, Inc. | Use of conantokins |
| EP1073432B1 (en) * | 1998-04-14 | 2007-08-15 | The General Hospital Corporation | Use of d-serine or d-alanine for treating schizophrenia |
| US6551993B1 (en) * | 1999-08-16 | 2003-04-22 | Thomas Jefferson University | Partial agonists at the glycine modulatory site of the NMDA receptor for treating cognitive dysfunction |
| US6399574B1 (en) | 2000-03-22 | 2002-06-04 | University Of Utah Research Foundation | Use of conantokins |
| US20040122090A1 (en) * | 2001-12-07 | 2004-06-24 | Lipton Stuart A. | Methods for treating neuropsychiatric disorders with nmda receptor antagonists |
| US20050096396A1 (en) * | 2002-03-28 | 2005-05-05 | Emory University | Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning |
| CA2442330A1 (en) * | 2001-03-29 | 2002-10-10 | Emory University | Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning |
| US6717012B2 (en) * | 2001-04-02 | 2004-04-06 | Neuromolecular, Inc. | Antioxidant nitroxides and nitrones as therapeutic agents |
| ES2314056T3 (es) * | 2001-05-02 | 2009-03-16 | Blanchette Rockefeller Neurosciences Institute | Activadores de la anhidrasa carbonica para mejorar el aprendizaje y la memoria. |
| EP1487542A1 (en) * | 2002-03-15 | 2004-12-22 | H. Lundbeck A/S | Use of asc-1 inhibitors to treat neurological and psychiatric disorders |
| EP2260844A1 (en) * | 2003-05-27 | 2010-12-15 | Merz Pharma GmbH & Co. KGaA | Combination of an NMDA Receptor Antagonist and a Selective Serotonin Reuptake Inhibitor for the Treatment of Depression and other Mood Disorders |
| US7244764B2 (en) | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| US20070010573A1 (en) | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
| US7414076B2 (en) | 2003-06-23 | 2008-08-19 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| EP1660634A4 (en) * | 2003-08-08 | 2009-02-18 | Burnham Inst | P16-mediated regulation of NMDA receptors |
| KR20070007276A (ko) | 2003-12-29 | 2007-01-15 | 제이슨 맥데빗 | 재발성 의학적 증상을 치료하기 위한 조성물 및 방법 |
| TW201206425A (en) | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Treatment of depressive disorders |
| US7619007B2 (en) * | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| BRPI0519243A2 (pt) | 2004-12-22 | 2009-01-06 | Neurochem Int Ltd | mÉtodos e composiÇÕes para tratar doenÇas relacionadas a amilàide |
| ATE481096T1 (de) | 2005-04-06 | 2010-10-15 | Adamas Pharmaceuticals Inc | Verfahren und zusammensetzungen zur behandlung von zns-erkrankungen |
| TW200716088A (en) | 2005-04-15 | 2007-05-01 | Neurochem Int Ltd | Formulations and methods for treating amyloidosis |
| DK2089417T3 (en) | 2006-10-12 | 2015-03-23 | Bhi Ltd Partnership | Methods, Compounds, Compositions and Vehicles for Delivery of 3-Amion-1-Propanesulfonic Acid |
| WO2008124814A2 (en) * | 2007-04-10 | 2008-10-16 | Mcdevitt Jason P | Sublingual formulations of d-cycloserine and methods of using same |
| BRPI0918868B8 (pt) | 2008-09-18 | 2021-05-25 | Naurex Inc | compostos moduladores do receptor de nmda e composições compreendendo os mesmos |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
| TWI544923B (zh) * | 2009-12-29 | 2016-08-11 | 何應瑞 | 用於治療神經退化性疾病之醫藥組合物 |
| KR101692275B1 (ko) | 2010-02-11 | 2017-01-04 | 노오쓰웨스턴 유니버시티 | 2차 구조 안정화된 nmda 수용체 조절제 및 그의 용도 |
| WO2011100585A1 (en) | 2010-02-11 | 2011-08-18 | Joseph Moskal | Secondary structure stabilized nmda receptor modulators and uses thereof |
| JP5689026B2 (ja) * | 2010-06-17 | 2015-03-25 | 株式会社 資生堂 | 水中油型乳化皮膚化粧料 |
| CA2826180C (en) * | 2011-01-31 | 2020-09-01 | Serotech, Llc | Dosage regimen, medication dispensing package and uses thereof for the treatment of major depressive disorder |
| EP2931291B1 (en) | 2012-12-11 | 2021-10-20 | The McLean Hospital Corporation | Xenon treatment as an adjunct to psychotherapy for psychiatric disorders |
| PE20151416A1 (es) | 2013-01-29 | 2015-10-10 | Naurex Inc | Moduladores de receptores nmda de espiro-lactama y sus usos |
| EP2951186B1 (en) | 2013-01-29 | 2018-07-25 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| US9758525B2 (en) | 2013-01-29 | 2017-09-12 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
| JP2016506962A (ja) | 2013-01-29 | 2016-03-07 | ノーレックス, インコーポレイテッドNaurex, Inc. | スピロラクタム系nmda受容体モジュレーターおよびその使用 |
| KR102410989B1 (ko) | 2013-01-29 | 2022-06-17 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조절인자 및 그의 용도 |
| US9877951B2 (en) | 2015-02-12 | 2018-01-30 | College Of William And Mary | Method for treating dementia |
| PE20190174A1 (es) | 2016-05-19 | 2019-02-01 | Aptinyx Inc | Moduladores del receptor espiro-lactama n-metil-d-aspartato y usos de los mismos |
| WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| WO2018026798A1 (en) | 2016-08-01 | 2018-02-08 | Aptinyx Inc. | Spiro-lactam nmda modulators and methods of using same |
| KR102465758B1 (ko) | 2016-08-01 | 2022-11-09 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조정제 및 그의 용도 |
| AU2017306158B2 (en) | 2016-08-01 | 2021-10-14 | Aptinyx Inc. | Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof |
| IL286107B2 (en) | 2016-08-01 | 2024-09-01 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and usesthereof |
| JP7036792B2 (ja) | 2016-08-01 | 2022-03-15 | アプティニックス インコーポレイテッド | スピロ-ラクタムnmda受容体修飾因子およびその使用 |
| EP3427729A1 (en) | 2017-07-13 | 2019-01-16 | Paris Sciences et Lettres - Quartier Latin | Probenecid for use in treating epileptic diseases, disorders or conditions |
| PE20210455A1 (es) | 2018-01-31 | 2021-03-08 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos |
| WO2020252384A1 (en) * | 2019-06-14 | 2020-12-17 | Vorsanger Gary | Treatment methods utilizing oxytocin receptor agonists |
| US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
| CN114786668B (zh) * | 2019-11-27 | 2024-07-16 | 诺罗瑞韦有限公司 | 用于治疗抑郁症的环丝氨酸和锂的组合疗法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3428730A (en) * | 1967-06-30 | 1969-02-18 | Hamao Umezawa | Antibacterial mixture of o-carbamyl-d-serine and d-4-amino-3-isoxazolidone |
| US4031231A (en) * | 1974-06-13 | 1977-06-21 | Merck & Co., Inc. | Antibacterial composition comprising 3-fluoro-D-alanine or deutero analog in combination with auto-antagonist inhibitor |
| US4904681A (en) * | 1987-12-01 | 1990-02-27 | G. D. Searle & Co. | D-cycloserine and its prodrugs as cognitive enhancers |
-
1990
- 1990-02-06 US US07/473,241 patent/US5061721A/en not_active Expired - Lifetime
- 1990-02-27 IL IL9356290A patent/IL93562A/en active IP Right Grant
- 1990-03-06 NZ NZ232809A patent/NZ232809A/en unknown
- 1990-03-06 AU AU50734/90A patent/AU624917B2/en not_active Ceased
- 1990-03-14 IE IE92190A patent/IE64130B1/en not_active IP Right Cessation
- 1990-03-14 CA CA002010635A patent/CA2010635C/en not_active Expired - Fee Related
- 1990-03-14 JP JP2063937A patent/JP2963720B2/ja not_active Expired - Lifetime
- 1990-03-14 NO NO90901198A patent/NO901198L/no unknown
- 1990-03-14 PT PT93424A patent/PT93424B/pt not_active IP Right Cessation
- 1990-03-15 DK DK90104875.1T patent/DK0387867T3/da active
- 1990-03-15 ES ES90104875T patent/ES2055197T3/es not_active Expired - Lifetime
- 1990-03-15 EP EP90104875A patent/EP0387867B1/en not_active Expired - Lifetime
- 1990-03-15 FI FI901289A patent/FI901289A7/fi not_active IP Right Cessation
- 1990-03-15 KR KR1019900003482A patent/KR900013961A/ko not_active Ceased
- 1990-03-15 AT AT90104875T patent/ATE88890T1/de not_active IP Right Cessation
- 1990-03-15 DE DE9090104875T patent/DE69001503T2/de not_active Expired - Fee Related
-
1993
- 1993-06-18 GR GR930400134T patent/GR3008225T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI901289A7 (fi) | 1990-09-16 |
| EP0387867A1 (en) | 1990-09-19 |
| CA2010635A1 (en) | 1990-09-15 |
| GR3008225T3 (enExample) | 1993-09-30 |
| IE64130B1 (en) | 1995-07-12 |
| NO901198L (no) | 1990-09-17 |
| AU5073490A (en) | 1990-09-20 |
| NO901198D0 (no) | 1990-03-14 |
| IL93562A (en) | 1996-01-31 |
| DE69001503T2 (de) | 1993-09-09 |
| DK0387867T3 (da) | 1993-06-01 |
| PT93424A (pt) | 1990-11-07 |
| IL93562A0 (en) | 1990-11-29 |
| ES2055197T3 (es) | 1994-08-16 |
| CA2010635C (en) | 2001-03-06 |
| AU624917B2 (en) | 1992-06-25 |
| EP0387867B1 (en) | 1993-05-05 |
| KR900013961A (ko) | 1990-10-22 |
| FI901289A0 (fi) | 1990-03-15 |
| US5061721A (en) | 1991-10-29 |
| ATE88890T1 (de) | 1993-05-15 |
| JPH03148221A (ja) | 1991-06-25 |
| NZ232809A (en) | 1992-05-26 |
| IE900921L (en) | 1990-09-15 |
| DE69001503D1 (de) | 1993-06-09 |
| JP2963720B2 (ja) | 1999-10-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19960502 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19971130 |