PT92509A - Process for the preparation of neutrophil-activating peptide-2 - Google Patents

Process for the preparation of neutrophil-activating peptide-2 Download PDF

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Publication number
PT92509A
PT92509A PT92509A PT9250989A PT92509A PT 92509 A PT92509 A PT 92509A PT 92509 A PT92509 A PT 92509A PT 9250989 A PT9250989 A PT 9250989A PT 92509 A PT92509 A PT 92509A
Authority
PT
Portugal
Prior art keywords
leu
ala
ile
ser
arg
Prior art date
Application number
PT92509A
Other languages
English (en)
Inventor
Marco Baggiolini
Kenneth John Clemetson
Alfred Walz
Original Assignee
Sandoz Sa
Kocher Theodor Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888828728A external-priority patent/GB8828728D0/en
Priority claimed from GB898909681A external-priority patent/GB8909681D0/en
Application filed by Sandoz Sa, Kocher Theodor Inst filed Critical Sandoz Sa
Publication of PT92509A publication Critical patent/PT92509A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5421—IL-8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Claims (7)

  1. R E ΓΤ IHPIOAQOBS ia. _ Processo para a preparação do péptido-2 acti-vador dos nautrófilofl (NSA-l/IAP-2) ou de um variante, um fragmento ou um derivado funcional do citado péptido-2, ca-racterizado pelo facto de compreender a purificação de leucócitos do sangue estimulados a partir de líquidos de cultura, mediante cromatografia em fosfocelulose e cromatogra- ! fia em fase inversa.
  2. 2^. - Processo de acordo com a reivindicação 1, ca-racterizado pelo facto de compreender a) a cromatografia em fosfocelulose, b) a cromatografia em fase' líquida inversa sob alta pressão, numa coluna 04, e c) a cromatografia em fase líquida inversa, sob alta pressão, numa coluna de OET-propilo.
  3. 3§. - Processo para a preparação de NSA-l/MAP-2 ou de um seu variante fragmento ou derivado funcionais, ou de uma sua estrutura relativa biologicamente activa, tal como -^-tromboglobilina (beta-TG·), péptido de activação do tecido conectivo III (CTAP-III (CTAP-III ou proteina básica de plaquetas (PEP) caracterizado pelo facto de compreender a clo-nação de um gene correspondente, que inclui uma sequência principal natural, a expressão do gene num hospedeiro adequa do e a recuperação, de forma apropriada, do péptido assim produzido, se for conveniente, através da utilização de uma protease apropriada.
  4. 4§. - Processo de acordo com a reivindicação 3> caracterizado pelo facto de a sequência principal codificar: 1 5
    10 MET-Ser-Ieu-Arg-leu-Asp-Thr-Thr-Pro-Ser-11 15 20 Cys-Asn-Ser-Ala-Arg-Pro-leu-His-Ala-Ieu-21 25 30 Gln-Val-Ieu-Leu-Ieu-leu-Ser-leu-Ieu-Leu-31 Thr-Ala-Ieu-Ala- ou um variante, um fragmento ou um derivado funcionais da referida sequência.
  5. 5-· - Processo de acordo com qualquer das reivin dicações 1 a 4, caracterizado pelo facto de se preparar o factor que tem a seguinte sequência de 70 aminoácidos 1 5 10 Ala-Glu-leu-Arg-Cys-Met-Cys-Ile-lys-Tlir-11 15 20 Thr-Ser-Gly-Ile-His-Pro-Lys-Asn-Ile-Gln-21 25 30 Ser-Ieu-Glu-Val-Ile-Gly-lys-Gly-Thr-His-31 35 40 Cys-Asn-Gin-Vai-Glu-Val-Ile-Ala-Thr-Ieu-41 45 50 Lys-Asp-Gly-Arg-lys-Ile-Cys-Ijeu-Asp-Pro-51 55 ' 60 Asp-Ala-Pro-Arg-Ile-lys-Iys-Ile-Val-Gln-61 65 70 lys -Iiys -le u-Ala- Gly-Asp- Glu-Ser-Ala-As p ou de um variante fragmento ou derivado funcionais da citada sequência.
  6. 6§. - Processo para a preparação do factor de acti-vação de neutrófilos ou de um seu variante, fragmento ou derivado, de acordo com a reivindicação 1, caracterizado pelo facto de a sua obtenção se fazer a partir de beta-IG-, CIAP--III ou PEP ou de um gene codificado com beta-TG·, CTAP-III ou PBP.
  7. 7-· - Processo para a preparação de um péptido prin cipal, caracterizado pelo facto de possuir a seguinte seçjuên cia de aminoáeidos: 15 10 MET-Ser-Ieu-Arg-Ieu-Asp-Tbr-Ihr-Pro-Ser-11 15 20 Cys-Asn-Ser-Ala-Arg-Pro-leu-His-Ala-Ieu-21 25 30 Gln-Val-Ieu-Leu-Ieu-leu-Ser-leu-Ieu-leu-31 Thr-Ala-leu-Ala- ou um variante, um fragmento ou um derivado funcionais, da mencionada sequência. Lisboa, 6 de Dezembro de 1989 0 Agente Oficial da Propriedade Industrial
    Américo da Silva Carvalho Agente Oficial de Propriedade industrial R. Castilho, 201-3. £.-1000 LiSBOA Telefs. Ó5 13 39-65 46 13
PT92509A 1988-12-08 1989-12-06 Process for the preparation of neutrophil-activating peptide-2 PT92509A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888828728A GB8828728D0 (en) 1988-12-08 1988-12-08 Neutrophil-stimulating activity i
GB898909681A GB8909681D0 (en) 1989-04-27 1989-04-27 Neutrophil-stimulating activity 1

Publications (1)

Publication Number Publication Date
PT92509A true PT92509A (pt) 1990-06-29

Family

ID=26294713

Family Applications (1)

Application Number Title Priority Date Filing Date
PT92509A PT92509A (pt) 1988-12-08 1989-12-06 Process for the preparation of neutrophil-activating peptide-2

Country Status (19)

Country Link
US (1) US5759533A (pt)
JP (1) JP3051160B2 (pt)
KR (1) KR910700260A (pt)
AU (1) AU634508B2 (pt)
BE (1) BE1003636A4 (pt)
CA (1) CA2004685A1 (pt)
CH (1) CH681625A5 (pt)
DK (1) DK188690D0 (pt)
ES (1) ES2047458A6 (pt)
FI (1) FI903931A0 (pt)
FR (1) FR2640142B1 (pt)
GB (1) GB2231872B (pt)
GR (1) GR1000455B (pt)
IL (1) IL92557A0 (pt)
NL (1) NL8921262A (pt)
NZ (1) NZ231652A (pt)
PT (1) PT92509A (pt)
SE (1) SE9002589L (pt)
WO (1) WO1990006321A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3051160B2 (ja) * 1988-12-08 2000-06-12 ノバルティス・アクチエンゲゼルシャフト 好中球活性化ペプチド‐２
US6673893B1 (en) * 1990-02-01 2004-01-06 University Of South Florida Leukocyte derived growth factor 2
WO1991011515A2 (en) * 1990-02-01 1991-08-08 University Of South Florida Leukocyte-derived growth factor
WO1993001826A1 (en) * 1991-07-19 1993-02-04 East Carolina University Method of treating asthma
WO1993009794A1 (en) * 1991-11-15 1993-05-27 University Of Pennsylvania Suppression of megakaryocytopoiesis by neutrophil activating peptide-2
AU6085694A (en) * 1993-01-07 1994-08-15 University Of South Florida Leukocyte derived growth factors
US5786327A (en) 1993-03-12 1998-07-28 Gensci Regeneration Sciences Inc. Bone stimulating factor, methods of isolating same, and methods of increasing bone growth comprising administering same
US5578569A (en) * 1993-03-12 1996-11-26 Tam; Cherk S. Method of increasing bone growth
US6174995B1 (en) 1994-08-23 2001-01-16 Haodong Li Human chemokines, CKβ4 and CKβ10/MCP-4
US6458349B1 (en) 1995-06-02 2002-10-01 Human Genome Sciences, Inc. Chemokine β-4 polypeptides
US6391589B1 (en) 1994-08-23 2002-05-21 Human Genome Sciences, Inc. Human chemokine beta-10 mutant polypeptides
US5912232A (en) * 1994-09-23 1999-06-15 Board Of Regents Of The University Of Nebraska Anti-inflammatory polypeptide antagonists of human I1-8
US6117839A (en) * 1995-06-07 2000-09-12 Gensci Regeneration Sciences, Inc. Bone stimulating factor
US6352973B1 (en) 1995-06-07 2002-03-05 Osteopharm Inc. Bone stimulating factor
US5880094A (en) * 1995-06-07 1999-03-09 Osteopharm Limited Polypeptides that stimulate bone growth
US6693081B2 (en) * 1995-09-26 2004-02-17 Osteopharm Inc. Bone stimulating factor
US6290948B1 (en) * 1996-05-14 2001-09-18 Smithkline Beecham Corporation Method of treating sepsis and ARDS using chamohine beta-10
JP2001517422A (ja) * 1997-09-25 2001-10-09 アカデミス・ジーケンハイス・ベイ・デ・ウニフェルジテイト・ファン・アムステルダム 単離したおよび組換えによる抗菌ペプチドトロンボシジン−１（ｔｃ−１）およびトロンボシジン−２（ｔｃ−２）またはその変異体
GB9807721D0 (en) 1998-04-08 1998-06-10 Chiron Spa Antigen
WO2001066734A1 (fr) * 2000-03-07 2001-09-13 Japan Tobacco Inc, Polypeptides capables le pouvoir de stimuler les neutrophiles
US6815421B1 (en) 2001-03-22 2004-11-09 Osteopharm Inc. Polypeptides for use in ameliorating effects of aging in mammals
EP1534752B1 (en) 2002-05-01 2011-08-03 Human Genome Sciences, Inc. Antibodies that specifically bind to chemokine beta-4
US7177246B2 (en) * 2003-09-12 2007-02-13 Hewlett-Packard Development Company, L.P. Optical disk drive focusing apparatus using sum signal
EA029419B1 (ru) 2010-11-19 2018-03-30 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Нейтрализующие антитела против ccl20
KR101993316B1 (ko) * 2017-04-11 2019-06-26 나민자 강아지 배변기
KR102453406B1 (ko) 2020-08-24 2022-10-11 연세흠 반려동물 배변수거기

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897348A (en) * 1983-08-25 1990-01-30 Sri International Recombinant materials and methods for producing human connective tissue-activating peptide-III and analogs thereof
DE3737703A1 (de) * 1987-11-06 1989-05-18 Ferring Arzneimittel Gmbh Neutrophilen aktivierendes polypeptid, verfahren zu dessen herstellung sowie dessen verwendung als arzneimittel und diagnostikum
US5026639A (en) * 1988-01-14 1991-06-25 Nippon Mining Company, Limited Method to improve mRNA translation and use thereof for production of platelet factor-4
JP3051160B2 (ja) * 1988-12-08 2000-06-12 ノバルティス・アクチエンゲゼルシャフト 好中球活性化ペプチド‐２

Also Published As

Publication number Publication date
IL92557A0 (en) 1990-08-31
GB9011468D0 (en) 1990-08-29
KR910700260A (ko) 1991-03-14
AU4655689A (en) 1990-06-26
JPH03503767A (ja) 1991-08-22
US5759533A (en) 1998-06-02
CA2004685A1 (en) 1990-06-08
GB2231872B (en) 1992-07-22
NZ231652A (en) 1993-02-25
JP3051160B2 (ja) 2000-06-12
FI903931A0 (fi) 1990-08-08
DK188690A (da) 1990-08-07
GB2231872A (en) 1990-11-28
FR2640142B1 (fr) 1994-09-23
SE9002589D0 (sv) 1990-08-07
ES2047458A6 (es) 1994-02-16
NL8921262A (nl) 1990-11-01
GR890100810A (en) 1991-03-15
GR1000455B (el) 1992-07-30
DK188690D0 (da) 1990-08-07
BE1003636A4 (fr) 1992-05-12
AU634508B2 (en) 1993-02-25
CH681625A5 (pt) 1993-04-30
SE9002589L (sv) 1990-08-07
FR2640142A1 (fr) 1990-06-15
WO1990006321A1 (en) 1990-06-14

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