GR1000455B - Μεθοδος για την παρασκευη πεπτιδιου-2 που ενεργοποιει ουδετεφιλα. - Google Patents

Μεθοδος για την παρασκευη πεπτιδιου-2 που ενεργοποιει ουδετεφιλα.

Info

Publication number
GR1000455B
GR1000455B GR890100810A GR890100810A GR1000455B GR 1000455 B GR1000455 B GR 1000455B GR 890100810 A GR890100810 A GR 890100810A GR 890100810 A GR890100810 A GR 890100810A GR 1000455 B GR1000455 B GR 1000455B
Authority
GR
Greece
Prior art keywords
agent
preparation
neutrophil activating
activating peptide
neutrophil
Prior art date
Application number
GR890100810A
Other languages
English (en)
Other versions
GR890100810A (en
Inventor
Marco Dr Prof Baggiolini
Kenneth John Dr Clemetson
Alfred Dr Walz
Original Assignee
Sandoz Ltd
Kocher Theodor Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888828728A external-priority patent/GB8828728D0/en
Priority claimed from GB898909681A external-priority patent/GB8909681D0/en
Application filed by Sandoz Ltd, Kocher Theodor Inst filed Critical Sandoz Ltd
Publication of GR890100810A publication Critical patent/GR890100810A/el
Publication of GR1000455B publication Critical patent/GR1000455B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5421—IL-8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Περιγράφεται ένας νέος παράγοντας που έχει ενεργότητα διέγερσης ουδετεροφίλων και απομονώνεται από λευκοκύτταρα και/η αιμοπετάλια αίματος. Είναι λειτουργικά και δομικά σχετικός με τον παράγοντα ενεργοποίησης ουδετεροφίλων NAF/NAP-1 και σχετίζεται ακόμη δομικά με την β- θρομβοσφαιρίνη, ΡΒΡ και CTAP-III. Η αλληλουχία έχει καθιερωθεί. Το μοριακό βάρος του παράγοντα είναι περίπου 6500-7700. 'Εχουν επίσης βρεθεί 3 παραλλαγές. Ο παράγοντας μπορεί να παρασκευασθεί από φυσικές πηγές ή με τεχνικές ανασυνδυαστικού DNA. ω
GR890100810A 1988-12-08 1989-12-06 Μεθοδος για την παρασκευη πεπτιδιου-2 που ενεργοποιει ουδετεφιλα. GR1000455B (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888828728A GB8828728D0 (en) 1988-12-08 1988-12-08 Neutrophil-stimulating activity i
GB898909681A GB8909681D0 (en) 1989-04-27 1989-04-27 Neutrophil-stimulating activity 1

Publications (2)

Publication Number Publication Date
GR890100810A GR890100810A (en) 1991-03-15
GR1000455B true GR1000455B (el) 1992-07-30

Family

ID=26294713

Family Applications (1)

Application Number Title Priority Date Filing Date
GR890100810A GR1000455B (el) 1988-12-08 1989-12-06 Μεθοδος για την παρασκευη πεπτιδιου-2 που ενεργοποιει ουδετεφιλα.

Country Status (19)

Country Link
US (1) US5759533A (el)
JP (1) JP3051160B2 (el)
KR (1) KR910700260A (el)
AU (1) AU634508B2 (el)
BE (1) BE1003636A4 (el)
CA (1) CA2004685A1 (el)
CH (1) CH681625A5 (el)
DK (1) DK188690A (el)
ES (1) ES2047458A6 (el)
FI (1) FI903931A0 (el)
FR (1) FR2640142B1 (el)
GB (1) GB2231872B (el)
GR (1) GR1000455B (el)
IL (1) IL92557A0 (el)
NL (1) NL8921262A (el)
NZ (1) NZ231652A (el)
PT (1) PT92509A (el)
SE (1) SE9002589L (el)
WO (1) WO1990006321A1 (el)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3051160B2 (ja) * 1988-12-08 2000-06-12 ノバルティス・アクチエンゲゼルシャフト 好中球活性化ペプチド‐２
US6673893B1 (en) * 1990-02-01 2004-01-06 University Of South Florida Leukocyte derived growth factor 2
WO1991011515A2 (en) * 1990-02-01 1991-08-08 University Of South Florida Leukocyte-derived growth factor
WO1993001826A1 (en) * 1991-07-19 1993-02-04 East Carolina University Method of treating asthma
AU3071492A (en) * 1991-11-15 1993-06-15 University Of Pennsylvania Suppression of megakaryocytopoiesis by neutrophil activating peptide-2
WO1994016070A1 (en) * 1993-01-07 1994-07-21 University Of South Florida Leukocyte derived growth factors
US5786327A (en) 1993-03-12 1998-07-28 Gensci Regeneration Sciences Inc. Bone stimulating factor, methods of isolating same, and methods of increasing bone growth comprising administering same
US5578569A (en) * 1993-03-12 1996-11-26 Tam; Cherk S. Method of increasing bone growth
US6174995B1 (en) 1994-08-23 2001-01-16 Haodong Li Human chemokines, CKβ4 and CKβ10/MCP-4
US6458349B1 (en) 1995-06-02 2002-10-01 Human Genome Sciences, Inc. Chemokine β-4 polypeptides
US6391589B1 (en) 1994-08-23 2002-05-21 Human Genome Sciences, Inc. Human chemokine beta-10 mutant polypeptides
US5912232A (en) * 1994-09-23 1999-06-15 Board Of Regents Of The University Of Nebraska Anti-inflammatory polypeptide antagonists of human I1-8
US5880094A (en) * 1995-06-07 1999-03-09 Osteopharm Limited Polypeptides that stimulate bone growth
US6117839A (en) * 1995-06-07 2000-09-12 Gensci Regeneration Sciences, Inc. Bone stimulating factor
US6352973B1 (en) 1995-06-07 2002-03-05 Osteopharm Inc. Bone stimulating factor
US6693081B2 (en) * 1995-09-26 2004-02-17 Osteopharm Inc. Bone stimulating factor
US6290948B1 (en) * 1996-05-14 2001-09-18 Smithkline Beecham Corporation Method of treating sepsis and ARDS using chamohine beta-10
JP2001517422A (ja) * 1997-09-25 2001-10-09 アカデミス・ジーケンハイス・ベイ・デ・ウニフェルジテイト・ファン・アムステルダム 単離したおよび組換えによる抗菌ペプチドトロンボシジン−１（ｔｃ−１）およびトロンボシジン−２（ｔｃ−２）またはその変異体
GB9807721D0 (en) * 1998-04-08 1998-06-10 Chiron Spa Antigen
EP1295943B1 (en) * 2000-03-07 2009-06-03 Japan Tobacco Inc. Polypeptides having activity of stimulating neutrophils
US6815421B1 (en) 2001-03-22 2004-11-09 Osteopharm Inc. Polypeptides for use in ameliorating effects of aging in mammals
EP1534752B1 (en) 2002-05-01 2011-08-03 Human Genome Sciences, Inc. Antibodies that specifically bind to chemokine beta-4
US7177246B2 (en) * 2003-09-12 2007-02-13 Hewlett-Packard Development Company, L.P. Optical disk drive focusing apparatus using sum signal
MX361929B (es) 2010-11-19 2018-12-19 Eisai R&D Man Co Ltd Star Anticuerpos anti-ligando de quimiocina cc 20 (ccl20) neutralizantes.
KR101993316B1 (ko) * 2017-04-11 2019-06-26 나민자 강아지 배변기
KR102453406B1 (ko) 2020-08-24 2022-10-11 연세흠 반려동물 배변수거기

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897348A (en) * 1983-08-25 1990-01-30 Sri International Recombinant materials and methods for producing human connective tissue-activating peptide-III and analogs thereof
DE3737703A1 (de) * 1987-11-06 1989-05-18 Ferring Arzneimittel Gmbh Neutrophilen aktivierendes polypeptid, verfahren zu dessen herstellung sowie dessen verwendung als arzneimittel und diagnostikum
US5026639A (en) * 1988-01-14 1991-06-25 Nippon Mining Company, Limited Method to improve mRNA translation and use thereof for production of platelet factor-4
JP3051160B2 (ja) * 1988-12-08 2000-06-12 ノバルティス・アクチエンゲゼルシャフト 好中球活性化ペプチド‐２

Also Published As

Publication number Publication date
JPH03503767A (ja) 1991-08-22
FR2640142B1 (fr) 1994-09-23
DK188690D0 (da) 1990-08-07
KR910700260A (ko) 1991-03-14
SE9002589D0 (sv) 1990-08-07
CA2004685A1 (en) 1990-06-08
AU634508B2 (en) 1993-02-25
NL8921262A (nl) 1990-11-01
AU4655689A (en) 1990-06-26
SE9002589L (sv) 1990-08-07
NZ231652A (en) 1993-02-25
CH681625A5 (el) 1993-04-30
GR890100810A (en) 1991-03-15
GB9011468D0 (en) 1990-08-29
JP3051160B2 (ja) 2000-06-12
GB2231872B (en) 1992-07-22
DK188690A (da) 1990-08-07
ES2047458A6 (es) 1994-02-16
PT92509A (pt) 1990-06-29
IL92557A0 (en) 1990-08-31
WO1990006321A1 (en) 1990-06-14
US5759533A (en) 1998-06-02
BE1003636A4 (fr) 1992-05-12
FR2640142A1 (fr) 1990-06-15
FI903931A0 (fi) 1990-08-08
GB2231872A (en) 1990-11-28

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