GR880100775A - Παράγοντας ενεργοποιήσεως ουδετεροφίλων. - Google Patents

Παράγοντας ενεργοποιήσεως ουδετεροφίλων.

Info

Publication number
GR880100775A
GR880100775A GR880100775A GR880100775A GR880100775A GR 880100775 A GR880100775 A GR 880100775A GR 880100775 A GR880100775 A GR 880100775A GR 880100775 A GR880100775 A GR 880100775A GR 880100775 A GR880100775 A GR 880100775A
Authority
GR
Greece
Prior art keywords
glu
lys
leu
val
ile
Prior art date
Application number
GR880100775A
Other languages
English (en)
Inventor
Heinrich Dr Aschauer
James Daldon Ivan Dr Lindley
Paola Dr Peveri
Alfred Dr Walz
Original Assignee
Sandoz Ag
Kocher Theodor Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27263673&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR880100775(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB878727053A external-priority patent/GB8727053D0/en
Priority claimed from GB888805070A external-priority patent/GB8805070D0/en
Priority claimed from GB888825258A external-priority patent/GB8825258D0/en
Application filed by Sandoz Ag, Kocher Theodor Inst filed Critical Sandoz Ag
Publication of GR880100775A publication Critical patent/GR880100775A/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5421—IL-8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Βιολογικώς δραστικός καθαρός παράγων ενεργοποιήσεως ουδετεροφίλου (NAF) απομονούται από ανθρώπινα μονοκύτταρα ή μετά από έκφρασιν ενος συνθετικού NAF γένους εις Ε. Coli. 'Εχει την ακόλουθο σειρά αμινοξέος:Ser-Ala-Lys-Glu-Leu-Arg-Cys-Gln-Cys-Ile-Lys-Thr-Tyr-Ser-Lys-Pro-Phe-His-Pro-Lys-Phe-Ile-His-Glu-Leu-Arg-Val-Ile-Glu-Ser-Gly- Pro-His-Gys-Ala-Asn-Thr-Glu-Ile-Lie-Val-Lys-Leu-Ser-Asp-Gly-Arg-Glu-Leu-Cys-Leu-Asp-Pro-Lys-Glu-Asn-Trp-Val-Gln-Arg-Val-Val-Glu- Lys-Phe-Leu-Lys-ArgAla-Glu-Asn-Ser.Υπάρχουν τρεις άλλες ελάχιστες παραλλαγές με μακρύτερες και βραχύτερες σειρές.Το φυσικό και συνθετικό NAF έχουν όμοια δομή και βιολογικές ιδιότητες.ω
GR880100775A 1987-11-19 1988-11-16 Παράγοντας ενεργοποιήσεως ουδετεροφίλων. GR880100775A (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878727053A GB8727053D0 (en) 1987-11-19 1987-11-19 Neutrophil-activating factor(naf)
GB888805070A GB8805070D0 (en) 1988-03-03 1988-03-03 Neutrophil-activating factor(naf)
GB888825258A GB8825258D0 (en) 1988-10-28 1988-10-28 Neutrophil-activating factor

Publications (1)

Publication Number Publication Date
GR880100775A true GR880100775A (el) 1994-03-31

Family

ID=27263673

Family Applications (1)

Application Number Title Priority Date Filing Date
GR880100775A GR880100775A (el) 1987-11-19 1988-11-16 Παράγοντας ενεργοποιήσεως ουδετεροφίλων.

Country Status (23)

Country Link
US (1) US6383479B1 (el)
JP (1) JP3133305B2 (el)
KR (1) KR890701625A (el)
AT (1) ATA901588A (el)
AU (1) AU622125B2 (el)
BE (1) BE1001817A5 (el)
CH (1) CH680001A5 (el)
DE (2) DE3890998T1 (el)
DK (1) DK354389A (el)
ES (1) ES2014546A6 (el)
FI (1) FI893474A0 (el)
FR (1) FR2623400B1 (el)
GB (1) GB2223225B (el)
GR (1) GR880100775A (el)
HU (1) HU205617B (el)
IL (1) IL88404A0 (el)
IT (1) IT1224574B (el)
NL (1) NL194982C (el)
NZ (1) NZ226990A (el)
PL (1) PL275881A1 (el)
PT (1) PT89026B (el)
SE (1) SE8902507L (el)
WO (1) WO1989004836A1 (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5652338A (en) * 1988-03-16 1997-07-29 The United States Of America As Represented By The Department Of Health And Human Services Neutrophil chemotactic factor
KR900701834A (ko) * 1988-07-07 1990-12-04 원본미기재 사람 호중구 화학주성 인자를 사람에게 투여하는 것에 의한 면역결핍 상태에 의해 유발된 질병의 치료방법
JPH04500076A (ja) * 1988-08-15 1992-01-09 ブリガム・アンド・ウイメンズ・ホスピタル 白血球付着阻害物質
JP3053631B2 (ja) * 1988-08-29 2000-06-19 アメリカ合衆国 活性型ヒト好中球走化因子ポリペプチドの製造方法
JP2844260B2 (ja) * 1988-11-10 1999-01-06 ステファン チャールズ マックケイブ シャワーヘッド組立体
US5241049A (en) * 1989-12-22 1993-08-31 Zymogenetics, Inc. Neutrophil chemoattractants
US5079228A (en) * 1990-02-05 1992-01-07 Board Of Regents, The University Of Texas System Peptide inhibitors of neutrophil activating factor induced chemotaxis
IE913192A1 (en) * 1990-09-12 1992-02-25 Scripps Research Inst Active site of interleukin-8: polypeptide analogs and¹antibodies
WO1993001826A1 (en) * 1991-07-19 1993-02-04 East Carolina University Method of treating asthma
US5401651A (en) * 1991-10-16 1995-03-28 Walz; Alfred DNA encoding ENA-78, a neutrophil activating factor
GB9124775D0 (en) * 1991-11-21 1992-01-15 Medical Res Council Cervical ripening
EP0616615B1 (en) * 1991-12-04 1998-08-12 The Biomedical Research Centre Limited Human interleukin-8 analogs
GB9807721D0 (en) * 1998-04-08 1998-06-10 Chiron Spa Antigen
CA3143956A1 (en) * 2019-06-27 2020-12-30 Binary, Llc Oxidase-based chemiluminescence assay of phagocytic leukocytes in whole blood and body fluids applicable to point-of-care (poc) diagnostic testing point-of-care (poc) measurement of absolute neutrophil function (anf))

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3737703A1 (de) * 1987-11-06 1989-05-18 Ferring Arzneimittel Gmbh Neutrophilen aktivierendes polypeptid, verfahren zu dessen herstellung sowie dessen verwendung als arzneimittel und diagnostikum
US5652338A (en) * 1988-03-16 1997-07-29 The United States Of America As Represented By The Department Of Health And Human Services Neutrophil chemotactic factor
EP0413818B1 (en) 1988-05-02 1994-12-28 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY of the DEPARTMENT OF HEALTH AND HUMAN SERVICES Process for producing a human neutrophil chemotactic factor polypeptide
JPH04500076A (ja) 1988-08-15 1992-01-09 ブリガム・アンド・ウイメンズ・ホスピタル 白血球付着阻害物質
AU4665689A (en) * 1989-12-11 1991-07-18 Wallac Oy Elastic scintillator material

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 104, no. 25, 23rd June 1986, page 478, abstract no. 223310t, Columbus, Ohio, US; E. KOWNATZKI et al.: "Novel neutrophil chemotactic factor derived from human peripheral blood mononuclear leukocytes", & CLIN. EXP. IMMUNOL. 1986, 64(1) 214-22 *
CLAIMS SEARCHED: ALL *
THE JOURNAL OF IMMUNOLOGY, vol. 139, no. 1, 1st July 1987, The American Association of Immunologists, US; J. SCHMID et al.: "Induction of mRNA for a serine protease and a beta-thrombo-globulin-like protein in mitogen-stimulated human leukocytes", pages 250-256 *
THE JOURNAL OF IMMUNOLOGY, vol. 139, no. 10, 15th November 1987, The American Association of Immunologists, US; J.-M. SCHR\DER et al.: "Purification and partial biochemical characterization of a human monocyte-derived, neutrophil-activating peptide that lacks interleukin 1 activity", pages 3474-3483 *
THE JOURNAL OF IMMUNOLOGY, vol. 139, no. 3, 1st August 1987, The American Association of Immunologists, US; T. YOSHIMURA et al.: "Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from interleukin 1 (IL 1)", pages 788-793 *

Also Published As

Publication number Publication date
HU886790D0 (en) 1990-01-28
BE1001817A5 (fr) 1990-03-13
IT8848572A0 (it) 1988-11-18
ATA901588A (de) 1994-07-15
CH680001A5 (el) 1992-05-29
DE3890998T1 (de) 1991-02-21
SE8902507D0 (sv) 1989-07-11
AU622125B2 (en) 1992-04-02
SE8902507L (sv) 1989-07-11
WO1989004836A1 (en) 1989-06-01
PL275881A1 (en) 1989-07-24
FR2623400A1 (fr) 1989-05-26
GB2223225A (en) 1990-04-04
GB2223225B (en) 1992-07-08
GB8913271D0 (en) 1989-12-06
PT89026B (pt) 1993-02-26
JP3133305B2 (ja) 2001-02-05
HU205617B (en) 1992-05-28
HUT52551A (en) 1990-07-28
FR2623400B1 (fr) 1995-06-23
AU2716288A (en) 1989-06-14
IT1224574B (it) 1990-10-04
KR890701625A (ko) 1989-12-21
IL88404A0 (en) 1989-06-30
NL194982C (nl) 2003-04-10
DK354389A (da) 1989-09-19
JPH02502825A (ja) 1990-09-06
FI893474A (fi) 1989-07-18
DK354389D0 (da) 1989-07-18
FI893474A0 (fi) 1989-07-18
DE3890998B4 (de) 2008-01-03
NL8820928A (nl) 1989-10-02
NZ226990A (en) 1991-10-25
US6383479B1 (en) 2002-05-07
PT89026A (pt) 1988-12-01
ES2014546A6 (es) 1990-07-16

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