IT8919730A0 - Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche. - Google Patents
Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche.Info
- Publication number
- IT8919730A0 IT8919730A0 IT8919730A IT1973089A IT8919730A0 IT 8919730 A0 IT8919730 A0 IT 8919730A0 IT 8919730 A IT8919730 A IT 8919730A IT 1973089 A IT1973089 A IT 1973089A IT 8919730 A0 IT8919730 A0 IT 8919730A0
- Authority
- IT
- Italy
- Prior art keywords
- bronchodilatator
- activity
- therapeutic applications
- xanthine derivatives
- xanthine
- Prior art date
Links
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 title 1
- 239000003465 bronchodilatator Substances 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 229940083747 low-ceiling diuretics xanthine derivative Drugs 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8919730A IT1229195B (it) | 1989-03-10 | 1989-03-10 | Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche. |
DE199090104229T DE386683T1 (de) | 1989-03-10 | 1990-03-05 | Xanthinderivate mit bronchodilatorischer aktivitaet, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate. |
EP19900104229 EP0386683A3 (en) | 1989-03-10 | 1990-03-05 | Xanthine derivatives having bronchodilating activity, a process for the preparation thereof and pharmaceutical compositions containing them |
ES90104229T ES2017899A4 (es) | 1989-03-10 | 1990-03-05 | Derivados xantino que tienen actividad broncodilatadora, un proceso para la preparacion de ello y compuestos farmaceuticos que los contienen |
JP2057835A JPH03200787A (ja) | 1989-03-10 | 1990-03-08 | キサンチン誘導体、その製造法及びそれらを含む気管支拡張剤 |
GR90300160T GR900300160T1 (en) | 1989-03-10 | 1991-09-27 | Xanthine derivatives having bronchodilating activity, a process for the preparation thereof and pharmaceutical compositions containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8919730A IT1229195B (it) | 1989-03-10 | 1989-03-10 | Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche. |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8919730A0 true IT8919730A0 (it) | 1989-03-10 |
IT1229195B IT1229195B (it) | 1991-07-25 |
Family
ID=11160729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT8919730A IT1229195B (it) | 1989-03-10 | 1989-03-10 | Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0386683A3 (it) |
JP (1) | JPH03200787A (it) |
DE (1) | DE386683T1 (it) |
ES (1) | ES2017899A4 (it) |
GR (1) | GR900300160T1 (it) |
IT (1) | IT1229195B (it) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9020921D0 (en) * | 1990-09-26 | 1990-11-07 | Beecham Group Plc | Novel compounds |
GB9210839D0 (en) * | 1992-05-21 | 1992-07-08 | Smithkline Beecham Plc | Novel compounds |
GB9312853D0 (en) | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
US5591776A (en) | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
US5922751A (en) | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
JPH10508032A (ja) | 1994-12-13 | 1998-08-04 | ユーロ−セルティーク,エス.エイ. | アリールチオキサンチン類 |
AU4527996A (en) | 1994-12-13 | 1996-07-03 | Euro-Celtique S.A. | Trisubstituted thioxanthines |
US6166041A (en) | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
US6075016A (en) | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
US5864037A (en) * | 1996-06-06 | 1999-01-26 | Euro-Celtique, S.A. | Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity |
US6403567B1 (en) | 1999-06-22 | 2002-06-11 | Cv Therapeutics, Inc. | N-pyrazole A2A adenosine receptor agonists |
USRE47351E1 (en) | 1999-06-22 | 2019-04-16 | Gilead Sciences, Inc. | 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists |
US6815446B1 (en) | 1999-08-31 | 2004-11-09 | Vanderbilt University | Selective antagonists of A2B adenosine receptors |
EP1251130B1 (en) | 1999-12-24 | 2005-02-16 | Kyowa Hakko Kogyo Co., Ltd. | Fused purine derivatives |
US20020012946A1 (en) | 2000-02-23 | 2002-01-31 | Luiz Belardinelli | Method of identifying partial agonists of the A2A receptor |
GB0005199D0 (en) * | 2000-03-04 | 2000-04-26 | Imp College Innovations Ltd | Modulation of histone deacetylase |
US7125993B2 (en) | 2001-11-09 | 2006-10-24 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
US7317017B2 (en) | 2002-11-08 | 2008-01-08 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
PL370207A1 (en) | 2001-11-09 | 2005-05-16 | Cv Therapeutics, Inc. | A2b adenosine receptor antagonists |
US6977300B2 (en) | 2001-11-09 | 2005-12-20 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
WO2003043637A1 (en) * | 2001-11-20 | 2003-05-30 | Bristol-Myers Squibb Pharma Company | 3,7-dihydro-purine-2,6-dione derivatives as crf receptor ligands |
US20050020915A1 (en) | 2002-07-29 | 2005-01-27 | Cv Therapeutics, Inc. | Myocardial perfusion imaging methods and compositions |
KR20050026546A (ko) | 2002-07-29 | 2005-03-15 | 씨브이 쎄러퓨틱스, 인코포레이티드 | A2a 수용체 작용제를 이용한 심근 관류 조영 |
US8470801B2 (en) | 2002-07-29 | 2013-06-25 | Gilead Sciences, Inc. | Myocardial perfusion imaging methods and compositions |
WO2006044856A2 (en) | 2004-10-20 | 2006-04-27 | Cv Therapeuitics, Inc. | Use of a2a adenosine receptor agonists |
KR101494125B1 (ko) | 2006-02-03 | 2015-02-16 | 길리애드 사이언시즈, 인코포레이티드 | A2a-아데노신 수용체 효능제 및 이의 다형체의 제조 방법 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1245969B (de) * | 1967-08-03 | VEB Arzneimittelwerk Dresden, Radebeul | Verfahren zur Herstellung von Xanthinderivaten | |
CA1077932A (en) * | 1976-03-31 | 1980-05-20 | Berlex Laboratories, Inc. | Xanthine compounds and method of treating bronchospastic and allergic diseases |
SE416810C (sv) * | 1977-10-14 | 1982-07-19 | Draco Ab | Forfarande for framstellning av xantinderivat med antiallergisk aktivitet |
SE7810947L (sv) * | 1978-10-20 | 1980-04-21 | Draco Ab | 3-alkylxanthines |
SE7810946L (sv) * | 1978-10-20 | 1980-04-21 | Draco Ab | Metod att behandla kronisk obstruktiv luftvegssjukdom |
US4338319A (en) * | 1979-11-27 | 1982-07-06 | Aktiebolaget Draco | Method for the treatment of chronic obstructive airway or cardiac diseases |
SE8002910L (sv) * | 1980-04-18 | 1981-10-19 | Draco Ab | 3,8-dialkylxantiner, forfarande for deras framstellning, beredning och metoder for behandling av kronisk obstruktiv luftvegssjukdom och kardiovaskulera sjukdomar |
SE8602887D0 (sv) * | 1986-06-27 | 1986-06-27 | Draco Ab | New chemical method |
-
1989
- 1989-03-10 IT IT8919730A patent/IT1229195B/it active
-
1990
- 1990-03-05 ES ES90104229T patent/ES2017899A4/es active Pending
- 1990-03-05 EP EP19900104229 patent/EP0386683A3/en not_active Withdrawn
- 1990-03-05 DE DE199090104229T patent/DE386683T1/de active Pending
- 1990-03-08 JP JP2057835A patent/JPH03200787A/ja active Pending
-
1991
- 1991-09-27 GR GR90300160T patent/GR900300160T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR900300160T1 (en) | 1991-09-27 |
JPH03200787A (ja) | 1991-09-02 |
IT1229195B (it) | 1991-07-25 |
EP0386683A3 (en) | 1992-01-15 |
DE386683T1 (de) | 1991-02-07 |
EP0386683A2 (en) | 1990-09-12 |
ES2017899A4 (es) | 1991-03-16 |
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