DE69226649D1 - Analoge des menschlichen Interleukin-8. - Google Patents
Analoge des menschlichen Interleukin-8.Info
- Publication number
- DE69226649D1 DE69226649D1 DE69226649T DE69226649T DE69226649D1 DE 69226649 D1 DE69226649 D1 DE 69226649D1 DE 69226649 T DE69226649 T DE 69226649T DE 69226649 T DE69226649 T DE 69226649T DE 69226649 D1 DE69226649 D1 DE 69226649D1
- Authority
- DE
- Germany
- Prior art keywords
- analogs
- pct
- leu5
- human interleukin
- arg6
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 101001055222 Homo sapiens Interleukin-8 Proteins 0.000 title abstract 3
- 102000052624 human CXCL8 Human genes 0.000 title abstract 3
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical class C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 abstract 9
- 102000004890 Interleukin-8 Human genes 0.000 abstract 5
- 108090001007 Interleukin-8 Proteins 0.000 abstract 5
- 229940096397 interleukin-8 Drugs 0.000 abstract 5
- 102100038796 E3 ubiquitin-protein ligase TRIM13 Human genes 0.000 abstract 3
- 101000664589 Homo sapiens E3 ubiquitin-protein ligase TRIM13 Proteins 0.000 abstract 3
- 101100491597 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) arg-6 gene Proteins 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000000440 neutrophil Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5421—IL-8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/141—Interleukin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80157891A | 1991-12-04 | 1991-12-04 | |
| PCT/CA1992/000528 WO1993011159A1 (en) | 1991-12-04 | 1992-12-03 | Human interleukin-8 analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69226649D1 true DE69226649D1 (de) | 1998-09-17 |
Family
ID=25181500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69226649T Expired - Lifetime DE69226649D1 (de) | 1991-12-04 | 1992-12-03 | Analoge des menschlichen Interleukin-8. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5665346A (de) |
| EP (1) | EP0616615B1 (de) |
| AT (1) | ATE169638T1 (de) |
| AU (1) | AU3078892A (de) |
| CA (1) | CA2124461A1 (de) |
| DE (1) | DE69226649D1 (de) |
| WO (1) | WO1993011159A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6258550B1 (en) | 1993-04-23 | 2001-07-10 | Virginia Commonwealth University | Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site |
| NZ273052A (en) | 1993-09-14 | 1997-12-19 | Imperial College | Chemoattractant protein capable of attracting eosinophils and inducing accumulation thereof |
| EP0766737A2 (de) * | 1994-06-20 | 1997-04-09 | Chiron Corporation | Polypeptide mit interleukin-8 rezeptor 1 (il8r1) bindungsdomänen |
| US5627156A (en) * | 1994-09-23 | 1997-05-06 | University Of Nebraska Board Of Regents | Polypeptide agonists for human interleukin-8 |
| AU3681795A (en) * | 1994-09-23 | 1996-04-09 | University Of Nebraska Board Of Regents | Polypeptide agonists and antagonists of human interleukin-8 |
| US5912232A (en) * | 1994-09-23 | 1999-06-15 | Board Of Regents Of The University Of Nebraska | Anti-inflammatory polypeptide antagonists of human I1-8 |
| US5656724A (en) * | 1994-10-26 | 1997-08-12 | Repligen Corporation | Chemokine-like proteins and methods of use |
| US5789539A (en) * | 1994-10-26 | 1998-08-04 | Repligen Corporation | Chemokine-like proteins and methods of use |
| AU6283996A (en) * | 1995-06-20 | 1997-01-22 | Chiron Corporation | Polypeptides with interleukin-8 receptor binding |
| US6989435B2 (en) | 1997-09-11 | 2006-01-24 | Cambridge University Technical Services Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
| US7067117B1 (en) | 1997-09-11 | 2006-06-27 | Cambridge University Technical Services, Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
| US7238711B1 (en) | 1999-03-17 | 2007-07-03 | Cambridge University Technical Services Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
| US20060233748A1 (en) * | 2002-09-13 | 2006-10-19 | Ahmed Merzouk | Mimetics of interleukin-8 and methods of using them in the prevention, treatment, diagnosis, and ameliorization of symptoms of a disease |
| US7091310B2 (en) * | 2002-09-13 | 2006-08-15 | Chemokine Therapeutics Corporation | Chemokine analogs for the treatment of human disease |
| US20070116669A1 (en) * | 2002-09-13 | 2007-05-24 | Chemokine Therapeutics Corporation | Interferon-inducible protein-10 (IP-10 or CXCL10) chemokine analogs for the treatment of human diseases |
| DK1363944T3 (da) * | 2001-03-01 | 2007-01-08 | Univ Saskatchewan | Höjaffinitetsantagonister for ELR-CXC-kemokiner |
| CA2534828A1 (en) * | 2003-10-22 | 2005-05-06 | Applied Research Systems Ars Holding N.V. | Novel cxcl8 antagonists |
| EP1894571A1 (de) * | 2006-08-29 | 2008-03-05 | Protaffin Biotechnologie AG | Verwendung von modifizierten IL-8 Proteinen zur Behandlung von Reperfusionsschäden und Transplantatabstossung |
| US20120288474A1 (en) * | 2009-11-06 | 2012-11-15 | Protaffin Biotechnologie Ag | Composition for treatment of cxcl8-mediated lung inflammation |
| EP3315510A4 (de) * | 2015-06-03 | 2019-02-20 | Rise Biopharmaceuticals, Inc. (Beijing) | Modifiziertes chemokinpeptid |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5093242A (en) * | 1986-10-02 | 1992-03-03 | Massachusetts Institute Of Technology | Methods of generating desired amino-terminal residues in proteins |
| ATA901588A (de) * | 1987-11-19 | 1994-07-15 | Sandoz Ag | Von humanmonozyten abgeleiteter neutrophilenaktivierungsfaktor (naf) und verfahren zu seiner herstellung |
| JPH04500076A (ja) * | 1988-08-15 | 1992-01-09 | ブリガム・アンド・ウイメンズ・ホスピタル | 白血球付着阻害物質 |
| EP0502897A4 (en) * | 1989-11-29 | 1993-03-03 | Brigham And Women's Hospital | Endothelial-derived il-8 |
| JPH05503512A (ja) * | 1989-11-29 | 1993-06-10 | ブリガム・アンド・ウイメンズ・ホスピタル | 白血球接着阻害因子としての［ａｌａ ｉｌ―８］↓７↓７ |
| US5079228A (en) * | 1990-02-05 | 1992-01-07 | Board Of Regents, The University Of Texas System | Peptide inhibitors of neutrophil activating factor induced chemotaxis |
| IE913192A1 (en) * | 1990-09-12 | 1992-02-25 | Scripps Research Inst | Active site of interleukin-8: polypeptide analogs and¹antibodies |
| WO1993001826A1 (en) * | 1991-07-19 | 1993-02-04 | East Carolina University | Method of treating asthma |
-
1992
- 1992-12-03 AT AT92924514T patent/ATE169638T1/de not_active IP Right Cessation
- 1992-12-03 CA CA002124461A patent/CA2124461A1/en not_active Abandoned
- 1992-12-03 DE DE69226649T patent/DE69226649D1/de not_active Expired - Lifetime
- 1992-12-03 EP EP92924514A patent/EP0616615B1/de not_active Expired - Lifetime
- 1992-12-03 US US08/244,702 patent/US5665346A/en not_active Expired - Fee Related
- 1992-12-03 AU AU30788/92A patent/AU3078892A/en not_active Abandoned
- 1992-12-03 WO PCT/CA1992/000528 patent/WO1993011159A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP0616615B1 (de) | 1998-08-12 |
| CA2124461A1 (en) | 1993-06-10 |
| EP0616615A1 (de) | 1994-09-28 |
| ATE169638T1 (de) | 1998-08-15 |
| US5665346A (en) | 1997-09-09 |
| AU3078892A (en) | 1993-06-28 |
| WO1993011159A1 (en) | 1993-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |