PT92399B - Processo para a preparacao de acidos fenilalifatilaminoalcano-difosfonicos - Google Patents

Processo para a preparacao de acidos fenilalifatilaminoalcano-difosfonicos Download PDF

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Publication number
PT92399B
PT92399B PT92399A PT9239989A PT92399B PT 92399 B PT92399 B PT 92399B PT 92399 A PT92399 A PT 92399A PT 9239989 A PT9239989 A PT 9239989A PT 92399 B PT92399 B PT 92399B
Authority
PT
Portugal
Prior art keywords
formula
compound
radical
alkyl
salt
Prior art date
Application number
PT92399A
Other languages
English (en)
Portuguese (pt)
Other versions
PT92399A (pt
Inventor
Knut A Jaeggi
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of PT92399A publication Critical patent/PT92399A/pt
Publication of PT92399B publication Critical patent/PT92399B/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)
PT92399A 1988-11-28 1989-11-24 Processo para a preparacao de acidos fenilalifatilaminoalcano-difosfonicos PT92399B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH440488 1988-11-28

Publications (2)

Publication Number Publication Date
PT92399A PT92399A (pt) 1990-05-31
PT92399B true PT92399B (pt) 1995-08-09

Family

ID=4275504

Family Applications (1)

Application Number Title Priority Date Filing Date
PT92399A PT92399B (pt) 1988-11-28 1989-11-24 Processo para a preparacao de acidos fenilalifatilaminoalcano-difosfonicos

Country Status (21)

Country Link
US (1) US5162310A (enExample)
EP (1) EP0371921B1 (enExample)
JP (1) JPH02184694A (enExample)
KR (1) KR900007858A (enExample)
AT (1) ATE106889T1 (enExample)
AU (1) AU624449B2 (enExample)
CA (1) CA2003766A1 (enExample)
DD (1) DD289276A5 (enExample)
DE (1) DE58907831D1 (enExample)
DK (1) DK170303B1 (enExample)
ES (1) ES2055157T3 (enExample)
FI (1) FI92705C (enExample)
HU (1) HU206119B (enExample)
IE (1) IE64074B1 (enExample)
IL (1) IL92380A0 (enExample)
MX (1) MX18478A (enExample)
NO (1) NO176569C (enExample)
NZ (1) NZ231521A (enExample)
PT (1) PT92399B (enExample)
TW (1) TW198039B (enExample)
ZA (1) ZA899024B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0541037A3 (en) * 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
HUT69699A (en) * 1992-05-29 1995-09-28 Procter & Gamble Pharma Sulfur-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism
CZ295994A3 (en) * 1992-05-29 1995-10-18 Procter & Gamble Pharma Thiosubstituted heterocyclic phosphonate compounds containing nitrogen for treating abnormal metabolism of calcium and phosphate
US5753634A (en) * 1992-05-29 1998-05-19 The Procter & Gamble Company Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
RU2126414C1 (ru) * 1992-05-29 1999-02-20 Дзе Проктер энд Гэмбл Фармасьютикалз, Инк. Содержащие четвертичный азот фосфонаты для лечения анормального кальциевого и фосфатного метаболизма, а также профилактики и лечения зубных налетов и зубных камней, фармацевтические композиции и способ лечения
US5763611A (en) * 1992-05-29 1998-06-09 The Procter & Gamble Company Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
US5391743A (en) * 1992-05-29 1995-02-21 Procter & Gamble Pharmaceuticals, Inc. Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
EP0650361B1 (en) * 1992-06-30 1999-04-28 PROCTER & GAMBLE PHARMACEUTICALS, INC. Compositions for the treatment of arthritis containing phosphonates and nsaids
US5591730A (en) * 1993-10-12 1997-01-07 The Regents Of The University Of California Inhibition of urinary calculi growth
US6315566B1 (en) 1999-05-18 2001-11-13 3M Innovative Properties Company Dental materials
US6143919A (en) * 1999-05-18 2000-11-07 3M Innovative Properties Company Polymerizable acidic compounds and methods of preparation
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
JP5828607B2 (ja) * 2005-02-01 2015-12-09 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ イバンドロネート多形ｂ
CN101111504B (zh) * 2005-02-01 2011-12-21 霍夫曼-拉罗奇有限公司 伊班膦酸盐多晶型物a
CN111542471A (zh) 2017-08-21 2020-08-14 劲锋铁马股份有限公司 具有夹紧连接的自行车塔轮

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
DE3428524A1 (de) * 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
DE3540150A1 (de) * 1985-11-13 1987-05-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3623397A1 (de) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3881659D1 (en) * 1987-12-11 1993-07-15 Ciba Geigy Ag Araliphatylaminoalkandiphosphonsaeuren.

Also Published As

Publication number Publication date
NO176569B (no) 1995-01-16
IE64074B1 (en) 1995-07-12
JPH02184694A (ja) 1990-07-19
TW198039B (enExample) 1993-01-11
KR900007858A (ko) 1990-06-02
DD289276A5 (de) 1991-04-25
EP0371921B1 (de) 1994-06-08
CA2003766A1 (en) 1990-05-28
EP0371921A2 (de) 1990-06-06
HUT52515A (en) 1990-07-28
NO176569C (no) 1995-04-26
PT92399A (pt) 1990-05-31
ES2055157T3 (es) 1994-08-16
MX18478A (es) 1994-01-31
ZA899024B (en) 1990-08-29
DK170303B1 (da) 1995-07-31
ATE106889T1 (de) 1994-06-15
DK596489A (da) 1990-05-29
NO894727L (no) 1990-05-29
US5162310A (en) 1992-11-10
FI92705C (fi) 1994-12-27
FI895634A0 (fi) 1989-11-24
AU624449B2 (en) 1992-06-11
AU4546789A (en) 1990-05-31
HU206119B (en) 1992-08-28
FI92705B (fi) 1994-09-15
IE893772L (en) 1990-05-28
IL92380A0 (en) 1990-07-26
DK596489D0 (da) 1989-11-27
EP0371921A3 (en) 1990-08-22
DE58907831D1 (de) 1994-07-14
NZ231521A (en) 1990-12-21
NO894727D0 (no) 1989-11-27

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FG3A Patent granted, date of granting

Effective date: 19950404

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Effective date: 19961031