PT923566E - Profarmacos de base polimerica de elevado peso molecular - Google Patents

Profarmacos de base polimerica de elevado peso molecular

Info

Publication number
PT923566E
PT923566E PT97938484T PT97938484T PT923566E PT 923566 E PT923566 E PT 923566E PT 97938484 T PT97938484 T PT 97938484T PT 97938484 T PT97938484 T PT 97938484T PT 923566 E PT923566 E PT 923566E
Authority
PT
Portugal
Prior art keywords
molecular weight
profilmacles
high molecular
substituted
polymeric base
Prior art date
Application number
PT97938484T
Other languages
English (en)
Inventor
Richard B Greenwald
Annapurna Pendri
Hong Zhao
Original Assignee
Enzon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzon Inc filed Critical Enzon Inc
Publication of PT923566E publication Critical patent/PT923566E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
PT97938484T 1996-08-20 1997-08-20 Profarmacos de base polimerica de elevado peso molecular PT923566E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/700,269 US5840900A (en) 1993-10-20 1996-08-20 High molecular weight polymer-based prodrugs

Publications (1)

Publication Number Publication Date
PT923566E true PT923566E (pt) 2004-03-31

Family

ID=24812855

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97938484T PT923566E (pt) 1996-08-20 1997-08-20 Profarmacos de base polimerica de elevado peso molecular

Country Status (13)

Country Link
US (1) US5840900A (pt)
EP (1) EP0923566B1 (pt)
JP (2) JP5008783B2 (pt)
AT (1) ATE253060T1 (pt)
AU (1) AU730244B2 (pt)
CA (1) CA2263409C (pt)
DE (1) DE69725862T2 (pt)
DK (1) DK0923566T3 (pt)
ES (1) ES2210564T3 (pt)
NZ (1) NZ334283A (pt)
PT (1) PT923566E (pt)
SI (1) SI0923566T1 (pt)
WO (1) WO1998007713A1 (pt)

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AU4079497A (en) 1998-03-06
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AU730244B2 (en) 2001-03-01
EP0923566A4 (en) 2001-10-10
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CA2263409C (en) 2011-02-22
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CA2263409A1 (en) 1998-02-26
DE69725862T2 (de) 2004-08-19
US5840900A (en) 1998-11-24
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EP0923566A1 (en) 1999-06-23

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