PT90619A - Processo para a preparacao de compostos de piperazina - Google Patents

Processo para a preparacao de compostos de piperazina

Info

Publication number
PT90619A
PT90619A PT90619A PT9061989A PT90619A PT 90619 A PT90619 A PT 90619A PT 90619 A PT90619 A PT 90619A PT 9061989 A PT9061989 A PT 9061989A PT 90619 A PT90619 A PT 90619A
Authority
PT
Portugal
Prior art keywords
preparation
piperazine compounds
piperazine
compounds
Prior art date
Application number
PT90619A
Other languages
English (en)
Other versions
PT90619B (pt
Inventor
Alan Naylor
Duncan Bruce Judd
Deare Sutherland Brow
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888812179A external-priority patent/GB8812179D0/en
Priority claimed from GB888820845A external-priority patent/GB8820845D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PT90619A publication Critical patent/PT90619A/pt
Publication of PT90619B publication Critical patent/PT90619B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
PT90619A 1988-05-23 1989-05-22 Processo para a preparacao de compostos de piperazina PT90619B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888812179A GB8812179D0 (en) 1988-05-23 1988-05-23 Chemical compounds
GB888820845A GB8820845D0 (en) 1988-09-05 1988-09-05 Chemical compounds

Publications (2)

Publication Number Publication Date
PT90619A true PT90619A (pt) 1989-11-30
PT90619B PT90619B (pt) 1994-10-31

Family

ID=26293920

Family Applications (1)

Application Number Title Priority Date Filing Date
PT90619A PT90619B (pt) 1988-05-23 1989-05-22 Processo para a preparacao de compostos de piperazina

Country Status (10)

Country Link
US (1) US4943578A (pt)
EP (1) EP0343900A3 (pt)
JP (1) JPH0256470A (pt)
KR (1) KR900018073A (pt)
AU (1) AU625192B2 (pt)
DK (1) DK247789A (pt)
FI (1) FI892468A (pt)
NZ (1) NZ229239A (pt)
PT (1) PT90619B (pt)
TW (1) TW199890B (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512567A (en) * 1988-08-24 1996-04-30 Sankyo Company, Limited Analgesic compounds, their preparation, and pharmaceutical compositions containing them
GB8908587D0 (en) * 1989-04-15 1989-06-01 Scras Societe De Conseils De R New 2-substituted n,n'-ditrimethoxybenzoyl piperazines
US5116842A (en) * 1989-05-18 1992-05-26 Glaxo Group Limited Chemical compounds
WO1992020661A1 (en) * 1991-05-22 1992-11-26 Merck & Co., Inc. N, n-diacylpiperazines
US5637699A (en) * 1992-06-29 1997-06-10 Merck & Co., Inc. Process for preparing morpholine tachykinin receptor antagonists
US6048859A (en) 1992-06-29 2000-04-11 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US5719147A (en) * 1992-06-29 1998-02-17 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US5387595A (en) * 1992-08-26 1995-02-07 Merck & Co., Inc. Alicyclic compounds as tachykinin receptor antagonists
US5344830A (en) * 1992-12-10 1994-09-06 Merck & Co., Inc. N,N-diacylpiperazine tachykinin antagonists
US5348955A (en) * 1993-06-22 1994-09-20 Merck & Co., Inc. N,N-diacylpiperazines
IT1273751B (it) * 1994-02-11 1997-07-10 Smithkline Beecham Farma Derivati azaciclici
US5610165A (en) * 1994-02-17 1997-03-11 Merck & Co., Inc. N-acylpiperidine tachykinin antagonists
IL112778A0 (en) * 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
US5646151A (en) * 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US6303611B1 (en) * 1996-03-08 2001-10-16 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5688797A (en) * 1996-04-26 1997-11-18 Thomas Jefferson University Treatment of acute central nervous system injury with piperazine derivatives
WO1999003459A1 (en) * 1997-07-14 1999-01-28 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
EP1140834A1 (en) * 1998-12-18 2001-10-10 Du Pont Pharmaceuticals Company Heterocyclic piperidines as modulators of chemokine receptor activity
US6677332B1 (en) 1999-05-25 2004-01-13 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US7361666B2 (en) 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6635661B2 (en) 2000-05-25 2003-10-21 Sepracor Inc. Heterocyclic analgesic compounds and methods of use thereof
WO2001068604A2 (en) 2000-03-14 2001-09-20 Sepracor, Inc. 3-substituted piperidines comprising urea functionality, and methods of use thereof
WO2001092226A1 (en) * 2000-05-25 2001-12-06 Sepracor, Inc. Heterocyclic analgesic compounds and method of use thereof
US7732451B2 (en) * 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
WO2003013571A1 (en) * 2001-08-10 2003-02-20 Palatin Technologies, Inc. Peptidomimetics of biologically active metallopeptides
US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US7456184B2 (en) * 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
US7354923B2 (en) * 2001-08-10 2008-04-08 Palatin Technologies, Inc. Piperazine melanocortin-specific compounds
US7655658B2 (en) * 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
GB0130393D0 (en) * 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
JP4499034B2 (ja) * 2003-02-19 2010-07-07 久光製薬株式会社 Ｎ−アリール又はｎ−ヘテロアリールピペラジン誘導体及びそれを含有する医薬
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
US7968548B2 (en) 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3184463A (en) * 1965-05-18 Piperazines and method of making same
GB1051328A (pt) * 1963-09-26
DE1570013B1 (de) * 1964-07-31 1970-07-02 Kyorin Seiyaku Kk 1,4-Bis-(phenoxyacetyl)-piperazinderivate und Verfahren zu ihrer Herstellung
US4579863A (en) * 1983-12-06 1986-04-01 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
US4618621A (en) * 1984-09-21 1986-10-21 The Upjohn Company Method for treating medical conditions involving cerebral ischemia
FR2592879B1 (fr) * 1986-01-13 1988-04-29 Roussel Uclaf Nouveaux derives de la decahydroquinoleine, leur procede de preparation, les intermediaires de preparation, leur application a titre de medicaments et les compositions les renfermant
CA1308352C (en) * 1986-08-15 1992-10-06 James V. Peck Compositions comprising 1-oxohydrocarbyl-substituted azacyclohexanes
JPH08776B2 (ja) * 1986-08-20 1996-01-10 日本ケミフア株式会社 脳細胞保護作用を有する医薬組成物
ES2039242T3 (es) * 1986-09-02 1993-09-16 Dr. Lo. Zambeletti S.P.A. Un procedimiento para la preparacion de nuevos derivados de piperidina.
US4705781A (en) * 1986-10-08 1987-11-10 Giba-Geigy Corporation Method of treating cerebral ischemia using 4-(phosphono substituted lower alkyl or lower alkenyl)piperazine-2-carboxylic acids and salts, esters and amides thereof
IL85700A0 (en) * 1987-03-24 1988-08-31 Takeda Chemical Industries Ltd 1,4-disubstituted piperazine compounds,their production and use

Also Published As

Publication number Publication date
AU3511989A (en) 1989-12-14
US4943578A (en) 1990-07-24
DK247789D0 (da) 1989-05-22
JPH0256470A (ja) 1990-02-26
FI892468A (fi) 1989-11-24
NZ229239A (en) 1991-06-25
EP0343900A2 (en) 1989-11-29
TW199890B (pt) 1993-02-11
AU625192B2 (en) 1992-07-02
KR900018073A (ko) 1990-12-20
EP0343900A3 (en) 1991-07-03
FI892468A0 (fi) 1989-05-22
PT90619B (pt) 1994-10-31
DK247789A (da) 1989-11-24

Similar Documents

Publication Publication Date Title
PT90619A (pt) Processo para a preparacao de compostos de piperazina
PT92534A (pt) Processo para a preparacao de compostos azabiciclicos
PT93785A (pt) Processo para a preparacao de derivados de 3-substituido-2-oxindole
PT91068A (pt) Processo para a preparacao de compostos biarilo
PT89264A (pt) Processo para a preparacao de compostos azabiciclicos
PT83152B (pt) Processo para a preparacao de compostos di-t-butilfenoicos
PT90293A (pt) Processo para a preparacao de macrolidos
PT82062B (pt) Processo para a preparacao de compostos piridinilimidazolidinona
PT91895A (pt) Processo para a preparacao de 9h-purinas substituidas
PT92786A (pt) Processo para a preparacao de compostos de tiazol
PT91872A (pt) Processo para a preparacao de compostos azabiciclicos
BR8601962A (pt) Processo para a preparacao de compostos
PT90266A (pt) Processo para a preparacao de compostos azabiciclicos
BR8906327A (pt) Processo para a preparacao de organoclorossilanos
PT90854A (pt) Processo para a preparacao de 1-aril-2-naftoilaminas
PT92638A (pt) Processo para a preparacao de poliazamacrociclos mono-n-alquilados
PT82678B (pt) Processo para a preparacao de compostos de cinolina
PT93629A (pt) Processo para a preparacao de derivados de tieno-triazolo-diazepina
PT89775A (pt) Processo para a preparacao de derivados de isoquinolina
PT91027A (pt) Processo para a preparacao de derivados peptidicos
PT92539A (pt) Processo para a preparacao de derivados de anfotericina b
BR8903367A (pt) Processo para a preparacao de organoclorossilanos
PT94890A (pt) Processo para a preparacao de compostos azofenilicos
PT99249A (pt) Processo para a preparacao de derivados de piperazina
BR8902030A (pt) Processo para a preparacao de n-fosfonometilglicina

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19940408

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19951031