PT90464A - Processo de preparacao de derivados da guanina imuno-estimulantes e de composicoes farmaceuticas que os contem - Google Patents
Processo de preparacao de derivados da guanina imuno-estimulantes e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT90464A PT90464A PT90464A PT9046489A PT90464A PT 90464 A PT90464 A PT 90464A PT 90464 A PT90464 A PT 90464A PT 9046489 A PT9046489 A PT 9046489A PT 90464 A PT90464 A PT 90464A
- Authority
- PT
- Portugal
- Prior art keywords
- derivatives
- guanina
- stimulants
- immuno
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/190,694 US5093318A (en) | 1983-11-01 | 1988-05-05 | Immunostimulating guanosine derivatives and their pharmaceutical compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
PT90464A true PT90464A (pt) | 1989-11-30 |
PT90464B PT90464B (pt) | 1994-12-30 |
Family
ID=22702383
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT90464A PT90464B (pt) | 1988-05-05 | 1989-05-04 | Processo de preparacao de derivados da guanina imuno-estimulantes e de composicoes farmaceuticas que os contem |
Country Status (12)
Country | Link |
---|---|
US (1) | US5093318A (pt) |
EP (1) | EP0341066B1 (pt) |
JP (1) | JP2790846B2 (pt) |
AT (1) | ATE113957T1 (pt) |
AU (1) | AU619539B2 (pt) |
CA (1) | CA1320196C (pt) |
DE (1) | DE68919266T2 (pt) |
DK (1) | DK170780B1 (pt) |
ES (1) | ES2063125T3 (pt) |
GR (1) | GR3015018T3 (pt) |
IE (1) | IE66321B1 (pt) |
PT (1) | PT90464B (pt) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5011828A (en) * | 1985-11-15 | 1991-04-30 | Michael Goodman | Immunostimulating guanine derivatives, compositions and methods |
US6060459A (en) * | 1987-10-28 | 2000-05-09 | Pro-Neuron, Inc. | Enhancing blood cell count with oxypurine nucleosides |
IE882585L (en) * | 1988-08-25 | 1990-02-25 | Prendergast Patrick T | Viral treatment system |
AU5165793A (en) * | 1992-10-01 | 1994-04-26 | Mcneilab, Inc. | Derivatives of 7,8-disubstituted guanosines |
US6727230B1 (en) * | 1994-03-25 | 2004-04-27 | Coley Pharmaceutical Group, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
US5786359A (en) * | 1994-05-27 | 1998-07-28 | The Scripps Research Institute | N9 alkyl or aralkyl derivatives of 7, 8-disubstituted guanines |
US5382580A (en) * | 1994-05-27 | 1995-01-17 | The Scripps Research Institute | N9 morpholino derivatives of 7,8-disubstituted guanines |
US5441942A (en) * | 1994-05-27 | 1995-08-15 | The Scripps Research Institute | 2'3'-dideoxy-2',3'-didehydro-7,8-disubstituted guanosines and their immunostimulative effect |
US6338963B1 (en) | 1994-07-25 | 2002-01-15 | Neotherapeutics, Inc. | Use of carbon monoxide dependent guanylyl cyclase modifiers to stimulate neuritogenesis |
US5773424A (en) * | 1994-12-16 | 1998-06-30 | Research Corporation Technologies, Inc. | Treatment of toxoplasmosis |
US20030100520A1 (en) * | 1997-01-21 | 2003-05-29 | Philip Needleman | Immunological process and constructs for increasing the hdl cholesterol concentration by dna vaccination |
WO1999057120A1 (en) | 1998-05-04 | 1999-11-11 | Neotherapeutics, Inc. | Novel serotonin-like 9-substituted hypoxanthine and methods of use |
AU4244400A (en) | 1999-04-15 | 2000-11-02 | Board Of Regents, The University Of Texas System | Ppgpp and pppgpp as immunomodulatory agents |
US6949520B1 (en) * | 1999-09-27 | 2005-09-27 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
US6288069B1 (en) | 1999-11-16 | 2001-09-11 | Neotherapeutics, Inc. | Use of 9-substituted hypoxanthine derivatives to stimulate regeneration of nervous tissue |
CA2396871A1 (en) * | 2000-01-20 | 2001-12-20 | Ottawa Health Research Institute | Immunostimulatory nucleic acids for inducing a th2 immune response |
US7585847B2 (en) * | 2000-02-03 | 2009-09-08 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for the treatment of asthma and allergy |
US6407237B1 (en) | 2001-02-21 | 2002-06-18 | Neotherapeutics, Inc. | Crystal forms of 9-substituted hypoxanthine derivatives |
US6849735B1 (en) | 2000-06-23 | 2005-02-01 | Merck Eprova Ag | Methods of synthesis for 9-substituted hypoxanthine derivatives |
AU2001271908A1 (en) | 2000-07-07 | 2002-01-21 | Neotherapeutics, Inc. | Methods for treatment of disease-induced peripheral neuropathy and related conditions |
US20030138769A1 (en) * | 2000-08-16 | 2003-07-24 | Birkett Ashley J. | Immunogenic HBc chimer particles having enhanced stability |
AU2001297693A1 (en) * | 2000-12-08 | 2002-09-12 | Coley Pharmaceutical Gmbh | Cpg-like nucleic acids and methods of use thereof |
US6759427B2 (en) * | 2001-04-20 | 2004-07-06 | Spectrum Pharmaceuticals, Inc. | Synthesis and methods of use of tetrahydroindolone analogues and derivatives |
US20030055249A1 (en) * | 2001-07-17 | 2003-03-20 | Fick David B. | Synthesis and methods of use of pyrimidine analogues and derivatives |
US20030175863A1 (en) * | 2001-08-15 | 2003-09-18 | Birkett Ashley J. | Influenza immunogen and vaccine |
US20030185858A1 (en) * | 2001-08-15 | 2003-10-02 | Birkett Ashley J. | Immunogenic HBc chimer particles stabilized with an N-terminal cysteine |
US7361352B2 (en) | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
US7351413B2 (en) * | 2002-02-21 | 2008-04-01 | Lorantis, Limited | Stabilized HBc chimer particles as immunogens for chronic hepatitis |
WO2004087203A2 (en) * | 2003-04-02 | 2004-10-14 | Coley Pharmaceutical Group, Ltd. | Immunostimulatory nucleic acid oil-in-water formulations for topical application |
BRPI0616385A2 (pt) * | 2005-09-22 | 2011-06-21 | Hoffmann La Roche | o-acilação seletiva de nucleosìdeos |
DK2173376T3 (en) * | 2007-08-02 | 2015-06-29 | Biondvax Pharmaceuticals Ltd | Multimeric multi-epitope influenza vaccines |
CA2744739A1 (en) | 2007-12-03 | 2009-06-11 | President And Fellows Of Harvard College | Chlamydia antigens |
BRPI0922132A2 (pt) | 2008-12-03 | 2018-10-23 | Protea Vaccine Tech Ltd | fragmentos glutamil trna sintetase (gts). |
WO2011067758A2 (en) | 2009-12-02 | 2011-06-09 | Protea Vaccine Technologies Ltd. | Immunogenic fragments and multimers from streptococcus pneumoniae proteins |
CA2828068C (en) | 2011-02-22 | 2019-03-19 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines |
EP2833900B1 (en) | 2012-04-01 | 2018-09-19 | Technion Research & Development Foundation Limited | Extracellular matrix metalloproteinase inducer (emmprin) peptides and binding antibodies |
AU2015242154B2 (en) | 2014-04-03 | 2019-04-04 | Biondvax Pharmaceuticals Ltd. | Compositions of multimeric-multiepitope influenza polypeptides and their production |
CR20200649A (es) | 2018-05-25 | 2021-05-11 | Primmune Therapeutics Inc | Agosnistas de tlr7 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4643992A (en) * | 1982-11-09 | 1987-02-17 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
US4539205A (en) * | 1982-11-09 | 1985-09-03 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
US4948730A (en) * | 1982-11-09 | 1990-08-14 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
US5011828A (en) * | 1985-11-15 | 1991-04-30 | Michael Goodman | Immunostimulating guanine derivatives, compositions and methods |
-
1988
- 1988-05-05 US US07/190,694 patent/US5093318A/en not_active Expired - Lifetime
-
1989
- 1989-05-03 AU AU33999/89A patent/AU619539B2/en not_active Ceased
- 1989-05-03 DK DK217289A patent/DK170780B1/da not_active IP Right Cessation
- 1989-05-04 IE IE146389A patent/IE66321B1/en not_active IP Right Cessation
- 1989-05-04 DE DE68919266T patent/DE68919266T2/de not_active Expired - Fee Related
- 1989-05-04 PT PT90464A patent/PT90464B/pt not_active IP Right Cessation
- 1989-05-04 CA CA000598688A patent/CA1320196C/en not_active Expired - Fee Related
- 1989-05-04 ES ES89304511T patent/ES2063125T3/es not_active Expired - Lifetime
- 1989-05-04 AT AT89304511T patent/ATE113957T1/de not_active IP Right Cessation
- 1989-05-04 EP EP89304511A patent/EP0341066B1/en not_active Expired - Lifetime
- 1989-05-06 JP JP1113992A patent/JP2790846B2/ja not_active Expired - Fee Related
-
1995
- 1995-02-08 GR GR950400261T patent/GR3015018T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0341066A2 (en) | 1989-11-08 |
DE68919266T2 (de) | 1995-06-01 |
IE891463L (en) | 1989-11-05 |
DK170780B1 (da) | 1996-01-15 |
DK217289D0 (da) | 1989-05-03 |
PT90464B (pt) | 1994-12-30 |
US5093318A (en) | 1992-03-03 |
ES2063125T3 (es) | 1995-01-01 |
EP0341066B1 (en) | 1994-11-09 |
DE68919266D1 (de) | 1994-12-15 |
JP2790846B2 (ja) | 1998-08-27 |
AU619539B2 (en) | 1992-01-30 |
IE66321B1 (en) | 1995-12-27 |
DK217289A (da) | 1989-11-06 |
JPH0256496A (ja) | 1990-02-26 |
CA1320196C (en) | 1993-07-13 |
AU3399989A (en) | 1989-11-09 |
GR3015018T3 (en) | 1995-05-31 |
EP0341066A3 (en) | 1990-05-30 |
ATE113957T1 (de) | 1994-11-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG3A | Patent granted, date of granting |
Effective date: 19940608 |
|
MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20081209 |
|
MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20090608 |