ES2063125T3 - Derivados de guanina inmunoestimulantes: composiciones y procedimientos. - Google Patents

Derivados de guanina inmunoestimulantes: composiciones y procedimientos.

Info

Publication number
ES2063125T3
ES2063125T3 ES89304511T ES89304511T ES2063125T3 ES 2063125 T3 ES2063125 T3 ES 2063125T3 ES 89304511 T ES89304511 T ES 89304511T ES 89304511 T ES89304511 T ES 89304511T ES 2063125 T3 ES2063125 T3 ES 2063125T3
Authority
ES
Spain
Prior art keywords
compositions
stimulant
immuno
procedures
guanine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89304511T
Other languages
English (en)
Inventor
Michael Goodman
Robert Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Clinic and Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic and Research Foundation filed Critical Scripps Clinic and Research Foundation
Application granted granted Critical
Publication of ES2063125T3 publication Critical patent/ES2063125T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A DERIVADOS 7,8 - DISUSTITUIDOS DEL NUCLEOSIDO GUANOSINA QUE SON AGENTES POTENTES QUE MEJORAN LA RESPUESTA INMUNE EN CELULAS HUMANAS Y ANIMALES. LOS SUSTITUYENTES EN LA POSICION 7 SON RADICALES HIDROCARBILO SUSTITUIDOS CON UN HETEROATOMO Y TIENEN UNA LONGITUD MAYOR QUE LA DEL ETILO Y MENOR QUE LA DEL DECILO. LOS SUSTITUYENTES EN LA POSICION 8 SON = O, = S, = SE Y = NCN. TAMBIEN SE REFIERE LA INVENCION A COMPOSICIONES QUE CONTIENEN ESTOS DERIVADOS Y A METODOS PARA SU EMPLEO.
ES89304511T 1988-05-05 1989-05-04 Derivados de guanina inmunoestimulantes: composiciones y procedimientos. Expired - Lifetime ES2063125T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/190,694 US5093318A (en) 1983-11-01 1988-05-05 Immunostimulating guanosine derivatives and their pharmaceutical compositions

Publications (1)

Publication Number Publication Date
ES2063125T3 true ES2063125T3 (es) 1995-01-01

Family

ID=22702383

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89304511T Expired - Lifetime ES2063125T3 (es) 1988-05-05 1989-05-04 Derivados de guanina inmunoestimulantes: composiciones y procedimientos.

Country Status (12)

Country Link
US (1) US5093318A (es)
EP (1) EP0341066B1 (es)
JP (1) JP2790846B2 (es)
AT (1) ATE113957T1 (es)
AU (1) AU619539B2 (es)
CA (1) CA1320196C (es)
DE (1) DE68919266T2 (es)
DK (1) DK170780B1 (es)
ES (1) ES2063125T3 (es)
GR (1) GR3015018T3 (es)
IE (1) IE66321B1 (es)
PT (1) PT90464B (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011828A (en) * 1985-11-15 1991-04-30 Michael Goodman Immunostimulating guanine derivatives, compositions and methods
US7307166B1 (en) 1987-10-28 2007-12-11 Wellstat Therapeutics Corporation Oxpurine nucleosides and their congeners, and acyl, derivatives thereof, for improvement of hematopoiesis
IE882585L (en) * 1988-08-25 1990-02-25 Prendergast Patrick T Viral treatment system
WO1994007904A1 (en) * 1992-10-01 1994-04-14 Mcneilab, Inc. Derivatives of 7,8-disubstituted guanosines
US6727230B1 (en) * 1994-03-25 2004-04-27 Coley Pharmaceutical Group, Inc. Immune stimulation by phosphorothioate oligonucleotide analogs
US5786359A (en) * 1994-05-27 1998-07-28 The Scripps Research Institute N9 alkyl or aralkyl derivatives of 7, 8-disubstituted guanines
US5382580A (en) * 1994-05-27 1995-01-17 The Scripps Research Institute N9 morpholino derivatives of 7,8-disubstituted guanines
US5441942A (en) * 1994-05-27 1995-08-15 The Scripps Research Institute 2'3'-dideoxy-2',3'-didehydro-7,8-disubstituted guanosines and their immunostimulative effect
US6338963B1 (en) 1994-07-25 2002-01-15 Neotherapeutics, Inc. Use of carbon monoxide dependent guanylyl cyclase modifiers to stimulate neuritogenesis
US5773424A (en) * 1994-12-16 1998-06-30 Research Corporation Technologies, Inc. Treatment of toxoplasmosis
US20030100520A1 (en) * 1997-01-21 2003-05-29 Philip Needleman Immunological process and constructs for increasing the hdl cholesterol concentration by dna vaccination
AU3786299A (en) 1998-05-04 1999-11-23 Neotherapeutics, Inc. Novel serotonin-like 9-substituted hypoxanthine and methods of use
WO2000062803A2 (en) * 1999-04-15 2000-10-26 Board Of Regents, The University Of Texas System ppGpp AND pppGpp AS IMMUNOMODULATORY AGENTS
US6949520B1 (en) * 1999-09-27 2005-09-27 Coley Pharmaceutical Group, Inc. Methods related to immunostimulatory nucleic acid-induced interferon
US6288069B1 (en) 1999-11-16 2001-09-11 Neotherapeutics, Inc. Use of 9-substituted hypoxanthine derivatives to stimulate regeneration of nervous tissue
CA2396871A1 (en) * 2000-01-20 2001-12-20 Ottawa Health Research Institute Immunostimulatory nucleic acids for inducing a th2 immune response
US7585847B2 (en) * 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
US6407237B1 (en) 2001-02-21 2002-06-18 Neotherapeutics, Inc. Crystal forms of 9-substituted hypoxanthine derivatives
US6849735B1 (en) 2000-06-23 2005-02-01 Merck Eprova Ag Methods of synthesis for 9-substituted hypoxanthine derivatives
WO2002004452A2 (en) 2000-07-07 2002-01-17 Neotherapeutics, Inc. Methods for treatment of disease-induced peripheral neuropathy and related conditions
US20030138769A1 (en) * 2000-08-16 2003-07-24 Birkett Ashley J. Immunogenic HBc chimer particles having enhanced stability
DE60134421D1 (de) * 2000-12-08 2008-07-24 Coley Pharmaceuticals Gmbh Cpg-artige nukleinsäuren und verfahren zu ihrer verwendung
US6759427B2 (en) * 2001-04-20 2004-07-06 Spectrum Pharmaceuticals, Inc. Synthesis and methods of use of tetrahydroindolone analogues and derivatives
US20030055249A1 (en) * 2001-07-17 2003-03-20 Fick David B. Synthesis and methods of use of pyrimidine analogues and derivatives
US7361352B2 (en) * 2001-08-15 2008-04-22 Acambis, Inc. Influenza immunogen and vaccine
US20030175863A1 (en) * 2001-08-15 2003-09-18 Birkett Ashley J. Influenza immunogen and vaccine
US20030185858A1 (en) * 2001-08-15 2003-10-02 Birkett Ashley J. Immunogenic HBc chimer particles stabilized with an N-terminal cysteine
US7351413B2 (en) * 2002-02-21 2008-04-01 Lorantis, Limited Stabilized HBc chimer particles as immunogens for chronic hepatitis
WO2004087203A2 (en) * 2003-04-02 2004-10-14 Coley Pharmaceutical Group, Ltd. Immunostimulatory nucleic acid oil-in-water formulations for topical application
CA2622191A1 (en) * 2005-09-22 2008-03-11 Keshab Sarma Selective o-acylation of nucleosides
HUE025149T2 (hu) * 2007-08-02 2016-01-28 Biondvax Pharmaceuticals Ltd Multimer multiepitóp influenza vakcinák
AU2008331800A1 (en) 2007-12-03 2009-06-11 President And Fellows Of Harvard College Chlamydia antigens
WO2010064243A1 (en) 2008-12-03 2010-06-10 Protea Vaccine Technologies Ltd. GLUTAMYL tRNA SYNTHETASE (GtS) FRAGMENTS
WO2011067758A2 (en) 2009-12-02 2011-06-09 Protea Vaccine Technologies Ltd. Immunogenic fragments and multimers from streptococcus pneumoniae proteins
WO2012114323A1 (en) 2011-02-22 2012-08-30 Biondvax Pharmaceuticals Ltd. Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines
EP3492095A1 (en) 2012-04-01 2019-06-05 Technion Research & Development Foundation Limited Extracellular matrix metalloproteinase inducer (emmprin) peptides and binding antibodies
WO2015151103A1 (en) 2014-04-03 2015-10-08 Biondvax Pharmaceuticals Ltd. Compositions of multimeric-multiepitope influenza polypeptides and their production
SG11202011667WA (en) 2018-05-25 2020-12-30 Primmune Therapeutics Inc Tlr7 agonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4539205A (en) * 1982-11-09 1985-09-03 Scripps Clinic And Research Foundation Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
US4643992A (en) * 1982-11-09 1987-02-17 Scripps Clinic And Research Foundation Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
US4948730A (en) * 1982-11-09 1990-08-14 Scripps Clinic And Research Foundation Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
US5011828A (en) * 1985-11-15 1991-04-30 Michael Goodman Immunostimulating guanine derivatives, compositions and methods

Also Published As

Publication number Publication date
DE68919266D1 (de) 1994-12-15
EP0341066A2 (en) 1989-11-08
IE891463L (en) 1989-11-05
GR3015018T3 (en) 1995-05-31
CA1320196C (en) 1993-07-13
IE66321B1 (en) 1995-12-27
PT90464B (pt) 1994-12-30
AU3399989A (en) 1989-11-09
US5093318A (en) 1992-03-03
JP2790846B2 (ja) 1998-08-27
EP0341066A3 (en) 1990-05-30
EP0341066B1 (en) 1994-11-09
DK170780B1 (da) 1996-01-15
DE68919266T2 (de) 1995-06-01
ATE113957T1 (de) 1994-11-15
AU619539B2 (en) 1992-01-30
DK217289A (da) 1989-11-06
JPH0256496A (ja) 1990-02-26
DK217289D0 (da) 1989-05-03
PT90464A (pt) 1989-11-30

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